BR0107645A - Oxazolidinona tiamidas com substituintes de piperazina amida - Google Patents
Oxazolidinona tiamidas com substituintes de piperazina amidaInfo
- Publication number
- BR0107645A BR0107645A BR0107645-0A BR0107645A BR0107645A BR 0107645 A BR0107645 A BR 0107645A BR 0107645 A BR0107645 A BR 0107645A BR 0107645 A BR0107645 A BR 0107645A
- Authority
- BR
- Brazil
- Prior art keywords
- oxazolidinone
- thiamides
- piperazine amide
- amide substituents
- piperazine
- Prior art date
Links
- IZXIZTKNFFYFOF-UHFFFAOYSA-N 2-Oxazolidone Chemical compound O=C1NCCO1 IZXIZTKNFFYFOF-UHFFFAOYSA-N 0.000 title abstract 2
- IVXQBCUBSIPQGU-UHFFFAOYSA-N piperazine-1-carboxamide Chemical group NC(=O)N1CCNCC1 IVXQBCUBSIPQGU-UHFFFAOYSA-N 0.000 title 1
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 abstract 2
- 241000670727 Amida Species 0.000 abstract 1
- 241000894006 Bacteria Species 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Ophthalmology & Optometry (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
"OXAZOLIDINONA TIAMIDAS COM SUBSTITUINTES DE PIPERAZINA AMIDA". A presente invenção fornece um composto de fórmula I que possui potentes atividades contra bactérias gram-positivas e gram-negativas.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US18164000P | 2000-02-10 | 2000-02-10 | |
PCT/US2001/000682 WO2001058885A1 (en) | 2000-02-10 | 2001-02-07 | Oxazolidinone thioamides with piperazine amide substituents |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0107645A true BR0107645A (pt) | 2002-10-08 |
Family
ID=22665142
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0107645-0A BR0107645A (pt) | 2000-02-10 | 2001-02-07 | Oxazolidinona tiamidas com substituintes de piperazina amida |
Country Status (17)
Country | Link |
---|---|
US (1) | US20010047004A1 (pt) |
EP (1) | EP1263742B1 (pt) |
JP (1) | JP2003522763A (pt) |
KR (1) | KR20020072311A (pt) |
CN (1) | CN1395569A (pt) |
AR (1) | AR029226A1 (pt) |
AT (1) | ATE302762T1 (pt) |
AU (1) | AU2001234428A1 (pt) |
BR (1) | BR0107645A (pt) |
CA (1) | CA2395648A1 (pt) |
CO (1) | CO5271737A1 (pt) |
DE (1) | DE60112903T2 (pt) |
ES (1) | ES2248284T3 (pt) |
MX (1) | MXPA02007719A (pt) |
NZ (1) | NZ520696A (pt) |
PE (1) | PE20011089A1 (pt) |
WO (1) | WO2001058885A1 (pt) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6465456B2 (en) * | 2000-06-29 | 2002-10-15 | Bristol-Myers Squibb Company | Isoxazolinone antibacterial agents |
WO2002032857A1 (en) * | 2000-10-17 | 2002-04-25 | Pharmacia & Upjohn Company | Methods of producing oxazolidinone compounds |
CN1653064A (zh) | 2002-02-28 | 2005-08-10 | 阿斯特拉曾尼卡有限公司 | 噁唑烷酮衍生物、其制备方法以及包含它们的药用组合物 |
CA2477344A1 (en) | 2002-02-28 | 2003-09-04 | Astrazeneca Ab | 3-cyclyl-5-(nitrogen-containing 5-membered ring) methyl-oxazolidinone derivatives and their use as antibacterial agents |
CA2478502A1 (en) * | 2002-04-01 | 2003-10-09 | Cadila Healthcare Limited | Novel antiinfective compounds, process for their preparation and pharmaceutical compositions containing them |
TW200403240A (en) | 2002-06-28 | 2004-03-01 | Upjohn Co | Difluorothioacetamides of oxazolidinones as antibacterial agents |
TW200404069A (en) * | 2002-06-28 | 2004-03-16 | Upjohn Co | Difluorothioacetamides of oxazolidinones with a glycoloylpiperazine substituent |
WO2004007488A2 (en) * | 2002-07-11 | 2004-01-22 | Wockhardt Limited | Antimicrobial oxazolidinones, process of their preparation, and pharmaceutical compositions containing them |
WO2004007489A2 (en) * | 2002-07-11 | 2004-01-22 | Wockhardt Limited | Antibacterial substituted cyanomethyl (ene) piperidinophenyl oxazolidinones, process or their preparation, and pharmaceutical compositions containing them |
US7217726B2 (en) * | 2002-08-22 | 2007-05-15 | Orchid Chemicals & Pharmaceuticals Limited | Antibacterial agents |
US7091196B2 (en) * | 2002-09-26 | 2006-08-15 | Rib-X Pharmaceuticals, Inc. | Bifunctional heterocyclic compounds and methods of making and using same |
US7141570B2 (en) | 2002-11-21 | 2006-11-28 | Pharmacia & Upjohn Company | N-aryl-2-oxazolidinone-5-carboxamides and their derivatives |
JP2007521283A (ja) * | 2003-07-02 | 2007-08-02 | メルク アンド カンパニー インコーポレーテッド | シクロプロピル基で置換されたオキサゾリジノン系抗生物質およびその誘導体 |
KR20060113625A (ko) | 2003-07-02 | 2006-11-02 | 머크 앤드 캄파니 인코포레이티드 | 시클로프로필기 치환된 옥사졸리디논 항생제 및 그의유도체 |
