AR035857A1 - Fenilindoles; sus composiciones farmaceuticas y sus usos - Google Patents
Fenilindoles; sus composiciones farmaceuticas y sus usosInfo
- Publication number
- AR035857A1 AR035857A1 ARP020101341A ARP020101341A AR035857A1 AR 035857 A1 AR035857 A1 AR 035857A1 AR P020101341 A ARP020101341 A AR P020101341A AR P020101341 A ARP020101341 A AR P020101341A AR 035857 A1 AR035857 A1 AR 035857A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- optionally substituted
- unsubstituted
- nhr2
- nr2r3
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Compuestos derivados de fenilindol de fórmula (1) o una sal o profármaco aceptable para uso farmacéutico del mismo, en donde: (a) R1 es hidrógeno, acilo, -C(=O)H, -C(=W)H, -C(=O)R2, -C(=W)R2, -C(=O)OH, -C(=W)OH, -C(=O)OR2, -C(=W)OR2, -C(=O)SH, -C(=W)SH, -C(=O)SR2, -C(=W)SR2, -C(=O)NH2, -C(=W)NH2, -C(=O)NHR2, -C(=W)NHR2, -C(=O)NR2R3, -C(=W)NR2R3, -C(=W)NH-(CH2)p-(aminoácido) ó -(CH2)p-aminoácido; (b) R4', R5', R6', R7', R2", R3", R4", R5" y R6" son cada uno independientemente H, halo (F, Cl, Br ó I), -NO2, -CN, -OH, -OR2, -SH, -SR2, -NH2, -NHR2, -NR2R3, -NHSO2-alquilo C1-3, -NR2SO2-alquilo C1-3, -NHCO-alquilo C1-3, -NR2CO-alquilo C1-3, alquilo lineal o ramificado opcionalmente sustituido o insustituido, alquenilo o alquinilo (tal como un lineal o ramificado opcionalmente sustituido o insustituido alquilo C1-6, alquenilo C2-6 o alquinilo C2-6 y en particular CH3, CF3, bromuro de vinilo, -CR2R2-S(O)n-R3, -CR2R2NH2, -CR2R2NHR2, -CR2R2NR2R3 y -CR2R2-C(=O)R2), alcacilo, acilo opcionalmente sustituido o insustituido, -C(=O)H, -C(=W)H, -C(=O)R2, -C(=W)R2, -C(=O)OH, -C(=W)OH, -C(=O)OR2, -C(=W)OR2, -C(=O)SH, -C(=W)SH, -C(=O)SR2, -C(=W)SR2, -C(=O)NH2, -C(=W)NH2, -C(=O)NHR2, -C(=W)NHR2, -C(=O)NR2R3, -C(=W)NR2R3, -C(=W)NH(CH2)p-(aminoácido), un residuo de un aminoácido o -(CH2)p(aminoácido), donde si R5' es hidrógeno, F, Cl, Br, -NO2, -CN, -OR2, -NR2R2, -NHSO2-alquilo C1-3 ó -NHCO-alquilo C1-3, entonces al menos uno de R4', R6' y R7' no es hidrógeno; (c) Z es acilo opcionalmente sustituido o insustituido , -C(=O)NH2, -C(=W)NH2, -C(=O)NHR2, -C(=W)NHR2, -C(=O)NR2R3, -C(=W)NR2R3, -C(=W)NH(CH2)p-(aminoácido), un residuo de un aminoácido, -(CH2)p(aminoácido), -C(=O)R3, -C(=O)H, -C(=W)H, -C(=O)R2, -C(=W)R2, -C(=O)OR3, -C(=O)OH, -C(=W)OH, -C(=O)OR2, -C(=W)OR2, -C(=O)SH, -C(=W)SH, -C(=O)SR2, -C(=W)SR2, alquilo lineal o ramificado opcionalmente sustituido o insustituido, alquenilo o alquinilo (tal como un lineal o ramificado opcionalmente sustituido o insustituido alquilo C1-6, alquenilo C2-6 o alquinilo C2-6 y en particular CH3, CF3, bromuro de vinilo, -CR2R2-S(O)n-R3, -CR2R2NH2, -CR2R2NHR2, -CR2R2NR2R3 y -CR2R2-C(=O)R2), -CN o halo (F, Cl, Br ó I); (d) Y es O, S ó S(O)n; (e) cada W es independientemente O, S, -NH2, -NHR2, -NR2R2, -N-CN, -N-NH2, -N-NHR2, -N-NR2R3, -N-OH ó -N-OR2; (f) cada R2 es independientemente hidrógeno, o un alquilo inferior lineal o ramificado opcionalmente sustituido o insustituido, alquenilo o alquinilo (tal como un lineal o ramificado opcionalmente sustituido alquilo C1-3, alquenilo C2-4 o alquinilo C2-4, y en particular CH3, CF3, bromuro de vinilo, -CR2R2-S(O)n-R3, -CR2R2NH2, -CR2R2NHR2, -CR2R2NR2R3 y -CR2R2-C(=O)R2); (g) cada R3 es independientemente hidrógeno, alquilo lineal o ramificado opcionalmente sustituido o insustituido, alquenilo o alquinilo (tal como un lineal o ramificado opcionalmente sustituido o insustituido alquilo C1-6, alquenilo C2-6 o alquinilo C2-6 y en particular