AR035857A1 - Fenilindoles; sus composiciones farmaceuticas y sus usos - Google Patents

Fenilindoles; sus composiciones farmaceuticas y sus usos

Info

Publication number
AR035857A1
AR035857A1 ARP020101341A ARP020101341A AR035857A1 AR 035857 A1 AR035857 A1 AR 035857A1 AR P020101341 A ARP020101341 A AR P020101341A AR P020101341 A ARP020101341 A AR P020101341A AR 035857 A1 AR035857 A1 AR 035857A1
Authority
AR
Argentina
Prior art keywords
alkyl
optionally substituted
unsubstituted
nhr2
nr2r3
Prior art date
Application number
ARP020101341A
Other languages
English (en)
Original Assignee
Novirio Pharmaceuticals Ltd
Univ Degli Studi Cagliari
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novirio Pharmaceuticals Ltd, Univ Degli Studi Cagliari filed Critical Novirio Pharmaceuticals Ltd
Publication of AR035857A1 publication Critical patent/AR035857A1/es

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404Indoles, e.g. pindolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • A61K31/41781,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/30Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Compuestos derivados de fenilindol de fórmula (1) o una sal o profármaco aceptable para uso farmacéutico del mismo, en donde: (a) R1 es hidrógeno, acilo, -C(=O)H, -C(=W)H, -C(=O)R2, -C(=W)R2, -C(=O)OH, -C(=W)OH, -C(=O)OR2, -C(=W)OR2, -C(=O)SH, -C(=W)SH, -C(=O)SR2, -C(=W)SR2, -C(=O)NH2, -C(=W)NH2, -C(=O)NHR2, -C(=W)NHR2, -C(=O)NR2R3, -C(=W)NR2R3, -C(=W)NH-(CH2)p-(aminoácido) ó -(CH2)p-aminoácido; (b) R4', R5', R6', R7', R2", R3", R4", R5" y R6" son cada uno independientemente H, halo (F, Cl, Br ó I), -NO2, -CN, -OH, -OR2, -SH, -SR2, -NH2, -NHR2, -NR2R3, -NHSO2-alquilo C1-3, -NR2SO2-alquilo C1-3, -NHCO-alquilo C1-3, -NR2CO-alquilo C1-3, alquilo lineal o ramificado opcionalmente sustituido o insustituido, alquenilo o alquinilo (tal como un lineal o ramificado opcionalmente sustituido o insustituido alquilo C1-6, alquenilo C2-6 o alquinilo C2-6 y en particular CH3, CF3, bromuro de vinilo, -CR2R2-S(O)n-R3, -CR2R2NH2, -CR2R2NHR2, -CR2R2NR2R3 y -CR2R2-C(=O)R2), alcacilo, acilo opcionalmente sustituido o insustituido, -C(=O)H, -C(=W)H, -C(=O)R2, -C(=W)R2, -C(=O)OH, -C(=W)OH, -C(=O)OR2, -C(=W)OR2, -C(=O)SH, -C(=W)SH, -C(=O)SR2, -C(=W)SR2, -C(=O)NH2, -C(=W)NH2, -C(=O)NHR2, -C(=W)NHR2, -C(=O)NR2R3, -C(=W)NR2R3, -C(=W)NH(CH2)p-(aminoácido), un residuo de un aminoácido o -(CH2)p(aminoácido), donde si R5' es hidrógeno, F, Cl, Br, -NO2, -CN, -OR2, -NR2R2, -NHSO2-alquilo C1-3 ó -NHCO-alquilo C1-3, entonces al menos uno de R4', R6' y R7' no es hidrógeno; (c) Z es acilo opcionalmente sustituido o insustituido , -C(=O)NH2, -C(=W)NH2, -C(=O)NHR2, -C(=W)NHR2, -C(=O)NR2R3, -C(=W)NR2R3, -C(=W)NH(CH2)p-(aminoácido), un residuo de un aminoácido, -(CH2)p(aminoácido), -C(=O)R3, -C(=O)H, -C(=W)H, -C(=O)R2, -C(=W)R2, -C(=O)OR3, -C(=O)OH, -C(=W)OH, -C(=O)OR2, -C(=W)OR2, -C(=O)SH, -C(=W)SH, -C(=O)SR2, -C(=W)SR2, alquilo lineal o ramificado opcionalmente sustituido o insustituido, alquenilo o alquinilo (tal como un lineal o ramificado opcionalmente sustituido o insustituido alquilo C1-6, alquenilo C2-6 