ATE302762T1 - Oxazolidinon-thioamide mit piperazinamid- substituenten - Google Patents
Oxazolidinon-thioamide mit piperazinamid- substituentenInfo
- Publication number
- ATE302762T1 ATE302762T1 AT01906529T AT01906529T ATE302762T1 AT E302762 T1 ATE302762 T1 AT E302762T1 AT 01906529 T AT01906529 T AT 01906529T AT 01906529 T AT01906529 T AT 01906529T AT E302762 T1 ATE302762 T1 AT E302762T1
- Authority
- AT
- Austria
- Prior art keywords
- piperazinamide
- thioamide
- oxazolidinone
- substituents
- piperazinamide substituents
- Prior art date
Links
- IZXIZTKNFFYFOF-UHFFFAOYSA-N 2-Oxazolidone Chemical compound O=C1NCCO1 IZXIZTKNFFYFOF-UHFFFAOYSA-N 0.000 title 1
- AEOCXXJPGCBFJA-UHFFFAOYSA-N ethionamide Chemical compound CCC1=CC(C(N)=S)=CC=N1 AEOCXXJPGCBFJA-UHFFFAOYSA-N 0.000 title 1
- IVXQBCUBSIPQGU-UHFFFAOYSA-N piperazine-1-carboxamide Chemical group NC(=O)N1CCNCC1 IVXQBCUBSIPQGU-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Ophthalmology & Optometry (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18164000P | 2000-02-10 | 2000-02-10 | |
| PCT/US2001/000682 WO2001058885A1 (en) | 2000-02-10 | 2001-02-07 | Oxazolidinone thioamides with piperazine amide substituents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE302762T1 true ATE302762T1 (de) | 2005-09-15 |
Family
ID=22665142
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01906529T ATE302762T1 (de) | 2000-02-10 | 2001-02-07 | Oxazolidinon-thioamide mit piperazinamid- substituenten |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20010047004A1 (de) |
| EP (1) | EP1263742B1 (de) |
| JP (1) | JP2003522763A (de) |
| KR (1) | KR20020072311A (de) |
| CN (1) | CN1395569A (de) |
| AR (1) | AR029226A1 (de) |
| AT (1) | ATE302762T1 (de) |
| AU (1) | AU2001234428A1 (de) |
| BR (1) | BR0107645A (de) |
| CA (1) | CA2395648A1 (de) |
| CO (1) | CO5271737A1 (de) |
| DE (1) | DE60112903T2 (de) |
| ES (1) | ES2248284T3 (de) |
| MX (1) | MXPA02007719A (de) |
| NZ (1) | NZ520696A (de) |
| PE (1) | PE20011089A1 (de) |
| WO (1) | WO2001058885A1 (de) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6465456B2 (en) * | 2000-06-29 | 2002-10-15 | Bristol-Myers Squibb Company | Isoxazolinone antibacterial agents |
| DE60118241T2 (de) * | 2000-10-17 | 2006-12-28 | Pharmacia & Upjohn Co. Llc, Kalamazoo | Verfahren zur herstellung von oxazolidinonverbindungen |
| NZ535591A (en) * | 2002-02-28 | 2006-07-28 | Astrazeneca Ab | Oxazolidinone derivatives, processes for their preparation, and pharmaceutical compositions containing them |
| JP2005524661A (ja) | 2002-02-28 | 2005-08-18 | アストラゼネカ アクチボラグ | ３−シクリル−５−（窒素含有５員環）メチル−オキサゾリジノン誘導体と抗菌剤としてのその使用 |
| EP1495021A2 (de) * | 2002-04-01 | 2005-01-12 | Cadila Healthcare Ltd. | Antiinfektive verbindungen, verfahren zu deren herstellung und pharmazeutische zusammensetzungen, die diese enthalten |
