AR042086A1 - N-aril-2- oxazolidinon -5- carboxamidas y sus derivados, usados como agentes antibacterianos - Google Patents
N-aril-2- oxazolidinon -5- carboxamidas y sus derivados, usados como agentes antibacterianosInfo
- Publication number
- AR042086A1 AR042086A1 ARP030104276A ARP030104276A AR042086A1 AR 042086 A1 AR042086 A1 AR 042086A1 AR P030104276 A ARP030104276 A AR P030104276A AR P030104276 A ARP030104276 A AR P030104276A AR 042086 A1 AR042086 A1 AR 042086A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- het
- formula
- optionally substituted
- proviso
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
Reivindicación 1: Un compuesto de fórmula (1) o sus sales farmacéuticamente aceptables, caracterizado porque A es una estructura i, ii, iii, o iv, B es (a), (b), W es -N(H)C(X)-R1, Het o -Y-HET, en la que Het o -Y-HET está opcionalmente sustituido con =S o =O, con la condición de que cuando A es la estructura iv, W no es -Y-HET o Het; X es O o S; Y es NH, O o S; Z es como se muestra en los restos de fórmulas (a), (b), (c), (d), (e), (f), R1 es a) H, b) NH2, c) NH(alquilo C1-4), d) alquilo C1-4, e) alquenilo C2-4, f) O-(alquilo C1-4), g) S-(alquilo C1-4), o h) (CH2)8(cicloalquilo C3-6), en la que cada vez que aparece alquilo o cicloalquilo en R1 está opcionalmente sustituido con uno, dos o tres halógenos (F o Cl); cada R2 y R3 es independientemente H, halógeno (F o Cl), metilo o etilo; R4 es H, -CH3 o F; R5 es H o alquilo C1-4; R6 es H, alquilo C1-4 o como se muestra en el resto de fórmula(2); o R5 y R6 forman juntos un heterociclo saturado opcionalmente sustituido; R7 es H, o alquilo C1-4 que puede estar opcionalmente sustituido con -OH, -NH2, -NH-C(=NH)-NH2, -SH, -SCH3, -COOH, -C(O)NH2, fenilo que puede estar opcionalmente sustituido con -OH; R8 es H o -CH3; R9 es H, -CH3, -C(O)-CH(R7)-NR8R8, como se muestra en el resto de fórmula (3); R10 o R11 es halógeno, alquilo C1-4, -CF3, -CN, -NO2, -OH, -O-alquilo C1-4, -NH-S(O)w(alquilo C1-4);o como se muestra en el resto de fórmula (4) y (5), R12 es H, alquilo C1-4, -S(O)2-alquilo C1-4, como se muestra en los restos de fórmulas (6), o R5 y R12 juntos forman un heterociclo saturado; R13 es H, o como se muestra en el resto de fórmula (7); R14 es -(CH2)tNHR13, -OH, -O(alquilo C1-4); m es 0,1, 2, 3, 4; n es 0, 1,2 ,3 ,4 con la condición de que m + n es 2, 3, 4, o 5; p es 2, 3; q es 1,2; r, s y t son independientemente 0, 1; u y w son independientemente 0, 1, 2; y con la condición de que W no es Het o -Y-HET cuando Z es (a), (b) o (d), y con la condición además de que Z no es (b) cuando A tiene la fórmula iii.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US42802502P | 2002-11-21 | 2002-11-21 | |
US44553003P | 2003-02-06 | 2003-02-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR042086A1 true AR042086A1 (es) | 2005-06-08 |
Family
ID=32329201
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP030104276A AR042086A1 (es) | 2002-11-21 | 2003-11-19 | N-aril-2- oxazolidinon -5- carboxamidas y sus derivados, usados como agentes antibacterianos |
Country Status (13)
Country | Link |
---|---|
US (1) | US7141570B2 (es) |
EP (1) | EP1565186B1 (es) |
JP (1) | JP2006509035A (es) |
AR (1) | AR042086A1 (es) |
AT (1) | ATE344036T1 (es) |
AU (1) | AU2003280143A1 (es) |
BR (1) | BR0316483A (es) |
CA (1) | CA2502017A1 (es) |
DE (1) | DE60309504T2 (es) |
ES (1) | ES2271660T3 (es) |
MX (1) | MXPA05005472A (es) |
TW (1) | TW200413360A (es) |
WO (1) | WO2004045616A1 (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2170874A4 (en) * | 2007-06-22 | 2011-08-31 | Orchid Res Lab Ltd | NEW COMPOUNDS AND THEIR USE |
CA2717138A1 (en) | 2008-03-05 | 2009-09-11 | Takeda Pharmaceutical Company Limited | 5-membered heterocyclic compounds and bicyclic heteroaryl having glucagon antagonistic action useful for treating diabetes |
JP5662940B2 (ja) * | 2008-11-20 | 2015-02-04 | パナセア バイオテック リミテッド | 新規な抗微生物薬 |
EP2864284B1 (de) * | 2012-06-22 | 2017-07-05 | Henkel AG & Co. KGaA | Photolabile duftspeicherstoffe |
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US4705799A (en) * | 1983-06-07 | 1987-11-10 | E. I. Du Pont De Nemours And Company | Aminomethyl oxooxazolidinyl benzenes useful as antibacterial agents |
US5043443A (en) * | 1988-07-29 | 1991-08-27 | Du Pont Merck Pharmaceutical Company | Aminomethyloxooxazolidinyl arylbenzene derivatives |
US5164510A (en) * | 1988-09-15 | 1992-11-17 | The Upjohn Company | 5'Indolinyl-5β-amidomethyloxazolidin-2-ones |
US5225565A (en) * | 1988-09-15 | 1993-07-06 | The Upjohn Company | Antibacterial 3-(fused-ring substituted)phenyl-5β-amidomethyloxazolidin-2-ones |
US5182403A (en) * | 1988-09-15 | 1993-01-26 | The Upjohn Company | Substituted 3(5'indazolyl) oxazolidin-2-ones |
US5231188A (en) * | 1989-11-17 | 1993-07-27 | The Upjohn Company | Tricyclic [6.5.51]-fused oxazolidinone antibacterial agents |
AU667198B2 (en) * | 1991-11-01 | 1996-03-14 | Pharmacia & Upjohn Company | Substituted aryl- and heteroarylphenyloxazolidinones useful as antibacterial agents |
SK283420B6 (sk) * | 1992-05-08 | 2003-07-01 | Pharmacia & Upjohn Company | Antimikrobiálne oxazolidinóny obsahujúce substituované diazínové skupiny |
EP0648119A1 (en) | 1992-07-08 | 1995-04-19 | The Upjohn Company | 5'-INDOLINYL OXAZOLIDINONES USEFUL AGAINST $i(MYCOBACTERIUM TUBERCULOSIS) |
KR100276382B1 (ko) * | 1992-12-08 | 2000-12-15 | 로렌스 티. 마이젠헬더 | 트로폰-치환된 페닐옥사졸리디논 항균제 |
US5688792A (en) * | 1994-08-16 | 1997-11-18 | Pharmacia & Upjohn Company | Substituted oxazine and thiazine oxazolidinone antimicrobials |
MY115155A (en) | 1993-09-09 | 2003-04-30 | Upjohn Co | Substituted oxazine and thiazine oxazolidinone antimicrobials. |
DE69419523T2 (de) * | 1993-11-22 | 1999-11-25 | Upjohn Co | Substituierte hydroxyacetyl piperazine phenyl oxazolidinonsäureester |
JPH0873455A (ja) | 1994-03-15 | 1996-03-19 | Upjohn Co:The | オキサゾリジノン誘導体及びこれを有効成分とする医薬組成物 |
DE4425613A1 (de) * | 1994-07-20 | 1996-01-25 | Bayer Ag | 5-gliedrige Heteroaryl-oxazolidinone |
DE4425609A1 (de) * | 1994-07-20 | 1996-01-25 | Bayer Ag | Benzofuranyl- und Benzothienyloxazolidinone |
DE4425612A1 (de) * | 1994-07-20 | 1996-04-04 | Bayer Ag | 6-gliedrige stickstoffhaltige Heteroaryl-oxazolidinone |
DE19514313A1 (de) * | 1994-08-03 | 1996-02-08 | Bayer Ag | Benzoxazolyl- und Benzothiazolyloxazolidinone |
CA2200433C (en) | 1994-10-26 | 2006-02-07 | Douglas K. Hutchinson | Phenyloxazolidinone antimicrobials |
AU702733B2 (en) | 1994-11-15 | 1999-03-04 | Pharmacia & Upjohn Company | Bicyclic oxazine and thiazine oxazolidinone antibacterials |
RU2154645C2 (ru) | 1995-02-03 | 2000-08-20 | Фармация Энд Апджон Компани | Фенилоксазолидиноны, замещенные в кольце гетероароматическими кольцами, в качестве антимикробных агентов |
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-
2003
- 2003-11-19 ES ES03772516T patent/ES2271660T3/es not_active Expired - Lifetime
- 2003-11-19 EP EP03772516A patent/EP1565186B1/en not_active Expired - Lifetime
- 2003-11-19 JP JP2004570322A patent/JP2006509035A/ja not_active Withdrawn
- 2003-11-19 MX MXPA05005472A patent/MXPA05005472A/es active IP Right Grant
- 2003-11-19 US US10/717,237 patent/US7141570B2/en not_active Expired - Fee Related
- 2003-11-19 DE DE60309504T patent/DE60309504T2/de not_active Expired - Fee Related
- 2003-11-19 WO PCT/IB2003/005355 patent/WO2004045616A1/en active IP Right Grant
- 2003-11-19 AU AU2003280143A patent/AU2003280143A1/en not_active Abandoned
- 2003-11-19 AR ARP030104276A patent/AR042086A1/es unknown
- 2003-11-19 BR BR0316483-7A patent/BR0316483A/pt not_active IP Right Cessation
- 2003-11-19 CA CA002502017A patent/CA2502017A1/en not_active Abandoned
- 2003-11-19 AT AT03772516T patent/ATE344036T1/de not_active IP Right Cessation
- 2003-11-20 TW TW092132583A patent/TW200413360A/zh unknown
Also Published As
Publication number | Publication date |
---|---|
US7141570B2 (en) | 2006-11-28 |
EP1565186B1 (en) | 2006-11-02 |
TW200413360A (en) | 2004-08-01 |
EP1565186A1 (en) | 2005-08-24 |
BR0316483A (pt) | 2005-10-11 |
AU2003280143A1 (en) | 2004-06-15 |
DE60309504D1 (de) | 2006-12-14 |
US20040142939A1 (en) | 2004-07-22 |
ATE344036T1 (de) | 2006-11-15 |
DE60309504T2 (de) | 2007-05-16 |
CA2502017A1 (en) | 2004-06-03 |
MXPA05005472A (es) | 2005-07-25 |
JP2006509035A (ja) | 2006-03-16 |
ES2271660T3 (es) | 2007-04-16 |
WO2004045616A1 (en) | 2004-06-03 |
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