ATE233766T1 - Antibakterielle bizyklische oxazin und thiazin- oxazolidinone - Google Patents

Antibakterielle bizyklische oxazin und thiazin- oxazolidinone

Info

Publication number
ATE233766T1
ATE233766T1 AT95938148T AT95938148T ATE233766T1 AT E233766 T1 ATE233766 T1 AT E233766T1 AT 95938148 T AT95938148 T AT 95938148T AT 95938148 T AT95938148 T AT 95938148T AT E233766 T1 ATE233766 T1 AT E233766T1
Authority
AT
Austria
Prior art keywords
pct
date
thiazine
oxazine
spp
Prior art date
Application number
AT95938148T
Other languages
English (en)
Inventor
Michael R Barbachyn
Richard C Thomas
Gary J Cleek
Lisa Marie Thomasco
Robert C Gadwood
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Application granted granted Critical
Publication of ATE233766T1 publication Critical patent/ATE233766T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT95938148T 1994-11-15 1995-10-31 Antibakterielle bizyklische oxazin und thiazin- oxazolidinone ATE233766T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33997994A 1994-11-15 1994-11-15
PCT/US1995/012751 WO1996015130A1 (en) 1994-11-15 1995-10-31 Bicyclic oxazine and thiazine oxazolidinone antibacterials

Publications (1)

Publication Number Publication Date
ATE233766T1 true ATE233766T1 (de) 2003-03-15

Family

ID=23331388

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95938148T ATE233766T1 (de) 1994-11-15 1995-10-31 Antibakterielle bizyklische oxazin und thiazin- oxazolidinone

Country Status (17)