CH3, CF3, bromuro de vinilo, -CR2R2-S(O)n-R3, -CR2R2NH2, -CR2R2NHR2, -CR2R2NR2R3 y -CR2R2-C(=O)R2), arilo opcionalmente sustituido o insustituido (tal como fenilo), heterociclo opcionalmente sustituido o insustituido, opcionalmente sustituido o insustituido alquilarilo, opcionalmente sustituido o insustituido alquilheterociclo, opcionalmente sustituido o insustituido aralquilo, heterociclo opcionalmente sustituido o insustituido-alquilo; (h) cada n es independientemente 0, 1 ó 2; y (i) cada p es independientemente 0, 1, 2, 3, 4 ó 5; (j) donde si uno o más de los sustituyentes lineales o ramificados opcionalmente sustituidos alquilo, alquenilo, alquinilo, alquilo inferior, alquenilo inferior o alquinilo inferior, acilo, arilo, heterociclo, alcarilo, alc-heteroarilo, arilalquilo o alquilheterociclo está sustituido, entonces preferentemente está sustituido con uno o más entre halógenos (F, Cl, Br ó I), -OH, -OR2, -SH, -SR2, oxima, hidrazina, -C(=O)H, -C(=W)H, -C(=O)R2, -C(=W)R2, -C(=O)OH, -C(=W)OH, -C(=O)OR2, -C(=W)OR2, -C(=O)SH, -C(=W)SH, -C(=O)SR2, -C(=W)SR2, -C(=O)NH2, -C(=W)NH2, -C(=O)NHR2, -C(=W)NHR2, -C(=O)NR2R3, -C(=W)NR2R3, -NH2, -NHR2, -NR2R3, -NHSO2-alquilo C1-3, -NR2SO2-alquilo C1-3, -NHCO-alquilo C1-3, -NR2CO-alquilo C1-3, -S(O)n-R3, alcoxi C1-3, tioéter C1-3, un residuo de un aminoácido tal como -NH(CH2)p-(aminoácido) ó -C(=W)NH(CH2)p-(aminoácido). Los compuestos poseen actividad antiviral (es decir anti VIH) o bien se metabolizan en un compuesto que presenta tal actividad. Composiciones farmacéuticas que los contienen y sus usos en la fabricación de medicamentos.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US28339301P | 2001-04-11 | 2001-04-11 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR035857A1 true AR035857A1 (es) | 2004-07-21 |
Family
ID=23085844
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP020101341A AR035857A1 (es) | 2001-04-11 | 2002-04-11 | Fenilindoles; sus composiciones farmaceuticas y sus usos |
Country Status (10)
Country | Link |
---|---|
US (3) | US6710068B2 (es) |
EP (1) | EP1390029B1 (es) |
AR (1) | AR035857A1 (es) |
AT (1) | ATE451921T1 (es) |
AU (1) | AU2002254616B2 (es) |
BR (1) | BR0208790A (es) |
CA (1) | CA2444501C (es) |
DE (1) | DE60234760D1 (es) |
TW (1) | TWI294875B (es) |
WO (1) | WO2002083126A1 (es) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1305313B1 (it) * | 1998-07-17 | 2001-05-04 | Colla Paolo | 3,4 - diidro- 6- benzil-4-oxopirimidine sostituite e relativo processodi produzione e impiego nella terapia delle infezioni da hiv-1. |
WO2002083126A1 (en) * | 2001-04-11 | 2002-10-24 | Idenix (Cayman) Limited | Phenylindoles for the treatment of hiv |
WO2004014364A1 (en) * | 2002-08-07 | 2004-02-19 | Idenix (Cayman) Limited | Substituted phenylindoles for the treatment of hiv |
WO2004041837A1 (en) | 2002-10-31 | 2004-05-21 | Metabasis Therapeutics, Inc. | Novel cytarabine monophosphate prodrugs |
WO2004096147A2 (en) * | 2003-04-28 | 2004-11-11 | Idenix (Cayman) Limited | Oxo-pyrimidine compounds |
US7439268B2 (en) * | 2003-07-18 | 2008-10-21 | Idexx Laboratories | Compositions containing prodrugs of florfenicol and methods of use |
US7265148B2 (en) * | 2003-09-25 | 2007-09-04 | Wyeth | Substituted pyrrole-indoles |
AU2005305609B2 (en) | 2004-09-17 | 2011-10-06 | Idenix Pharmaceuticals, Inc. | Phosphoindoles as HIV inhibitors |
WO2006041961A1 (en) * | 2004-10-05 | 2006-04-20 | GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTHAND HUMAN SERVICES | Arylthioindole tubulin polymerization inhibitors and methods of treating or preventing cancer using same |
