EA200900631A1 - Замещённые пиразолы и триазолы, как ингибиторы кбв (кинезин-белок веретена) - Google Patents

Замещённые пиразолы и триазолы, как ингибиторы кбв (кинезин-белок веретена)

Info

Publication number
EA200900631A1
EA200900631A1 EA200900631A EA200900631A EA200900631A1 EA 200900631 A1 EA200900631 A1 EA 200900631A1 EA 200900631 A EA200900631 A EA 200900631A EA 200900631 A EA200900631 A EA 200900631A EA 200900631 A1 EA200900631 A1 EA 200900631A1
Authority
EA
Eurasian Patent Office
Prior art keywords
triazoles
vereten
kynesin
kibb
inhibitors
Prior art date
Application number
EA200900631A
Other languages
English (en)
Other versions
EA017748B1 (ru
Inventor
И Ся
Крис Г. Менденхолл
Пол А. Барсанти
Аннетте О. Вальтер
Дейвид Дал
Пол А. Ренхоу
Original Assignee
Новартис Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Новартис Аг filed Critical Новартис Аг
Publication of EA200900631A1 publication Critical patent/EA200900631A1/ru
Publication of EA017748B1 publication Critical patent/EA017748B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

В заявке описаны новые соединения представляющие собой замещенные пиразолы и триазолы формулы (I) и их фармацевтически приемлемые соли, сложные эфиры или пролекарства, композиции, содержащие эти производные совместно с фармацевтически приемлемыми носителями, и их использование.
EA200900631A 2006-11-13 2007-11-08 Замещённые триазолы в качестве ингибиторов кбв EA017748B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US85896406P 2006-11-13 2006-11-13
PCT/US2007/084154 WO2008063912A1 (en) 2006-11-13 2007-11-08 Substituted pyrazole and triazole compounds as ksp inhibitors

Publications (2)

Publication Number Publication Date
EA200900631A1 true EA200900631A1 (ru) 2009-12-30
EA017748B1 EA017748B1 (ru) 2013-02-28

Family

ID=39144618

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200900631A EA017748B1 (ru) 2006-11-13 2007-11-08 Замещённые триазолы в качестве ингибиторов кбв

Country Status (32)

Country Link
US (2) US8129358B2 (ru)
EP (1) EP2091926B1 (ru)
JP (1) JP5264755B2 (ru)
KR (1) KR20090081020A (ru)
CN (1) CN101558049B (ru)
AR (1) AR063805A1 (ru)
AU (1) AU2007323998B2 (ru)
BR (1) BRPI0719002A2 (ru)
CA (1) CA2668661A1 (ru)
CL (1) CL2007003272A1 (ru)
CO (1) CO6382171A2 (ru)
CR (1) CR10787A (ru)
DO (1) DOP2009000106A (ru)
EA (1) EA017748B1 (ru)
EC (1) ECSP099326A (ru)
ES (1) ES2557478T3 (ru)
GE (1) GEP20125389B (ru)
GT (1) GT200900122A (ru)
HN (1) HN2009000968A (ru)
IL (1) IL198471A0 (ru)
MA (1) MA30959B1 (ru)
MX (1) MX2009005071A (ru)
NI (1) NI200900084A (ru)
NO (1) NO20092226L (ru)
NZ (1) NZ576640A (ru)
PE (1) PE20081169A1 (ru)
SM (1) SMP200900045B (ru)
TN (1) TN2009000178A1 (ru)
TW (1) TW200831480A (ru)
UA (1) UA97256C2 (ru)
WO (1) WO2008063912A1 (ru)
ZA (1) ZA200902940B (ru)

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US8129358B2 (en) * 2006-11-13 2012-03-06 Novartis Ag Substituted pyrazole and triazole compounds as KSP inhibitors
CN101622247A (zh) * 2007-01-05 2010-01-06 诺瓦提斯公司 作为驱动蛋白纺锤体蛋白抑制剂的咪唑衍生物
EP2558452A2 (en) * 2010-04-15 2013-02-20 Novartis AG Oxazole and thiazole compounds as ksp inhibitors
WO2011128381A1 (en) * 2010-04-15 2011-10-20 Novartis Ag Triazole compounds as ksp inhibitors
CN104994855B (zh) * 2012-12-05 2018-06-05 默沙东公司 制备逆转录酶抑制剂的方法
EP2968591A1 (en) * 2013-03-15 2016-01-20 Novartis AG Cell proliferation inhibitors and conjugates thereof
US9498540B2 (en) 2013-03-15 2016-11-22 Novartis Ag Cell proliferation inhibitors and conjugates thereof
ES2759976T3 (es) 2013-12-04 2020-05-12 Merck Sharp & Dohme Proceso para fabricar inhibidores de la transcriptasa inversa
WO2016020791A1 (en) 2014-08-05 2016-02-11 Novartis Ag Ckit antibody drug conjugates
WO2017097927A1 (en) * 2015-12-11 2017-06-15 Syngenta Participations Ag Pesticidally active 1,2,4-triazole derivatives
US11091447B2 (en) 2020-01-03 2021-08-17 Berg Llc UBE2K modulators and methods for their use

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Also Published As

Publication number Publication date
MA30959B1 (fr) 2009-12-01
MX2009005071A (es) 2009-05-25
JP2010509365A (ja) 2010-03-25
SMAP200900045A (it) 2009-07-14
EA017748B1 (ru) 2013-02-28
NI200900084A (es) 2010-01-29
DOP2009000106A (es) 2009-05-31
PE20081169A1 (es) 2008-09-24
KR20090081020A (ko) 2009-07-27
ECSP099326A (es) 2009-06-30
HN2009000968A (es) 2011-10-25
US7902240B2 (en) 2011-03-08
BRPI0719002A2 (pt) 2013-12-17
US8129358B2 (en) 2012-03-06
AU2007323998B2 (en) 2011-09-22
ZA200902940B (en) 2010-05-26
CN101558049B (zh) 2012-08-15
TW200831480A (en) 2008-08-01
NZ576640A (en) 2011-10-28
NO20092226L (no) 2009-08-12
CR10787A (es) 2009-07-02
GT200900122A (es) 2011-09-14
UA97256C2 (ru) 2012-01-25
AU2007323998A1 (en) 2008-05-29
CA2668661A1 (en) 2008-05-29
WO2008063912A1 (en) 2008-05-29
CL2007003272A1 (es) 2008-03-24
US20100034813A1 (en) 2010-02-11
AR063805A1 (es) 2009-02-18
IL198471A0 (en) 2010-02-17
GEP20125389B (en) 2012-01-25
US20080200462A1 (en) 2008-08-21
EP2091926A1 (en) 2009-08-26
TN2009000178A1 (en) 2010-10-18
JP5264755B2 (ja) 2013-08-14
CN101558049A (zh) 2009-10-14
EP2091926B1 (en) 2015-10-21
SMP200900045B (it) 2010-03-01
CO6382171A2 (es) 2012-02-15
ES2557478T3 (es) 2016-01-26

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU