MA30959B1 - Composes de pyrazole et de triazole substitues comme inhibiteurs de ksp - Google Patents

Composes de pyrazole et de triazole substitues comme inhibiteurs de ksp

Info

Publication number
MA30959B1
MA30959B1 MA31938A MA31938A MA30959B1 MA 30959 B1 MA30959 B1 MA 30959B1 MA 31938 A MA31938 A MA 31938A MA 31938 A MA31938 A MA 31938A MA 30959 B1 MA30959 B1 MA 30959B1
Authority
MA
Morocco
Prior art keywords
triazole compounds
substituted pyrazole
ksp inhibitors
pharmaceutically acceptable
ksp
Prior art date
Application number
MA31938A
Other languages
English (en)
Inventor
Yi Xia
Kris G Mendenhall
Paul A Barsanti
Annette O Walter
David Duhl
Paul A Renhowe
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MA30959B1 publication Critical patent/MA30959B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

L'INVENTION CONCERNE DE NOUVEAUX COMPOSÉS DE PYRAZOLE ET DE TRIAZOLE SUBSTITUÉS REPRÉSENTÉS PAR LA FORMULE (I), ET DES SELS, DES ESTERS OU DES PROMÉDICAMENTS PHARMACEUTIQUEMENT ACCEPTABLES DE CEUX-CI, DES COMPOSITIONS DE CES DÉRIVÉS CONTENANT DES EXCIPIENTS PHARMACEUTIQUEMENT ACCEPTABLES AINSI QUE DES UTILISATIONS DE CELLES-CI.
MA31938A 2006-11-13 2009-06-01 Composes de pyrazole et de triazole substitues comme inhibiteurs de ksp MA30959B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US85896406P 2006-11-13 2006-11-13

Publications (1)

Publication Number Publication Date
MA30959B1 true MA30959B1 (fr) 2009-12-01

Family

ID=39144618

Family Applications (1)

Application Number Title Priority Date Filing Date
MA31938A MA30959B1 (fr) 2006-11-13 2009-06-01 Composes de pyrazole et de triazole substitues comme inhibiteurs de ksp

Country Status (32)

Country Link
US (2) US8129358B2 (fr)
EP (1) EP2091926B1 (fr)
JP (1) JP5264755B2 (fr)
KR (1) KR20090081020A (fr)
CN (1) CN101558049B (fr)
AR (1) AR063805A1 (fr)
AU (1) AU2007323998B2 (fr)
BR (1) BRPI0719002A2 (fr)
CA (1) CA2668661A1 (fr)
CL (1) CL2007003272A1 (fr)
CO (1) CO6382171A2 (fr)
CR (1) CR10787A (fr)
DO (1) DOP2009000106A (fr)
EA (1) EA017748B1 (fr)
EC (1) ECSP099326A (fr)
ES (1) ES2557478T3 (fr)
GE (1) GEP20125389B (fr)
GT (1) GT200900122A (fr)
HN (1) HN2009000968A (fr)
IL (1) IL198471A0 (fr)
MA (1) MA30959B1 (fr)
MX (1) MX2009005071A (fr)
NI (1) NI200900084A (fr)
NO (1) NO20092226L (fr)
NZ (1) NZ576640A (fr)
PE (1) PE20081169A1 (fr)
SM (1) SMP200900045B (fr)
TN (1) TN2009000178A1 (fr)
TW (1) TW200831480A (fr)
UA (1) UA97256C2 (fr)
WO (1) WO2008063912A1 (fr)
ZA (1) ZA200902940B (fr)

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EP2091926B1 (fr) * 2006-11-13 2015-10-21 Novartis AG Composés de pyrazole et de triazole substitués comme inhibiteurs de ksp
JP2010515687A (ja) * 2007-01-05 2010-05-13 ノバルティス アーゲー キネシンスピンドルタンパク質阻害剤（ｅｇ−５）としてのイミダゾール誘導体
CA2794406A1 (fr) * 2010-04-15 2011-10-20 Novartis Ag Composes de triazole comme inhibiteurs de la ksp
JP2013525290A (ja) * 2010-04-15 2013-06-20 ノバルティス アーゲー Ｋｓｐ阻害剤としてのオキサゾールおよびチアゾール化合物
WO2014089140A1 (fr) * 2012-12-05 2014-06-12 Merck Sharp & Dohme Corp. Procédé de préparation d'inhibiteurs de transcriptase inverse
CN105451773A (zh) * 2013-03-15 2016-03-30 诺华股份有限公司 细胞增殖抑制剂及其缀合物
US9498540B2 (en) 2013-03-15 2016-11-22 Novartis Ag Cell proliferation inhibitors and conjugates thereof
KR101803671B1 (ko) 2013-12-04 2017-11-30 머크 샤프 앤드 돔 코포레이션 역전사효소 억제제의 제조 방법
WO2016020791A1 (fr) 2014-08-05 2016-02-11 Novartis Ag Conjugués anticorps ckit-médicament
US20190161499A1 (en) * 2015-12-11 2019-05-30 Syngenta Participations Ag Pesticidally active 1,2,4-triazole derivatives
CA3166630A1 (fr) 2020-01-03 2021-07-08 Berg Llc Amides polycycliques utilises en tant que modulateurs d'ube2k pour le traitement du cancer

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Also Published As

Publication number Publication date
NI200900084A (es) 2010-01-29
CL2007003272A1 (es) 2008-03-24
US8129358B2 (en) 2012-03-06
CN101558049B (zh) 2012-08-15
UA97256C2 (ru) 2012-01-25
CA2668661A1 (fr) 2008-05-29
EP2091926B1 (fr) 2015-10-21
GT200900122A (es) 2011-09-14
EA017748B1 (ru) 2013-02-28
CN101558049A (zh) 2009-10-14
ECSP099326A (es) 2009-06-30
EA200900631A1 (ru) 2009-12-30
US20100034813A1 (en) 2010-02-11
NZ576640A (en) 2011-10-28
US7902240B2 (en) 2011-03-08
KR20090081020A (ko) 2009-07-27
ZA200902940B (en) 2010-05-26
SMAP200900045A (it) 2009-07-14
BRPI0719002A2 (pt) 2013-12-17
ES2557478T3 (es) 2016-01-26
MX2009005071A (es) 2009-05-25
EP2091926A1 (fr) 2009-08-26
WO2008063912A1 (fr) 2008-05-29
AU2007323998A1 (en) 2008-05-29
CO6382171A2 (es) 2012-02-15
DOP2009000106A (es) 2009-05-31
JP2010509365A (ja) 2010-03-25
IL198471A0 (en) 2010-02-17
PE20081169A1 (es) 2008-09-24
TW200831480A (en) 2008-08-01
CR10787A (es) 2009-07-02
NO20092226L (no) 2009-08-12
JP5264755B2 (ja) 2013-08-14
GEP20125389B (en) 2012-01-25
HN2009000968A (es) 2011-10-25
US20080200462A1 (en) 2008-08-21
TN2009000178A1 (en) 2010-10-18
AR063805A1 (es) 2009-02-18
SMP200900045B (it) 2010-03-01
AU2007323998B2 (en) 2011-09-22

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