DOP2011000053A - Agentes antifungicos - Google Patents

Agentes antifungicos

Info

Publication number
DOP2011000053A
DOP2011000053A DO2011000053A DO2011000053A DOP2011000053A DO P2011000053 A DOP2011000053 A DO P2011000053A DO 2011000053 A DO2011000053 A DO 2011000053A DO 2011000053 A DO2011000053 A DO 2011000053A DO P2011000053 A DOP2011000053 A DO P2011000053A
Authority
DO
Dominican Republic
Prior art keywords
compounds
prodrugs
hydrates
compositions
pharmaceutically acceptable
Prior art date
Application number
DO2011000053A
Other languages
English (en)
Inventor
Dongfang Meng
Mark L Greenlee
Robert R Wilkening
James Apgar
Kenneth James Wildonger
Dan L Parker Jr
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41669132&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DOP2011000053(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of DOP2011000053A publication Critical patent/DOP2011000053A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
    • A01N43/647—Triazoles; Hydrogenated triazoles
    • A01N43/653—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring

Abstract

Se describen novedosos derivados de enfumafungina, junto con sus sales, hidratos y prodrogas farmacéuticamente aceptables. También se describen composiciones que comprenden dichos compuestos, métodos para preparar dichos compuestos y métodos para usar dichos compuestos como agentes antifúngicos y/o inhibidores de (1,3)--D-g1ucan sintasa. Los compuestos descriptos, sus sales, hidratos y prodrogas farmacéuticamente aceptables, así como las composiciones que comprenden dichas sales, hidratos y prodrogas, son útiles para tratar yio prevenir infecciones fúngicas y enfermedades y afecciones asociadas.
DO2011000053A 2008-08-12 2011-02-11 Agentes antifungicos DOP2011000053A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US13610608P 2008-08-12 2008-08-12

Publications (1)

Publication Number Publication Date
DOP2011000053A true DOP2011000053A (es) 2011-04-30

Family

ID=41669132

Family Applications (1)

Application Number Title Priority Date Filing Date
DO2011000053A DOP2011000053A (es) 2008-08-12 2011-02-11 Agentes antifungicos

Country Status (31)

Country Link
EP (1) EP2326172B1 (es)
KR (1) KR101686075B1 (es)
AR (1) AR073037A1 (es)
BR (1) BRPI0912074B1 (es)
CL (1) CL2011000292A1 (es)
CO (1) CO6351686A2 (es)
CR (1) CR20110075A (es)
DK (1) DK2326172T3 (es)
DO (1) DOP2011000053A (es)
EA (1) EA018337B1 (es)
ES (1) ES2526652T3 (es)
GT (1) GT201100039A (es)
HK (1) HK1158017A1 (es)
HN (1) HN2011000404A (es)
HR (1) HRP20150009T1 (es)
IL (2) IL210975A (es)
MA (1) MA32628B1 (es)
MX (1) MX2011001656A (es)
MY (1) MY156955A (es)
NI (1) NI201100035A (es)
NZ (1) NZ590914A (es)
PE (1) PE20110676A1 (es)
PL (1) PL2326172T3 (es)
PT (1) PT2326172E (es)
RS (1) RS53731B1 (es)
SI (1) SI2326172T1 (es)
SV (1) SV2011003839A (es)
TW (1) TWI439458B (es)
UA (1) UA105639C2 (es)
WO (1) WO2010019203A1 (es)
ZA (1) ZA201100788B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2913111T3 (es) * 2015-01-19 2022-05-31 Scynexis Inc Novedosas sales y polimorfos de SCY-078
CN110769854B (zh) * 2017-04-10 2023-01-13 西尼克斯公司 组合使用的抗真菌剂
EA202090445A1 (ru) 2017-08-04 2020-06-23 Сайнексис, Инк. ПРОТИВОГРИБКОВЫЕ СРЕДСТВА С ПОВЫШЕННОЙ АКТИВНОСТЬЮ ПРИ КИСЛОМ pH
CN113498343A (zh) * 2019-01-30 2021-10-12 西尼克斯公司 用于治疗真菌性骨关节感染的三萜抗真菌剂
US20220211684A1 (en) * 2019-05-16 2022-07-07 Scynexis, Inc. Antifungal agents for candida auris decolonization
WO2021239992A1 (en) 2020-05-29 2021-12-02 Centre National De La Recherche Scientifique Antifungal prodrugs

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5756472A (en) 1996-01-31 1998-05-26 Merck & Co., Inc. Antifungal agent obtained from hormonema
EP0877618B1 (en) * 1996-01-31 2003-01-02 Merck & Co., Inc. Antifungal agent
EP1497281A4 (en) * 2002-04-17 2005-11-02 Ranbaxy Lab Ltd AZOLE DERIVATIVES AS ANTIFUNGAL AGENTS
WO2007126900A2 (en) * 2006-04-03 2007-11-08 Merck & Co., Inc. Antifungal agents

Also Published As

Publication number Publication date
EP2326172B1 (en) 2014-10-22
SV2011003839A (es) 2011-07-06
EA201100350A1 (ru) 2011-08-30
HK1158017A1 (en) 2012-07-13
EA018337B1 (ru) 2013-07-30
DK2326172T3 (da) 2015-01-26
CL2011000292A1 (es) 2011-11-04
NZ590914A (en) 2011-11-25
ZA201100788B (en) 2012-05-01
BRPI0912074A2 (pt) 2018-10-02
CR20110075A (es) 2011-06-03
HN2011000404A (es) 2013-09-23
KR20110045054A (ko) 2011-05-03
BRPI0912074B1 (pt) 2021-08-03
TW201011004A (en) 2010-03-16
CO6351686A2 (es) 2011-12-20
PT2326172E (pt) 2015-02-04
SI2326172T1 (sl) 2015-02-27
WO2010019203A1 (en) 2010-02-18
GT201100039A (es) 2013-08-21
MY156955A (en) 2016-04-15
EP2326172A1 (en) 2011-06-01
IL242031A0 (en) 2015-11-30
WO2010019203A8 (en) 2011-03-17
PE20110676A1 (es) 2011-09-23
MX2011001656A (es) 2011-05-25
IL210975A (en) 2015-10-29
ES2526652T3 (es) 2015-01-14
TWI439458B (zh) 2014-06-01
HRP20150009T1 (hr) 2015-02-27
KR101686075B1 (ko) 2016-12-13
EP2326172A4 (en) 2012-06-06
UA105639C2 (uk) 2014-06-10
NI201100035A (es) 2011-09-20
MA32628B1 (fr) 2011-09-01
RS53731B1 (en) 2015-06-30
PL2326172T3 (pl) 2015-03-31
IL210975A0 (en) 2011-04-28
AR073037A1 (es) 2010-10-06

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