o alquinilo C2-6 y en particular CH3, CF3, bromuro de vinilo, -CR2R2-S(O)n-R3, -CR2R2NH2, -CR2R2NHR2, -CR2R2NR2R3 y -CR2R2-C(=O)R2), -CN o halo (F, Cl, Br ó I); (d) Y es O, S ó S(O)n; (e) cada W es independientemente O, S, -NH2, -NHR2, -NR2R2, -N-CN, -N-NH2, -N-NHR2, -N-NR2R3, -N-OH ó -N-OR2; (f) cada R2 es independientemente hidrógeno, o un alquilo inferior lineal o ramificado opcionalmente sustituido o insustituido, alquenilo o alquinilo (tal como un lineal o ramificado opcionalmente sustituido alquilo C1-3, alquenilo C2-4 o alquinilo C2-4, y en particular CH3, CF3, bromuro de vinilo, -CR2R2-S(O)n-R3, -CR2R2NH2, -CR2R2NHR2, -CR2R2NR2R3 y -CR2R2-C(=O)R2); (g) cada R3 es independientemente hidrógeno, alquilo lineal o ramificado opcionalmente sustituido o insustituido, alquenilo o alquinilo (tal como un lineal o ramificado opcionalmente sustituido o insustituido alquilo C1-6, alquenilo C2-6 o alquinilo C2-6 y en particular CH3, CF3, bromuro de vinilo, -CR2R2-S(O)n-R3, -CR2R2NH2, -CR2R2NHR2, -CR2R2NR2R3 y -CR2R2-C(=O)R2), arilo opcionalmente sustituido o insustituido (tal como fenilo), heterociclo opcionalmente sustituido o insustituido, opcionalmente sustituido o insustituido alquilarilo, opcionalmente sustituido o insustituido alquilheterociclo, opcionalmente sustituido o insustituido aralquilo, heterociclo opcionalmente sustituido o insustituido-alquilo; (h) cada n es independientemente 0, 1 ó 2; y (i) cada p es independientemente 0, 1, 2, 3, 4 ó 5; (j) donde si uno o más de los sustituyentes lineales o ramificados opcionalmente sustituidos alquilo, alquenilo, alquinilo, alquilo inferior, alquenilo inferior o alquinilo inferior, acilo, arilo, heterociclo, alcarilo, alc-heteroarilo, arilalquilo o alquilheterociclo está sustituido, entonces preferentemente está sustituido con uno o más entre halógenos (F, Cl, Br ó I), -OH, -OR2, -SH, -SR2, oxima, hidrazina, -C(=O)H, -C(=W)H, -C(=O)R2, -C(=W)R2, -C(=O)OH, -C(=W)OH, -C(=O)OR2, -C(=W)OR2, -C(=O)SH, -C(=W)SH, -C(=O)SR2, -C(=W)SR2, -C(=O)NH2, -C(=W)NH2, -C(=O)NHR2, -C(=W)NHR2, -C(=O)NR2R3, -C(=W)NR2R3, -NH2, -NHR2, -NR2R3, -NHSO2-alquilo C1-3, -NR2SO2-alquilo C1-3, -NHCO-alquilo C1-3, -NR2CO-alquilo C1-3, -S(O)n-R3, alcoxi C1-3, tioéter C1-3, un residuo de un aminoácido tal como -NH(CH2)p-(aminoácido) ó -C(=W)NH(CH2)p-(aminoácido). Los compuestos poseen actividad antiviral (es decir anti VIH) o bien se metabolizan en un compuesto que presenta tal actividad. Composiciones farmacéuticas que los contienen y sus usos en la fabricación de medicamentos.
ARP020101341A 2001-04-11 2002-04-11 Fenilindoles; sus composiciones farmaceuticas y sus usos AR035857A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US28339301P 2001-04-11 2001-04-11

Publications (1)

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AR035857A1 true AR035857A1 (es) 2004-07-21

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ID=23085844

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Application Number Title Priority Date Filing Date
ARP020101341A AR035857A1 (es) 2001-04-11 2002-04-11 Fenilindoles; sus composiciones farmaceuticas y sus usos