Country Link
US (1) US5952324A (de)
EP (1) EP0792273B1 (de)
JP (1) JPH10508844A (de)
KR (1) KR100392216B1 (de)
CN (1) CN1046520C (de)
AT (1) ATE233766T1 (de)
AU (1) AU702733B2 (de)
BR (1) BR9509673A (de)
DE (1) DE69529838T2 (de)
DK (1) DK0792273T3 (de)
ES (1) ES2193201T3 (de)
MX (1) MX9703543A (de)
NO (1) NO972222L (de)
NZ (1) NZ295528A (de)
PT (1) PT792273E (de)
RU (1) RU2128660C1 (de)
WO (1) WO1996015130A1 (de)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2214546T3 (es) * 1995-09-15 2004-09-16 PHARMACIA & UPJOHN COMPANY N-oxidos de aminoariloxazolidinona.
ZA968661B (en) * 1995-11-17 1998-04-14 Upjohn Co Oxazolidinone antibacterial agent with tricyclic substituents.
GB9601666D0 (en) * 1996-01-27 1996-03-27 Zeneca Ltd Chemical compounds
GB9702213D0 (en) 1996-02-24 1997-03-26 Zeneca Ltd Chemical compounds
US5837870A (en) * 1996-04-11 1998-11-17 Pharmacia & Upjohn Company Process to prepare oxazolidinones
GB9609919D0 (en) * 1996-05-11 1996-07-17 Zeneca Ltd Chemical compounds
KR100307211B1 (ko) * 1997-05-24 2001-11-30 손 경 식 옥사졸리디논유도체,이의제조방법및그를함유한항균제조성물
GB9717804D0 (en) 1997-08-22 1997-10-29 Zeneca Ltd Chemical compounds
GB9717807D0 (en) 1997-08-22 1997-10-29 Zeneca Ltd Chemical compounds
KR100467309B1 (ko) * 1997-09-04 2005-07-18 씨제이 주식회사 옥사졸리디논유도체및그의제조방법및항균제조성물
KR100463111B1 (ko) * 1997-10-30 2005-06-13 씨제이 주식회사 신규한옥사졸리디논유도체및제조방법및그를함유하는항균제조성물
GB9725244D0 (en) 1997-11-29 1998-01-28 Zeneca Ltd Chemical compounds
HUP0103082A3 (en) * 1998-06-05 2002-12-28 Astrazeneca Ab Oxazolidinone derivatives, process for their preparation and pharmaceutical compositions containing them
US6608081B2 (en) 1999-08-12 2003-08-19 Ortho-Mcneil Pharmaceutical, Inc. Bicyclic heterocyclic substituted phenyl oxazolidinone antibacterials, and related compositions and methods
US6413981B1 (en) * 1999-08-12 2002-07-02 Ortho-Mcneil Pharamceutical, Inc. Bicyclic heterocyclic substituted phenyl oxazolidinone antibacterials, and related compositions and methods
GB9928568D0 (en) 1999-12-03 2000-02-02 Zeneca Ltd Chemical compounds
IL150348A0 (en) * 1999-12-21 2002-12-01 Upjohn Co Oxazolidinones having a sulfoximine functionality and their use as antimicrobial agents
US6518285B2 (en) 1999-12-21 2003-02-11 Ortho Mcneil Pharmaceutical, Inc. Piperidinyloxy and pyrrolidinyloxy oxazolidinone antibacterials
GB0009803D0 (en) * 2000-04-25 2000-06-07 Astrazeneca Ab Chemical compounds
MXPA03003473A (es) 2000-10-17 2003-08-19 Upjohn Co Metodos para producir compuestos de oxazolidinona.
US20050032861A1 (en) * 2001-04-07 2005-02-10 Betts Michael John Oxazolidines containing a sulfonimid group as antibiotics
GB0108793D0 (en) * 2001-04-07 2001-05-30 Astrazeneca Ab Chemical compounds
US6887995B2 (en) * 2001-04-20 2005-05-03 Pharmacia & Upjohn Company Process to prepare oxazolidinones
TW200302095A (en) * 2002-01-25 2003-08-01 Upjohn Co Oxazolidinone cotherapy
US7141588B2 (en) * 2002-02-25 2006-11-28 Pfizer, Inc. N-aryl-2-oxazolidinone-5-carboxamides and their derivatives
AR038536A1 (es) 2002-02-25 2005-01-19 Upjohn Co N-aril-2-oxazolidinona-5- carboxamidas y sus derivados
US20030216330A1 (en) * 2002-03-29 2003-11-20 Pharmacia & Upjohn Parenteral, intravenous, and oral administration of oxazolidinones for treating diabetic foot infections
MXPA05001558A (es) 2002-08-12 2005-09-08 Pharmacia & Upjohn Co Llc N-aril-2-oxazolidinonas y sus derivados.
JP2006509035A (ja) * 2002-11-21 2006-03-16 ファルマシア・アンド・アップジョン・カンパニー・エルエルシー 抗菌剤としてのｎ−（４−（ピペラジン−１−イル）−フェニル−２−オキサゾリジノン−５−カルボキサミド誘導体および関連化合物
CA2515311A1 (en) * 2003-02-07 2004-08-19 Warner-Lambert Company Llc Antibacterial agents
MXPA05007937A (es) * 2003-02-07 2005-09-30 Warner Lambert Co Agentes antibacterianos.
US20040204463A1 (en) * 2003-04-01 2004-10-14 Harris Christina Renee N-aryl-2-oxazolidinone-5-carboxamides and their derivatives
US7304050B2 (en) 2003-09-16 2007-12-04 Pfizer Inc. Antibacterial agents
US20070004679A1 (en) * 2004-05-17 2007-01-04 Nathalie Schlienger Androgen receptor modulators and methods of treating disease using the same
US7268232B2 (en) * 2004-05-17 2007-09-11 Acadia Pharmaceuticals Inc. Androgen receptor modulators and method of treating disease using the same
US20050261278A1 (en) * 2004-05-21 2005-11-24 Weiner David M Selective serotonin receptor inverse agonists as therapeutics for disease
US20080262056A1 (en) * 2004-08-06 2008-10-23 Pfizer Inc Oxindole Oxazolidinones as Antibacterial Agents
WO2006137932A2 (en) 2004-11-03 2006-12-28 Leucadia Technologies, Inc. Homogeneous analyte detection
ATE530666T1 (de) 2004-11-03 2011-11-15 Iris Molecular Diagnostics Inc Mikrobläschen zur affinitätstrennung
CN101119993B (zh) * 2005-01-10 2015-03-04 阿卡蒂亚药品公司 作为选择性雄激素受体调节剂的氨基苯基衍生物
US20060173037A1 (en) * 2005-01-10 2006-08-03 Nathalie Schlienger Aminophenyl derivatives as selective androgen receptor modulators
JP2008544979A (ja) 2005-06-29 2008-12-11 ファルマシア・アンド・アップジョン・カンパニー・エルエルシー 抗菌剤としてのホモモルホリンオキサゾリジノン
EP2254892B1 (de) * 2008-03-26 2014-04-23 Global Alliance For Tb Drug Development Kovalent mit substituierten phenyloxazolidinonen vernetzte bizyklische nitroimidazole
CN107708809A (zh) 2015-07-02 2018-02-16 爱尔兰詹森科学公司 抗细菌化合物
AU2016295165B2 (en) * 2015-07-17 2021-04-22 The Global Alliance For Tb Drug Development, Inc. Substituted phenyloxazolidinones for antimicrobial therapy
MA45377A (fr) 2016-06-16 2019-04-24 Janssen Sciences Ireland Unlimited Co Composés hétérocycliques en tant qu'agents antibacteriens
CN110831630A (zh) 2017-03-01 2020-02-21 爱尔兰詹森科学公司 组合疗法
WO2020147504A1 (en) * 2019-01-18 2020-07-23 Merck Sharp & Dohme Corp. Oxazolidinone compounds and methods of use thereof as antibacterial agents
WO2020234636A1 (en) 2019-05-17 2020-11-26 Cadila Healthcare Limited Novel compounds for the treatment of mammalian infections

