MX2007004215A - Proceso para la sintesis de 4-(3-metansulfonilfenil)-1-n- propilpiperidina. - Google Patents
Proceso para la sintesis de 4-(3-metansulfonilfenil)-1-n- propilpiperidina.Info
- Publication number
- MX2007004215A MX2007004215A MX2007004215A MX2007004215A MX2007004215A MX 2007004215 A MX2007004215 A MX 2007004215A MX 2007004215 A MX2007004215 A MX 2007004215A MX 2007004215 A MX2007004215 A MX 2007004215A MX 2007004215 A MX2007004215 A MX 2007004215A
- Authority
- MX
- Mexico
- Prior art keywords
- methanesulfonylphenyl
- piperidine
- propyl
- synthesis
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/24—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by sulfur atoms to which a second hetero atom is attached
Abstract
La presente invencion se dirige al proceso para la preparacion de 4-(3-metansulfonil)-1-n-propilpiperidina (I), o una sal aceptada para uso farmaceutico de esta, el cual consiste en: oxidar un sulfuro de la formula (II), con un agente oxidante catalitico y un oxidante para obtener un compuesto de formula (III), seguido por la reduccion catalitica del compuesto de la formula (III).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US61819604P | 2004-10-13 | 2004-10-13 | |
PCT/EP2005/011020 WO2006040155A1 (en) | 2004-10-13 | 2005-10-13 | Process for the synthesis of 4-(3-methanesulfonylphenyl)-1-n-propyl-piperidine |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2007004215A true MX2007004215A (es) | 2007-12-12 |
Family
ID=35478927
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2007004215A MX2007004215A (es) | 2004-10-13 | 2005-10-13 | Proceso para la sintesis de 4-(3-metansulfonilfenil)-1-n- propilpiperidina. |
Country Status (15)
Country | Link |
---|---|
US (1) | US7923459B2 (es) |
EP (1) | EP1802573B1 (es) |
JP (1) | JP4891908B2 (es) |
KR (1) | KR101319235B1 (es) |
CN (1) | CN101056854B (es) |
AU (1) | AU2005293754B2 (es) |
CA (1) | CA2584831C (es) |
DK (1) | DK1802573T3 (es) |
ES (1) | ES2659577T3 (es) |
HK (1) | HK1105195A1 (es) |
HU (1) | HUE029790T2 (es) |
MX (1) | MX2007004215A (es) |
NZ (1) | NZ555094A (es) |
PL (1) | PL1802573T3 (es) |
WO (1) | WO2006040155A1 (es) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
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USRE46117E1 (en) | 1999-12-22 | 2016-08-23 | Teva Pharmaceuticals International Gmbh | Modulators of dopamine neurotransmission |
DE602005021641D1 (de) | 2004-06-08 | 2010-07-15 | Nsab, Filial Af Neurosearch Sweden Ab | Neue disubstituierte phenylpiperidine und piperazine als modulatoren der dopamin-neurotransmission |
SE0401465D0 (sv) | 2004-06-08 | 2004-06-08 | Carlsson A Research Ab | New substituted piperdines as modulators of dopamine neurotransmission |
WO2006040156A1 (en) * | 2004-10-13 | 2006-04-20 | Neurosearch Sweden Ab | Process for the synthesis of 4-(3-sulfonylphenyl)-piperidines |
WO2006040155A1 (en) | 2004-10-13 | 2006-04-20 | Neurosearch Sweden Ab | Process for the synthesis of 4-(3-methanesulfonylphenyl)-1-n-propyl-piperidine |
PT2146961E (pt) * | 2007-04-12 | 2014-04-30 | Ivax Int Gmbh | Derivados de n-óxido e/ou di-n-óxido de estabilizadores / moduladores dos recetores da dopamina exibindo perfis de efeitos secundários cardiovasculares melhorados |
WO2011107583A1 (en) | 2010-03-04 | 2011-09-09 | Nsab, Filial Af Neurosearch Sweden Ab, Sverige | Substituted 4-phenyl-n-alkyl-piperidines for preventing onset or slowing progression of neurodegenerative disorders |
CA2810092A1 (en) | 2010-09-03 | 2012-03-08 | IVAX International GmbH | Deuterated analogs of pridopidine useful as dopaminergic stabilizers |
EA023462B1 (ru) | 2011-09-07 | 2016-06-30 | Тева Фармасьютикалз Интернэшнл Гмбх | Полиморфная форма гидрохлорида придопидина |
US9012476B2 (en) * | 2011-12-08 | 2015-04-21 | IVAX International GmbH | Hydrobromide salt of pridopidine |
CA2869145A1 (en) | 2012-04-04 | 2013-10-10 | IVAX International GmbH | Pharmaceutical compositions for combination therapy |
US11090297B2 (en) | 2013-06-21 | 2021-08-17 | Prilenia Neurotherapeutics Ltd. | Pridopidine for treating huntington's disease |
