IT1305313B1 - 3,4 - diidro- 6- benzil-4-oxopirimidine sostituite e relativo processodi produzione e impiego nella terapia delle infezioni da hiv-1. - Google Patents

3,4 - diidro- 6- benzil-4-oxopirimidine sostituite e relativo processodi produzione e impiego nella terapia delle infezioni da hiv-1.

Info

Publication number
IT1305313B1
IT1305313B1 IT1998CA000015A ITCA980015A IT1305313B1 IT 1305313 B1 IT1305313 B1 IT 1305313B1 IT 1998CA000015 A IT1998CA000015 A IT 1998CA000015A IT CA980015 A ITCA980015 A IT CA980015A IT 1305313 B1 IT1305313 B1 IT 1305313B1
Authority
IT
Italy
Prior art keywords
oxopyrimidine
hiv
dihydro
infections
benzyl
Prior art date
Application number
IT1998CA000015A
Other languages
English (en)
Inventor
Colla Paolo La
Marino Artico
Original Assignee
Colla Paolo
Marino Artico
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to IT1998CA000015A priority Critical patent/IT1305313B1/it
Application filed by Colla Paolo, Marino Artico filed Critical Colla Paolo
Priority to CN99808760A priority patent/CN1309647A/zh
Priority to BR9912142-5A priority patent/BR9912142A/pt
Priority to KR1020017000635A priority patent/KR100578478B1/ko
Priority to PCT/EP1999/005134 priority patent/WO2000003998A1/en
Priority to AU52848/99A priority patent/AU771209B2/en
Priority to US09/744,038 priority patent/US6635636B1/en
Priority to EP99938288A priority patent/EP1098887A1/en
Priority to CA002338014A priority patent/CA2338014A1/en
Publication of ITCA980015A1 publication Critical patent/ITCA980015A1/it
Application granted granted Critical
Publication of IT1305313B1 publication Critical patent/IT1305313B1/it
Priority to HK02100571.5A priority patent/HK1039122A1/zh
Priority to US10/689,982 priority patent/US20040092539A1/en
Priority to AU2004200446A priority patent/AU2004200446A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/56—One oxygen atom and one sulfur atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
IT1998CA000015A 1998-07-17 1998-07-17 3,4 - diidro- 6- benzil-4-oxopirimidine sostituite e relativo processodi produzione e impiego nella terapia delle infezioni da hiv-1. IT1305313B1 (it)

Priority Applications (12)

Application Number Priority Date Filing Date Title
IT1998CA000015A IT1305313B1 (it) 1998-07-17 1998-07-17 3,4 - diidro- 6- benzil-4-oxopirimidine sostituite e relativo processodi produzione e impiego nella terapia delle infezioni da hiv-1.
CA002338014A CA2338014A1 (en) 1998-07-17 1999-07-19 Substituted 6-benzyl-4-oxopyrimidines, process for their preparation and pharmaceutical compositions containing them
KR1020017000635A KR100578478B1 (ko) 1998-07-17 1999-07-19 치환된 6-벤질-4-옥소피리미딘, 그의 제조방법 및 그를함유하는 약제학적 조성물
PCT/EP1999/005134 WO2000003998A1 (en) 1998-07-17 1999-07-19 Substituted 6-benzyl-4-oxopyrimidines, process for their preparation and pharmaceutical compositions containing them
AU52848/99A AU771209B2 (en) 1998-07-17 1999-07-19 Substituted 6-benzyl-4-oxopyrimidines, process for their preparation and pharmaceutical compositions containing them
US09/744,038 US6635636B1 (en) 1998-07-17 1999-07-19 Substituted 6-benzyl-4-oxopyrimidines, process for their preparation and pharmaceutical compositions containing them
CN99808760A CN1309647A (zh) 1998-07-17 1999-07-19 取代的6－苄基－4－氧代嘧啶,其制备方法以及含该化合物的药物组合物
BR9912142-5A BR9912142A (pt) 1998-07-17 1999-07-19 6-benzil-4-oxipirimidinas substituìdas, processopara sua preparação e composições contendo-as
EP99938288A EP1098887A1 (en) 1998-07-17 1999-07-19 Substituted 6-benzyl-4-oxopyrimidines, process for their preparation and pharmaceutical compositions containing them
HK02100571.5A HK1039122A1 (zh) 1998-07-17 2002-01-24 取代的6-苄基-4-氧代嘧啶，其製備方法以及含該化合物的藥物組合物
US10/689,982 US20040092539A1 (en) 1998-07-17 2003-10-21 Substituted 6-benzyl-4-oxopyrimidines, process for their preparation and pharmaceutical compositions containing them
AU2004200446A AU2004200446A1 (en) 1998-07-17 2004-02-06 Substituted 6-Benzyl-4-Oxopyrimidines, process for their preparation and pharmaceutical compositions containing them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT1998CA000015A IT1305313B1 (it) 1998-07-17 1998-07-17 3,4 - diidro- 6- benzil-4-oxopirimidine sostituite e relativo processodi produzione e impiego nella terapia delle infezioni da hiv-1.