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US (3) US6710068B2 (es)
EP (1) EP1390029B1 (es)
AR (1) AR035857A1 (es)
AT (1) ATE451921T1 (es)
AU (1) AU2002254616B2 (es)
BR (1) BR0208790A (es)
CA (1) CA2444501C (es)
DE (1) DE60234760D1 (es)
TW (1) TWI294875B (es)
WO (1) WO2002083126A1 (es)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1305313B1 (it) * 1998-07-17 2001-05-04 Colla Paolo 3,4 - diidro- 6- benzil-4-oxopirimidine sostituite e relativo processodi produzione e impiego nella terapia delle infezioni da hiv-1.
WO2002083126A1 (en) * 2001-04-11 2002-10-24 Idenix (Cayman) Limited Phenylindoles for the treatment of hiv
WO2004014364A1 (en) * 2002-08-07 2004-02-19 Idenix (Cayman) Limited Substituted phenylindoles for the treatment of hiv
WO2004041837A1 (en) 2002-10-31 2004-05-21 Metabasis Therapeutics, Inc. Novel cytarabine monophosphate prodrugs
WO2004096147A2 (en) * 2003-04-28 2004-11-11 Idenix (Cayman) Limited Oxo-pyrimidine compounds
US7439268B2 (en) * 2003-07-18 2008-10-21 Idexx Laboratories Compositions containing prodrugs of florfenicol and methods of use
US7265148B2 (en) * 2003-09-25 2007-09-04 Wyeth Substituted pyrrole-indoles
AU2005305609B2 (en) 2004-09-17 2011-10-06 Idenix Pharmaceuticals, Inc. Phosphoindoles as HIV inhibitors
WO2006041961A1 (en) * 2004-10-05 2006-04-20 GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTHAND HUMAN SERVICES Arylthioindole tubulin polymerization inhibitors and methods of treating or preventing cancer using same
AU2005302706B2 (en) 2004-10-27 2011-12-15 Janssen Pharmaceutica N.V. Indole derivatives useful as progesterone receptor modulators
US7524831B2 (en) 2005-03-02 2009-04-28 Schering Corporation Treatments for Flaviviridae virus infection
UA95788C2 (en) 2005-12-15 2011-09-12 Ф. Хоффманн-Ля Рош Аг Fused pyrrole derivatives
EP1973876A2 (en) * 2006-01-13 2008-10-01 Wyeth Sulfonyl substituted 1h-indoles as ligands for the 5-hydroxytryptamine receptors
NZ575831A (en) * 2006-09-29 2011-12-22 Idenix Pharmaceuticals Inc Enantiomerically pure phosphoindoles as hiv inhibitors
US20100113421A1 (en) * 2006-10-06 2010-05-06 Williams Theresa M Non-nucleoside reverse transcriptase inhibitors
US7550625B2 (en) * 2007-10-19 2009-06-23 Idexx Laboratories Esters of florfenicol
EP2217069A4 (en) * 2007-11-09 2012-03-14 Salk Inst For Biological Studi INHIBITORS OF NON-NUCLEOSIDE INHIBITORS OF THE REVERSE TRANSCRIPTASE
WO2009079797A1 (en) 2007-12-26 2009-07-02 Critical Outcome Technologies, Inc. Compounds and method for treatment of cancer
US20110172244A1 (en) * 2008-02-22 2011-07-14 Irm Llc Compounds and compositions as modulators of gpr119 activity
CA2730890C (en) 2008-07-17 2018-05-15 Critical Outcome Technologies Inc. Thiosemicarbazone inhibitor compounds and cancer treatment methods
CA2999435A1 (en) 2010-04-01 2011-10-06 Critical Outcome Technologies Inc. Compounds and method for treatment of hiv
ES2646834T3 (es) 2010-08-20 2017-12-18 Amira Pharmaceuticals, Inc. Inhibidores de autotaxina y usos de los mismos
EP2508511A1 (en) * 2011-04-07 2012-10-10 Laboratoire Biodim Inhibitors of viral replication, their process of preparation and their therapeutical uses
US9260416B2 (en) 2011-05-27 2016-02-16 Amira Pharmaceuticals, Inc. Heterocyclic autotaxin inhibitors and uses thereof
WO2015042052A1 (en) 2013-09-17 2015-03-26 Pharmakea, Inc. Heterocyclic vinyl autotaxin inhibitor compounds
US9714240B2 (en) 2013-09-17 2017-07-25 Pharmakea, Inc. Vinyl autotaxin inhibitor compounds
US9850203B2 (en) 2013-09-26 2017-12-26 Pharmakea, Inc. Autotaxin inhibitor compounds
CA2930737C (en) 2013-11-22 2023-02-21 Pharmakea, Inc. Autotaxin inhibitor compounds
EP3105238A4 (en) 2014-02-13 2017-11-08 Ligand Pharmaceuticals, Inc. Prodrug compounds and their uses
WO2016003812A1 (en) 2014-07-02 2016-01-07 Ligand Pharmaceuticals, Inc. Prodrug compounds and uses therof
KR20240060887A (ko) 2015-05-27 2024-05-08 사브레 테라퓨틱스 엘엘씨 오토탁신 억제제 및 이의 용도
CN111788196A (zh) 2018-01-09 2020-10-16 配体药物公司 缩醛化合物及其治疗用途

