PE20090213A1 - Agonistas del receptor acoplado a la proteina g gpr119 [6,5]-biciclicos - Google Patents
Agonistas del receptor acoplado a la proteina g gpr119 [6,5]-biciclicosInfo
- Publication number
- PE20090213A1 PE20090213A1 PE2008000776A PE2008000776A PE20090213A1 PE 20090213 A1 PE20090213 A1 PE 20090213A1 PE 2008000776 A PE2008000776 A PE 2008000776A PE 2008000776 A PE2008000776 A PE 2008000776A PE 20090213 A1 PE20090213 A1 PE 20090213A1
- Authority
- PE
- Peru
- Prior art keywords
- cr9r9
- aryl
- gpr119
- protein
- agonists
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Abstract
SE REFIERE A COMPUESTOS DE FORMULA I, DONDE A, B Y D SON CR4b O N, CON LA CONDICION DE QUE AL MENOS UNO DE A, B O D ES N; E ES CR9R9, CR9, O, N Y NH; G ES CH O N; J ES CR9R9, CR9, C=O, C=S O N; LA LINEA DE PUNTOS REPRESENTA UN ENLACE DOBLE OPCIONAL, CON LA CONDICION QUE J NO ES C=O, C=S O CR9R9 CUANDO UN ENLACE DOBLE SE PRESENTA; Y ES -NR3, O U S; n2 Y n3 SON DE 0 A 2; n4 ES DE 0 A 3; R1 ES ARILO O HETEROARILO(C6-C10); R2 ES -C(=O)R5, ARILO(C6-C10); OXADIAZOLILO, ENTRE OTROS; R3 ES H, ALQUILO(C1-C4), ALCOXI, ENTRE OTROS; R4b ES H, -NH2, -C(=O)OH, -P(O)3H2, ENTRE OTROS; R5 Y R9 SON INDEPENDIENTEMENTE ALQUILO(C1-C6), ARILO(C6-C10), CICLOALQUILO(C3-C6), ENTRE OTROS. SON SELECCIONADOS 4-(4-(2-FLUORO-4-(METILSULFONIL)FENILAMINO)-1H-[1,2,3]TRIAZOLO[4,5-c]PIRIDIN-1-IL)PIPERIDIN-1-CARBOXILATO DE TERT-BUTILO, (4-(4-(2-CIANOPIRIDIN-3-ILOXI)-1H-PIRAZOLO[3,4-d]PIRIMIDIN-1-IL)PIPERIDIN-1-CARBOXILATO DE ISOPROPILO, ENTRE OTROS. SE REFIERE TAMBIEN A UN PROCEDIMIENTO DE PREPARACION Y COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON MODULADORES DEL RECEPTOR QUE ACOPLA LA PROTEINA G GPR119 UTILES EN EL TRATAMIENTO Y/O PREVENCION DE HIPERGLICEMIA, DIABETES, ATEROSCLEROSIS, ABESIDAD, HIPERTENSION, DETERIORO COGNITIVO, ENTRE OTROS
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US91595207P | 2007-05-04 | 2007-05-04 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20090213A1 true PE20090213A1 (es) | 2009-02-28 |
Family
ID=39691096
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2008000776A PE20090213A1 (es) | 2007-05-04 | 2008-04-30 | Agonistas del receptor acoplado a la proteina g gpr119 [6,5]-biciclicos |
Country Status (10)
Country | Link |
---|---|
US (2) | US8093257B2 (es) |
EP (1) | EP2152707B1 (es) |
JP (1) | JP2010526146A (es) |
CN (1) | CN101668759A (es) |
AR (1) | AR066438A1 (es) |
CL (1) | CL2008001270A1 (es) |
ES (1) | ES2388315T3 (es) |
PE (1) | PE20090213A1 (es) |
TW (1) | TW200848047A (es) |
WO (1) | WO2008137436A1 (es) |
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JP2010526145A (ja) | 2007-05-04 | 2010-07-29 | ブリストル−マイヤーズ スクイブ カンパニー | [6,6]および[6,7]−二環式gpr119gタンパク質結合受容体アゴニスト |
PL2173737T3 (pl) * | 2007-07-17 | 2012-06-29 | Bristol Myers Squibb Co | Sposób modulowania receptora GPR119 sprzężonego z białkiem G i wybrane związki |
KR20100033419A (ko) | 2007-07-19 | 2010-03-29 | 메타볼렉스, 인코포레이티드 | 당뇨병 및 대사 장애의 치료를 위한 rup3 또는 gpr119 수용체의 작용제로서 n-아자시클릭 치환된 피롤, 피라졸, 이미다졸, 트리아졸 및 테트라졸 유도체 |
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WO2004076413A2 (en) | 2003-02-24 | 2004-09-10 | Arena Pharmaceuticals, Inc. | Phenyl- and pyridylpiperidine-derivatives as modulators of glucose metabolism |
SE0301010D0 (sv) | 2003-04-07 | 2003-04-07 | Astrazeneca Ab | Novel compounds |
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ATE519495T1 (de) | 2004-03-17 | 2011-08-15 | 7Tm Pharma As | Y4-selektiver rezeptoragonist pp2-36 für therapeutische eingriffe |
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MY148521A (en) | 2005-01-10 | 2013-04-30 | Arena Pharm Inc | Substituted pyridinyl and pyrimidinyl derivatives as modulators of metabolism and the treatment of disorders related thereto |
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-
2008
- 2008-04-30 EP EP08747131A patent/EP2152707B1/en not_active Not-in-force
- 2008-04-30 CN CN200880013802A patent/CN101668759A/zh active Pending
- 2008-04-30 PE PE2008000776A patent/PE20090213A1/es not_active Application Discontinuation
- 2008-04-30 WO PCT/US2008/061930 patent/WO2008137436A1/en active Application Filing
- 2008-04-30 US US12/112,053 patent/US8093257B2/en active Active
- 2008-04-30 ES ES08747131T patent/ES2388315T3/es active Active
- 2008-04-30 JP JP2010507529A patent/JP2010526146A/ja not_active Withdrawn
- 2008-05-02 TW TW097116366A patent/TW200848047A/zh unknown
- 2008-05-02 AR ARP080101888A patent/AR066438A1/es not_active Application Discontinuation
- 2008-05-02 CL CL200801270A patent/CL2008001270A1/es unknown
-
2011
- 2011-11-30 US US13/307,698 patent/US8476283B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
EP2152707B1 (en) | 2012-06-20 |
US20090018055A1 (en) | 2009-01-15 |
AR066438A1 (es) | 2009-08-19 |
ES2388315T3 (es) | 2012-10-11 |
JP2010526146A (ja) | 2010-07-29 |
US8476283B2 (en) | 2013-07-02 |
TW200848047A (en) | 2008-12-16 |
US20120077826A1 (en) | 2012-03-29 |
US8093257B2 (en) | 2012-01-10 |
EP2152707A1 (en) | 2010-02-17 |
WO2008137436A1 (en) | 2008-11-13 |
CN101668759A (zh) | 2010-03-10 |
CL2008001270A1 (es) | 2008-09-12 |
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