DE60329126D1 - Konjugate mit biologisch abbaubarem polymer und verwendung dafür - Google Patents

Konjugate mit biologisch abbaubarem polymer und verwendung dafür

Info

Publication number
DE60329126D1
DE60329126D1 DE60329126T DE60329126T DE60329126D1 DE 60329126 D1 DE60329126 D1 DE 60329126D1 DE 60329126 T DE60329126 T DE 60329126T DE 60329126 T DE60329126 T DE 60329126T DE 60329126 D1 DE60329126 D1 DE 60329126D1
Authority
DE
Germany
Prior art keywords
conjugates
polymer
biodegradable polymer
apyrase
biologically active
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60329126T
Other languages
English (en)
Inventor
David R Elmaleh
Simon C Robson
Mikhail I Papisov
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
General Hospital Corp
Beth Israel Deaconess Medical Center Inc
Original Assignee
General Hospital Corp
Beth Israel Deaconess Medical Center Inc
Beth Israel Hospital Association
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by General Hospital Corp, Beth Israel Deaconess Medical Center Inc, Beth Israel Hospital Association filed Critical General Hospital Corp
Application granted granted Critical
Publication of DE60329126D1 publication Critical patent/DE60329126D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L59/00Compositions of polyacetals; Compositions of derivatives of polyacetals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/08Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer
    • C12N11/089Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
DE60329126T 2002-02-20 2003-02-19 Konjugate mit biologisch abbaubarem polymer und verwendung dafür Expired - Lifetime DE60329126D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35830302P 2002-02-20 2002-02-20
PCT/US2003/004845 WO2003070823A2 (en) 2002-02-20 2003-02-19 Conjugates comprising a biodegradable polymer and uses therefor

Publications (1)

Publication Number Publication Date
DE60329126D1 true DE60329126D1 (de) 2009-10-15

Family

ID=27757725

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60329126T Expired - Lifetime DE60329126D1 (de) 2002-02-20 2003-02-19 Konjugate mit biologisch abbaubarem polymer und verwendung dafür

Country Status (6)

Country Link
US (2) US7785618B2 (de)
EP (2) EP2138575B8 (de)
AT (1) ATE441706T1 (de)
AU (1) AU2003219796A1 (de)
DE (1) DE60329126D1 (de)
WO (1) WO2003070823A2 (de)

