CL2008001671A1 - Compuestos derivados de piperidina/piperazina inhibidores de dgat1, composicion farmaceutica que los comprende; y su uso en el tratamiento de enfermedades metabolicas especialmente diabetes. - Google Patents
Compuestos derivados de piperidina/piperazina inhibidores de dgat1, composicion farmaceutica que los comprende; y su uso en el tratamiento de enfermedades metabolicas especialmente diabetes.Info
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- CL2008001671A1 CL2008001671A1 CL2008001671A CL2008001671A CL2008001671A1 CL 2008001671 A1 CL2008001671 A1 CL 2008001671A1 CL 2008001671 A CL2008001671 A CL 2008001671A CL 2008001671 A CL2008001671 A CL 2008001671A CL 2008001671 A1 CL2008001671 A1 CL 2008001671A1
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- piperidine
- treatment
- pharmaceutical composition
- metabolic diseases
- derivative compounds
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- C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
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- C—CHEMISTRY; METALLURGY
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- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/04—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
- C07D317/58—Radicals substituted by nitrogen atoms
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- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
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Abstract
Compuestos derivados de piperidina/piperazina inhibidores de dgat, procedimiento para su preparación, composición farmacéutica que comprende a estos compuestos y su uso para el tratamiento de trastornos del metabolismo como la obesidad, diabetes mellitus tipo II, dislipidemia, entre otras.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07109868 | 2007-06-08 | ||
EP07115805 | 2007-09-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2008001671A1 true CL2008001671A1 (es) | 2009-07-17 |
Family
ID=39865125
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2008001671A CL2008001671A1 (es) | 2007-06-08 | 2008-06-06 | Compuestos derivados de piperidina/piperazina inhibidores de dgat1, composicion farmaceutica que los comprende; y su uso en el tratamiento de enfermedades metabolicas especialmente diabetes. |
Country Status (16)
Country | Link |
---|---|
US (1) | US8981094B2 (es) |
EP (1) | EP2152270B1 (es) |
JP (1) | JP5385263B2 (es) |
CN (1) | CN101678019B (es) |
AR (1) | AR066911A1 (es) |
AU (1) | AU2008258487B2 (es) |
BR (1) | BRPI0813331A2 (es) |
CA (1) | CA2687754C (es) |
CL (1) | CL2008001671A1 (es) |
ES (1) | ES2536406T3 (es) |
MX (1) | MX2009013335A (es) |
PA (1) | PA8783601A1 (es) |
PE (1) | PE20090362A1 (es) |
RU (1) | RU2470017C2 (es) |
TW (1) | TWI426070B (es) |
WO (1) | WO2008148868A1 (es) |
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US7749997B2 (en) | 2005-12-22 | 2010-07-06 | Astrazeneca Ab | Pyrimido [4,5-B] -Oxazines for use as DGAT inhibitors |
ES2430115T3 (es) | 2006-03-31 | 2013-11-19 | Novartis Ag | Inhibidor de DGAT |
US8084478B2 (en) | 2006-05-30 | 2011-12-27 | Asstrazeneca Ab | Substituted 5- phenylamino- 1, 3, 4-oxadiazol-2-ylcarbonylamino-4-phenoxy-cyclohexane carboxylic acid as inhibitors of acetyl coenzyme A diacylglycerol acyltransferase |
WO2008148851A1 (en) | 2007-06-08 | 2008-12-11 | Janssen Pharmaceutica N.V. | Piperidine/piperazine derivatives |
AR066911A1 (es) | 2007-06-08 | 2009-09-23 | Janssen Pharmaceutica Nv | Derivados de piperidina / piperazina |
JP5443342B2 (ja) | 2007-06-08 | 2014-03-19 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ピペリジン/ピペラジン誘導体 |
JO2972B1 (en) | 2007-06-08 | 2016-03-15 | جانسين فارماسوتيكا ان. في | Piperidine / piperazine derivatives |
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CA3006911A1 (en) | 2015-12-22 | 2017-06-29 | Syngenta Participations Ag | Pesticidally active pyrazole derivatives |
KR102537050B1 (ko) | 2016-03-17 | 2023-05-26 | 에프. 호프만-라 로슈 아게 | Taar의 작용제로서 활성을 갖는 5-에틸-4-메틸-피라졸-3-카복스아미드 유도체 |
CN108250185B (zh) * | 2018-01-24 | 2020-08-21 | 浙江工业大学 | 6-(2-(邻甲苯氨基)乙酰氨基)喹唑啉类化合物及制备和应用 |
CN109516919B (zh) * | 2018-12-27 | 2021-12-14 | 安徽工业大学科技园有限公司 | 一种三(2-氨基乙基)胺的制备方法 |
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-
2008
- 2008-06-06 AR ARP080102427A patent/AR066911A1/es unknown
- 2008-06-06 CL CL2008001671A patent/CL2008001671A1/es unknown
- 2008-06-06 US US12/663,013 patent/US8981094B2/en active Active
- 2008-06-06 EP EP08760634.9A patent/EP2152270B1/en active Active
- 2008-06-06 PE PE2008000972A patent/PE20090362A1/es not_active Application Discontinuation
- 2008-06-06 CN CN200880019198.0A patent/CN101678019B/zh active Active
- 2008-06-06 WO PCT/EP2008/057060 patent/WO2008148868A1/en active Application Filing
- 2008-06-06 PA PA20088783601A patent/PA8783601A1/es unknown
- 2008-06-06 TW TW097121019A patent/TWI426070B/zh not_active IP Right Cessation
- 2008-06-06 BR BRPI0813331-0A2A patent/BRPI0813331A2/pt not_active Application Discontinuation
- 2008-06-06 RU RU2009148320/04A patent/RU2470017C2/ru active
- 2008-06-06 JP JP2010510816A patent/JP5385263B2/ja active Active
- 2008-06-06 ES ES08760634.9T patent/ES2536406T3/es active Active
- 2008-06-06 MX MX2009013335A patent/MX2009013335A/es active IP Right Grant
- 2008-06-06 AU AU2008258487A patent/AU2008258487B2/en not_active Ceased
- 2008-06-06 CA CA2687754A patent/CA2687754C/en active Active
Also Published As
Publication number | Publication date |
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WO2008148868A1 (en) | 2008-12-11 |
TW200911771A (en) | 2009-03-16 |
JP5385263B2 (ja) | 2014-01-08 |
CA2687754C (en) | 2015-12-08 |
CA2687754A1 (en) | 2008-12-11 |
WO2008148868A8 (en) | 2009-03-05 |
TWI426070B (zh) | 2014-02-11 |
PE20090362A1 (es) | 2009-04-04 |
BRPI0813331A2 (pt) | 2014-12-23 |
PA8783601A1 (es) | 2009-01-23 |
EP2152270B1 (en) | 2015-03-04 |
EP2152270A1 (en) | 2010-02-17 |
AU2008258487B2 (en) | 2012-11-15 |
US20100190789A1 (en) | 2010-07-29 |
US8981094B2 (en) | 2015-03-17 |
AU2008258487A1 (en) | 2008-12-11 |
ES2536406T3 (es) | 2015-05-25 |
RU2009148320A (ru) | 2011-07-20 |
CN101678019A (zh) | 2010-03-24 |
JP2010529089A (ja) | 2010-08-26 |
RU2470017C2 (ru) | 2012-12-20 |
AR066911A1 (es) | 2009-09-23 |
MX2009013335A (es) | 2010-01-20 |
CN101678019B (zh) | 2016-03-30 |
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