ATE316076T1 - Benzimidazol-derivate und diese enthaltende pharmazeutische zusammensetzungen - Google Patents
Benzimidazol-derivate und diese enthaltende pharmazeutische zusammensetzungenInfo
- Publication number
- ATE316076T1 ATE316076T1 AT00938584T AT00938584T ATE316076T1 AT E316076 T1 ATE316076 T1 AT E316076T1 AT 00938584 T AT00938584 T AT 00938584T AT 00938584 T AT00938584 T AT 00938584T AT E316076 T1 ATE316076 T1 AT E316076T1
- Authority
- AT
- Austria
- Prior art keywords
- pharmaceutical compositions
- compositions containing
- benzimidazole derivatives
- compounds
- containing same
- Prior art date
Links
- 229940058303 antinematodal benzimidazole derivative Drugs 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 150000001556 benzimidazoles Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 208000015114 central nervous system disease Diseases 0.000 abstract 2
- 206010002091 Anaesthesia Diseases 0.000 abstract 1
- 208000002091 Febrile Seizures Diseases 0.000 abstract 1
- 206010021118 Hypotonia Diseases 0.000 abstract 1
- 206010039897 Sedation Diseases 0.000 abstract 1
- 230000037005 anaesthesia Effects 0.000 abstract 1
- 125000003785 benzimidazolyl group Chemical class N1=C(NC2=C1C=CC=C2)* 0.000 abstract 1
- 229960003692 gamma aminobutyric acid Drugs 0.000 abstract 1
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000036640 muscle relaxation Effects 0.000 abstract 1
- 230000036280 sedation Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DKPA199900888 | 1999-06-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE316076T1 true ATE316076T1 (de) | 2006-02-15 |
Family
ID=8098669
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT00938584T ATE316076T1 (de) | 1999-06-22 | 2000-06-22 | Benzimidazol-derivate und diese enthaltende pharmazeutische zusammensetzungen |
Country Status (14)
Country | Link |
---|---|
US (2) | US6649609B2 (de) |
EP (1) | EP1194410B1 (de) |
JP (1) | JP2003502405A (de) |
CN (1) | CN1167686C (de) |
AT (1) | ATE316076T1 (de) |
AU (1) | AU777961B2 (de) |
BR (1) | BR0011823A (de) |
CA (1) | CA2373921A1 (de) |
DE (1) | DE60025604T2 (de) |
IL (2) | IL146403A0 (de) |
MX (1) | MXPA02000107A (de) |
NZ (1) | NZ515543A (de) |
RU (1) | RU2243226C2 (de) |
WO (1) | WO2000078728A1 (de) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6489346B1 (en) * | 1996-01-04 | 2002-12-03 | The Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and method of using same |
US5840737A (en) | 1996-01-04 | 1998-11-24 | The Curators Of The University Of Missouri | Omeprazole solution and method for using same |
NZ515543A (en) * | 1999-06-22 | 2003-11-28 | Neurosearch As | Novel benzimidazole derivatives and pharmaceutical compositions comprising these compounds |
SE9904723D0 (sv) | 1999-12-22 | 1999-12-22 | Carlsson A Research Ab | New modulators of dopamine neurotransmission II |
SE9904724D0 (sv) | 1999-12-22 | 1999-12-22 | Carlsson A Research Ab | New modulators of dopamine neurotransmission I |
USRE46117E1 (en) | 1999-12-22 | 2016-08-23 | Teva Pharmaceuticals International Gmbh | Modulators of dopamine neurotransmission |