KR102316933B1 (ko) | 2013-06-21 | 2021-10-26 | 프리레니아 뉴로테라퓨틱스 엘티디. | 헌팅턴병 치료를 위한 프리도피딘의 용도 |
US20150202302A1 (en) | 2014-01-22 | 2015-07-23 | IVAX International GmbH | Modified release formulations of pridopidine |
TW201613859A (en) | 2014-06-30 | 2016-04-16 | Teva Pharma | Analogs of PRIDOPIDINE, their preparation and use |
WO2016106142A1 (en) * | 2014-12-22 | 2016-06-30 | Teva Pharmaceuticals International Gmbh | L-tartrate salt of pridopidine |
HUE060353T2 (hu) | 2015-02-25 | 2023-02-28 | Prilenia Neurotherapeutics Ltd | Pridopidin alkalmazása memória javítására |
US11471449B2 (en) | 2015-02-25 | 2022-10-18 | Prilenia Neurotherapeutics Ltd. | Use of pridopidine to improve cognitive function and for treating Alzheimer's disease |
AR105434A1 (es) * | 2015-07-22 | 2017-10-04 | Teva Pharmaceuticals Int Gmbh | Proceso para preparar pridopidina |
US11738012B2 (en) | 2016-02-24 | 2023-08-29 | Prilenia Neurotherapeutics Ltd. | Treatment of neurodegenerative eye disease using pridopidine |
EP3504187A4 (en) | 2016-08-24 | 2020-05-06 | Prilenia Neurotherapeutics Ltd. | USE OF PRIDOPIDINE FOR THE TREATMENT OF FUNCTIONAL DECLINE |
MX2019002190A (es) | 2016-08-24 | 2019-09-11 | Prilenia Therapeutics Dev Ltd | Uso de pridopidina para tratar distonías. |
CA3036984C (en) | 2016-09-16 | 2023-07-18 | Prilenia Therapeutics Development Ltd. | Use of pridopidine for treating rett syndrome |
CN110505902B (zh) | 2017-01-20 | 2022-11-11 | 普瑞尼亚神经治疗有限公司 | 普利多匹定用于治疗脆性x综合征的应用 |
EP3357909A1 (en) | 2017-02-02 | 2018-08-08 | Sandoz AG | Crystalline 4-[3-(methylsulfonyl)phenyl]-1-propyl-piperidine |
EP3668509B1 (en) | 2017-08-14 | 2022-11-16 | Prilenia Neurotherapeutics Ltd. | Method of treating amyotrophic lateral sclerosis with pridopidine |
CA3073568A1 (en) | 2017-08-30 | 2019-03-07 | Prilenia Neurotherapeutics Ltd. | High concentration dosage forms of pridopidine |
CN111343982A (zh) | 2017-09-08 | 2020-06-26 | 普瑞尼亚神经治疗有限公司 | 用于治疗药物诱发的异动症的普利多匹定 |
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WO2006040155A1 (en) | 2004-10-13 | 2006-04-20 | Neurosearch Sweden Ab | Process for the synthesis of 4-(3-methanesulfonylphenyl)-1-n-propyl-piperidine |
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-
2005
- 2005-10-13 WO PCT/EP2005/011020 patent/WO2006040155A1/en active Application Filing
- 2005-10-13 PL PL05793645T patent/PL1802573T3/pl unknown
- 2005-10-13 JP JP2007536091A patent/JP4891908B2/ja not_active Expired - Fee Related
- 2005-10-13 KR KR1020077010900A patent/KR101319235B1/ko not_active IP Right Cessation
- 2005-10-13 MX MX2007004215A patent/MX2007004215A/es active IP Right Grant
- 2005-10-13 CA CA2584831A patent/CA2584831C/en active Active
- 2005-10-13 NZ NZ555094A patent/NZ555094A/en unknown
- 2005-10-13 DK DK05793645.2T patent/DK1802573T3/en active
- 2005-10-13 CN CN2005800385910A patent/CN101056854B/zh not_active Expired - Fee Related
- 2005-10-13 EP EP05793645.2A patent/EP1802573B1/en active Active
- 2005-10-13 HU HUE05793645A patent/HUE029790T2/hu unknown
- 2005-10-13 ES ES05793645.2T patent/ES2659577T3/es active Active
- 2005-10-13 AU AU2005293754A patent/AU2005293754B2/en not_active Ceased
-
2007
- 2007-04-10 US US11/733,512 patent/US7923459B2/en active Active
- 2007-09-27 HK HK07110459.6A patent/HK1105195A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
JP2008515951A (ja) | 2008-05-15 |
EP1802573A1 (en) | 2007-07-04 |
AU2005293754A1 (en) | 2006-04-20 |
US20070238879A1 (en) | 2007-10-11 |
PL1802573T3 (pl) | 2017-03-31 |
AU2005293754B2 (en) | 2011-07-21 |
CA2584831C (en) | 2013-09-17 |
CN101056854A (zh) | 2007-10-17 |
KR20070065911A (ko) | 2007-06-25 |
EP1802573B1 (en) | 2016-09-28 |
ES2659577T3 (es) | 2018-03-16 |
HUE029790T2 (hu) | 2017-04-28 |
JP4891908B2 (ja) | 2012-03-07 |
NZ555094A (en) | 2009-07-31 |
DK1802573T3 (en) | 2016-12-19 |
US7923459B2 (en) | 2011-04-12 |
CN101056854B (zh) | 2013-06-05 |
HK1105195A1 (zh) | 2008-02-06 |
KR101319235B1 (ko) | 2013-10-16 |
CA2584831A1 (en) | 2006-04-20 |
WO2006040155A1 (en) | 2006-04-20 |
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