AU2005302706B2 (en) | 2004-10-27 | 2011-12-15 | Janssen Pharmaceutica N.V. | Indole derivatives useful as progesterone receptor modulators |
US7524831B2 (en) | 2005-03-02 | 2009-04-28 | Schering Corporation | Treatments for Flaviviridae virus infection |
UA95788C2 (en) | 2005-12-15 | 2011-09-12 | Ф. Хоффманн-Ля Рош Аг | Fused pyrrole derivatives |
EP1973876A2 (en) * | 2006-01-13 | 2008-10-01 | Wyeth | Sulfonyl substituted 1h-indoles as ligands for the 5-hydroxytryptamine receptors |
NZ575831A (en) * | 2006-09-29 | 2011-12-22 | Idenix Pharmaceuticals Inc | Enantiomerically pure phosphoindoles as hiv inhibitors |
US20100113421A1 (en) * | 2006-10-06 | 2010-05-06 | Williams Theresa M | Non-nucleoside reverse transcriptase inhibitors |
US7550625B2 (en) * | 2007-10-19 | 2009-06-23 | Idexx Laboratories | Esters of florfenicol |
EP2217069A4 (en) * | 2007-11-09 | 2012-03-14 | Salk Inst For Biological Studi | INHIBITORS OF NON-NUCLEOSIDE INHIBITORS OF THE REVERSE TRANSCRIPTASE |
WO2009079797A1 (en) | 2007-12-26 | 2009-07-02 | Critical Outcome Technologies, Inc. | Compounds and method for treatment of cancer |
US20110172244A1 (en) * | 2008-02-22 | 2011-07-14 | Irm Llc | Compounds and compositions as modulators of gpr119 activity |
CA2730890C (en) | 2008-07-17 | 2018-05-15 | Critical Outcome Technologies Inc. | Thiosemicarbazone inhibitor compounds and cancer treatment methods |
CA2999435A1 (en) | 2010-04-01 | 2011-10-06 | Critical Outcome Technologies Inc. | Compounds and method for treatment of hiv |
ES2646834T3 (es) | 2010-08-20 | 2017-12-18 | Amira Pharmaceuticals, Inc. | Inhibidores de autotaxina y usos de los mismos |
EP2508511A1 (en) * | 2011-04-07 | 2012-10-10 | Laboratoire Biodim | Inhibitors of viral replication, their process of preparation and their therapeutical uses |
US9260416B2 (en) | 2011-05-27 | 2016-02-16 | Amira Pharmaceuticals, Inc. | Heterocyclic autotaxin inhibitors and uses thereof |
WO2015042052A1 (en) | 2013-09-17 | 2015-03-26 | Pharmakea, Inc. | Heterocyclic vinyl autotaxin inhibitor compounds |
US9714240B2 (en) | 2013-09-17 | 2017-07-25 | Pharmakea, Inc. | Vinyl autotaxin inhibitor compounds |
US9850203B2 (en) | 2013-09-26 | 2017-12-26 | Pharmakea, Inc. | Autotaxin inhibitor compounds |
CA2930737C (en) | 2013-11-22 | 2023-02-21 | Pharmakea, Inc. | Autotaxin inhibitor compounds |
EP3105238A4 (en) | 2014-02-13 | 2017-11-08 | Ligand Pharmaceuticals, Inc. | Prodrug compounds and their uses |
WO2016003812A1 (en) | 2014-07-02 | 2016-01-07 | Ligand Pharmaceuticals, Inc. | Prodrug compounds and uses therof |
KR20240060887A (ko) | 2015-05-27 | 2024-05-08 | 사브레 테라퓨틱스 엘엘씨 | 오토탁신 억제제 및 이의 용도 |
CN111788196A (zh) | 2018-01-09 | 2020-10-16 | 配体药物公司 | 缩醛化合物及其治疗用途 |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3304019A1 (de) * | 1983-02-07 | 1984-08-09 | Kali-Chemie Pharma Gmbh, 3000 Hannover | 3-acyloxy-1-phenyl-2-aminocarbonylindol-verbindungen sowie verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
US4866084A (en) | 1987-07-17 | 1989-09-12 | Harbor Branch Oceanographic Institution, Inc. | Topsentin compounds effective against viruses and certain tumors |
GB8823693D0 (en) * | 1988-10-08 | 1988-11-16 | Hartopp R | Injector cleaning apparatus |
WO1993005020A1 (en) * | 1991-09-06 | 1993-03-18 | Merck & Co., Inc. | Indoles as inhibitors of hiv reverse transcriptase |
US5527819A (en) | 1991-09-06 | 1996-06-18 | Merck & Co., Inc. | Inhibitors of HIV reverse transcriptase |