DE60115282T2 (de) * | 2000-11-10 | 2006-08-10 | Merck Sharp & Dohme Ltd., Hoddesdon | Imidazotriazin-derivate als liganden für gaba-rezeptoren |
GB0117277D0 (en) * | 2001-07-16 | 2001-09-05 | Merck Sharp & Dohme | Therapeutic agents |
AU2002221566A1 (en) * | 2000-12-20 | 2002-07-01 | Neurosearch A/S | Novel benzimidazole derivatives for the treatment of gaba-alpha mediated disorders |
PA8535601A1 (es) * | 2000-12-21 | 2002-11-28 | Pfizer | Derivados benzimidazol y piridilimidazol como ligandos para gabaa |
US6743796B2 (en) | 2001-05-07 | 2004-06-01 | Wyeth | Piperazinyl-isatins |
AUPR625901A0 (en) * | 2001-07-10 | 2001-08-02 | Mcgregor, Neil | A method for treatment and/or prophylaxis |
GB0212048D0 (en) * | 2002-05-24 | 2002-07-03 | Merck Sharp & Dohme | Therapeutic agents |
WO2004087690A2 (en) | 2003-04-03 | 2004-10-14 | Neurosearch A/S | Benzimidazole derivatives and their use for modulating the gaba-a receptor complex |
WO2004087137A1 (en) | 2003-04-03 | 2004-10-14 | Neurosearch A/S | Benzimidazole derivatives and their use for modulating the gabaa receptor complex |
DE602004013299T2 (de) * | 2003-04-10 | 2009-06-25 | Neurosearch A/S | Neue benzimidazolderivative und ihre pharmazeutische zusammensetzungen |
JP2007509108A (ja) * | 2003-10-23 | 2007-04-12 | アクゾ ノベル ナムローゼ フェンノートシャップ | 1,5,7−三置換ベンズイミダゾール誘導体及びgabaa受容体複合体を調節するためのその使用 |
WO2005042497A2 (en) * | 2003-10-28 | 2005-05-12 | Vertex Pharmaceuticals, Incorporated | Benzimidazoles useful as modulators of ion channels |
ZA200603165B (en) * | 2003-11-03 | 2007-07-25 | Probiodrug Ag | Combinations useful for the treatment of neuronal disorders |
US20060185357A1 (en) * | 2004-05-07 | 2006-08-24 | Kovacevich Ian D | Independently drawing and tensioning lines with bi-directional rotary device having two spools |
US7851629B2 (en) | 2004-06-08 | 2010-12-14 | Nsab, Filial Af Neurosearch Sweden Ab, Sverige | Disubstituted phenylpiperidines as modulators of dopamine and serotonin neurotransmission |
DE602005021641D1 (de) | 2004-06-08 | 2010-07-15 | Nsab, Filial Af Neurosearch Sweden Ab | Neue disubstituierte phenylpiperidine und piperazine als modulatoren der dopamin-neurotransmission |
CN101056854B (zh) | 2004-10-13 | 2013-06-05 | Nsab神经研究瑞典公司分公司 | 合成4-(3-甲磺酰基苯基)-1-n-丙基-哌啶的方法 |
CA2595607C (en) * | 2005-01-25 | 2014-07-15 | Epix Delaware, Inc. | Substituted arylamine compounds and their use as 5-ht6 modulators |
PL1877052T3 (pl) * | 2005-04-13 | 2010-01-29 | Neurosearch As | Pochodne benzimidazolu i ich zastosowanie do modulowania kompleksu receptora GABAA |
EP1874735A1 (de) * | 2005-04-19 | 2008-01-09 | Neurosearch A/S | Benzimidazol-derivate und ihre verwendung zur modulierung des gabaa-rezeptor-komplexes |
US20090062304A1 (en) * | 2005-04-19 | 2009-03-05 | Lene Teuber | Benzimidazole derivatives and their use for modulating the gaba-alpha receptor complex |
US7776900B2 (en) | 2005-04-19 | 2010-08-17 | Neurosearch A/S | Benzimidazole derivatives and their use for modulating the GABAAreceptor complex |
SE529246C2 (sv) | 2005-10-13 | 2007-06-12 | Neurosearch Sweden Ab | Nya disubstituerade fenyl-piperidiner som modulatorer för dopaminneurotransmission |
WO2007042544A2 (en) * | 2005-10-14 | 2007-04-19 | Neurosearch A/S | Imidazole derivatives and their use for modulating the gabaa receptor complex |
WO2007042545A1 (en) * | 2005-10-14 | 2007-04-19 | Neurosearch A/S | Imidazole derivatives and their use for modulating the gaba-a receptor complex |
JP2009518292A (ja) * | 2005-12-05 | 2009-05-07 | ノイロサーチ アクティーゼルスカブ | ベンズイミダゾール誘導体及びgabaa受容体複合体を調節するためのそれらの使用 |
TWI391381B (zh) | 2006-03-24 | 2013-04-01 | Neurosearch As | 新穎的苯并咪唑衍生物、含有其之醫藥組成物、及其於製造藥物之用途 |
EP2152269B1 (de) * | 2007-06-08 | 2014-04-23 | Janssen Pharmaceutica, N.V. | Piperidin-/piperazinderivate |
US8835437B2 (en) | 2007-06-08 | 2014-09-16 | Janssen Pharmaceutica N.V. | Piperidine/piperazine derivatives |
JO2972B1 (en) * | 2007-06-08 | 2016-03-15 | جانسين فارماسوتيكا ان. في | Piperidine / piperazine derivatives |
US8981094B2 (en) * | 2007-06-08 | 2015-03-17 | Janssen Pharmaceutica N.V. | Piperidine/piperazine derivatives |
PE20140572A1 (es) * | 2008-06-05 | 2014-05-16 | Janssen Pharmaceutica Nv | Combinaciones de drogas que comprenden un inhibidor de dgat y un agonista de ppar |
CN102206204B (zh) * | 2011-04-08 | 2012-12-12 | 奇方(天津)医药科技有限公司 | 一种苯并咪唑类化合物及其医药用途 |
UY34503A (es) | 2011-12-08 | 2013-07-31 | Ivax Int Gmbh | ?sal de bromhidrato de pridopidina? |
JP6177875B2 (ja) | 2012-04-04 | 2017-08-09 | テバ・ファーマシューティカルズ・インターナショナル・ゲーエムベーハーTeva Pharmaceuticals International GmbH | 併用療法のための医薬組成物 |
KR20200023034A (ko) * | 2018-08-24 | 2020-03-04 | 일양약품주식회사 | 이속사졸 유도체 및 그의 제조방법 |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
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BE788751A (fr) * | 1971-09-13 | 1973-01-02 | Teijin Ltd | Membranes polymeres permselectives |
US5149814A (en) * | 1987-09-30 | 1992-09-22 | Pfizer Inc | Alkyl 2-benzylidene-4-(2-alkylimidazopyrid-1-yl) benzoylacetate esters as intermediate compounds |
DE3928177A1 (de) * | 1989-04-08 | 1991-02-28 | Thomae Gmbh Dr K | Benzimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
WO1991016313A1 (en) * | 1990-04-13 | 1991-10-31 | Smithkline Beecham Corporation | Substituted benzimidazoles |
US6034114A (en) * | 1990-12-14 | 2000-03-07 | Smithkline Beecham Plc | Medicament |
DK40192D0 (da) * | 1992-03-26 | 1992-03-26 | Neurosearch As | Imidazolforbindelser, deres fremstilling og anvendelse |
US5612360A (en) * | 1992-06-03 | 1997-03-18 | Eli Lilly And Company | Angiotensin II antagonists |
DE4237656A1 (de) * | 1992-06-13 | 1993-12-16 | Merck Patent Gmbh | Benzimidazolderivate |
AU675484B2 (en) * | 1993-03-24 | 1997-02-06 | Neurosearch A/S | Benzimidazole compounds, their use and preparation |
US5554630A (en) * | 1993-03-24 | 1996-09-10 | Neurosearch A/S | Benzimidazole compounds |
PL184020B1 (pl) * | 1995-04-21 | 2002-08-30 | Neurosearch As | Nowe związki benzimidazolowe i kompozycje farmaceutyczne zawierające takie związki |
ATE210132T1 (de) * | 1995-04-21 | 2001-12-15 | Neurosearch As | Benzmidazolverbindungen und ihre verwendung als modulatoren des gabaa-rezeptor-komplexes |
US5977101A (en) * | 1995-06-29 | 1999-11-02 | Smithkline Beecham Corporation | Benzimidazoles/Imidazoles Linked to a Fibrinogen Receptor Antagonist Template Having Vitronectin Receptor Antagonist Activity |
AU726447B2 (en) * | 1996-10-21 | 2000-11-09 | Neurosearch A/S | 1-phenyl-benzimidazole compounds and their use as BAGA-A receptor modulators |
FR2755364B1 (fr) * | 1996-11-06 | 1999-01-22 | Eugene Perma Sa | Composition pour la deformation permanente des fibres keratiniques, obtention et mise en oeuvre |
GB9702524D0 (en) * | 1997-02-07 | 1997-03-26 | Merck Sharp & Dohme | Therapeutic agents |
CN1275127A (zh) * | 1997-10-10 | 2000-11-29 | 神经研究公司 | 苯并咪唑化合物、含该化合物的药物组合物及其应用 |
US6124463A (en) * | 1998-07-02 | 2000-09-26 | Dupont Pharmaceuticals | Benzimidazoles as corticotropin release factor antagonists |
NZ515543A (en) * | 1999-06-22 | 2003-11-28 | Neurosearch As | Novel benzimidazole derivatives and pharmaceutical compositions comprising these compounds |
DE10060292A1 (de) * | 2000-12-05 | 2002-06-20 | Aventis Pharma Gmbh | Verwendung substituierter Benzimidazole zur Herstellung eines Medikaments zur Behandlung von Krankheiten, welche durch Inhibierung des Na+/H+-Austauschers beeinflusst werden können und sie enthaltendes Medikament |
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2000
- 2000-06-22 NZ NZ515543A patent/NZ515543A/en not_active IP Right Cessation
- 2000-06-22 DE DE60025604T patent/DE60025604T2/de not_active Expired - Lifetime
- 2000-06-22 IL IL14640300A patent/IL146403A0/xx active IP Right Grant
- 2000-06-22 AT AT00938584T patent/ATE316076T1/de not_active IP Right Cessation
- 2000-06-22 MX MXPA02000107A patent/MXPA02000107A/es active IP Right Grant
- 2000-06-22 AU AU53910/00A patent/AU777961B2/en not_active Ceased
- 2000-06-22 BR BR0011823-0A patent/BR0011823A/pt not_active Application Discontinuation
- 2000-06-22 RU RU2001131104/04A patent/RU2243226C2/ru not_active IP Right Cessation
- 2000-06-22 EP EP00938584A patent/EP1194410B1/de not_active Expired - Lifetime
- 2000-06-22 CA CA002373921A patent/CA2373921A1/en not_active Abandoned
- 2000-06-22 CN CNB008091730A patent/CN1167686C/zh not_active Expired - Fee Related
- 2000-06-22 JP JP2001504895A patent/JP2003502405A/ja not_active Ceased
- 2000-06-22 WO PCT/DK2000/000333 patent/WO2000078728A1/en active IP Right Grant
-
2001
- 2001-11-08 IL IL146403A patent/IL146403A/en not_active IP Right Cessation
- 2001-12-12 US US10/012,490 patent/US6649609B2/en not_active Expired - Fee Related
-
2003
- 2003-07-15 US US10/618,727 patent/US6936613B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JP2003502405A (ja) | 2003-01-21 |
CN1356987A (zh) | 2002-07-03 |
US6936613B2 (en) | 2005-08-30 |
NZ515543A (en) | 2003-11-28 |
CN1167686C (zh) | 2004-09-22 |
BR0011823A (pt) | 2002-03-19 |
AU5391000A (en) | 2001-01-09 |
DE60025604T2 (de) | 2006-07-27 |
EP1194410A1 (de) | 2002-04-10 |
WO2000078728A1 (en) | 2000-12-28 |
DE60025604D1 (de) | 2006-04-06 |
US6649609B2 (en) | 2003-11-18 |
CA2373921A1 (en) | 2000-12-28 |
IL146403A (en) | 2007-08-19 |
EP1194410B1 (de) | 2006-01-18 |
RU2243226C2 (ru) | 2004-12-27 |
AU777961B2 (en) | 2004-11-04 |
MXPA02000107A (es) | 2002-07-02 |
US20040097570A1 (en) | 2004-05-20 |
IL146403A0 (en) | 2002-07-25 |
US20030055055A1 (en) | 2003-03-20 |
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