| TW200404069A (en) * | 2002-06-28 | 2004-03-16 | Upjohn Co | Difluorothioacetamides of oxazolidinones with a glycoloylpiperazine substituent |
| TW200403240A (en) | 2002-06-28 | 2004-03-01 | Upjohn Co | Difluorothioacetamides of oxazolidinones as antibacterial agents |
| AU2003272071A1 (en) * | 2002-07-11 | 2004-02-02 | Wockhardt Limited | Antibacterial substituted cyanomethyl (ene) piperidinophenyl oxazolidinones, process or their preparation, and pharmaceutical compositions containing them |
| US20040235900A1 (en) * | 2002-07-11 | 2004-11-25 | Yati Chugh | Antimicrobial oxazolifinones with improved pharmacokinetic profile and safety advantages |
| WO2004018439A1 (en) * | 2002-08-22 | 2004-03-04 | Orchid Chemicals & Pharmaceuticals Ltd | Novel antibacterial agents |
| AR043050A1 (es) | 2002-09-26 | 2005-07-13 | Rib X Pharmaceuticals Inc | Compuestos heterociclicos bifuncionales y metodos para preparar y usar los mismos |
| ES2271660T3 (es) * | 2002-11-21 | 2007-04-16 | PHARMACIA & UPJOHN COMPANY LLC | Derivados de n-(4-piperazin-1-il)-fenil-2-oxazolidinona-5-carboxamida y compuestos relacionados como agentes antibacterianos. |
| US20070185132A1 (en) * | 2003-07-02 | 2007-08-09 | Yasumichi Fukuda | Cyclopropyl group substituted oxazolidinone antibiotics and derivatives thereo |
| EP1646629B1 (de) | 2003-07-02 | 2010-06-23 | Merck Sharp & Dohme Corp. | Cyclopropylgruppensubstituierte oxazolidinonantibiotika und derivate davon |
| JP5383037B2 (ja) | 2004-02-27 | 2014-01-08 | リブ−エックス ファーマシューティカルズ，インコーポレイテッド | 大環状化合物およびそれらを製造し使用する方法 |
| JP2009506063A (ja) | 2005-08-24 | 2009-02-12 | リブ−エックス ファーマシューティカルズ，インコーポレイテッド | トリアゾール化合物ならびにこれを作製する方法および使用する方法 |
| EP3290427A1 (de) | 2005-08-24 | 2018-03-07 | Melinta Therapeutics, Inc. | Triazolverbindungen und verfahren zur herstellung und verwendung davon |
| US20100210602A1 (en) * | 2006-12-12 | 2010-08-19 | The Johns Hopkins University | PhoU (PerF), A PERSISTENCE SWITCH INVOLVED IN PERSISTER FORMATION AND TOLERANCE TO MULTIPLE ANTIBIOTICS AND STRESSES AS A DRUG TARGET FOR PERSISTER BACTERIA |
| CA2687912C (en) * | 2007-06-08 | 2015-11-03 | Janssen Pharmaceutica N.V. | Piperidine/piperazine derivatives |
| WO2008148868A1 (en) | 2007-06-08 | 2008-12-11 | Janssen Pharmaceutica N.V. | Piperidine/piperazine derivatives |
| JO2972B1 (en) | 2007-06-08 | 2016-03-15 | جانسين فارماسوتيكا ان. في | Piperidine / piperazine derivatives |
| EP2152269B1 (de) | 2007-06-08 | 2014-04-23 | Janssen Pharmaceutica, N.V. | Piperidin-/piperazinderivate |
| EP2170874A4 (de) * | 2007-06-22 | 2011-08-31 | Orchid Res Lab Ltd | Neue verbindungen und deren verwendung |
| AU2009253892B2 (en) | 2008-06-05 | 2015-07-30 | Janssen Pharmaceutica Nv | Drug combinations comprising a DGAT inhibitor and a PPAR-agonist |
