PA8783601A1 - Derivados de piperidina/piperazina - Google Patents

Derivados de piperidina/piperazina

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Publication number
PA8783601A1
PA8783601A1 PA20088783601A PA8783601A PA8783601A1 PA 8783601 A1 PA8783601 A1 PA 8783601A1 PA 20088783601 A PA20088783601 A PA 20088783601A PA 8783601 A PA8783601 A PA 8783601A PA 8783601 A1 PA8783601 A1 PA 8783601A1
Authority
PA
Panama
Prior art keywords
nrx
nry
rent
same
compounds
Prior art date
Application number
PA20088783601A
Other languages
English (en)
Inventor
Jean-Pierre Andre Marc Bongartz
Joannes Theodorus Maria Linders
Lieven Meerpoel
Lommen Guy Rosalia Eugeen Van
Peter Walter Maria Roevens
Erwin Coesemans
Mirielle Braeken
Christophe Francis Robert Nestor Buyck
Monique Jenny Marie Berwaer
Gustaaf Maria Boeckx
Petr Vladimirivich Davidenko
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39865125&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PA8783601(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of PA8783601A1 publication Critical patent/PA8783601A1/es

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    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/205—Radicals derived from carbonic acid
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    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/26—Sulfur atoms
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    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
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    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/04—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/58—Radicals substituted by nitrogen atoms
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    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Abstract

LA INVENCIÓN SE REFIERE A UN INHIBIDOR DE DGAT DE FÓRMULA QUE INCLUYE CUALQUUIER FORMA ESTEREOQUÍMICAMENTE ISOMÉRICA DEL MISMO,DONDE A REPRESENTA CH O N;LA LINEA PUNTEADA REPRESENTA UN ENLACE OPCIONAL EN EL CASO EN QUE A REPRESENTE UN ÁTOMO DE CARBONO;X REPRESENTA-C(=O)-;-C(=O)-;-C(=O)-C(=O)-;-NRX-C(=O)-;-Z1-C(=O)-;-Z1-NRX-C(=O)-;-C(=O)-Z1-;-S(=O)P-;-C(=S)-;-NRX-C(=S)-;-Z1-C(=S)-;-Z1-NRX-C(=S)-;-C(=S)-Z1-;-NRX-C(=S)-Z1-;Y REPRESENTA NRX-C(=O)-Z2-;-NRX-C(=O)-Z2-NRY-;-NRX-C(=O)-Z2-NRY-C(=O)-;-NRX-C(=O)-Z2-NRY-C(=O)-O-;-NRX-C(=O)-Z2-O-;-NRX-C(=O)-Z2-O-C(=O)-;-NRX-C(=O)-Z2-C(=O)-;-NRX-C(=O)-Z2-C(=O)-O-;-NRX-C(=O)-O-Z"-C(=O)-;-NRX-C(=O)-O-Z2-C(=O)-O-;-NRX-C(=O)-O-Z2-O-C(=O)-;-NRX-C(=O)-Z2-C(=O)-NRY-; -NRX-C(=O)-Z2-NRY-CCCCCC(=O)-NRY-;-C(=O)-Z2-;-C(=O)-NRY-;-C(=O)-Z2-;-C(=O)-Z2-;O-;-C(=O)-NRX-Z2-;-C(=O)-NRX-Z2-O-;-C(=O)-NRX-Z2-C(=O)-;-C(=O)-NRX-Z2-C(=O)-O-;-C(=O)-MRX-Z2-O-C(=O)-NRX-O-Z2-;-C(=O)-NRX-Z2-NRY-;-C(=O)-NRX-Z2-NRY-C(=O)-;-C(=0)-NRX-Z2-NRY-C(=O)-0-;R1 REPRESENTA ALQUILOC1-12 OPCIONALMENTE SUSTITUIDO CON CIANO,ALQUILOXI C1-4, ALQUIL C1-4-OXI ALQUILOXI C1-4, CICLOALQUILO C3-6 O ARILO;ALQUENILO C2-6:ALQUINILO C2-6;CICLOALQUILO C3-6;ADAMANTANILO;ARILO1;ARIL1 ALQUILO C1-6;HET1; O HET 1 ALQUILO C1-6;CON LA SALVEDAD DE QUE CUANDO Y REPRESENTA-NRX-C(=O)-Z2-;-NRX-C(=O)-Z2-NRY;-NRX-C(=O)-Z2-C(=O)-NRY-;-C(=O)-Z2-;-NRX-C(=O)-Z2-NRY-C(=O)-NRY-;-C(=O)-NRX-Z2-;-C(=O)-NRX-O-Z2-;O-C(=O)-NRX-Z2-NRY-;ENTONCES R1 PUEDE TAMBIÉN REPRESENTAR HIDRÒGENO;R2 REPRESENTA HIDRÓGENO,ALQUUILO C1-12,ALQUENILO C2-6 O R3;CON LA SALVEDAD DE QUE SI X REPRESENTA-O-C(=O)-,ENTONCES R2 REPRESENTA R3;Y CONLA SALVEDAD DE QUE SI X REPRESENTA -O-C(=O)-, ENTONCES R2 REPRESENTA R3; Y CON LA SALVEDAD DE QUE SE EXCLUYE; UN N-ÓXIDO DE LOS MISMOS,UNA SAL ACEPTABLE PARA USO FARMACÉUTICO DE LOS MISMOS O UN SOLVATO DE LOS MISMOS. ADEMÁS,LA INVENCIÓN SE REFIERE A MÉTODOS PARA PREPARAR TALES COMPUESTOS,COMPOSICIONES FARMACÉUTICAS QUE COMPRENDEN DICHOS COMPUESTOS ASÍ COMO AL USO COMO MEDICAMENTOS DE DICHOS COMPUESTOS.
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AU2008258487A1 (en) 2008-12-11
TW200911771A (en) 2009-03-16
US8981094B2 (en) 2015-03-17
WO2008148868A8 (en) 2009-03-05
RU2470017C2 (ru) 2012-12-20

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