PE20090362A1 - Derivados de piperidina/piperazina como moduladores de dgat - Google Patents
Derivados de piperidina/piperazina como moduladores de dgatInfo
- Publication number
- PE20090362A1 PE20090362A1 PE2008000972A PE2008000972A PE20090362A1 PE 20090362 A1 PE20090362 A1 PE 20090362A1 PE 2008000972 A PE2008000972 A PE 2008000972A PE 2008000972 A PE2008000972 A PE 2008000972A PE 20090362 A1 PE20090362 A1 PE 20090362A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- dgat
- piperidine
- nrx
- modulators
- Prior art date
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- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
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- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
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- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/04—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
- C07D317/58—Radicals substituted by nitrogen atoms
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- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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Abstract
REFERIDA A UN DERIVADO DE PIPERIDINA O PIPERAZINA DE FORMULA (I), DONDE A ES CH O N; LA LINEA PUNTEADA REPRESENTA UN ENLACE; X ES C(=O), O-C(=O), C(=O)-C(=O), ENTRE OTROS; Y ES NRx-C(=O)-Z2, NRx-C(=O)-Z2-O, NRx-C(=O)-Z2-O-C(=O), ENTRE OTROS; Z2 ES ALCANDIILO C1-C6, ALQUENDIILO C2-C6, ALQUINDIILO C2-C6, ENTRE OTROS; Rx ES H O LAQUILO C1-C4; R1 ES ALQUILO C1-C12, ALQUILOXI C1-C4, ALQUENILO C2-C6, ENTRE OTROS; R2 ES H, ALQUILO C1-C12, ALQUENILO C2-C6. SON COMPUESTOS PREFERIDOS: (a), (b), ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA Y A UN PROCEDIMIENTO DE PREPARACION. DICHOS COMPUESTOS INHIBEN LA ENZIMA DIACILGLICEROL ACILTRANSFERASA (DGAT) Y SON UTILES EN EL TRATAMIENTO DE LA ENFERMEDAD DE PARKINSON, DE ALZHEIMER, APOPLEJIA, ENTRE OTROS
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EP07109868 | 2007-06-08 | ||
EP07115805 | 2007-09-06 |
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US (1) | US8981094B2 (es) |
EP (1) | EP2152270B1 (es) |
JP (1) | JP5385263B2 (es) |
CN (1) | CN101678019B (es) |
AR (1) | AR066911A1 (es) |
AU (1) | AU2008258487B2 (es) |
BR (1) | BRPI0813331A2 (es) |
CA (1) | CA2687754C (es) |
CL (1) | CL2008001671A1 (es) |
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MX (1) | MX2009013335A (es) |
PA (1) | PA8783601A1 (es) |
PE (1) | PE20090362A1 (es) |
RU (1) | RU2470017C2 (es) |
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- 2008-06-06 AU AU2008258487A patent/AU2008258487B2/en not_active Ceased
- 2008-06-06 TW TW097121019A patent/TWI426070B/zh not_active IP Right Cessation
- 2008-06-06 ES ES08760634.9T patent/ES2536406T3/es active Active
- 2008-06-06 EP EP08760634.9A patent/EP2152270B1/en active Active
- 2008-06-06 WO PCT/EP2008/057060 patent/WO2008148868A1/en active Application Filing
- 2008-06-06 CA CA2687754A patent/CA2687754C/en active Active
- 2008-06-06 PE PE2008000972A patent/PE20090362A1/es not_active Application Discontinuation
- 2008-06-06 PA PA20088783601A patent/PA8783601A1/es unknown
- 2008-06-06 CN CN200880019198.0A patent/CN101678019B/zh active Active
Also Published As
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WO2008148868A1 (en) | 2008-12-11 |
CN101678019B (zh) | 2016-03-30 |
US20100190789A1 (en) | 2010-07-29 |
EP2152270A1 (en) | 2010-02-17 |
BRPI0813331A2 (pt) | 2014-12-23 |
US8981094B2 (en) | 2015-03-17 |
CL2008001671A1 (es) | 2009-07-17 |
AU2008258487A1 (en) | 2008-12-11 |
JP5385263B2 (ja) | 2014-01-08 |
CN101678019A (zh) | 2010-03-24 |
RU2009148320A (ru) | 2011-07-20 |
AR066911A1 (es) | 2009-09-23 |
TWI426070B (zh) | 2014-02-11 |
CA2687754C (en) | 2015-12-08 |
PA8783601A1 (es) | 2009-01-23 |
ES2536406T3 (es) | 2015-05-25 |
RU2470017C2 (ru) | 2012-12-20 |
MX2009013335A (es) | 2010-01-20 |
EP2152270B1 (en) | 2015-03-04 |
AU2008258487B2 (en) | 2012-11-15 |
JP2010529089A (ja) | 2010-08-26 |
WO2008148868A8 (en) | 2009-03-05 |
TW200911771A (en) | 2009-03-16 |
CA2687754A1 (en) | 2008-12-11 |
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