EP2716647A3 (en) | 2004-02-27 | 2014-08-20 | Rib-X Pharmaceuticals, Inc. | Macrocyclic compounds and methods of making and using the same |
US8278281B2 (en) | 2005-08-24 | 2012-10-02 | Rib-X Pharmaceuticals, Inc. | Triazole compounds and methods of making and using the same |
US8470985B2 (en) | 2005-08-24 | 2013-06-25 | Rib-X Pharmaceuticals, Inc. | Triazole compounds and methods of making and using the same |
US20100210602A1 (en) * | 2006-12-12 | 2010-08-19 | The Johns Hopkins University | PhoU (PerF), A PERSISTENCE SWITCH INVOLVED IN PERSISTER FORMATION AND TOLERANCE TO MULTIPLE ANTIBIOTICS AND STRESSES AS A DRUG TARGET FOR PERSISTER BACTERIA |
CA2687912C (en) | 2007-06-08 | 2015-11-03 | Janssen Pharmaceutica N.V. | Piperidine/piperazine derivatives |
JO2972B1 (en) | 2007-06-08 | 2016-03-15 | جانسين فارماسوتيكا ان. في | Piperidine / piperazine derivatives |
US8633197B2 (en) | 2007-06-08 | 2014-01-21 | Janssen Pharmaceutica N.V. | Piperidine/piperazine derivatives |
CA2687754C (en) | 2007-06-08 | 2015-12-08 | Janssen Pharmaceutica N.V. | Piperidine, piperazine derivatives for use as dgat inhibitors |
EP2170874A4 (en) * | 2007-06-22 | 2011-08-31 | Orchid Res Lab Ltd | NEW COMPOUNDS AND THEIR USE |
UY31863A (es) | 2008-06-05 | 2010-01-05 | Janssen Pharmaceutica Nv | Combinaciones de drogas que comprenden un inhibidor de dgat y un agonista de ppar |
CN115466253B (zh) * | 2021-06-16 | 2024-08-20 | 沈阳药科大学 | 含二硫代氨基甲酸酯结构的噁唑烷酮类化合物及其制备方法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL66726A0 (en) * | 1981-09-08 | 1982-12-31 | Lilly Co Eli | Improvements in or relating to thieno and furopyridinium-substituted cephalosporin derivatives |
WO1998054161A1 (en) * | 1997-05-30 | 1998-12-03 | Pharmacia & Upjohn Company | Oxazolidinone antibacterial agents having a thiocarbonyl functionality |
WO1999012914A1 (fr) * | 1997-09-11 | 1999-03-18 | Hokuriku Seiyaku Co., Ltd. | Derives de thiouree |
JPH11322729A (ja) * | 1998-03-09 | 1999-11-24 | Hokuriku Seiyaku Co Ltd | ジチオカルバミド酸誘導体 |
JP2000204084A (ja) * | 1998-11-11 | 2000-07-25 | Hokuriku Seiyaku Co Ltd | チオカルバミド酸誘導体 |
MXPA01012167A (es) * | 1999-05-27 | 2002-06-21 | Upjohn Co | Nuevas oxazolidinonas biciclicas como agentes antibacterianos. |
-
2001
- 2001-02-07 AT AT01906529T patent/ATE302762T1/de not_active IP Right Cessation
- 2001-02-07 WO PCT/US2001/000682 patent/WO2001058885A1/en active IP Right Grant
- 2001-02-07 EP EP01906529A patent/EP1263742B1/en not_active Expired - Lifetime
- 2001-02-07 JP JP2001558436A patent/JP2003522763A/ja active Pending
- 2001-02-07 NZ NZ520696A patent/NZ520696A/en unknown
- 2001-02-07 KR KR1020027010298A patent/KR20020072311A/ko not_active Application Discontinuation
- 2001-02-07 ES ES01906529T patent/ES2248284T3/es not_active Expired - Lifetime
- 2001-02-07 BR BR0107645-0A patent/BR0107645A/pt not_active IP Right Cessation
- 2001-02-07 MX MXPA02007719A patent/MXPA02007719A/es unknown
- 2001-02-07 DE DE60112903T patent/DE60112903T2/de not_active Expired - Fee Related
- 2001-02-07 US US09/778,603 patent/US20010047004A1/en not_active Abandoned
- 2001-02-07 PE PE2001000132A patent/PE20011089A1/es not_active Application Discontinuation
- 2001-02-07 AU AU2001234428A patent/AU2001234428A1/en not_active Abandoned
- 2001-02-07 CA CA002395648A patent/CA2395648A1/en not_active Abandoned
- 2001-02-07 CN CN01803631A patent/CN1395569A/zh active Pending
- 2001-02-08 CO CO01009443A patent/CO5271737A1/es not_active Application Discontinuation
- 2001-02-09 AR ARP010100602A patent/AR029226A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
NZ520696A (en) | 2004-03-26 |
CN1395569A (zh) | 2003-02-05 |
ATE302762T1 (de) | 2005-09-15 |
MXPA02007719A (es) | 2002-10-11 |
WO2001058885A1 (en) | 2001-08-16 |
CO5271737A1 (es) | 2003-04-30 |
KR20020072311A (ko) | 2002-09-14 |
DE60112903D1 (de) | 2005-09-29 |
CA2395648A1 (en) | 2001-08-16 |
JP2003522763A (ja) | 2003-07-29 |
DE60112903T2 (de) | 2006-06-14 |
ES2248284T3 (es) | 2006-03-16 |
US20010047004A1 (en) | 2001-11-29 |
EP1263742B1 (en) | 2005-08-24 |
AR029226A1 (es) | 2003-06-18 |
PE20011089A1 (es) | 2001-10-04 |
EP1263742A1 (en) | 2002-12-11 |
AU2001234428A1 (en) | 2001-08-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE 6A., 7A. E 8A. ANUIDADES |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 DA RPI 2012 DE 28/07/2009. |