CN101056854B - 合成4-(3-甲磺酰基苯基)-1-n-丙基-哌啶的方法 - Google Patents
合成4-(3-甲磺酰基苯基)-1-n-丙基-哌啶的方法 Download PDFInfo
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- CN101056854B CN101056854B CN2005800385910A CN200580038591A CN101056854B CN 101056854 B CN101056854 B CN 101056854B CN 2005800385910 A CN2005800385910 A CN 2005800385910A CN 200580038591 A CN200580038591 A CN 200580038591A CN 101056854 B CN101056854 B CN 101056854B
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- Expired - Fee Related
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- 0 CCCN(CC1)CCC1c1cccc(*)c1 Chemical compound CCCN(CC1)CCC1c1cccc(*)c1 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/24—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by sulfur atoms to which a second hetero atom is attached
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (15)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US61819604P | 2004-10-13 | 2004-10-13 | |
US60/618,196 | 2004-10-13 | ||
PCT/EP2005/011020 WO2006040155A1 (en) | 2004-10-13 | 2005-10-13 | Process for the synthesis of 4-(3-methanesulfonylphenyl)-1-n-propyl-piperidine |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101056854A CN101056854A (zh) | 2007-10-17 |
CN101056854B true CN101056854B (zh) | 2013-06-05 |
Family
ID=35478927
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2005800385910A Expired - Fee Related CN101056854B (zh) | 2004-10-13 | 2005-10-13 | 合成4-(3-甲磺酰基苯基)-1-n-丙基-哌啶的方法 |
Country Status (15)
Country | Link |
---|---|
US (1) | US7923459B2 (zh) |
EP (1) | EP1802573B1 (zh) |
JP (1) | JP4891908B2 (zh) |
KR (1) | KR101319235B1 (zh) |
CN (1) | CN101056854B (zh) |
AU (1) | AU2005293754B2 (zh) |
CA (1) | CA2584831C (zh) |
DK (1) | DK1802573T3 (zh) |
ES (1) | ES2659577T3 (zh) |
HK (1) | HK1105195A1 (zh) |
HU (1) | HUE029790T2 (zh) |
MX (1) | MX2007004215A (zh) |
NZ (1) | NZ555094A (zh) |
PL (1) | PL1802573T3 (zh) |
WO (1) | WO2006040155A1 (zh) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
USRE46117E1 (en) | 1999-12-22 | 2016-08-23 | Teva Pharmaceuticals International Gmbh | Modulators of dopamine neurotransmission |
SE0401465D0 (sv) | 2004-06-08 | 2004-06-08 | Carlsson A Research Ab | New substituted piperdines as modulators of dopamine neurotransmission |
DE602005017784D1 (de) | 2004-06-08 | 2009-12-31 | Nsab, Filial Af Neurosearch Sweden Ab | Neue disubstituierte phenylpiperidine als modulatoren der dopamin- und serotoninneurotransmission |
CN101056854B (zh) | 2004-10-13 | 2013-06-05 | Nsab神经研究瑞典公司分公司 | 合成4-(3-甲磺酰基苯基)-1-n-丙基-哌啶的方法 |
AU2005293755A1 (en) * | 2004-10-13 | 2006-04-20 | Nsab, Filial Af Neurosearch Sweden Ab, Sverige | Process for the synthesis of 4-(3-sulfonylphenyl)-piperidines |
AU2008239841B2 (en) * | 2007-04-12 | 2013-07-18 | Teva Pharmaceuticals International Gmbh | N-oxide and/or di-N-oxide derivatives of dopamine receptor stabilizers/modulators displaying improved cardiovascular side-effects profiles |
WO2011107583A1 (en) | 2010-03-04 | 2011-09-09 | Nsab, Filial Af Neurosearch Sweden Ab, Sverige | Substituted 4-phenyl-n-alkyl-piperidines for preventing onset or slowing progression of neurodegenerative disorders |
US20130197031A1 (en) | 2010-09-03 | 2013-08-01 | IVAX International GmbH | Deuterated analogs of pridopidine useful as dopaminergic stabilizers |
JP6189299B2 (ja) | 2011-09-07 | 2017-08-30 | テバ・ファーマシューティカルズ・インターナショナル・ゲーエムベーハー | プリドピジン塩酸塩の新規な多形形態 |
US9012476B2 (en) | 2011-12-08 | 2015-04-21 | IVAX International GmbH | Hydrobromide salt of pridopidine |
CN104470585A (zh) | 2012-04-04 | 2015-03-25 | 爱华克斯国际有限公司 | 用于联合疗法的药物组合物 |
