AU2008258487B2 - Piperidine/piperazine derivatives - Google Patents

Piperidine/piperazine derivatives Download PDF

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Publication number
AU2008258487B2
AU2008258487B2 AU2008258487A AU2008258487A AU2008258487B2 AU 2008258487 B2 AU2008258487 B2 AU 2008258487B2 AU 2008258487 A AU2008258487 A AU 2008258487A AU 2008258487 A AU2008258487 A AU 2008258487A AU 2008258487 B2 AU2008258487 B2 AU 2008258487B2
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Australia
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alkyl
aryl
het
substituted
alkyloxy
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AU2008258487A
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AU2008258487A1 (en
Inventor
Monique Jenny Marie Berwaer
Gustaaf Maria Boeckx
Jean-Pierre Andre Marc Bongartz
Mirielle Braeken
Christophe Francis Robert Nestor Buyck
Erwin Coesemans
Petr Vladimirivich Davidenko
Katharina Antonia Germania J.M. De Waepenaert
Joannes Theodorus Maria Linders
Lieven Meerpoel
Peter Walter Maria Roevens
Guy Rosalia Eugeen Van Lommen
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Janssen Pharmaceutica NV
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Janssen Pharmaceutica NV
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    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
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    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
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Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE46117E1 (en) 1999-12-22 2016-08-23 Teva Pharmaceuticals International Gmbh Modulators of dopamine neurotransmission
CA2588162A1 (en) 2004-12-14 2006-06-22 Astrazeneca Ab Oxadiazole derivatives as dgat inhibitors
EP1966221A1 (en) 2005-12-22 2008-09-10 AstraZeneca AB Pyrimido- [4, 5-]-oxazines for use as dgat inhibitors
DK2402317T3 (da) 2006-03-31 2013-10-07 Novartis Ag DGAT-inhibitor
MX2008015228A (es) 2006-05-30 2008-12-12 Astrazeneca Ab Acido 5-fenilamino-1,3,4-oxadiazol-2-ilcarbonilamino-4-fenoxi-cicl ohexanocarboxilico sustituido como inhibidor de diacilglicerol aciltransferasa de acetil coenzima a.
AU2008258487B2 (en) 2007-06-08 2012-11-15 Janssen Pharmaceutica N.V. Piperidine/piperazine derivatives
JP5464709B2 (ja) 2007-06-08 2014-04-09 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ピペリジン／ピペラジン誘導体
CA2687912C (en) 2007-06-08 2015-11-03 Janssen Pharmaceutica N.V. Piperidine/piperazine derivatives
JO2972B1 (en) 2007-06-08 2016-03-15 جانسين فارماسوتيكا ان. في Piperidine / piperazine derivatives
AR066169A1 (es) 2007-09-28 2009-07-29 Novartis Ag Derivados de benzo-imidazoles, utiles para trastornos asociados con la actividad de dgat
AU2009253892B2 (en) * 2008-06-05 2015-07-30 Janssen Pharmaceutica Nv Drug combinations comprising a DGAT inhibitor and a PPAR-agonist
US9012159B2 (en) 2009-02-04 2015-04-21 Janssen Research & Development, Llc Cell based screening assays for the triglyceride synthesis pathway
US9452980B2 (en) * 2009-12-22 2016-09-27 Hoffmann-La Roche Inc. Substituted benzamides
CA2946538A1 (en) 2014-04-04 2015-10-08 Del Mar Pharmaceuticals Use of dianhydrogalactitol and analogs or derivatives thereof to treat non-small-cell carcinoma of the lung and ovarian cancer
EP3188731B1 (en) * 2014-09-05 2019-04-03 Merck Sharp & Dohme Corp. Isoquinoline derivatives useful as inhibitors of diacylglyceride o-acyltransferase 2
CN108463109B (zh) 2015-12-22 2022-04-29 先正达参股股份有限公司 杀有害生物活性吡唑衍生物
CR20180443A (es) 2016-03-17 2018-11-21 Hoffmann La Roche Derivado de morfolina
CN108250185B (zh) * 2018-01-24 2020-08-21 浙江工业大学 6-(2-(邻甲苯氨基)乙酰氨基)喹唑啉类化合物及制备和应用
CN109516919B (zh) * 2018-12-27 2021-12-14 安徽工业大学科技园有限公司 一种三(2-氨基乙基)胺的制备方法
CN109438252B (zh) * 2018-12-27 2021-12-14 安徽工业大学科技园有限公司 一种三(2-氨基乙基)胺的合成工艺

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006134317A1 (en) * 2005-06-11 2006-12-21 Astrazeneca Ab Oxadiazole derivatives as dgat inhibitors
EP1764360A1 (en) * 2004-07-02 2007-03-21 Sankyo Company, Limited Urea derivative

Family Cites Families (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1383906A (en) 1971-02-22 1974-02-12 Bdh Pharmaceuticals Ltd Pyridazinones
JPS5692887A (en) 1979-12-05 1981-07-27 Sumitomo Chem Co Ltd N-substituted imidazole derivative
DE3338846A1 (de) * 1982-10-29 1984-05-03 Toyama Chemical Co. Ltd., Tokyo Neue 4-oxo-1,4-dihydronicotinsaeurederivate und salze derselben, verfahren zu ihrer herstellung und antibakterielle mittel mit einem gehalt derselben
GB8729083D0 (en) 1987-12-12 1988-01-27 Pfizer Ltd Triazole antifungal agents
JP2969359B2 (ja) * 1989-01-13 1999-11-02 武田薬品工業株式会社 環状アミン化合物
DE4317093A1 (de) * 1993-05-21 1994-11-24 Basf Ag Niedermolekulare und polymere flüssigkristalline Benztriazole und deren Verwendung
TW286317B (es) * 1993-12-13 1996-09-21 Hoffmann La Roche
US5639754A (en) 1994-07-12 1997-06-17 Janssen Pharmaceutica N.V. Urea and thiourea derivatives of azolones
US5637592A (en) 1994-07-12 1997-06-10 Janssen Pharmaceutica N.V. Acyl derivatives of azolones
FR2722788B1 (fr) * 1994-07-20 1996-10-04 Pf Medicament Nouvelles piperazides derivees d'aryl piperazine, leurs procedes de preparation, leur utilisation a titre de medicament et les compositions pharmaceutiques les comprenant
SK282252B6 (sk) 1995-01-11 2001-12-03 Samjin Pharmaceutical Co., Ltd. Piperazínové deriváty a farmaceutický prostriedok s ich obsahom
AU705082B2 (en) 1995-08-10 1999-05-13 Merck & Co., Inc. 2-substituted aryl pyrroles, compositions containing such compounds and methods of use
CA2228050A1 (en) 1995-08-10 1997-02-20 Harold G. Selnick 2,5-substituted aryl pyrroles, compositions containing such compounds and methods of use
GB9702213D0 (en) 1996-02-24 1997-03-26 Zeneca Ltd Chemical compounds
HN1997000027A (es) 1996-12-06 1997-06-05 Pfizer Prod Inc Derivados de 6-fenil piridil - 2 amina
JPH11139969A (ja) 1997-08-07 1999-05-25 Tanabe Seiyaku Co Ltd 医薬組成物
DE19743435A1 (de) 1997-10-01 1999-04-08 Merck Patent Gmbh Benzamidinderivate
SK492001A3 (en) 1998-07-20 2001-08-06 Merck Patent Gmbh Biphenyl derivatives
GB9826412D0 (en) 1998-12-03 1999-01-27 Glaxo Group Ltd Chemical compounds
AUPP999799A0 (en) * 1999-04-27 1999-05-20 Fujisawa Pharmaceutical Co., Ltd. New compound
MXPA01011978A (es) 1999-05-21 2002-05-06 Pfizer Prod Inc Nuevas combinaciones farmaceuticas para inhibidores de la nos.
CA2373921A1 (en) * 1999-06-22 2000-12-28 Neurosearch A/S Novel benzimidazole derivatives and pharmaceutical compositions comprising these compounds
NZ520696A (en) 2000-02-10 2004-03-26 Upjohn Co Piperazine amide substituted oxazolidinone thioamides useful for treating bacteria infections
GB0013378D0 (en) 2000-06-01 2000-07-26 Glaxo Group Ltd Use of therapeutic benzamide derivatives
WO2001095856A2 (en) 2000-06-15 2001-12-20 Chaconne Nsi Co., Ltd. Urea derivative useful as an anti-cancer agent and process for preparing same
US20030060472A1 (en) * 2000-06-21 2003-03-27 Learmonth David Alexander Novel substituted nitrocatechols, their use in the treatment of some central and peripheral nervous system disorders and pharmaceutical compositions containing them
GB2363792A (en) 2000-06-21 2002-01-09 Portela & Ca Sa Nitrocatechols
JO2654B1 (en) 2000-09-04 2012-06-17 شركة جانسين فارماسوتيكا ان. في Multiple aryl caroxa amides are useful as lipid - lowering agents
US7186683B2 (en) * 2000-09-18 2007-03-06 Sanos Bioscience A/S Use of GLP for the treatment, prevention, diagnosis, and prognosis of bone-related and nutrition-related disorders
AUPR201600A0 (en) * 2000-12-11 2001-01-11 Fujisawa Pharmaceutical Co., Ltd. Quinazolinone derivative
DE10063008A1 (de) * 2000-12-16 2002-06-20 Merck Patent Gmbh Carbonsäureamidderivate
IL156595A0 (en) 2001-01-16 2004-01-04 Astrazeneca Ab Therapeutic heterocyclic compounds
JO2390B1 (en) 2001-04-06 2007-06-17 شركة جانسين فارماسوتيكا ان. في Diphenylcarboxamides act as lipid-lowering agents
DE10204116A1 (de) 2002-02-01 2003-08-07 Bayer Cropscience Ag DELTA·1·-Pyrroline
CN100445276C (zh) * 2002-03-13 2008-12-24 詹森药业有限公司 用作组蛋白去乙酰酶抑制剂的磺酰基衍生物
EA007272B1 (ru) * 2002-03-13 2006-08-25 Янссен Фармацевтика Н. В. Новые ингибиторы гистондеацетилазы
AU2003231920A1 (en) 2002-04-01 2003-10-13 Cadila Healthcare Limited Antiinfectve compounds, process for their preparation and pharmaceutical compositions containing them
TWI319387B (en) 2002-04-05 2010-01-11 Astrazeneca Ab Benzamide derivatives
US7842693B2 (en) * 2002-06-12 2010-11-30 Chemocentryx, Inc. Substituted piperazines
WO2004018439A1 (en) 2002-08-22 2004-03-04 Orchid Chemicals & Pharmaceuticals Ltd Novel antibacterial agents
MXPA05005425A (es) 2002-11-22 2005-11-23 Japan Tobacco Inc Heterociclos que contienen nitrogeno, biciclicos, fusionados.
AU2004209456A1 (en) 2003-02-03 2004-08-19 Janssen Pharmaceutica N.V. Quinoline-derived amide modulators of vanilloid VR1 receptor
US7223788B2 (en) * 2003-02-14 2007-05-29 Sanofi-Aventis Deutschland Gmbh Substituted N-aryl heterocycles, process for their preparation and their use as medicaments
DE10306250A1 (de) * 2003-02-14 2004-09-09 Aventis Pharma Deutschland Gmbh Substituierte N-Arylheterozyklen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
AR044152A1 (es) 2003-05-09 2005-08-24 Bayer Corp Derivados de alquilarilo, metodo de preparacion y uso para el tratamiento de la obesidad
EP1635832A2 (en) 2003-06-06 2006-03-22 Merck & Co., Inc. Combination therapy for the treatment of diabetes
WO2005007658A2 (en) * 2003-07-14 2005-01-27 Arena Pharmaceuticals, Inc. Fused-aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto
ME00116B (me) * 2003-08-11 2010-10-10 Hoffmann La Roche Piperazin sa ili supstituisanom fenil grupom i njihova upotreba kao inhibitora glyt1
JP2005206492A (ja) * 2004-01-21 2005-08-04 Sankyo Co Ltd スルホンアミド化合物
EP1718309A2 (en) * 2004-01-30 2006-11-08 Japan Tobacco, Inc. Anorectic compounds
JP4787529B2 (ja) 2004-04-09 2011-10-05 大塚製薬株式会社 医薬組成物
CA2575180A1 (en) * 2004-08-03 2006-02-16 Wyeth Indazoles useful in treating cardiovascular diseases
CN100360525C (zh) 2004-09-16 2008-01-09 中国科学院上海药物研究所 一类新的噁唑烷酮衍生物、其制备方法和用途
CN101084207A (zh) 2004-09-20 2007-12-05 泽农医药公司 杂环衍生物及其作为硬脂酰CoA去饱和酶抑制剂的用途
GB0421908D0 (en) * 2004-10-01 2004-11-03 Angeletti P Ist Richerche Bio New uses
DE602005025517D1 (de) 2004-10-15 2011-02-03 Bayer Healthcare Llc Herstellung und anwendung von biphenyl-4-yl-carbonylaminosäurederivaten zur behandlung von obesitas
PL1807077T3 (pl) 2004-10-22 2017-05-31 Janssen Pharmaceutica Nv Inhibitory kinazy c-fms
CA2588162A1 (en) 2004-12-14 2006-06-22 Astrazeneca Ab Oxadiazole derivatives as dgat inhibitors
NZ554516A (en) 2004-12-22 2010-07-30 Janssen Pharmaceutica Nv Diacylglycerol acyltransferase assay
GT200600046A (es) 2005-02-09 2006-09-25 Terapia de combinacion
GB0505084D0 (en) 2005-03-11 2005-04-20 Glaxo Group Ltd Compounds
EP1866298A2 (en) 2005-03-31 2007-12-19 Takeda San Diego, Inc. Hydroxysteroid dehydrogenase inhibitors
CA2601983A1 (en) 2005-04-06 2006-10-12 Astrazeneca Ab Substituted heterocycles and their use as chk1, pdk1 and pak inhibitors
US20090215780A1 (en) 2005-04-19 2009-08-27 Bayer Pharmaceuticals Corporation Preparation and Use of Aryl Alkyl Acid Derivatives for the Treatment of Obesity
MX2008001468A (es) * 2005-06-30 2008-04-07 Sod Conseils Rech Applic Composiciones farmaceuticas del peptido similar al glucagon-1.
JP2007131584A (ja) * 2005-11-11 2007-05-31 Sankyo Co Ltd 新規ベンゾオキサゾール誘導体
US7799787B2 (en) 2005-12-20 2010-09-21 Merck Frosst Canada Ltd. Heteroaromatic compounds as inhibitors of stearoyl-coenzyme a delta-9 desaturase
EP1966221A1 (en) 2005-12-22 2008-09-10 AstraZeneca AB Pyrimido- [4, 5-]-oxazines for use as dgat inhibitors
US7569561B2 (en) * 2006-02-22 2009-08-04 Boehringer Ingelheim International Gmbh 2,4-diaminopyrimidines useful for treating cell proliferation diseases
US7728031B2 (en) 2006-02-24 2010-06-01 Abbott Laboratories Octahydro-pyrrolo[3,4-b]pyrrole derivatives
CA2654670A1 (en) 2006-07-06 2008-01-10 Boehringer Ingelheim International Gmbh New compounds
EP1918285A1 (en) 2006-11-03 2008-05-07 Merck Sante Diazepane-acetamide derivatives as selective 11beta-HSD1 inhibitors
GB0706793D0 (en) 2007-04-05 2007-05-16 Evotec Ag Compounds
EP2155687A1 (en) 2007-05-22 2010-02-24 Via Pharmaceuticals, Inc. Diacylglycerol acyltransferase inhibitors
AU2008258487B2 (en) 2007-06-08 2012-11-15 Janssen Pharmaceutica N.V. Piperidine/piperazine derivatives
JP5464709B2 (ja) * 2007-06-08 2014-04-09 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ピペリジン／ピペラジン誘導体
JO2972B1 (en) 2007-06-08 2016-03-15 جانسين فارماسوتيكا ان. في Piperidine / piperazine derivatives
CA2687912C (en) 2007-06-08 2015-11-03 Janssen Pharmaceutica N.V. Piperidine/piperazine derivatives
AU2009253892B2 (en) 2008-06-05 2015-07-30 Janssen Pharmaceutica Nv Drug combinations comprising a DGAT inhibitor and a PPAR-agonist

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1764360A1 (en) * 2004-07-02 2007-03-21 Sankyo Company, Limited Urea derivative
WO2006134317A1 (en) * 2005-06-11 2006-12-21 Astrazeneca Ab Oxadiazole derivatives as dgat inhibitors

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