US5124327A (en) | 1991-09-06 | 1992-06-23 | Merck & Co., Inc. | HIV reverse transcriptase |
DE4217964A1 (de) | 1992-05-30 | 1993-12-02 | Goedecke Ag | Indolocarbazol-Imide und deren Verwendung |
US5633457A (en) * | 1992-06-05 | 1997-05-27 | Triangle Special Products | Fuel injection cleaning and testing system and apparatus |
CA2156420A1 (en) | 1993-02-24 | 1994-09-01 | Theresa M. Williams | Inhibitors of hiv reverse transcriptase |
US5489685A (en) | 1994-05-12 | 1996-02-06 | Merck & Co., Ltd. | Method of synthesizing furo[2,3-b]pyridine carboxylic acid esters |
ES2172585T3 (es) | 1994-05-31 | 2002-10-01 | Mitsui Chemicals Inc | Derivado de benzoimidazol. |
US5734081A (en) | 1994-08-05 | 1998-03-31 | Warner-Lambert Company | Arylthio compounds |
JPH10512251A (ja) | 1995-01-10 | 1998-11-24 | スミスクライン・ビーチャム・ソシエタ・ペル・アチオニ | 骨粗鬆症の治療に有用なインドール誘導体 |
GB9614347D0 (en) | 1996-07-09 | 1996-09-04 | Smithkline Beecham Spa | Novel compounds |
US5830894A (en) | 1997-02-21 | 1998-11-03 | Viropharma Incorporated | Methods for preventing and treating pestivirus infection and associated diseases |
US5935982A (en) | 1997-02-28 | 1999-08-10 | The University Of North Carolina At Chapel Hill | Methods of treating retroviral infection and compounds useful therefor |
US20020091148A1 (en) * | 2000-09-15 | 2002-07-11 | Bamaung Nwe Y. | 3-substituted indole antiproliferative angiogenesis inhibitors |
WO2002083126A1 (en) * | 2001-04-11 | 2002-10-24 | Idenix (Cayman) Limited | Phenylindoles for the treatment of hiv |
WO2004014364A1 (en) * | 2002-08-07 | 2004-02-19 | Idenix (Cayman) Limited | Substituted phenylindoles for the treatment of hiv |
US7481048B2 (en) * | 2005-06-30 | 2009-01-27 | Caterpillar Inc. | Regeneration assembly |
US7406822B2 (en) * | 2005-06-30 | 2008-08-05 | Caterpillar Inc. | Particulate trap regeneration system and control strategy |
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2002
- 2002-04-11 WO PCT/US2002/011736 patent/WO2002083126A1/en not_active Application Discontinuation
- 2002-04-11 BR BR0208790-1A patent/BR0208790A/pt not_active IP Right Cessation
- 2002-04-11 AU AU2002254616A patent/AU2002254616B2/en not_active Ceased
- 2002-04-11 DE DE60234760T patent/DE60234760D1/de not_active Expired - Fee Related
- 2002-04-11 EP EP02723853A patent/EP1390029B1/en not_active Expired - Lifetime
- 2002-04-11 US US10/122,252 patent/US6710068B2/en not_active Expired - Lifetime
- 2002-04-11 AT AT02723853T patent/ATE451921T1/de not_active IP Right Cessation
- 2002-04-11 CA CA002444501A patent/CA2444501C/en not_active Expired - Fee Related
- 2002-04-11 AR ARP020101341A patent/AR035857A1/es unknown
- 2002-04-16 TW TW093117031A patent/TWI294875B/zh active
-
2004
- 2004-03-22 US US10/806,295 patent/US20040180888A1/en not_active Abandoned
-
2007
- 2007-07-20 US US11/880,303 patent/US20070293668A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
AU2002254616B2 (en) | 2007-09-06 |
EP1390029B1 (en) | 2009-12-16 |
US20070293668A1 (en) | 2007-12-20 |
CA2444501A1 (en) | 2002-10-24 |
EP1390029A4 (en) | 2005-11-30 |
US20040180888A1 (en) | 2004-09-16 |
BR0208790A (pt) | 2004-03-30 |
TWI294875B (en) | 2008-03-21 |
EP1390029A1 (en) | 2004-02-25 |
WO2002083126A1 (en) | 2002-10-24 |
US6710068B2 (en) | 2004-03-23 |
DE60234760D1 (de) | 2010-01-28 |
ATE451921T1 (de) | 2010-01-15 |
US20020193415A1 (en) | 2002-12-19 |
TW200422291A (en) | 2004-11-01 |
CA2444501C (en) | 2009-11-17 |
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