CO5271737A1 - Tioamidas de oxazolidinona con substituyentes de piperazin-amida - Google Patents
Tioamidas de oxazolidinona con substituyentes de piperazin-amidaInfo
- Publication number
- CO5271737A1 CO5271737A1 CO01009443A CO01009443A CO5271737A1 CO 5271737 A1 CO5271737 A1 CO 5271737A1 CO 01009443 A CO01009443 A CO 01009443A CO 01009443 A CO01009443 A CO 01009443A CO 5271737 A1 CO5271737 A1 CO 5271737A1
- Authority
- CO
- Colombia
- Prior art keywords
- alkyl
- thioamids
- amida
- oxazolidinone
- piperazin
- Prior art date
Links
- IZXIZTKNFFYFOF-UHFFFAOYSA-N 2-Oxazolidone Chemical compound O=C1NCCO1 IZXIZTKNFFYFOF-UHFFFAOYSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 7
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 4
- 125000002861 (C1-C4) alkanoyl group Chemical group 0.000 abstract 2
- CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical compound O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000006555 (C3-C5) cycloalkyl group Chemical group 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Ophthalmology & Optometry (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Un compuesto de fórmula I<EMI FILE="01009443_1" ID="1" IMF=JPEG >o una sal farmacéuticamente aceptable en donde:A es una estructura i, ii, iii, o iv:<EMI FILE="01009443_2" ID="2" IMF=JPEG >W es NHC(=S)R1, o -Y-het; siempre que cuando A es una estructura iv, W no es -Y-het;Y es NH, O, o S;R1 es H,NH2,NHC1-4 alquilo,C1-4 alquenilo,OC1-4 alquilo,SC1-4 alquilo,(CH2)n-C3-6 cicloalquilo, oC1-4 alquilo, opcionalmente sustituido con 1-3 F, 1-2 Cl o CN;R2 y R3 son independientemente H, F, CI o C1-2 alquilo;R4 es -C(=O)-CR5R6-O-R7,-C(=O)-CH2S(O)n-CH3,-C(=O)-CH2-S(=O)(=NR8)CH3,-C(=S)-R9,-C(=O)-CH2-O-R10,-C(=O)-(CH2)m-C(=O)-CH3,-C(=O)-(CH2OH)2-CH3,-C(=O)-CH2-CH2-OR14, o-CN;R5 es H;R6 es fenilo, bencilo, CH2OH o CH2OCH3; oR5 y R6 conjuntamente forman C3-5 cicloalquilo;R7 es H, CH3 o C1-4 alcanoilo;R8 es H, C1-4 alquilo, C1-4 alcanoilo, -C(=O)NH-C1-4 alquilo o -CO2C1-4 alquilo;R9 es C1-4 alquilo, CH2OR11, S-C1-4 alquilo, OC1-4 alquilo, o NR12R13;R10 es fenilo, -CO2-(CH2)2-OCH3, -P(=O)(OH)2, -C(=O)-NR12R13, o ...
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18164000P | 2000-02-10 | 2000-02-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO5271737A1 true CO5271737A1 (es) | 2003-04-30 |
Family
ID=22665142
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO01009443A CO5271737A1 (es) | 2000-02-10 | 2001-02-08 | Tioamidas de oxazolidinona con substituyentes de piperazin-amida |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20010047004A1 (es) |
| EP (1) | EP1263742B1 (es) |
| JP (1) | JP2003522763A (es) |
| KR (1) | KR20020072311A (es) |
| CN (1) | CN1395569A (es) |
| AR (1) | AR029226A1 (es) |
| AT (1) | ATE302762T1 (es) |
| AU (1) | AU2001234428A1 (es) |
| BR (1) | BR0107645A (es) |
| CA (1) | CA2395648A1 (es) |
| CO (1) | CO5271737A1 (es) |
| DE (1) | DE60112903T2 (es) |
| ES (1) | ES2248284T3 (es) |
| MX (1) | MXPA02007719A (es) |
| NZ (1) | NZ520696A (es) |
| PE (1) | PE20011089A1 (es) |
| WO (1) | WO2001058885A1 (es) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6465456B2 (en) * | 2000-06-29 | 2002-10-15 | Bristol-Myers Squibb Company | Isoxazolinone antibacterial agents |
| ATE321024T1 (de) | 2000-10-17 | 2006-04-15 | Pharmacia & Upjohn Co Llc | Verfahren zur herstellung von oxazolidinonverbindungen |
| WO2003072575A1 (en) | 2002-02-28 | 2003-09-04 | Astrazeneca Ab | 3-cyclyl-5-(nitrogen-containing 5-membered ring) methyl-oxazolidinone derivatives and their use as antibacterial agents |
| NZ535591A (en) * | 2002-02-28 | 2006-07-28 | Astrazeneca Ab | Oxazolidinone derivatives, processes for their preparation, and pharmaceutical compositions containing them |
| CA2478502A1 (en) * | 2002-04-01 | 2003-10-09 | Cadila Healthcare Limited | Novel antiinfective compounds, process for their preparation and pharmaceutical compositions containing them |
| TW200403240A (en) | 2002-06-28 | 2004-03-01 | Upjohn Co | Difluorothioacetamides of oxazolidinones as antibacterial agents |
| TW200404069A (en) * | 2002-06-28 | 2004-03-16 | Upjohn Co | Difluorothioacetamides of oxazolidinones with a glycoloylpiperazine substituent |
| CA2492194A1 (en) * | 2002-07-11 | 2004-01-22 | Wockhardt Limited | Antibacterial cyano-(substituted)-methylenepiperidinophenyl oxazolidinones targeting multiple ribonucleoproteins sites |
| CA2492743A1 (en) * | 2002-07-11 | 2004-01-22 | Wockhardt Limited | Antimicrobial oxazolidinones, process of their preparation, and pharmaceutical compositions containing them |
| AU2003253141A1 (en) * | 2002-08-22 | 2004-03-11 | Orchid Chemicals And Pharmaceuticals Ltd | Novel antibacterial agents |
| US7091196B2 (en) | 2002-09-26 | 2006-08-15 | Rib-X Pharmaceuticals, Inc. | Bifunctional heterocyclic compounds and methods of making and using same |
| BR0316483A (pt) | 2002-11-21 | 2005-10-11 | Upjohn Co | Derivados de n-(4-(piperazin-1-il)-fenil-2-oxazolidinona-5-carboxami da e compostos relacionados como agentes antibacterianos |
| JP4607107B2 (ja) | 2003-07-02 | 2011-01-05 | メルク・シャープ・エンド・ドーム・コーポレイション | シクロプロピル基置換されたオキサゾリジノン抗生物質およびこれらの誘導体 |
| WO2005005420A1 (en) * | 2003-07-02 | 2005-01-20 | Merck & Co., Inc. | Cyclopropyl group substituted oyazolidinone antibiotics and derivatives thereof |
| CN102816194A (zh) | 2004-02-27 | 2012-12-12 | 瑞伯-X医药品有限公司 | 大环化合物以及其制作和使用方法 |
| EP1934237A2 (en) | 2005-08-24 | 2008-06-25 | Rib-X Pharmaceuticals, Inc. | Triazole compounds and methods of making and using the same |
| DK1934238T3 (en) | 2005-08-24 | 2017-09-18 | Melinta Therapeutics Inc | TRIAZOL COMPOUNDS AND METHODS FOR THE PREPARATION AND USE OF THESE |
| US20100210602A1 (en) * | 2006-12-12 | 2010-08-19 | The Johns Hopkins University | PhoU (PerF), A PERSISTENCE SWITCH INVOLVED IN PERSISTER FORMATION AND TOLERANCE TO MULTIPLE ANTIBIOTICS AND STRESSES AS A DRUG TARGET FOR PERSISTER BACTERIA |
| JO2972B1 (en) | 2007-06-08 | 2016-03-15 | جانسين فارماسوتيكا ان. في | Piperidine / piperazine derivatives |
| AR066911A1 (es) | 2007-06-08 | 2009-09-23 | Janssen Pharmaceutica Nv | Derivados de piperidina / piperazina |
| WO2008148851A1 (en) | 2007-06-08 | 2008-12-11 | Janssen Pharmaceutica N.V. | Piperidine/piperazine derivatives |
| JP5443342B2 (ja) | 2007-06-08 | 2014-03-19 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ピペリジン／ピペラジン誘導体 |
| EP2170874A4 (en) * | 2007-06-22 | 2011-08-31 | Orchid Res Lab Ltd | NEW COMPOUNDS AND THEIR USE |
| JP5579170B2 (ja) | 2008-06-05 | 2014-08-27 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | Ｄｇａｔ阻害剤とｐｐａｒ作動薬を含有する薬剤組み合わせ物 |
| CN115466253A (zh) * | 2021-06-16 | 2022-12-13 | 沈阳药科大学 | 含二硫代氨基甲酸酯结构的噁唑烷酮类化合物及其制备方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RO84456B (ro) * | 1981-09-08 | 1984-08-30 | Eli Lilly And Co | Procedeu pentru prepararea unor derivati de cefalosporina tieno si furopiridiniu substituita |
| US6218413B1 (en) * | 1997-05-30 | 2001-04-17 | Pharmacia & Upjohn Company | Oxazolidinone antibacterial agents having a thiocarbonyl functionality |
| AU9001598A (en) * | 1997-09-11 | 1999-03-29 | Hokuriku Seiyaku Co. Ltd | Thiourea derivatives |
| JPH11322729A (ja) * | 1998-03-09 | 1999-11-24 | Hokuriku Seiyaku Co Ltd | ジチオカルバミド酸誘導体 |
| JP2000204084A (ja) * | 1998-11-11 | 2000-07-25 | Hokuriku Seiyaku Co Ltd | チオカルバミド酸誘導体 |
| NZ515754A (en) * | 1999-05-27 | 2003-10-31 | Upjohn Co | Bicyclic oxazolidinone compounds, pharmaceuticals thereof and their use as antibacterial agents |
-
2001
- 2001-02-07 CA CA002395648A patent/CA2395648A1/en not_active Abandoned
- 2001-02-07 ES ES01906529T patent/ES2248284T3/es not_active Expired - Lifetime
- 2001-02-07 NZ NZ520696A patent/NZ520696A/en unknown
- 2001-02-07 KR KR1020027010298A patent/KR20020072311A/ko not_active Application Discontinuation
- 2001-02-07 AU AU2001234428A patent/AU2001234428A1/en not_active Abandoned
- 2001-02-07 PE PE2001000132A patent/PE20011089A1/es not_active Application Discontinuation
- 2001-02-07 CN CN01803631A patent/CN1395569A/zh active Pending
- 2001-02-07 EP EP01906529A patent/EP1263742B1/en not_active Expired - Lifetime
- 2001-02-07 US US09/778,603 patent/US20010047004A1/en not_active Abandoned
- 2001-02-07 BR BR0107645-0A patent/BR0107645A/pt not_active IP Right Cessation
- 2001-02-07 AT AT01906529T patent/ATE302762T1/de not_active IP Right Cessation
- 2001-02-07 MX MXPA02007719A patent/MXPA02007719A/es unknown
- 2001-02-07 DE DE60112903T patent/DE60112903T2/de not_active Expired - Fee Related
- 2001-02-07 WO PCT/US2001/000682 patent/WO2001058885A1/en active IP Right Grant
- 2001-02-07 JP JP2001558436A patent/JP2003522763A/ja active Pending
- 2001-02-08 CO CO01009443A patent/CO5271737A1/es not_active Application Discontinuation
- 2001-02-09 AR ARP010100602A patent/AR029226A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NZ520696A (en) | 2004-03-26 |
| DE60112903D1 (de) | 2005-09-29 |
| BR0107645A (pt) | 2002-10-08 |
| CA2395648A1 (en) | 2001-08-16 |
| US20010047004A1 (en) | 2001-11-29 |
| ES2248284T3 (es) | 2006-03-16 |
| ATE302762T1 (de) | 2005-09-15 |
| EP1263742B1 (en) | 2005-08-24 |
| WO2001058885A1 (en) | 2001-08-16 |
| KR20020072311A (ko) | 2002-09-14 |
| AR029226A1 (es) | 2003-06-18 |
| DE60112903T2 (de) | 2006-06-14 |
| EP1263742A1 (en) | 2002-12-11 |
| JP2003522763A (ja) | 2003-07-29 |
| AU2001234428A1 (en) | 2001-08-20 |
| CN1395569A (zh) | 2003-02-05 |
| PE20011089A1 (es) | 2001-10-04 |
| MXPA02007719A (es) | 2002-10-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Application refused |