Publications (2)

Publication Number Publication Date
ITCA980015A1 ITCA980015A1 (it) 2000-01-17
IT1305313B1 true IT1305313B1 (it) 2001-05-04

Family

ID=11347180

Family Applications (1)

Application Number Title Priority Date Filing Date
IT1998CA000015A IT1305313B1 (it) 1998-07-17 1998-07-17 3,4 - diidro- 6- benzil-4-oxopirimidine sostituite e relativo processodi produzione e impiego nella terapia delle infezioni da hiv-1.

Country Status (10)

Country Link
US (2) US6635636B1 (it)
EP (1) EP1098887A1 (it)
KR (1) KR100578478B1 (it)
CN (1) CN1309647A (it)
AU (2) AU771209B2 (it)
BR (1) BR9912142A (it)
CA (1) CA2338014A1 (it)
HK (1) HK1039122A1 (it)
IT (1) IT1305313B1 (it)
WO (1) WO2000003998A1 (it)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1305313B1 (it) 1998-07-17 2001-05-04 Colla Paolo 3,4 - diidro- 6- benzil-4-oxopirimidine sostituite e relativo processodi produzione e impiego nella terapia delle infezioni da hiv-1.
US6136335A (en) * 1998-12-31 2000-10-24 Hughes Institute Phenethyl-5-bromopyridylthiourea (PBT) and dihydroalkoxybenzyloxopyrimidine (DABO) derivatives exhibiting spermicidal activity
AU6111000A (en) * 1999-07-22 2001-02-13 Vertex Pharmaceuticals Incorporated Inhibitors of viral helcase
WO2002040021A2 (en) * 2000-11-17 2002-05-23 Idenix (Cayman) Limited Methods for inhibiting the transmission of hiv using topically applied substituted 6-benzyl-4-oxopyrimidines
US7151092B2 (en) * 2002-10-31 2006-12-19 Metabasis Therapeutics, Inc. Cytarabine monophosphate prodrugs
US7642277B2 (en) 2002-12-04 2010-01-05 Boehringer Ingelheim International Gmbh Non-nucleoside reverse transcriptase inhibitors
EP1620407A2 (en) * 2003-04-28 2006-02-01 Idenix (Cayman) Limited Oxo-pyrimidine compounds
EP1773790B1 (en) 2004-07-27 2012-08-15 F.Hoffmann-La Roche Ag Benzyltriazolone compounds as non-nucleoside reverse transcriptase inhibitors
KR100803481B1 (ko) * 2004-07-27 2008-02-14 에프. 호프만-라 로슈 아게 비-뉴클레오사이드 역전사효소 억제제로서의벤질트라이아졸론 화합물
US8293778B2 (en) 2004-07-27 2012-10-23 Roche Palo Alto Llc Heterocyclic antiviral compounds
ITRM20050512A1 (it) * 2005-10-13 2007-04-14 Univ Siena Derivati 6-pirimidinici e pirimidinonici, e loro uso.
RU2469032C2 (ru) * 2006-12-13 2012-12-10 Ф.Хоффманн-Ля Рош Аг Производные 2-(пиперидин-4-ил)-4-фенокси- или фениламинопиримидина в качестве ненуклеозидных ингибиторов обратной транскриптазы
CN100519540C (zh) * 2007-01-09 2009-07-29 云南大学 S-dabo类化合物、其合成方法和用途
JO3470B1 (ar) 2012-10-08 2020-07-05 Merck Sharp & Dohme مشتقات 5- فينوكسي-3h-بيريميدين-4-أون واستخدامها كمثبطات ناسخ عكسي ل hiv
AU2015217221A1 (en) 2014-02-13 2016-08-11 Ligand Pharmaceuticals, Inc. Prodrug compounds and their uses
KR102440843B1 (ko) 2014-04-01 2022-09-29 머크 샤프 앤드 돔 엘엘씨 Hiv 역전사효소 억제제의 전구약물
EP3164136A4 (en) 2014-07-02 2018-04-04 Ligand Pharmaceuticals, Inc. Prodrug compounds and uses therof
AU2019207625A1 (en) 2018-01-09 2020-07-30 Ligand Pharmaceuticals, Inc. Acetal compounds and therapeutic uses thereof

