EA200800834A1 - Модуляторы метаболизма и лечение связанных с ним нарушений - Google Patents

Модуляторы метаболизма и лечение связанных с ним нарушений

Info

Publication number
EA200800834A1
EA200800834A1 EA200800834A EA200800834A EA200800834A1 EA 200800834 A1 EA200800834 A1 EA 200800834A1 EA 200800834 A EA200800834 A EA 200800834A EA 200800834 A EA200800834 A EA 200800834A EA 200800834 A1 EA200800834 A1 EA 200800834A1
Authority
EA
Eurasian Patent Office
Prior art keywords
treatment
metabolism modulators
yloxy
methyl
modulators
Prior art date
Application number
EA200800834A
Other languages
English (en)
Other versions
EA013084B1 (ru
Inventor
Роберт М. Джонс
Юэрг Леманн
Original Assignee
Арена Фармасьютикалз, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37845245&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA200800834(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Арена Фармасьютикалз, Инк. filed Critical Арена Фармасьютикалз, Инк.
Publication of EA200800834A1 publication Critical patent/EA200800834A1/ru
Publication of EA013084B1 publication Critical patent/EA013084B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Настоящее изобретение относится к изопропиловому эфиру 4-[5-метил-6-(2-метилпиридин-3-илокси)пиримидин-4-илокси]пиперидин-1-карбоновой кислоты, его фармацевтически приемлемым солям, сольватам и гидратам, которые являются модуляторами метаболизма глюкозы. В соответствии с этим соединения по настоящему изобретению применимы в лечении связанных с метаболизмом нарушений и как следствие осложнений, таких как диабет и ожирение.
EA200800834A 2005-09-16 2006-09-14 Модуляторы метаболизма и лечение связанных с ним нарушений EA013084B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US71801505P 2005-09-16 2005-09-16
PCT/US2006/035651 WO2007035355A2 (en) 2005-09-16 2006-09-14 Modulators of metabolism and the treatment of disorders related thereto

Publications (2)

Publication Number Publication Date
EA200800834A1 true EA200800834A1 (ru) 2008-08-29
EA013084B1 EA013084B1 (ru) 2010-02-26

Family

ID=37845245

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200800834A EA013084B1 (ru) 2005-09-16 2006-09-14 Модуляторы метаболизма и лечение связанных с ним нарушений

Country Status (26)

Country Link
US (1) US20100160359A1 (ru)
EP (1) EP1931654B1 (ru)
JP (1) JP2009508861A (ru)
KR (1) KR20080044296A (ru)
CN (1) CN101263135A (ru)
AT (1) ATE429430T1 (ru)
AU (1) AU2006292620A1 (ru)
BR (1) BRPI0616245A2 (ru)
CA (1) CA2619093A1 (ru)
DE (1) DE602006006461D1 (ru)
DK (1) DK1931654T3 (ru)
EA (1) EA013084B1 (ru)
EC (1) ECSP088281A (ru)
ES (1) ES2326391T3 (ru)
GE (1) GEP20104966B (ru)
HK (1) HK1112908A1 (ru)
IL (1) IL189490A0 (ru)
MA (1) MA29860B1 (ru)
MX (1) MX2008003634A (ru)
NI (1) NI200800078A (ru)
NO (1) NO20081810L (ru)
NZ (1) NZ565898A (ru)
RS (1) RS20080112A (ru)
TN (1) TNSN08097A1 (ru)
WO (1) WO2007035355A2 (ru)
ZA (1) ZA200801704B (ru)

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NO20081810L (no) 2008-04-14
EA013084B1 (ru) 2010-02-26
JP2009508861A (ja) 2009-03-05
BRPI0616245A2 (pt) 2011-06-14
US20100160359A1 (en) 2010-06-24
EP1931654B1 (en) 2009-04-22
AU2006292620A1 (en) 2007-03-29
MA29860B1 (fr) 2008-10-03
EP1931654A2 (en) 2008-06-18
ATE429430T1 (de) 2009-05-15
HK1112908A1 (en) 2008-09-19
CA2619093A1 (en) 2007-03-29
NZ565898A (en) 2010-07-30
NI200800078A (es) 2009-03-03
ZA200801704B (en) 2008-11-26
ECSP088281A (es) 2008-04-28
WO2007035355A2 (en) 2007-03-29
RS20080112A (en) 2009-05-06
CN101263135A (zh) 2008-09-10
ES2326391T3 (es) 2009-10-08
DE602006006461D1 (de) 2009-06-04
MX2008003634A (es) 2009-10-08
WO2007035355A3 (en) 2007-06-21
IL189490A0 (en) 2008-08-07
DK1931654T3 (da) 2009-07-27
TNSN08097A1 (en) 2009-07-14

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