EA201100350A1 - Противогрибковые средства - Google Patents

Противогрибковые средства

Info

Publication number
EA201100350A1
EA201100350A1 EA201100350A EA201100350A EA201100350A1 EA 201100350 A1 EA201100350 A1 EA 201100350A1 EA 201100350 A EA201100350 A EA 201100350A EA 201100350 A EA201100350 A EA 201100350A EA 201100350 A1 EA201100350 A1 EA 201100350A1
Authority
EA
Eurasian Patent Office
Prior art keywords
compounds
prodrugs
hydrates
disclosed
antigrebic
Prior art date
Application number
EA201100350A
Other languages
English (en)
Other versions
EA018337B1 (ru
Inventor
Марк Л. Гринли
Роберт Вилкенинг
Джеймс Апгар
Кеннет Джеймс Вилдонгер
Донфан Мен
Данн Л. мл. Паркер
Original Assignee
Мерк Шарп Энд Дом Корп.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41669132&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201100350(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Мерк Шарп Энд Дом Корп. filed Critical Мерк Шарп Энд Дом Корп.
Publication of EA201100350A1 publication Critical patent/EA201100350A1/ru
Publication of EA018337B1 publication Critical patent/EA018337B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
    • A01N43/647—Triazoles; Hydrogenated triazoles
    • A01N43/653—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Agronomy & Crop Science (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Environmental Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Cosmetics (AREA)

Abstract

Раскрыты новые производные энфумафунгина, наряду с их фармацевтически приемлемыми солями, гидратами и пролекарствами. Также раскрываются композиции, содержащие такие соединения, способы получения таких соединений и способы применения таких соединений в качестве противогрибковых средств и/или ингибиторов (1,3)-β-D-глюкансинтазы. Раскрытые соединения, их фармацевтически приемлемые соли, гидраты и пролекарства, а также композиции, содержащие указанные соединения, соли, гидраты и пролекарства, могут применяться для лечения и/или профилактики грибковых инфекций и связанных с ними заболеваний и состояний.
EA201100350A 2008-08-12 2009-08-07 Противогрибковые средства EA018337B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13610608P 2008-08-12 2008-08-12
PCT/US2009/004557 WO2010019203A1 (en) 2008-08-12 2009-08-07 Antifungal agents

Publications (2)

Publication Number Publication Date
EA201100350A1 true EA201100350A1 (ru) 2011-08-30
EA018337B1 EA018337B1 (ru) 2013-07-30

Family

ID=41669132

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201100350A EA018337B1 (ru) 2008-08-12 2009-08-07 Противогрибковые средства

Country Status (31)

Country Link
EP (1) EP2326172B1 (ru)
KR (1) KR101686075B1 (ru)
AR (1) AR073037A1 (ru)
BR (1) BRPI0912074B1 (ru)
CL (1) CL2011000292A1 (ru)
CO (1) CO6351686A2 (ru)
CR (1) CR20110075A (ru)
DK (1) DK2326172T3 (ru)
DO (1) DOP2011000053A (ru)
EA (1) EA018337B1 (ru)
ES (1) ES2526652T3 (ru)
GT (1) GT201100039A (ru)
HK (1) HK1158017A1 (ru)
HN (1) HN2011000404A (ru)
HR (1) HRP20150009T1 (ru)
IL (2) IL210975A (ru)
MA (1) MA32628B1 (ru)
MX (1) MX2011001656A (ru)
MY (1) MY156955A (ru)
NI (1) NI201100035A (ru)
NZ (1) NZ590914A (ru)
PE (1) PE20110676A1 (ru)
PL (1) PL2326172T3 (ru)
PT (1) PT2326172E (ru)
RS (1) RS53731B1 (ru)
SI (1) SI2326172T1 (ru)
SV (1) SV2011003839A (ru)
TW (1) TWI439458B (ru)
UA (1) UA105639C2 (ru)
WO (1) WO2010019203A1 (ru)
ZA (1) ZA201100788B (ru)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RS63234B1 (sr) 2015-01-19 2022-06-30 Scynexis Inc Nove soli i polimorfi scy-078
CN110769854B (zh) * 2017-04-10 2023-01-13 西尼克斯公司 组合使用的抗真菌剂
EP3661503B1 (en) * 2017-08-04 2022-09-07 Scynexis, Inc. Antifungal agents with enhanced activity in acidic ph
EP3917534A1 (en) * 2019-01-30 2021-12-08 Scynexis, Inc. Triterpenoid antifungals for the treatment of fungal osteo-articular infections
EA202193146A1 (ru) * 2019-05-16 2022-02-11 Сайнексис, Инк. Противогрибковые агенты для деколонизации candida auris
US20230218652A1 (en) 2020-05-29 2023-07-13 Centre National De La Recherche Scientifique Antifungal prodrugs

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5756472A (en) 1996-01-31 1998-05-26 Merck & Co., Inc. Antifungal agent obtained from hormonema
WO1997027860A1 (en) * 1996-01-31 1997-08-07 Merck & Co., Inc. Antifungal agent
US20050131041A1 (en) * 2002-04-17 2005-06-16 Mohammad Salman Azole derivatives as antifungal agents
CN101454010B (zh) * 2006-04-03 2012-06-20 默克夏普和道赫莫公司 抗真菌剂

Also Published As

Publication number Publication date
MX2011001656A (es) 2011-05-25
KR20110045054A (ko) 2011-05-03
PL2326172T3 (pl) 2015-03-31
ES2526652T3 (es) 2015-01-14
GT201100039A (es) 2013-08-21
IL210975A (en) 2015-10-29
RS53731B1 (en) 2015-06-30
SI2326172T1 (sl) 2015-02-27
SV2011003839A (es) 2011-07-06
DK2326172T3 (da) 2015-01-26
CR20110075A (es) 2011-06-03
WO2010019203A1 (en) 2010-02-18
AR073037A1 (es) 2010-10-06
UA105639C2 (ru) 2014-06-10
MY156955A (en) 2016-04-15
HRP20150009T1 (hr) 2015-02-27
EA018337B1 (ru) 2013-07-30
DOP2011000053A (es) 2011-04-30
KR101686075B1 (ko) 2016-12-13
HN2011000404A (es) 2013-09-23
WO2010019203A8 (en) 2011-03-17
BRPI0912074B1 (pt) 2021-08-03
ZA201100788B (en) 2012-05-01
TWI439458B (zh) 2014-06-01
NZ590914A (en) 2011-11-25
HK1158017A1 (en) 2012-07-13
IL210975A0 (en) 2011-04-28
TW201011004A (en) 2010-03-16
EP2326172A4 (en) 2012-06-06
CO6351686A2 (es) 2011-12-20
IL242031A0 (en) 2015-11-30
EP2326172B1 (en) 2014-10-22
BRPI0912074A2 (pt) 2018-10-02
NI201100035A (es) 2011-09-20
PT2326172E (pt) 2015-02-04
PE20110676A1 (es) 2011-09-23
EP2326172A1 (en) 2011-06-01
MA32628B1 (fr) 2011-09-01
CL2011000292A1 (es) 2011-11-04

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Legal Events

Date Code Title Description
PC4A Registration of transfer of a eurasian patent by assignment
QB4A Registration of a licence in a contracting state
QB4A Registration of a licence in a contracting state
QB4A Registration of a licence in a contracting state
QB4A Registration of a licence in a contracting state
QB4A Registration of a licence in a contracting state
QB4A Registration of a licence in a contracting state
TK4A Corrections in published eurasian patents