MX2016013027A - Uso de dianhidrogalactitol y analogos o derivados del mismo para tratar cancer de celulas no pequeñas del pulmon y cancer de ovario. - Google Patents

Uso de dianhidrogalactitol y analogos o derivados del mismo para tratar cancer de celulas no pequeñas del pulmon y cancer de ovario.

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Publication number
MX2016013027A
MX2016013027A MX2016013027A MX2016013027A MX2016013027A MX 2016013027 A MX2016013027 A MX 2016013027A MX 2016013027 A MX2016013027 A MX 2016013027A MX 2016013027 A MX2016013027 A MX 2016013027A MX 2016013027 A MX2016013027 A MX 2016013027A
Authority
MX
Mexico
Prior art keywords
dianhydrogalactitol
small
ovarian cancer
analogs
lung
Prior art date
Application number
MX2016013027A
Other languages
English (en)
Inventor
Dennis M Brown
A Bacha Jeffrey
Steinø Anne
Original Assignee
Del Mar Pharmaceuticals
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Del Mar Pharmaceuticals filed Critical Del Mar Pharmaceuticals
Publication of MX2016013027A publication Critical patent/MX2016013027A/es

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/336—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having three-membered rings, e.g. oxirane, fumagillin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/04—Nitro compounds
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
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    • A61K9/51—Nanocapsules; Nanoparticles
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    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

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  • Health & Medical Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
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Abstract

El uso de dianhidrogalactitol proporciona una novedosa modalidad terapéutica para el tratamiento de carcinoma del pulmón de células no pequeñas (CSCLC) y cáncer de ovario; el dianhidrogalactitol actúa como un agente de alquilación sobre el ADN que crea una metilación en N7; el dianhidrogalactitol es eficaz para suprimir el crecimiento de células madre del cáncer y es activo contra tumores que son refractarios a temozolomida, cisplatino e inhibidores de timidina cinasa; el fármaco actúa independientemente del mecanismo de reparación MGMT; el dianhidrogalactitol puede ser utilizado junto con otros agentes anti-neoplásicos y puede poseer efectos aditivos o súper-aditivos.
MX2016013027A 2014-04-04 2015-04-06 Uso de dianhidrogalactitol y analogos o derivados del mismo para tratar cancer de celulas no pequeñas del pulmon y cancer de ovario. MX2016013027A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461975587P 2014-04-04 2014-04-04
US201462062246P 2014-10-10 2014-10-10
PCT/US2015/024462 WO2015154064A2 (en) 2014-04-04 2015-04-06 Use of dianhydrogalactitol and analogs or derivatives thereof to treat non-small-cell carcinoma of the lung and ovarian cancer

Publications (1)

Publication Number Publication Date
MX2016013027A true MX2016013027A (es) 2017-05-23

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MX2016013027A MX2016013027A (es) 2014-04-04 2015-04-06 Uso de dianhidrogalactitol y analogos o derivados del mismo para tratar cancer de celulas no pequeñas del pulmon y cancer de ovario.

Country Status (13)

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US (2) US11541027B2 (es)
EP (2) EP3125920B1 (es)
JP (2) JP6783224B2 (es)
KR (2) KR102456088B1 (es)
CN (1) CN106659765B (es)
AU (2) AU2015240465B2 (es)
CA (1) CA2946538A1 (es)
CL (1) CL2016002514A1 (es)
IL (1) IL248189B (es)
MX (1) MX2016013027A (es)
SG (1) SG11201608303QA (es)
TW (1) TW201713326A (es)
WO (2) WO2015154064A2 (es)

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