CO6260062A2 - (carboxilalquilenfenil)feniloxamidas metodo para su produccion y uso de las mismas como medicamentos - Google Patents
(carboxilalquilenfenil)feniloxamidas metodo para su produccion y uso de las mismas como medicamentosInfo
- Publication number
- CO6260062A2 CO6260062A2 CO10030971A CO10030971A CO6260062A2 CO 6260062 A2 CO6260062 A2 CO 6260062A2 CO 10030971 A CO10030971 A CO 10030971A CO 10030971 A CO10030971 A CO 10030971A CO 6260062 A2 CO6260062 A2 CO 6260062A2
- Authority
- CO
- Colombia
- Prior art keywords
- alkyl
- phenyl
- substituted
- nr9r10
- independently
- Prior art date
Links
- 229940079593 drug Drugs 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 11
- -1 SCF3 Chemical group 0.000 abstract 8
- 125000000217 alkyl group Chemical group 0.000 abstract 7
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 7
- 229910006069 SO3H Inorganic materials 0.000 abstract 4
- 101100054666 Streptomyces halstedii sch3 gene Proteins 0.000 abstract 4
- 125000000896 monocarboxylic acid group Chemical group 0.000 abstract 4
- 125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 abstract 4
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 4
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 3
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 2
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 2
- 125000002947 alkylene group Chemical group 0.000 abstract 2
- 125000004786 difluoromethoxy group Chemical group [H]C(F)(F)O* 0.000 abstract 2
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/72—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms
- C07C235/80—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms having carbon atoms of carboxamide groups and keto groups bound to the same carbon atom, e.g. acetoacetamides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
Abstract
en la que los significados son R3, independientemente uno de otro, H, F, CI, Br, CN, CF3, OH, OCF3, OCHF2, SCH3, SCF3, fenilo, O-fenilo, COOH, COO-alquil (C1-C6), CO-alquil (C1-C6), alquilo (C1-C6), cicloalquilo (C3-C8), O-alquil (C1-C6), OBn, SO2-alquil (C1-C4), SO3H, SO2NR9R10, NR9R10 o SO2-N-piperidinilo, en los que alquilo y fenilo pueden estar sustituidos una o más veces por R12; R1, R5, independientemente uno de otro, H, F, CI, Br, CN, CF3, SCH3, SCF3, fenilo, O-fenilo, COOH, COO-alquil (C1-C6), CO-alquil (C1-C6), alquilo (C1-C6), SO2-alquil (C1-C4), SO3H, SO2R9R10, NR9R10 o SO2-N-piperidinilo, en los que alquilo y fenilo pueden estar sustituidos una o más veces por R12; R2 y R4, independientemente uno de otro, H, F, CI, Br, CN, CF3, OCF3, OCHF2, SCH3, SCF3, fenilo, O-fenilo, COOH, COO-alquil (C1-C6), CO-alquil (C1-C6), alquilo (C1-C6), O-alquil (C1-C6), OBn, SO2-alquil (C1-C4), SO3H, SO2NR9R10, NR9R10 o SO2-N-piperidinilo, en los que alquilo y fenilo pueden estar sustituidos una o más veces por R12; R7, R8, independientemente uno de otro, H o alquilo (C1-C6); X alquileno (C2-C3), en el que el alquileno puede estar sustituido una o más veces por R11; m 0, 1, 2, 3 o 4; R6 OH, F, CI, Br, CN, OCH3, OCF3, CH3, CF3, alquilo (C1-C6) o O-alquilo (C1-C6), en los que el alquilo puede estar sustituido una o más veces con OH, F, CI, Br o CN; R9, R10, independientemente uno de otro H, alquilo (C1-C6) o fenilo, en el que el alquilo puede estar sustituido una o más veces por R6;R11 F, CI o Br, CN, OH, O-alquil (C1-C6), alquilo (C1-C6), alquenilo (C2-C6), alquinilo (C2-C6) o NR9R10; R12 F, CI, Br, CN, OH, O-alquil (C1-C6), alquilo (C1-C6), alquenilo (C2-C6), alquinilo (C2-C6), NR9R10, COOH, COO-alquil (C1-C4), SCH3, SCF3, SO2-alquil (C1-C4), SO3H o SO2NR9R10; y sus sales fisiológicamente toleradas.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07291132 | 2007-09-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO6260062A2 true CO6260062A2 (es) | 2011-03-22 |