MX2015017307A (es) | 2013-06-21 | 2016-08-03 | Teva Pharmaceuticals Int Gmbh | Uso de pridopidina en dosis altas para el tratamiento de enfermedad de huntington. |
US11090297B2 (en) | 2013-06-21 | 2021-08-17 | Prilenia Neurotherapeutics Ltd. | Pridopidine for treating huntington's disease |
EP3096759B1 (en) | 2014-01-22 | 2022-04-06 | Prilenia Neurotherapeutics Ltd. | Modified release formulations of pridopidine |
TW201613859A (en) * | 2014-06-30 | 2016-04-16 | Teva Pharma | Analogs of PRIDOPIDINE, their preparation and use |
CA2970799A1 (en) | 2014-12-22 | 2016-06-30 | Teva Pharmaceuticals International Gmbh | L-tartrate salt of pridopidine |
JP6887952B2 (ja) | 2015-02-25 | 2021-06-16 | プリレニア ニューロセラピューティクス リミテッド | 認知機能を改善するため、およびアルツハイマー病を治療するためのプリドピジンの使用 |
US11471449B2 (en) | 2015-02-25 | 2022-10-18 | Prilenia Neurotherapeutics Ltd. | Use of pridopidine to improve cognitive function and for treating Alzheimer's disease |
AR105434A1 (es) | 2015-07-22 | 2017-10-04 | Teva Pharmaceuticals Int Gmbh | Proceso para preparar pridopidina |
US11738012B2 (en) | 2016-02-24 | 2023-08-29 | Prilenia Neurotherapeutics Ltd. | Treatment of neurodegenerative eye disease using pridopidine |
JP7278210B2 (ja) | 2016-08-24 | 2023-05-19 | プリレニア ニューロセラピューティクス リミテッド | ジストニアを治療するためのプリドピジンの使用 |
JP6912574B2 (ja) | 2016-08-24 | 2021-08-04 | プリレニア ニューロセラピューティクス リミテッド | 機能低下を治療するためのプリドピジンの使用 |
CN109982686A (zh) | 2016-09-16 | 2019-07-05 | 普瑞尼亚医疗发展有限公司 | 普利多匹定用于治疗rett综合征的用途 |
BR112019015000A2 (pt) | 2017-01-20 | 2020-04-07 | Agency Science Tech & Res | uso de pridopidina para o tratamento da síndrome do x frágil |
EP3357909A1 (en) | 2017-02-02 | 2018-08-08 | Sandoz AG | Crystalline 4-[3-(methylsulfonyl)phenyl]-1-propyl-piperidine |
JP7082186B2 (ja) | 2017-08-14 | 2022-06-07 | プリレニア ニューロセラピューティクス リミテッド | プリドピジンによる筋萎縮性側索硬化症の治療方法 |
CN111278431A (zh) | 2017-08-30 | 2020-06-12 | 普瑞尼亚神经治疗有限公司 | 普利多匹定的高浓度剂型 |
JP2020533296A (ja) | 2017-09-08 | 2020-11-19 | プリレニア ニューロセラピューティクス リミテッド | 薬物誘発性ジスキネジアを治療するためのプリドピジン |
Citations (2)
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CN1420869A (zh) * | 1999-12-22 | 2003-05-28 | A·卡尔松研究股份公司 | 新的多巴胺神经传递调节剂 |
EP0867183B1 (en) * | 1996-07-22 | 2004-10-06 | Daiichi Suntory Pharma Co., Ltd. | Arylpiperidinol and arylpiperidine derivatives and drugs containing the same |
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FR1459013A (fr) | 1964-08-05 | 1966-04-29 | Allen & Hanburys Ltd | Procédé de préparation de dérivés de la 4-phényl-pipéridine |
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FR2459797A2 (fr) | 1978-08-01 | 1981-01-16 | Synthelabo | Derives de phenyl-1 piperazine et leur application en therapeutique |
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FR2501506A1 (fr) | 1981-03-11 | 1982-09-17 | Sanofi Sa | Compositions pharmaceutiques a action anorexigene contenant des derives de la tetrahydropyridine |
US4415736A (en) | 1981-12-28 | 1983-11-15 | E. I. Du Pont De Nemours & Co. | Certain tetrahydropyridine intermediates |
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FR2639226B1 (fr) | 1988-11-18 | 1993-11-05 | Sanofi | Utilisation de trifluoromethylphenyltetrahydropyridines pour la preparation de medicaments destines a combattre les troubles anxio-depressifs |
WO1991009594A1 (en) | 1989-12-28 | 1991-07-11 | Virginia Commonwealth University | Sigma receptor ligands and the use thereof |
JP3176063B2 (ja) | 1991-04-17 | 2001-06-11 | ファルマシア・アンド・アップジョン・カンパニー | 新規中枢神経作用性置換フェニルアザシクロアルカン類 |
EP0591426A4 (en) | 1991-06-27 | 1996-08-21 | Univ Virginia Commonwealth | Sigma receptor ligands and the use thereof |
