BR0316483A - Derivados de n-(4-(piperazin-1-il)-fenil-2-oxazolidinona-5-carboxami da e compostos relacionados como agentes antibacterianos - Google Patents
Derivados de n-(4-(piperazin-1-il)-fenil-2-oxazolidinona-5-carboxami da e compostos relacionados como agentes antibacterianosInfo
- Publication number
- BR0316483A BR0316483A BR0316483-7A BR0316483A BR0316483A BR 0316483 A BR0316483 A BR 0316483A BR 0316483 A BR0316483 A BR 0316483A BR 0316483 A BR0316483 A BR 0316483A
- Authority
- BR
- Brazil
- Prior art keywords
- antibacterial agents
- oxazolidinone
- piperazin
- related compounds
- phenyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
"DERIVADOS DE N-(4-(PIPERAZIN-1-IL)-FENIL-2-OXAZOLIDINONA-5-CARBOXAMI DA E COMPOSTOS RELACIONADOS COMO AGENTES ANTIBACTERIANOS". A presente invenção proporciona agentes antibacterianos possuindo a fórmula I aqui descrita, ou seus sais farmaceuticamente aceitáveis em que: A é uma estrutura i, ii, iii, ou iv, W é N (H) C (X) -R, Het, ou -Y -HET, no qual o Hot ou Y HET é opcionalmente substituído com =S ou =O, desde que quando A é estrutura iv, W não é - Y--1¬ -¬MT ou Het.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US42802502P | 2002-11-21 | 2002-11-21 | |
US44553003P | 2003-02-06 | 2003-02-06 | |
PCT/IB2003/005355 WO2004045616A1 (en) | 2002-11-21 | 2003-11-19 | N-(4-(piperazin-1-yl)-phenyl-2-oxazolidinone-5-carboxamide derivates and related compounds as antibacterial agents |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0316483A true BR0316483A (pt) | 2005-10-11 |
Family
ID=32329201
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0316483-7A BR0316483A (pt) | 2002-11-21 | 2003-11-19 | Derivados de n-(4-(piperazin-1-il)-fenil-2-oxazolidinona-5-carboxami da e compostos relacionados como agentes antibacterianos |
Country Status (13)
Country | Link |
---|---|
US (1) | US7141570B2 (pt) |
EP (1) | EP1565186B1 (pt) |
JP (1) | JP2006509035A (pt) |
AR (1) | AR042086A1 (pt) |
AT (1) | ATE344036T1 (pt) |
AU (1) | AU2003280143A1 (pt) |
BR (1) | BR0316483A (pt) |
CA (1) | CA2502017A1 (pt) |
DE (1) | DE60309504T2 (pt) |
ES (1) | ES2271660T3 (pt) |
MX (1) | MXPA05005472A (pt) |
TW (1) | TW200413360A (pt) |
WO (1) | WO2004045616A1 (pt) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2692255A1 (en) * | 2007-06-22 | 2008-12-31 | Orchid Research Laboratories Limited | Novel compounds and their use |
MY158982A (en) | 2008-03-05 | 2016-11-30 | Takeda Pharmaceuticals Co | Heterocyclic compound |
KR20110092309A (ko) * | 2008-11-20 | 2011-08-17 | 파나세아 바이오테크 리미티드 | 신규 항균제 |
PL2864284T3 (pl) * | 2012-06-22 | 2017-12-29 | Henkel Ag & Co. Kgaa | Fotolabilne substancje gromadzące substancje zapachowe |
Family Cites Families (55)
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US4705799A (en) * | 1983-06-07 | 1987-11-10 | E. I. Du Pont De Nemours And Company | Aminomethyl oxooxazolidinyl benzenes useful as antibacterial agents |
US5043443A (en) * | 1988-07-29 | 1991-08-27 | Du Pont Merck Pharmaceutical Company | Aminomethyloxooxazolidinyl arylbenzene derivatives |
US5225565A (en) * | 1988-09-15 | 1993-07-06 | The Upjohn Company | Antibacterial 3-(fused-ring substituted)phenyl-5β-amidomethyloxazolidin-2-ones |
US5164510A (en) * | 1988-09-15 | 1992-11-17 | The Upjohn Company | 5'Indolinyl-5β-amidomethyloxazolidin-2-ones |
US5182403A (en) * | 1988-09-15 | 1993-01-26 | The Upjohn Company | Substituted 3(5'indazolyl) oxazolidin-2-ones |
US5231188A (en) * | 1989-11-17 | 1993-07-27 | The Upjohn Company | Tricyclic [6.5.51]-fused oxazolidinone antibacterial agents |
EP0610265B1 (en) * | 1991-11-01 | 1996-12-27 | PHARMACIA & UPJOHN COMPANY | Substituted aryl- and heteroarylphenyloxazolidinones useful as antibacterial agents |
SK283420B6 (sk) * | 1992-05-08 | 2003-07-01 | Pharmacia & Upjohn Company | Antimikrobiálne oxazolidinóny obsahujúce substituované diazínové skupiny |
EP0648119A1 (en) | 1992-07-08 | 1995-04-19 | The Upjohn Company | 5'-INDOLINYL OXAZOLIDINONES USEFUL AGAINST $i(MYCOBACTERIUM TUBERCULOSIS) |
DK0673370T3 (da) * | 1992-12-08 | 1998-09-07 | Upjohn Co | Troponsubstituerede phenyloxazolidinoner som antibakterielle midler |
US5688792A (en) * | 1994-08-16 | 1997-11-18 | Pharmacia & Upjohn Company | Substituted oxazine and thiazine oxazolidinone antimicrobials |
MY115155A (en) | 1993-09-09 | 2003-04-30 | Upjohn Co | Substituted oxazine and thiazine oxazolidinone antimicrobials. |
CN1046276C (zh) * | 1993-11-22 | 1999-11-10 | 法玛西雅厄普约翰美国公司 | 取代羟基乙酰基哌嗪苯基唑烷酮酯及其用途 |
JPH0873455A (ja) | 1994-03-15 | 1996-03-19 | Upjohn Co:The | オキサゾリジノン誘導体及びこれを有効成分とする医薬組成物 |
DE4425609A1 (de) * | 1994-07-20 | 1996-01-25 | Bayer Ag | Benzofuranyl- und Benzothienyloxazolidinone |
DE4425612A1 (de) * | 1994-07-20 | 1996-04-04 | Bayer Ag | 6-gliedrige stickstoffhaltige Heteroaryl-oxazolidinone |
DE4425613A1 (de) * | 1994-07-20 | 1996-01-25 | Bayer Ag | 5-gliedrige Heteroaryl-oxazolidinone |
DE19514313A1 (de) * | 1994-08-03 | 1996-02-08 | Bayer Ag | Benzoxazolyl- und Benzothiazolyloxazolidinone |
CZ291847B6 (cs) | 1994-10-26 | 2003-06-18 | Pharmacia Upjohn Company | Antimikrobiální fenyloxazolidinony |
ATE233766T1 (de) * | 1994-11-15 | 2003-03-15 | Upjohn Co | Antibakterielle bizyklische oxazin und thiazin- oxazolidinone |
JPH10513446A (ja) | 1995-02-03 | 1998-12-22 | ファルマシア・アンド・アップジョン・カンパニー | ヘテロ芳香族環置換フェニルオキサゾリジノン抗微生物剤 |
HRP960159A2 (en) * | 1995-04-21 | 1997-08-31 | Bayer Ag | Benzocyclopentane oxazolidinones containing heteroatoms |
ES2162047T3 (es) | 1995-05-11 | 2001-12-16 | Upjohn Co | Oxazolidinonas con resto diazinilo y carbazinilo espirociclico y biciclico. |
ATE207487T1 (de) * | 1995-09-01 | 2001-11-15 | Upjohn Co | Phenyloxazolidinone mit einer c-c-bindung zu 4-8 gliedrigen heterocyclen |
PT1019385E (pt) | 1995-09-15 | 2004-06-30 | Upjohn Co | N-oxidos de aminoaril-oxazolidinona |
WO1997010235A1 (en) | 1995-09-15 | 1997-03-20 | Pharmacia & Upjohn Company | 5-AMIDOMETHYL α, β-SATURATED AND -UNSATURATED 3-ARYL BUTYROLACTONE ANTIBACTERIAL AGENTS |
ZA968661B (en) | 1995-11-17 | 1998-04-14 | Upjohn Co | Oxazolidinone antibacterial agent with tricyclic substituents. |
ZA969622B (en) | 1995-12-13 | 1998-05-15 | Upjohn Co | Oxazolidinone antibacterial agents having a six-membered heteroaromatic ring. |
DE19601265A1 (de) * | 1996-01-16 | 1997-07-17 | Bayer Ag | 2-Oxo- und 2-Thio-1,2-dihydrochinolinyl-oxazolidinone |
DE19601264A1 (de) * | 1996-01-16 | 1997-07-17 | Bayer Ag | Pyrido-annellierte Thienyl- und Furanyl-Oxazolidinone |
DE19601627A1 (de) * | 1996-01-18 | 1997-07-24 | Bayer Ag | Heteroatomhaltige Cyclopentanopyridyl-Oxazolidinone |
GB9601666D0 (en) * | 1996-01-27 | 1996-03-27 | Zeneca Ltd | Chemical compounds |
DE19604223A1 (de) * | 1996-02-06 | 1997-08-07 | Bayer Ag | Neue substituierte Oxazolidinone |
GB9702213D0 (en) | 1996-02-24 | 1997-03-26 | Zeneca Ltd | Chemical compounds |
MY116093A (en) | 1996-02-26 | 2003-11-28 | Upjohn Co | Azolyl piperazinyl phenyl oxazolidinone antimicrobials |
GB9609919D0 (en) * | 1996-05-11 | 1996-07-17 | Zeneca Ltd | Chemical compounds |
US6255304B1 (en) * | 1997-05-30 | 2001-07-03 | Pharmacia & Upjohn Company | Oxazolidinone antibacterial agents having a thiocarbonyl functionality |
ATE293609T1 (de) | 1997-05-30 | 2005-05-15 | Upjohn Co | Antibakteriell wirksam oxazolidinone mit einer thiocarbonylfunktionalität |
DE19730847A1 (de) | 1997-07-18 | 1999-01-28 | Bayer Ag | Tricyclisch substituierte Oxazolidinone |
GB9717804D0 (en) * | 1997-08-22 | 1997-10-29 | Zeneca Ltd | Chemical compounds |
US6083967A (en) | 1997-12-05 | 2000-07-04 | Pharmacia & Upjohn Company | S-oxide and S,S-dioxide tetrahydrothiopyran phenyloxazolidinones |
DE19802239A1 (de) | 1998-01-22 | 1999-07-29 | Bayer Ag | Neue mit Bicyclen substituierte Oxazolidinone |
DE19802235A1 (de) | 1998-01-22 | 1999-07-29 | Bayer Ag | Mit tricyclischen Indolen substituierte Oxazolidinone |
WO1999037630A1 (en) * | 1998-01-23 | 1999-07-29 | Versicor, Inc. | Oxazolidinone combinatorial libraries, compositions and methods of preparation |
DE19805117A1 (de) | 1998-02-09 | 1999-08-12 | Bayer Ag | Neue Oxazolidinone mit azolhaltigen Tricyclen |
GB9821938D0 (en) | 1998-10-09 | 1998-12-02 | Zeneca Ltd | Chemical compounds |
JP2000204084A (ja) * | 1998-11-11 | 2000-07-25 | Hokuriku Seiyaku Co Ltd | チオカルバミド酸誘導体 |
GB9928499D0 (en) | 1999-12-03 | 2000-02-02 | Zeneca Ltd | Chemical processes and intermediates |
GB9928568D0 (en) | 1999-12-03 | 2000-02-02 | Zeneca Ltd | Chemical compounds |
PE20010851A1 (es) * | 1999-12-14 | 2001-08-17 | Upjohn Co | Esteres del acido benzoico de oxazolidinonas que tienen un substituyente hidroxiacetilpiperazina |
US6642238B2 (en) * | 2000-02-10 | 2003-11-04 | Pharmacia And Upjohn Company | Oxazolidinone thioamides with piperazine amide substituents |
US20010047004A1 (en) | 2000-02-10 | 2001-11-29 | Hester Jackson B. | Oxazolidinone thioamides with piperazine amide substituents |
GB0009803D0 (en) | 2000-04-25 | 2000-06-07 | Astrazeneca Ab | Chemical compounds |
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-
2003
- 2003-11-19 AT AT03772516T patent/ATE344036T1/de not_active IP Right Cessation
- 2003-11-19 ES ES03772516T patent/ES2271660T3/es not_active Expired - Lifetime
- 2003-11-19 DE DE60309504T patent/DE60309504T2/de not_active Expired - Fee Related
- 2003-11-19 AR ARP030104276A patent/AR042086A1/es unknown
- 2003-11-19 AU AU2003280143A patent/AU2003280143A1/en not_active Abandoned
- 2003-11-19 MX MXPA05005472A patent/MXPA05005472A/es active IP Right Grant
- 2003-11-19 BR BR0316483-7A patent/BR0316483A/pt not_active IP Right Cessation
- 2003-11-19 JP JP2004570322A patent/JP2006509035A/ja not_active Withdrawn
- 2003-11-19 EP EP03772516A patent/EP1565186B1/en not_active Expired - Lifetime
- 2003-11-19 WO PCT/IB2003/005355 patent/WO2004045616A1/en active IP Right Grant
- 2003-11-19 CA CA002502017A patent/CA2502017A1/en not_active Abandoned
- 2003-11-19 US US10/717,237 patent/US7141570B2/en not_active Expired - Fee Related
- 2003-11-20 TW TW092132583A patent/TW200413360A/zh unknown
Also Published As
Publication number | Publication date |
---|---|
TW200413360A (en) | 2004-08-01 |
CA2502017A1 (en) | 2004-06-03 |
ATE344036T1 (de) | 2006-11-15 |
JP2006509035A (ja) | 2006-03-16 |
EP1565186B1 (en) | 2006-11-02 |
MXPA05005472A (es) | 2005-07-25 |
ES2271660T3 (es) | 2007-04-16 |
DE60309504D1 (de) | 2006-12-14 |
AU2003280143A1 (en) | 2004-06-15 |
US20040142939A1 (en) | 2004-07-22 |
US7141570B2 (en) | 2006-11-28 |
EP1565186A1 (en) | 2005-08-24 |
AR042086A1 (es) | 2005-06-08 |
DE60309504T2 (de) | 2007-05-16 |
WO2004045616A1 (en) | 2004-06-03 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B15K | Others concerning applications: alteration of classification |
Free format text: PARA: INT. CL. A61K 31/496, 31/422, 31/5355; C07D 263/20, 413/10; A61P 31/00 Ipc: A61K 31/496 (2011.01), A61K 31/422 (2011.01), A61K |
|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 6A, 7A E 8A ANUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2160 DE 29/05/2012. |