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4801600A (en) * 1987-10-09 1989-01-31 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents
US4921869A (en) * 1987-10-09 1990-05-01 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents
CA1320730C (en) * 1987-10-16 1993-07-27 The Du Pont Merck Pharmaceutical Company Aminomethyl oxooxazolidinyl aroylbenzene derivatives useful as antibacterial agents
DE3884563T2 (de) * 1987-10-21 1994-02-17 Du Pont Merck Pharma Aminomethyl-oxo-oxazolidinyl-ethenylbenzen-Derivate, nützlich als antibakterielles Mittel.
US4948801A (en) * 1988-07-29 1990-08-14 E. I. Du Pont De Nemours And Company Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents
ES2157934T3 (es) * 1988-09-15 2001-09-01 Upjohn Co Fenil-5-beta-amidometiloxazolidin-2-onas sustituidas con nitrogeno en la posicion 3.
DK0610265T3 (da) * 1991-11-01 1997-06-09 Upjohn Co Substituerede aryl- og heteroarylphenyloxazolidioner, som kan anvendes som antibakterielle midler
SK283420B6 (sk) * 1992-05-08 2003-07-01 Pharmacia & Upjohn Company Antimikrobiálne oxazolidinóny obsahujúce substituované diazínové skupiny
MY115155A (en) * 1993-09-09 2003-04-30 Upjohn Co Substituted oxazine and thiazine oxazolidinone antimicrobials.
DE69419523T2 (de) * 1993-11-22 1999-11-25 Upjohn Co Substituierte hydroxyacetyl piperazine phenyl oxazolidinonsäureester
US5668286A (en) * 1994-03-15 1997-09-16 Pharmacia & Upjohn Company Oxazolidinone derivatives and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
CN1163615A (zh) 1997-10-29
JPH10508844A (ja) 1998-09-02
MX9703543A (es) 1997-08-30
DE69529838T2 (de) 2003-11-13
ES2193201T3 (es) 2003-11-01
NO972222D0 (no) 1997-05-14
PT792273E (pt) 2003-06-30
NZ295528A (en) 1999-03-29
EP0792273A1 (de) 1997-09-03
RU2128660C1 (ru) 1999-04-10
US5952324A (en) 1999-09-14
DK0792273T3 (da) 2003-06-16
NO972222L (no) 1997-05-14
BR9509673A (pt) 1997-09-30
CN1046520C (zh) 1999-11-17
AU3889095A (en) 1996-06-06
WO1996015130A1 (en) 1996-05-23
KR100392216B1 (ko) 2003-10-17
DE69529838D1 (de) 2003-04-10
AU702733B2 (en) 1999-03-04
EP0792273B1 (de) 2003-03-05

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