NZ240863A (en) | 1991-09-11 | 1995-04-27 | Mcneilab Inc | Substituted 4-aryl piperidine and 4-aryl piperazine derivatives, preparation and pharmaceutical compositions thereof |
ATE204262T1 (de) | 1991-09-18 | 2001-09-15 | Glaxo Group Ltd | Benzanilidderivate als 5-ht1d-antagonisten |
GB9119920D0 (en) | 1991-09-18 | 1991-10-30 | Glaxo Group Ltd | Chemical compounds |
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ATE481969T1 (de) | 2004-10-01 | 2010-10-15 | Merck Sharp & Dohme | Aminopiperidine als dipeptidylpeptidase-iv- inhibitoren zur behandlung oder prävention von diabetes |
AU2005293755A1 (en) | 2004-10-13 | 2006-04-20 | Nsab, Filial Af Neurosearch Sweden Ab, Sverige | Process for the synthesis of 4-(3-sulfonylphenyl)-piperidines |
CN101056854B (zh) | 2004-10-13 | 2013-06-05 | Nsab神经研究瑞典公司分公司 | 合成4-(3-甲磺酰基苯基)-1-n-丙基-哌啶的方法 |
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WO2007065655A1 (en) | 2005-12-07 | 2007-06-14 | Neurosearch Sweden Ab | Disubstituted phenylpiperidines as modulators of cortical catecholaminergic neurotransmission |
-
2005
- 2005-10-13 CN CN2005800385910A patent/CN101056854B/zh not_active Expired - Fee Related
- 2005-10-13 KR KR1020077010900A patent/KR101319235B1/ko not_active IP Right Cessation
- 2005-10-13 DK DK05793645.2T patent/DK1802573T3/en active
- 2005-10-13 CA CA2584831A patent/CA2584831C/en active Active
- 2005-10-13 HU HUE05793645A patent/HUE029790T2/hu unknown
- 2005-10-13 NZ NZ555094A patent/NZ555094A/en unknown
- 2005-10-13 EP EP05793645.2A patent/EP1802573B1/en active Active
- 2005-10-13 ES ES05793645.2T patent/ES2659577T3/es active Active
- 2005-10-13 WO PCT/EP2005/011020 patent/WO2006040155A1/en active Application Filing
- 2005-10-13 MX MX2007004215A patent/MX2007004215A/es active IP Right Grant
- 2005-10-13 JP JP2007536091A patent/JP4891908B2/ja not_active Expired - Fee Related
- 2005-10-13 AU AU2005293754A patent/AU2005293754B2/en not_active Ceased
- 2005-10-13 PL PL05793645T patent/PL1802573T3/pl unknown
-
2007
- 2007-04-10 US US11/733,512 patent/US7923459B2/en active Active
- 2007-09-27 HK HK07110459.6A patent/HK1105195A1/zh not_active IP Right Cessation
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0867183B1 (en) * | 1996-07-22 | 2004-10-06 | Daiichi Suntory Pharma Co., Ltd. | Arylpiperidinol and arylpiperidine derivatives and drugs containing the same |
CN1420869A (zh) * | 1999-12-22 | 2003-05-28 | A·卡尔松研究股份公司 | 新的多巴胺神经传递调节剂 |
Non-Patent Citations (2)
Title |
---|
Kazuhiko Sato et al.Oxidation of sulfides to sulfoxides and sulfones with30%hydrogen peroxide under organic solvent-andhalogen-free conditions.Tetrahedron57 13.2001,57(13),2469-2476. |
Kazuhiko Sato et al.Oxidation of sulfides to sulfoxides and sulfones with30%hydrogen peroxide under organic solvent-andhalogen-free conditions.Tetrahedron57 13.2001,57(13),2469-2476. * |
Also Published As
Publication number | Publication date |
---|---|
CN101056854A (zh) | 2007-10-17 |
AU2005293754A1 (en) | 2006-04-20 |
WO2006040155A1 (en) | 2006-04-20 |
EP1802573B1 (en) | 2016-09-28 |
HK1105195A1 (zh) | 2008-02-06 |
HUE029790T2 (hu) | 2017-04-28 |
AU2005293754B2 (en) | 2011-07-21 |
US7923459B2 (en) | 2011-04-12 |
PL1802573T3 (pl) | 2017-03-31 |
DK1802573T3 (en) | 2016-12-19 |
KR20070065911A (ko) | 2007-06-25 |
JP2008515951A (ja) | 2008-05-15 |
CA2584831A1 (en) | 2006-04-20 |
US20070238879A1 (en) | 2007-10-11 |
KR101319235B1 (ko) | 2013-10-16 |
NZ555094A (en) | 2009-07-31 |
CA2584831C (en) | 2013-09-17 |
JP4891908B2 (ja) | 2012-03-07 |
MX2007004215A (es) | 2007-12-12 |
EP1802573A1 (en) | 2007-07-04 |
ES2659577T3 (es) | 2018-03-16 |
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