Families Citing this family (89)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8106098B2 (en) * 1999-08-09 2012-01-31 The General Hospital Corporation Protein conjugates with a water-soluble biocompatible, biodegradable polymer
US20060177416A1 (en) 2003-10-14 2006-08-10 Medivas, Llc Polymer particle delivery compositions and methods of use
US7723296B2 (en) 2001-01-18 2010-05-25 Genzyme Corporation Methods for introducing mannose-6-phosphate and other oligosaccharides onto glycoproteins and its application thereof
ATE410459T1 (de) 2002-01-14 2008-10-15 Gen Hospital Corp Bioabbaubare polyketale, verfahren zu ihrer herstellung sowie ihre verwendung
AU2003219796A1 (en) * 2002-02-20 2003-09-09 Beth Israel Deaconess Medical Center Conjugates comprising a biodegradable polymer and uses therefor
JP4800614B2 (ja) * 2002-07-19 2011-10-26 ザ ジェネラル ホスピタル コーポレイション オキシム結合体、およびそれらの形成および使用のための方法
CA2537993C (en) 2003-09-05 2012-08-28 The General Hospital Corporation Dual phase drug release system
EP1877099B1 (de) * 2005-04-06 2012-09-19 Genzyme Corporation Therapeutische konjugate beinhaltend ein lysosomales enzym, polysialinsäure und eine zielkomponente
WO2007038246A2 (en) 2005-09-22 2007-04-05 Medivas, Llc Solid polymer delivery compositions and methods for use thereof
EP1926780B1 (de) 2005-09-22 2013-08-14 Medivas, LLC Bis-( -amino)-diol-diester-haltige poly(esteramid) und poly(esterurethan)-zusammensetzungen und verwendungsverfahren
DE102006046411A1 (de) * 2006-09-20 2008-03-27 Eberhard-Karls-Universität Tübingen Universitätsklinikum Arzneimittel zur Prophylaxe oder Behandlung oder Diagnostik von akutem Lungenversagen (ALI)
KR101273813B1 (ko) * 2006-10-04 2013-06-11 메드라드, 인크. 중재 카테터
EP2089438B1 (de) * 2006-11-07 2010-03-03 DSM IP Assets B.V. Carbamat, thiocarbamat oder carbamid mit einer biomolekularen gruppierung
HUE036140T2 (hu) 2007-01-18 2018-06-28 Genzyme Corp Aminooxi-csoportot tartalmazó oligoszacharidok és ezek konjugátjai
WO2008104200A1 (en) * 2007-03-01 2008-09-04 Gelato Corporation N.V. Use of apyrase for the treatment of a pathology resulting from endotoxin activity
US8202528B2 (en) * 2007-06-05 2012-06-19 Abbott Cardiovascular Systems Inc. Implantable medical devices with elastomeric block copolymer coatings
CA2700441A1 (en) 2007-09-24 2009-04-02 Noxxon Pharma Ag C5a binding nucleic acids
BRPI0820229A2 (pt) * 2007-11-28 2017-05-09 A Stevenson Cheri conjugados de análogos de fumagilina biodegradáveis biocompatíveis
WO2009111615A2 (en) 2008-03-05 2009-09-11 Thrombovision, Inc. Systems for measuring properties of a physiological fluid suspension
US20090292042A1 (en) * 2008-05-21 2009-11-26 Patterson Greg S Biodegradable material and plant container
CA2833960C (en) 2008-09-22 2015-12-22 Tyrx, Inc. Linear polyesteramides from aminophenolic esters
US8491880B2 (en) * 2008-12-10 2013-07-23 Mersana Therapeutics, Inc. Pharmaceutical formulations of biodegradable biocompatible camptothecin-polymer conjugates
BRPI0923047B8 (pt) 2008-12-16 2021-05-25 Genzyme Corp métodos para preparação de conjugados de proteínas- oligossacarídeos
US20120065254A1 (en) 2009-03-23 2012-03-15 Noxxon Pharma Ag C5A binding nucleic acids and the use thereof
US9839628B2 (en) 2009-06-01 2017-12-12 Tyrx, Inc. Compositions and methods for preventing sternal wound infections
ITAN20100002A1 (it) * 2010-01-25 2011-07-26 Biolog S R L Materiale polimerico sintentico biodegradabile
EP2553019A1 (de) 2010-03-26 2013-02-06 Mersana Therapeutics, Inc. Modifizierte polymere zur freisetzung von polynukleotiden, verfahren zu ihrer herstellung und verfahren zu ihrer verwendung
EP2561079A1 (de) 2010-04-21 2013-02-27 Noxxon Pharma AG Lipidbindende nukleinsäuren
KR101210713B1 (ko) * 2010-06-29 2012-12-10 가톨릭대학교 산학협력단 온도 민감성 생리활성 물질 전달체 및 이의 제조방법
EP2605650A4 (de) 2010-08-18 2014-05-21 Del Mar Pharmaceuticals Zusammensetzungen und verfahren zur erhöhung des therapeutischen nutzens suboptimal verabreichter chemischer verbindungen einschliesslich substituierter hexitole wie dianhydrogalactitol und diacetyldianhydrogalactitol
WO2012025251A1 (en) 2010-08-27 2012-03-01 Noxxon Pharma Ag Nucleic acids for treatment of chronic complications of diabetes
SG188220A1 (en) 2010-09-09 2013-04-30 Noxxon Pharma Ag Sdf-1 binding nucleic acids and the use thereof in cancer treatment
JP2014503187A (ja) 2010-10-29 2014-02-13 ノクソン ファーマ エージー 身体からヘプシジンを除去するためのヘプシジン結合核酸の使用
WO2012095303A1 (en) 2011-01-10 2012-07-19 Noxxon Pharma Ag Nucleic acid molecule having binding affinity to a target molecule and a method for generating the same
US8815226B2 (en) 2011-06-10 2014-08-26 Mersana Therapeutics, Inc. Protein-polymer-drug conjugates
AU2012267447B2 (en) * 2011-06-10 2016-10-20 Mersana Therapeutics, Inc. Protein-polymer-drug conjugates
US9873765B2 (en) 2011-06-23 2018-01-23 Dsm Ip Assets, B.V. Biodegradable polyesteramide copolymers for drug delivery
CA2839526A1 (en) 2011-06-23 2012-12-27 Dsm Ip Assets B.V. Micro- or nanoparticles comprising a biodegradable polyesteramide copolymer for use in the delivery of bioactive agents
WO2014081405A2 (en) 2011-08-17 2014-05-30 Dennis Brown Compositions and methods to improve the therapeutic benefit of suboptimally administered chemical compounds including substituted hexitols such as dibromodulcitol
AU2012325233A1 (en) 2011-10-21 2014-04-24 Noxxon Pharma Ag Glucagon binding nucleic acids
US9518265B2 (en) 2012-01-10 2016-12-13 Noxxon Pharma Ag C5a binding nucleic acids
SG11201403769YA (en) 2012-01-10 2014-07-30 Noxxon Pharma Ag Nucleic acids specifically binding cgrp
CN110711188A (zh) 2012-01-20 2020-01-21 德玛公司 经取代的己糖醇类用于治疗恶性肿瘤的用途
CA2868302A1 (en) 2012-03-23 2013-09-26 Dennis M. Brown Compositions and methods to improve the therapeutic benefit of indirubin and analogs thereof, including meisoindigo
WO2013169600A1 (en) 2012-05-09 2013-11-14 Delmar Pharmaceuticals Veterinary use of dianhydrogalactitol, diacetyldianhydrogalactitol, and dibromodulcitol to treat malignancies
MX367055B (es) 2012-06-26 2019-08-02 Del Mar Pharmaceuticals El uso de una composición que comprende dianhidrogalactitol, diacetildianhidrogalactitol, y dibromodulcitol, y análogos o derivados de cada uno para el tratamiento de malignidades resistentes a inhibidores de tirosina cinasa.
WO2014026078A1 (en) * 2012-08-10 2014-02-13 Rutgers, The State University Of New Jersey Asb Iii Attenuating or treating sepsis or septic shock
US11491154B2 (en) 2013-04-08 2022-11-08 Dennis M. Brown Therapeutic benefit of suboptimally administered chemical compounds
RU2015148055A (ru) * 2013-04-11 2017-05-16 Вандербилт Юниверсити Полиплексы
KR20160104612A (ko) 2013-07-26 2016-09-05 업데이트 파마 인코포레이트 비산트렌의 치료 효과 개선용 조성물
JP6747971B2 (ja) 2013-10-15 2020-08-26 シアトル ジェネティックス, インコーポレイテッド 改善されたリガンド−薬物コンジュゲート薬物動態のためのpeg化薬物−リンカー
WO2015062743A1 (en) 2013-11-04 2015-05-07 Noxxon Pharma Ag Means and methods for the treatment of nephropathy
WO2015154064A2 (en) 2014-04-04 2015-10-08 Del Mar Pharmaceuticals Use of dianhydrogalactitol and analogs or derivatives thereof to treat non-small-cell carcinoma of the lung and ovarian cancer
US10293044B2 (en) 2014-04-18 2019-05-21 Auburn University Particulate formulations for improving feed conversion rate in a subject
US20150297706A1 (en) 2014-04-18 2015-10-22 Auburn University Particulate Vaccine Formulations for Inducing Innate and Adaptive Immunity
US10434071B2 (en) 2014-12-18 2019-10-08 Dsm Ip Assets, B.V. Drug delivery system for delivery of acid sensitivity drugs
MX2018006218A (es) 2015-12-04 2018-09-05 Seattle Genetics Inc Conjugados de compuestos de tubulisina cuaternizada.
US11793880B2 (en) 2015-12-04 2023-10-24 Seagen Inc. Conjugates of quaternized tubulysin compounds
GB201522541D0 (en) * 2015-12-21 2016-02-03 Inst Research In Biomedicine Compositions
US10973792B2 (en) 2019-02-13 2021-04-13 Axcess Global Sciences, Llc Racemic beta-hydroxybutyrate mixed salt-acid compositions and methods of use
US11103470B2 (en) 2017-11-22 2021-08-31 Axcess Global Sciences, Llc Non-racemic beta-hydroxybutyrate compounds and compositions enriched with the R-enantiomer and methods of use
US10596130B2 (en) 2017-12-19 2020-03-24 Axcess Global Sciences, Llc Non-racemic beta-hydroxybutyrate compounds and compositions enriched with the S-enantiomer and methods of use
US11185518B2 (en) 2017-12-19 2021-11-30 Axcess Global Sciences, Llc S-beta-hydroxybutyrate compounds and compositions enriched with S-enantiomer
US11241403B2 (en) 2016-03-11 2022-02-08 Axcess Global Sciences, Llc Beta-hydroxybutyrate mixed salt compositions and methods of use
US10736861B2 (en) 2016-03-11 2020-08-11 Axcess Global Sciences, Llc Mixed salt compositions for producing elevated and sustained ketosis
US10596129B2 (en) 2017-11-22 2020-03-24 Axcess Global Sciences, Llc Non-racemic beta-hydroxybutyrate compounds and compositions enriched with the R-enantiomer and methods of use
US10245242B1 (en) 2017-11-22 2019-04-02 Axcess Global Sciences, Llc Non-racemic beta-hydroxybutyrate compounds and compositions enriched with the R-enantiomer and methods of use
US10973786B2 (en) 2016-03-11 2021-04-13 Axcess Global Sciences, Llc R-beta-hydroxybutyrate, S-beta-hydroxybutyrate, and RS-beta-hydroxybutyrate mixed salt compositions
US10245243B1 (en) 2017-12-19 2019-04-02 Axcess Global Sciences, Llc Non-racemic beta-hydroxybutyrate compounds and compositions enriched with the S-enantiomer and methods of use
US10596131B2 (en) 2017-11-22 2020-03-24 Axcess Global Sciences, Llc Non-racemic beta-hydroxybutyrate compounds and compositions enriched with the R-enantiomer and methods of use
EA201892040A1 (ru) 2016-03-25 2019-04-30 Сиэтл Дженетикс, Инк. Способ получения пегилированных соединений лекарственный препарат - линкер и их промежуточных соединений
EP3443095A1 (de) 2016-04-15 2019-02-20 Noxxon Pharma AG Verfahren zur modulation der anzahl und der verteilung von tumorinfiltrierenden leukozyten bei tumoren
US10583199B2 (en) 2016-04-26 2020-03-10 Northwestern University Nanocarriers having surface conjugated peptides and uses thereof for sustained local release of drugs
JP2020512312A (ja) 2017-03-24 2020-04-23 シアトル ジェネティックス, インコーポレイテッド グルクロニド薬物−リンカーの調製のためのプロセスおよびその中間体
US11202769B2 (en) 2017-11-22 2021-12-21 Axcess Global Sciences, Llc Ketone body esters of s-beta-hydroxybutyrate and/or s-1,3-butanediol for modifying metabolic function
US10925843B2 (en) * 2018-04-18 2021-02-23 Axcess Global Sciences, Llc Compositions and methods for keto stacking with beta-hydroxybutyrate and acetoacetate
US11944598B2 (en) 2017-12-19 2024-04-02 Axcess Global Sciences, Llc Compositions containing s-beta-hydroxybutyrate or non-racemic mixtures enriched with the s-enatiomer
US10512615B1 (en) 2018-08-27 2019-12-24 Axcess Global Sciences, Llc Compositions and methods for delivering cannabidiol and ketone bodies
US11806324B2 (en) 2018-04-18 2023-11-07 Axcess Global Sciences, Llc Beta-hydroxybutyric acid compositions and methods for oral delivery of ketone bodies
US11419836B2 (en) 2019-02-13 2022-08-23 Axcess Global Sciences, Llc Racemic and near racemic beta-hydroxybutyrate mixed salt-acid compositions
US11129802B2 (en) 2018-08-27 2021-09-28 Axcess Global Sciences, Llc Compositions and methods for delivering cannabidiol and ketone bodies
US11241401B2 (en) 2020-02-06 2022-02-08 Axcess Global Sciences, Llc Enantiomerically pure r-beta-hydroxybutyrate mixed salt-acid compositions
US10980772B2 (en) 2018-08-27 2021-04-20 Axcess Global Sciences, Llc Compositions and methods for delivering tetrahydrocannabinol and ketone bodies
CN109303923B (zh) * 2018-11-09 2021-05-11 东南大学 一种制备类羟基磷灰石成分的纳米簇凝胶的方法
CN113660930A (zh) * 2019-02-11 2021-11-16 阿克塞斯全球科学有限责任公司 β-羟基丁酸盐混合盐-酸组合物和使用方法
US11950616B2 (en) 2019-06-21 2024-04-09 Axcess Global Sciences, Llc Non-vasoconstricting energy-promoting compositions containing ketone bodies
US11033553B2 (en) 2019-06-21 2021-06-15 Axcess Global Sciences, Llc Non-vasoconstricting energy-promoting compositions containing ketone bodies
EP4306640A1 (de) 2022-06-21 2024-01-17 TME Pharma AG Verfahren zur behandlung eines tumors in einem patienten
WO2023247651A1 (en) 2022-06-21 2023-12-28 TME Pharma AG Methods for treating a tumor in a subject

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES437153A1 (es) * 1974-05-06 1977-04-16 Marburgnlahn Procedimiento para la preparacion de un compuesto biologica-mente activo a base de poli(hidroximetileno) o poli(carbona-to de vinileno).
SU761477A1 (ru) * 1978-07-10 1980-09-07 Datse Yu Baltsere Способ получения водорастворимого препарата целлюлазы . . 1
US4215051A (en) 1979-08-29 1980-07-29 Standard Oil Company (Indiana) Formation, purification and recovery of phthalic anhydride
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4766072A (en) 1985-07-17 1988-08-23 Promega Corporation Vectors for in vitro production of RNA copies of either strand of a cloned DNA sequence
US4729956A (en) * 1986-05-01 1988-03-08 Phillips Petroleum Company Stabilized alcohol oxidase compositions and method for producing same
US4843147A (en) * 1986-11-06 1989-06-27 University Of British Columbia Anhydrous enhanced coupling of proteins
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
GB8826429D0 (en) * 1988-11-11 1988-12-14 Univ Leeds Ind Service Ltd Enzyme stabilisation systems
US5198346A (en) 1989-01-06 1993-03-30 Protein Engineering Corp. Generation and selection of novel DNA-binding proteins and polypeptides
US5096815A (en) 1989-01-06 1992-03-17 Protein Engineering Corporation Generation and selection of novel dna-binding proteins and polypeptides
JPH03158758A (ja) * 1989-11-17 1991-07-08 Tosoh Corp デキストランを介して結合した二以上の物質の複合体及び該複合体の製造方法
US5221495A (en) * 1990-04-13 1993-06-22 Colgate-Palmolive Company Enzyme stabilizing composition and stabilized enzyme containing built detergent compositions
NZ237570A (en) * 1990-04-13 1993-09-27 Colgate Palmolive Co Enzyme stabilising composition and stabilised enzyme-containing built detergent compositions
EP0606217B2 (de) 1991-06-27 2008-12-03 Bristol-Myers Squibb Company CTL4A Rezeptor, ihn enthaltenden Fusionsproteine und deren Verwendungen
ZA933926B (en) * 1992-06-17 1994-01-03 Amgen Inc Polyoxymethylene-oxyethylene copolymers in conjuction with blomolecules
AU4778893A (en) 1992-07-21 1994-02-14 General Hospital Corporation, The System of drug delivery to the lymphatic tissues
US5378601A (en) 1992-07-24 1995-01-03 Montefiore Medical Center Method of preserving platelets with apyrase and an antioxidant
US5399665A (en) 1992-11-05 1995-03-21 Massachusetts Institute Of Technology Biodegradable polymers for cell transplantation
US5279565A (en) 1993-02-03 1994-01-18 Localmed, Inc. Intravascular treatment apparatus and method
JP3158758B2 (ja) * 1993-02-19 2001-04-23 松下電器産業株式会社 端末アダプタ装置とデータ伝送方法
US6179817B1 (en) 1995-02-22 2001-01-30 Boston Scientific Corporation Hybrid coating for medical devices
CA2216445A1 (en) 1995-03-24 1996-10-03 Novartis Ag Gene therapy for transplantation and inflammatory or thrombotic conditions
US5811510A (en) 1995-04-14 1998-09-22 General Hospital Corporation Biodegradable polyacetal polymers and methods for their formation and use
WO1996040792A1 (en) * 1995-06-07 1996-12-19 Novo Nordisk A/S Modification of polypeptides
US6312921B1 (en) 1996-07-26 2001-11-06 Genetics Institute, Inc. Secreted proteins and polynucleotides encoding them
US6248327B1 (en) 1998-09-11 2001-06-19 Vanderbilt University Modulation of endothelial cell surface receptor activity in the regulation of angiogenesis
WO2000023459A1 (en) 1998-10-16 2000-04-27 Immunex Corporation Inhibitors of platelet activation and recruitment
US6822086B1 (en) 1999-08-09 2004-11-23 The General Hospital Corporation Drug-carrier complexes and methods of use thereof
US7160924B2 (en) 2002-07-19 2007-01-09 The General Hospital Corporation Protein conjugates with a water-soluble biocompatible, biodegradable polymer
ATE410459T1 (de) * 2002-01-14 2008-10-15 Gen Hospital Corp Bioabbaubare polyketale, verfahren zu ihrer herstellung sowie ihre verwendung
AU2003219796A1 (en) * 2002-02-20 2003-09-09 Beth Israel Deaconess Medical Center Conjugates comprising a biodegradable polymer and uses therefor
US20040205840A1 (en) * 2003-04-11 2004-10-14 Pioneer Hi-Bred International, Inc. Method for reducing gene expression

Also Published As

Publication number Publication date
WO2003070823A2 (en) 2003-08-28
EP2138575B1 (de) 2013-06-19
EP2138575A1 (de) 2009-12-30
US20110044967A1 (en) 2011-02-24
ATE441706T1 (de) 2009-09-15
AU2003219796A1 (en) 2003-09-09
AU2003219796A8 (en) 2003-09-09
US7785618B2 (en) 2010-08-31
EP1585817B1 (de) 2009-09-02
EP1585817A2 (de) 2005-10-19
WO2003070823A3 (en) 2004-08-26
EP2138575B8 (de) 2013-07-24
EP1585817A4 (de) 2005-12-28
WO2003070823A9 (en) 2005-06-02
US20050169968A1 (en) 2005-08-04

Similar Documents

Publication Publication Date Title
DE60329126D1 (de) Konjugate mit biologisch abbaubarem polymer und verwendung dafür
EP1196444B8 (de) Exendin-4 konjugate und ihre medizinische verwendung
DE69910216D1 (de) Konjugate zur behandlung von entzündungskrankheiten und von assozierter gewebeschädigung
ATE263579T1 (de) Abgabe von polyethylene glycol-molekül- konjugaten aus abbaubarem hydrogel
ATE296116T1 (de) Ein kovalentes konjugat von clozapine und einer fettsäure und dessen verwendung zur behandlung von schizophrenie
CY1109458T1 (el) Ιστικο μοσχευμα
CY1110505T1 (el) Ανθρωπινα αντισωματα dr4 και χρησεις αυτων
BR0100084A (pt) Lagarta de borracha sem-fim e veìculo contendo tal lagarta
CY1109151T1 (el) Αντισωματα dr4 και χρησεις αυτων
BR0308090A (pt) conjugados de agentes citotóxicos ou terapêuticos e peptìdios biologicamente ativos
MXPA03010085A (es) Composiciones y su uso en la hiperplasia.
TR200101867T2 (tr) CCR5 modülatörleri olarak piperidinler
ATE336255T1 (de) Hyaluronsäure-ester zur behandlung von normotrophischen hautnarben
ATE444086T1 (de) Therapeutische zusammensetzungen und verfahren zur behandlung von periodontitis mit entzündunshemmenden mitteln
DE60143065D1 (de) Bildgebende Verfahren, Diagnose und Behandlung von Krankheiten
BR0007666A (pt) Composição cosmética com base em mentol e mentil lactato, tendo pouco odor e sendo não irritante
DE60140864D1 (de) Therapeutische zusammenfassungen und verfahren zur modulierung von v3, eine isoform von versican
PT1150716E (pt) Composicao farmaceutica de proteinas hedgehog hidrofobicamente modificadas e sua utilizacao
WO2000050023A8 (en) Use of tamoxifen and related compounds as clc3 blockers in the treatment of vascular diseases
DE59706692D1 (de) Konjugat, geeignet zur bindung von substanzen

Legal Events

Date Code Title Description
8364 No opposition during term of opposition