| CN115466253A (zh) * | 2021-06-16 | 2022-12-13 | 沈阳药科大学 | 含二硫代氨基甲酸酯结构的噁唑烷酮类化合物及其制备方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU1169542A3 (ru) * | 1981-09-08 | 1985-07-23 | Эли Лилли Энд Компани (Фирма) | Способ получени тиенопиридиний- или фуропиридиний-замещенных производных цефалоспорина |
| NZ501412A (en) * | 1997-05-30 | 2001-11-30 | Upjohn Co | Oxazolidinone antibacterial agents having a thiocarbonyl functionality |
| AU9001598A (en) * | 1997-09-11 | 1999-03-29 | Hokuriku Seiyaku Co. Ltd | Thiourea derivatives |
| JPH11322729A (ja) * | 1998-03-09 | 1999-11-24 | Hokuriku Seiyaku Co Ltd | ジチオカルバミド酸誘導体 |
| JP2000204084A (ja) * | 1998-11-11 | 2000-07-25 | Hokuriku Seiyaku Co Ltd | チオカルバミド酸誘導体 |
| PT1181288E (pt) * | 1999-05-27 | 2003-12-31 | Upjohn Co | Oxazolidinonas biciclicas como agentes antibacterianos |
-
2001
- 2001-02-07 EP EP01906529A patent/EP1263742B1/de not_active Expired - Lifetime
- 2001-02-07 DE DE60112903T patent/DE60112903T2/de not_active Expired - Fee Related
- 2001-02-07 PE PE2001000132A patent/PE20011089A1/es not_active Application Discontinuation
- 2001-02-07 ES ES01906529T patent/ES2248284T3/es not_active Expired - Lifetime
- 2001-02-07 CA CA002395648A patent/CA2395648A1/en not_active Abandoned
- 2001-02-07 BR BR0107645-0A patent/BR0107645A/pt not_active IP Right Cessation
- 2001-02-07 CN CN01803631A patent/CN1395569A/zh active Pending
- 2001-02-07 MX MXPA02007719A patent/MXPA02007719A/es unknown
- 2001-02-07 WO PCT/US2001/000682 patent/WO2001058885A1/en active IP Right Grant
- 2001-02-07 JP JP2001558436A patent/JP2003522763A/ja active Pending
- 2001-02-07 KR KR1020027010298A patent/KR20020072311A/ko not_active Application Discontinuation
- 2001-02-07 AU AU2001234428A patent/AU2001234428A1/en not_active Abandoned
- 2001-02-07 US US09/778,603 patent/US20010047004A1/en not_active Abandoned
- 2001-02-07 NZ NZ520696A patent/NZ520696A/en unknown
- 2001-02-07 AT AT01906529T patent/ATE302762T1/de not_active IP Right Cessation
- 2001-02-08 CO CO01009443A patent/CO5271737A1/es not_active Application Discontinuation
- 2001-02-09 AR ARP010100602A patent/AR029226A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN1395569A (zh) | 2003-02-05 |
| BR0107645A (pt) | 2002-10-08 |
| MXPA02007719A (es) | 2002-10-11 |
| AU2001234428A1 (en) | 2001-08-20 |
| PE20011089A1 (es) | 2001-10-04 |
| EP1263742B1 (de) | 2005-08-24 |
| KR20020072311A (ko) | 2002-09-14 |
| JP2003522763A (ja) | 2003-07-29 |
| EP1263742A1 (de) | 2002-12-11 |
| NZ520696A (en) | 2004-03-26 |
| DE60112903D1 (de) | 2005-09-29 |
| US20010047004A1 (en) | 2001-11-29 |
| CA2395648A1 (en) | 2001-08-16 |
| DE60112903T2 (de) | 2006-06-14 |
| WO2001058885A1 (en) | 2001-08-16 |
| CO5271737A1 (es) | 2003-04-30 |
| ES2248284T3 (es) | 2006-03-16 |
| AR029226A1 (es) | 2003-06-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |