GEP20084437B - Novel lincomycin derivatives possessing antimicrobial activity - Google Patents

Novel lincomycin derivatives possessing antimicrobial activity

Info

Publication number
GEP20084437B
GEP20084437B GEAP20049117A GEAP2004009117A GEP20084437B GE P20084437 B GEP20084437 B GE P20084437B GE AP20049117 A GEAP20049117 A GE AP20049117A GE AP2004009117 A GEAP2004009117 A GE AP2004009117A GE P20084437 B GEP20084437 B GE P20084437B
Authority
GE
Georgia
Prior art keywords
antimicrobial activity
derivatives possessing
lincomycin derivatives
possessing antimicrobial
novel lincomycin
Prior art date
Application number
GEAP20049117A
Inventor
Jason G Lewis
Sampath K Anandan
Hardwin O'dowd
Mikhail F Gordeev
Original Assignee
Vicuron Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/642,807 external-priority patent/US7164011B2/en
Priority claimed from US10/777,455 external-priority patent/US7199105B2/en
Application filed by Vicuron Pharm Inc filed Critical Vicuron Pharm Inc
Publication of GEP20084437B publication Critical patent/GEP20084437B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/14—Acyclic radicals, not substituted by cyclic structures attached to a sulfur, selenium or tellurium atom of a saccharide radical
    • C07H15/16—Lincomycin; Derivatives thereof

Abstract

Compounds of the formula (1A) (values of R1, R2, R3, R6, R9, t and m are provided in the description), or its prodrug and/or pharmaceutically acceptable salts, a pharmaceutical composition comprising them and use thereof for mammals when treating microbial infections.
GEAP20049117A 2003-06-17 2004-06-17 Novel lincomycin derivatives possessing antimicrobial activity GEP20084437B (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US47950203P 2003-06-17 2003-06-17
US47929603P 2003-06-17 2003-06-17
US10/642,807 US7164011B2 (en) 2002-08-15 2003-08-15 Lincomycin derivatives possessing antibacterial activity
US10/777,455 US7199105B2 (en) 2002-08-15 2004-02-11 Lincomycin derivatives possessing antibacterial activity

Publications (1)

Publication Number Publication Date
GEP20084437B true GEP20084437B (en) 2008-07-25

Family

ID=40203032

Family Applications (1)

Application Number Title Priority Date Filing Date
GEAP20049117A GEP20084437B (en) 2003-06-17 2004-06-17 Novel lincomycin derivatives possessing antimicrobial activity

Country Status (17)

Country Link
EP (1) EP1644393A2 (en)
JP (1) JP2007516172A (en)
KR (1) KR20060091050A (en)
AU (1) AU2004261550A1 (en)
BR (1) BRPI0411534A (en)
CA (1) CA2528592A1 (en)
EC (1) ECSP056233A (en)
GE (1) GEP20084437B (en)
HK (1) HK1090061A1 (en)
IL (1) IL172183A0 (en)
IS (1) IS8147A (en)
MA (1) MA27860A1 (en)
MX (1) MXPA05013915A (en)
NO (1) NO20055893L (en)
OA (1) OA13179A (en)
RS (1) RS20050931A (en)
WO (1) WO2005012320A2 (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ538141A (en) 2002-08-15 2007-06-29 Vicuron Pharm Inc Lincomycin derivatives possessing antibacterial activity
US7199105B2 (en) 2002-08-15 2007-04-03 Vicuron Pharmaceuticals, Inc. Lincomycin derivatives possessing antibacterial activity
US7199106B2 (en) 2003-06-17 2007-04-03 Vicuron Pharmaceuticals, Inc. Lincomycin derivatives possessing antimicrobial activity
WO2005007665A2 (en) * 2003-06-17 2005-01-27 Vicuron Pharmaceuticals Inc. Lincomycin derivatives possessing antibacterial activity
US7256177B2 (en) 2003-06-17 2007-08-14 Vicuron Pharmaceuticals, Inc. Lincomycin derivatives possessing antibacterial activity
US7361743B2 (en) * 2004-02-11 2008-04-22 Pfizer Inc Lincomycin derivatives possessing antibacterial activity
JP2009507793A (en) * 2005-08-31 2009-02-26 ワイス 9-aminocarbonyl substituted derivatives of glycylcycline
JP5064237B2 (en) 2005-12-09 2012-10-31 Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 Lincomycin derivatives and antibacterial agents containing the same as active ingredients
US7867980B2 (en) 2007-05-31 2011-01-11 Meiji Seika Kaisha, Ltd. Lincosamide derivatives and antimicrobial agents comprising the same as active ingredient
US7879808B2 (en) 2007-05-31 2011-02-01 Meiji Seika Kaisha, Ltd. Lincomycin derivatives and antimicrobial agents comprising the same as active ingredient
US20130267699A1 (en) 2011-06-24 2013-10-10 California Institute Of Technology Quaternary heteroatom containing compounds
US8822679B2 (en) * 2011-06-24 2014-09-02 California Institute Of Technology Quaternary heteroatom containing compounds
US10421696B2 (en) 2014-12-18 2019-09-24 California Institute Of Technology Enantioselective synthesis of α-quaternary mannich adducts by palladium-catalyzed allylic alkylation
CA2981041C (en) 2015-03-27 2023-09-05 California Institute Of Technology Asymmetric catalytic decarboxylative alkyl alkylation using low catalyst concentrations and a robust precatalyst
US10040784B2 (en) 2016-03-11 2018-08-07 California Institute Of Technology Compositions and methods for acylating lactams
EP3480190B1 (en) 2017-11-01 2023-01-04 California Institute of Technology Methods for enantioselective allylic alkylation of esters, lactones, and lactams with unactivated allylic alcohols
US11214568B2 (en) 2018-10-18 2022-01-04 California Institute Of Technology Gem-disubstituted pyrrolidines, piperazines, and diazepanes, and compositions and methods of making the same
CN110357839A (en) * 2019-08-29 2019-10-22 重庆经致制药技术开发有限公司 The preparation method of Bu Waxitan chiral intermediate