Family
ID=39111451
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO10030971A CO6260062A2 (es) | 2007-09-21 | 2010-03-16 | (carboxilalquilenfenil)feniloxamidas metodo para su produccion y uso de las mismas como medicamentos |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US8518875B2 (es) |
| EP (1) | EP2203416B1 (es) |
| JP (1) | JP5427784B2 (es) |
| KR (1) | KR20100061692A (es) |
| CN (1) | CN101796017A (es) |
| AR (1) | AR068479A1 (es) |
| AU (1) | AU2008303976B9 (es) |
| CA (1) | CA2700028A1 (es) |
| CL (1) | CL2008002742A1 (es) |
| CO (1) | CO6260062A2 (es) |
| IL (1) | IL204555A0 (es) |
| MA (1) | MA31710B1 (es) |
| MX (1) | MX2010002461A (es) |
| MY (1) | MY149648A (es) |
| NZ (1) | NZ584049A (es) |
| RU (1) | RU2488578C2 (es) |
| TW (1) | TWI439265B (es) |
| UY (1) | UY31350A1 (es) |
| WO (1) | WO2009039943A1 (es) |
| ZA (1) | ZA201001015B (es) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20130004262A (ko) | 2009-12-25 | 2013-01-09 | 모찌다 세이야쿠 가부시끼가이샤 | 신규 3-히드록시-5-아릴이소티아졸 유도체 |
| WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
| TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
| TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
| TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
| CN103298469A (zh) | 2010-08-31 | 2013-09-11 | 首尔大学校产学协力财团 | PPARδ激动剂的胎儿重编程的用途 |
| AU2011313191A1 (en) | 2010-10-08 | 2013-05-02 | Mochida Pharmaceutical Co., Ltd. | Cyclic amide derivative |
| CN103517898B (zh) | 2011-04-27 | 2015-09-30 | 持田制药株式会社 | 新的3-羟基异噻唑 1-氧化物衍生物 |
| WO2012147516A1 (ja) | 2011-04-28 | 2012-11-01 | 持田製薬株式会社 | 環状アミド誘導体 |
| WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| EP2760862B1 (en) | 2011-09-27 | 2015-10-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| EP2800736A1 (en) * | 2012-01-04 | 2014-11-12 | Sanofi | 3-[4-(phenylaminooxalylamino)phenyl]hex-4-ynoic acids, process for preparation thereof and use thereof as a medicament |
| CN105142621A (zh) | 2012-10-24 | 2015-12-09 | 国家健康科学研究所 | 用于预防或治疗糖尿病和促进β-细胞存活的TPL2激酶抑制剂 |
| JPWO2015046317A1 (ja) * | 2013-09-30 | 2017-03-09 | 国立大学法人 岡山大学 | 新規アセチレンアミド誘導体 |
| US9957219B2 (en) | 2013-12-04 | 2018-05-01 | Merck Sharp & Dohme Corp. | Antidiabetic bicyclic compounds |
| EP3102198B1 (en) | 2014-02-06 | 2020-08-26 | Merck Sharp & Dohme Corp. | Antidiabetic compounds |
| EP3273981B1 (en) | 2015-03-24 | 2020-04-29 | INSERM - Institut National de la Santé et de la Recherche Médicale | Method and pharmaceutical composition for use in the treatment of diabetes |
| WO2019160882A1 (en) | 2018-02-13 | 2019-08-22 | Gilead Sciences, Inc. | Pd-1/pd-l1 inhibitors |
| TWI712412B (zh) | 2018-04-19 | 2020-12-11 | 美商基利科學股份有限公司 | Pd‐1/pd‐l1抑制劑 |
| KR20230159715A (ko) | 2018-07-13 | 2023-11-21 | 길리애드 사이언시즈, 인코포레이티드 | Pd-1/pd-l1 억제제 |
| CN112955435A (zh) | 2018-10-24 | 2021-06-11 | 吉利德科学公司 | Pd-1/pd-l1抑制剂 |
| CA3156985A1 (en) | 2019-10-07 | 2021-04-15 | Kallyope, Inc. | Gpr119 agonists |
| WO2021110076A1 (zh) * | 2019-12-04 | 2021-06-10 | 深圳信立泰药业股份有限公司 | 草酰胺类衍生物、其制备方法及其在医药上的应用 |
| CA3178994A1 (en) | 2020-05-19 | 2021-11-25 | Iyassu Sebhat | Ampk activators |
| CN116390925A (zh) | 2020-06-26 | 2023-07-04 | 卡尔优普公司 | Ampk活化剂 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1618197B1 (de) * | 1966-02-07 | 1971-12-09 | Ciba Geigy | Verwendung von asymmetrischen Oxalsäure-diarylamiden als Ultraviolettschutzmittel für organische Materialien |
| FR2727114B1 (fr) * | 1994-11-17 | 1996-12-27 | Oreal | Nouveaux filtres solaires, compositions cosmetiques photoprotectrices les contenant et utilisations |
| DE04029691T1 (de) * | 1998-02-02 | 2007-11-08 | Trustees Of Tufts College, Medford | Verwendung von Dipetidylpeptidasehemmer zur Regulierung des Glukosemetabolismus |