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3304019A1 (de) * 1983-02-07 1984-08-09 Kali-Chemie Pharma Gmbh, 3000 Hannover 3-acyloxy-1-phenyl-2-aminocarbonylindol-verbindungen sowie verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
US4866084A (en) 1987-07-17 1989-09-12 Harbor Branch Oceanographic Institution, Inc. Topsentin compounds effective against viruses and certain tumors
GB8823693D0 (en) * 1988-10-08 1988-11-16 Hartopp R Injector cleaning apparatus
WO1993005020A1 (en) * 1991-09-06 1993-03-18 Merck & Co., Inc. Indoles as inhibitors of hiv reverse transcriptase
US5527819A (en) 1991-09-06 1996-06-18 Merck & Co., Inc. Inhibitors of HIV reverse transcriptase
US5124327A (en) 1991-09-06 1992-06-23 Merck & Co., Inc. HIV reverse transcriptase
DE4217964A1 (de) 1992-05-30 1993-12-02 Goedecke Ag Indolocarbazol-Imide und deren Verwendung
US5633457A (en) * 1992-06-05 1997-05-27 Triangle Special Products Fuel injection cleaning and testing system and apparatus
CA2156420A1 (en) 1993-02-24 1994-09-01 Theresa M. Williams Inhibitors of hiv reverse transcriptase
US5489685A (en) 1994-05-12 1996-02-06 Merck & Co., Ltd. Method of synthesizing furo[2,3-b]pyridine carboxylic acid esters
ES2172585T3 (es) 1994-05-31 2002-10-01 Mitsui Chemicals Inc Derivado de benzoimidazol.
US5734081A (en) 1994-08-05 1998-03-31 Warner-Lambert Company Arylthio compounds
JPH10512251A (ja) 1995-01-10 1998-11-24 スミスクライン・ビーチャム・ソシエタ・ペル・アチオニ 骨粗鬆症の治療に有用なインドール誘導体
GB9614347D0 (en) 1996-07-09 1996-09-04 Smithkline Beecham Spa Novel compounds
US5830894A (en) 1997-02-21 1998-11-03 Viropharma Incorporated Methods for preventing and treating pestivirus infection and associated diseases
US5935982A (en) 1997-02-28 1999-08-10 The University Of North Carolina At Chapel Hill Methods of treating retroviral infection and compounds useful therefor
US20020091148A1 (en) * 2000-09-15 2002-07-11 Bamaung Nwe Y. 3-substituted indole antiproliferative angiogenesis inhibitors
WO2002083126A1 (en) * 2001-04-11 2002-10-24 Idenix (Cayman) Limited Phenylindoles for the treatment of hiv
WO2004014364A1 (en) * 2002-08-07 2004-02-19 Idenix (Cayman) Limited Substituted phenylindoles for the treatment of hiv
US7481048B2 (en) * 2005-06-30 2009-01-27 Caterpillar Inc. Regeneration assembly
US7406822B2 (en) * 2005-06-30 2008-08-05 Caterpillar Inc. Particulate trap regeneration system and control strategy

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AU2002254616B2 (en) 2007-09-06
EP1390029B1 (en) 2009-12-16
US20070293668A1 (en) 2007-12-20
CA2444501A1 (en) 2002-10-24
EP1390029A4 (en) 2005-11-30
US20040180888A1 (en) 2004-09-16
BR0208790A (pt) 2004-03-30
TWI294875B (en) 2008-03-21
EP1390029A1 (en) 2004-02-25
WO2002083126A1 (en) 2002-10-24
US6710068B2 (en) 2004-03-23
DE60234760D1 (de) 2010-01-28
ATE451921T1 (de) 2010-01-15
US20020193415A1 (en) 2002-12-19
TW200422291A (en) 2004-11-01
CA2444501C (en) 2009-11-17

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