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3956302A (en) * 1974-05-24 1976-05-11 The Upjohn Company Substituted pyrimidines
GB9012592D0 (en) * 1990-06-06 1990-07-25 Smithkline Beecham Intercredit Compounds
US5314917A (en) 1991-03-22 1994-05-24 E. B. Michaels Research Associates, Inc. Method for inactivating enveloped viruses and sperm
KR0151811B1 (ko) * 1993-12-21 1998-10-15 강박광 신규한 항바이러스성 2,4-피리미딘디온 유도체 및 그의 제조방법
KR100187475B1 (ko) * 1996-05-17 1999-05-01 이서봉 1-아릴-4-옥소 피롤로(3,2-c)퀴놀린 유도체의 제조방법
US5998411A (en) * 1998-03-17 1999-12-07 Hughes Institute Heterocyclic nonnucleoside inhibitors of reverse transcriptase
IT1305313B1 (it) 1998-07-17 2001-05-04 Colla Paolo 3,4 - diidro- 6- benzil-4-oxopirimidine sostituite e relativo processodi produzione e impiego nella terapia delle infezioni da hiv-1.
US6177437B1 (en) 1998-09-04 2001-01-23 University Of Massachusetts Medical Center Inhibitors of Herpes Simplex virus uracil-DNA glycosylase
US6136335A (en) 1998-12-31 2000-10-24 Hughes Institute Phenethyl-5-bromopyridylthiourea (PBT) and dihydroalkoxybenzyloxopyrimidine (DABO) derivatives exhibiting spermicidal activity
US6117904A (en) 1999-09-03 2000-09-12 Murphy; Donald M. Treatment of pruritus
WO2002040021A2 (en) * 2000-11-17 2002-05-23 Idenix (Cayman) Limited Methods for inhibiting the transmission of hiv using topically applied substituted 6-benzyl-4-oxopyrimidines
CA2444501C (en) * 2001-04-11 2009-11-17 Idenix (Cayman) Limited Phenylindoles for the treatment of hiv

Also Published As

Publication number Publication date
ITCA980015A1 (it) 2000-01-17
US20040092539A1 (en) 2004-05-13
HK1039122A1 (zh) 2002-04-12
CA2338014A1 (en) 2000-01-27
CN1309647A (zh) 2001-08-22
WO2000003998A1 (en) 2000-01-27
US6635636B1 (en) 2003-10-21
EP1098887A1 (en) 2001-05-16
KR20010099594A (ko) 2001-11-09
AU5284899A (en) 2000-02-07
AU771209B2 (en) 2004-03-18
KR100578478B1 (ko) 2006-05-11
BR9912142A (pt) 2001-10-30
AU2004200446A1 (en) 2004-03-11

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