| US6890568B2 (en) * | 1999-05-24 | 2005-05-10 | Grant Pierce | Method for management of blood glucose levels |
| US6867299B2 (en) * | 2000-02-24 | 2005-03-15 | Hoffmann-La Roche Inc. | Oxamide IMPDH inhibitors |
| HU227197B1 (en) | 2000-10-24 | 2010-10-28 | Richter Gedeon Nyrt | Nmda receptor antagonist carboxylic acid amide derivatives and pharmaceutical compositions containing them |
| JP2004531571A (ja) * | 2001-05-25 | 2004-10-14 | ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド | サイトカイン生産のインヒビターとしてのカルバメート及びオキサミド化合物 |
| ITRM20020016A1 (it) * | 2002-01-15 | 2003-07-15 | Sigma Tau Ind Farmaceuti | Derivati di acidi fenil(alchil)carbossilici e derivati fenilalchileterociclici dionici, loro uso come medicamenti ad attivita' ipoglicemizza |
| JP4224979B2 (ja) * | 2002-04-09 | 2009-02-18 | 大正製薬株式会社 | インターロイキン１２抑制剤 |
| CA2744893A1 (en) * | 2002-06-27 | 2004-01-08 | Novo Nordisk A/S | Aryl carbonyl derivatives as glucokinase activators |
| US20050124667A1 (en) * | 2003-10-30 | 2005-06-09 | Eric Sartori | Oxamide inhibitors of plasminogen activator inhibitor-1 |
-
2008
- 2008-09-04 KR KR1020107006034A patent/KR20100061692A/ko not_active Application Discontinuation
- 2008-09-04 MY MYPI2010000692A patent/MY149648A/en unknown
- 2008-09-04 MX MX2010002461A patent/MX2010002461A/es active IP Right Grant
- 2008-09-04 WO PCT/EP2008/007218 patent/WO2009039943A1/de active Application Filing
- 2008-09-04 RU RU2010115748/04A patent/RU2488578C2/ru not_active IP Right Cessation
- 2008-09-04 CN CN200880105281A patent/CN101796017A/zh active Pending
- 2008-09-04 JP JP2010525227A patent/JP5427784B2/ja not_active Expired - Fee Related
- 2008-09-04 NZ NZ584049A patent/NZ584049A/en not_active IP Right Cessation
- 2008-09-04 AU AU2008303976A patent/AU2008303976B9/en not_active Ceased
- 2008-09-04 CA CA2700028A patent/CA2700028A1/en not_active Abandoned
- 2008-09-04 EP EP08785815.5A patent/EP2203416B1/de active Active
- 2008-09-15 CL CL2008002742A patent/CL2008002742A1/es unknown
- 2008-09-18 AR ARP080104056A patent/AR068479A1/es not_active Application Discontinuation
- 2008-09-18 TW TW097135728A patent/TWI439265B/zh not_active IP Right Cessation
- 2008-09-19 UY UY31350A patent/UY31350A1/es not_active Application Discontinuation
-
2010
- 2010-02-11 ZA ZA201001015A patent/ZA201001015B/xx unknown
- 2010-03-16 CO CO10030971A patent/CO6260062A2/es active IP Right Grant
- 2010-03-16 US US12/724,519 patent/US8518875B2/en active Active
- 2010-03-16 IL IL204555A patent/IL204555A0/en not_active IP Right Cessation
- 2010-03-19 MA MA32711A patent/MA31710B1/fr unknown
-
2013
- 2013-04-17 US US13/864,622 patent/US20130231388A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP2203416B1 (de) | 2016-10-26 |
| AR068479A1 (es) | 2009-11-18 |
| RU2488578C2 (ru) | 2013-07-27 |
| JP5427784B2 (ja) | 2014-02-26 |
| MX2010002461A (es) | 2010-03-26 |
| AU2008303976B2 (en) | 2013-04-18 |
| WO2009039943A1 (de) | 2009-04-02 |
| IL204555A0 (en) | 2010-11-30 |
| CA2700028A1 (en) | 2009-04-02 |
| MA31710B1 (fr) | 2010-09-01 |
| EP2203416A1 (de) | 2010-07-07 |
| US8518875B2 (en) | 2013-08-27 |
| US20130231388A1 (en) | 2013-09-05 |
| CN101796017A (zh) | 2010-08-04 |
| JP2010539199A (ja) | 2010-12-16 |
| TWI439265B (zh) | 2014-06-01 |
| CL2008002742A1 (es) | 2009-01-16 |
| MY149648A (en) | 2013-09-30 |
| US20100261645A1 (en) | 2010-10-14 |
| RU2010115748A (ru) | 2011-10-27 |
| TW200927088A (en) | 2009-07-01 |
| KR20100061692A (ko) | 2010-06-08 |
| UY31350A1 (es) | 2009-04-30 |
| AU2008303976B9 (en) | 2013-09-12 |
| ZA201001015B (en) | 2010-10-27 |
| NZ584049A (en) | 2011-05-27 |
| AU2008303976A1 (en) | 2009-04-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Application refused | ||
| FG | Application granted |