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3268556A (en) * 1964-04-13 1966-08-23 Upjohn Co Novel lincomycin derivatives
NL128232C (en) * 1964-04-13
NL146501C (en) * 1964-07-01
US3282917A (en) * 1964-08-17 1966-11-01 Upjohn Co Methyl n-(1-alkyl-4-alkoxy-prolyl)-alpha-thiolincosaminide compounds and process therefor
US3496163A (en) * 1965-02-08 1970-02-17 Upjohn Co 7-halo-7-deoxylincomycins and process for preparing the same
NL140527B (en) * 1965-02-08 1973-12-17 Upjohn Co PROCESS FOR PREPARING LINCOMYCIN RELATED COMPOUNDS.
US3555007A (en) * 1968-07-22 1971-01-12 Upjohn Co 7-deoxy-7-halo lincomycin d derivatives
US3549615A (en) * 1968-10-17 1970-12-22 Upjohn Co Lincomycin derivatives and process for producing the same
DE2118636A1 (en) * 1970-04-20 1971-11-04 The Upjohn Co., Kalamazoo, Mich. (V.StA.) 3-nucleotides of lincomycin and their analogues, processes for their preparation and their use in therapeutic preparations
US3787390A (en) * 1971-06-23 1974-01-22 Upjohn Co Analogs of lincomycin and process
US3849396A (en) * 1973-01-08 1974-11-19 Upjohn Co Lincomycin and clindamycin 1-o-ethers
US3923602A (en) * 1973-10-25 1975-12-02 Upjohn Co Composition of matter and process
JPS5641239A (en) * 1979-09-13 1981-04-17 Hitachi Cable Ltd Flame-retardant composition
US4278789A (en) * 1979-11-23 1981-07-14 The Upjohn Company Lincomycin compounds
NZ538141A (en) * 2002-08-15 2007-06-29 Vicuron Pharm Inc Lincomycin derivatives possessing antibacterial activity
BRPI0411537A (en) * 2003-06-17 2006-08-01 Vicuron Pharm Inc lincomycin derivatives that have antibacterial activity

Also Published As

Publication number Publication date
RS20050931A (en) 2008-04-04
OA13179A (en) 2006-12-13
JP2007516172A (en) 2007-06-21
KR20060091050A (en) 2006-08-17
EP1644393A2 (en) 2006-04-12
AU2004261550A1 (en) 2005-02-10
IS8147A (en) 2005-11-24
MA27860A1 (en) 2006-04-03
ECSP056233A (en) 2006-04-19
WO2005012320A2 (en) 2005-02-10
BRPI0411534A (en) 2006-08-22
MXPA05013915A (en) 2006-07-03
WO2005012320A3 (en) 2005-10-20
NO20055893L (en) 2006-03-14
IL172183A0 (en) 2011-08-01
CA2528592A1 (en) 2005-02-10
HK1090061A1 (en) 2006-12-15

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