MA30988B1 - Composes destines a inhiber la progression mitotique - Google Patents
Composes destines a inhiber la progression mitotiqueInfo
- Publication number
- MA30988B1 MA30988B1 MA31985A MA31985A MA30988B1 MA 30988 B1 MA30988 B1 MA 30988B1 MA 31985 A MA31985 A MA 31985A MA 31985 A MA31985 A MA 31985A MA 30988 B1 MA30988 B1 MA 30988B1
- Authority
- MA
- Morocco
- Prior art keywords
- compounds
- mitotic progression
- inhibiting mitotic
- cancer
- treatment
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Enzymes And Modification Thereof (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
LA PRÉSENTE INVENTION CONCERNE DES COMPOSÉS REPRÉSENTÉS PAR LA FORMULE GÉNÉRALE (I), AINSI QUE DES PROCÉDÉS DESTINÉS AU TRAITEMENT DU CANCER. L'INVENTION CONCERNE PLUS PARTICULIÈREMENT DE PUISSANTS INHIBITEURS DE LA KINASE AURORA A, DES COMPOSITIONS PHARMACEUTIQUES COMPRENANT LES COMPOSÉS, AINSI QUE DES PROCÉDÉS D'UTILISATION DE CES COMPOSÉS POUR LE TRAITEMENT DU CANCER.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US85934006P | 2006-11-16 | 2006-11-16 |
Publications (1)
Publication Number | Publication Date |
---|---|
MA30988B1 true MA30988B1 (fr) | 2009-12-01 |
Family
ID=39315133
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA31985A MA30988B1 (fr) | 2006-11-16 | 2009-06-12 | Composes destines a inhiber la progression mitotique |
Country Status (35)
Country | Link |
---|---|
US (6) | US8026246B2 (fr) |
EP (4) | EP2497773B1 (fr) |
JP (3) | JP5102839B2 (fr) |
KR (2) | KR101110458B1 (fr) |
CN (2) | CN103483343B (fr) |
AR (1) | AR064246A1 (fr) |
AT (1) | ATE556076T1 (fr) |
AU (1) | AU2007322046B2 (fr) |
BR (1) | BRPI0718803B8 (fr) |
CA (1) | CA2669680C (fr) |
CL (1) | CL2007003244A1 (fr) |
CR (3) | CR10782A (fr) |
CY (1) | CY1112828T1 (fr) |
DK (2) | DK2086981T3 (fr) |
EA (1) | EA015779B1 (fr) |
ES (3) | ES2384123T3 (fr) |
GE (1) | GEP20125459B (fr) |
HK (4) | HK1134672A1 (fr) |
HR (2) | HRP20120490T1 (fr) |
IL (1) | IL198690A0 (fr) |
MA (1) | MA30988B1 (fr) |
MX (3) | MX343391B (fr) |
MY (1) | MY153243A (fr) |
NO (1) | NO343338B1 (fr) |
NZ (3) | NZ577042A (fr) |
PH (1) | PH12012502057A1 (fr) |
PL (2) | PL2497772T3 (fr) |
PT (2) | PT2086981E (fr) |
RS (2) | RS53788B1 (fr) |
SG (2) | SG176443A1 (fr) |
SI (2) | SI2086981T1 (fr) |
TW (1) | TWI401255B (fr) |
UA (1) | UA94129C2 (fr) |
WO (1) | WO2008063525A1 (fr) |
ZA (1) | ZA200903279B (fr) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4467616B2 (ja) | 2004-05-14 | 2010-05-26 | ミレニアム・ファーマシューティカルズ・インコーポレイテッド | Auroraキナーゼの阻害により有糸分裂の進行を阻止するための化合物および方法 |
CL2007003244A1 (es) | 2006-11-16 | 2008-04-04 | Millennium Pharm Inc | Compuestos derivados de pirimido[5,4-d][2]benzazepina; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento del cancer. |
AR074487A1 (es) * | 2008-12-05 | 2011-01-19 | Millennium Pharm Inc | Tiolactamas inhibidoras de proteinquinasas plk, composiciones farmaceuticas que las contienen y usos de las mismas para el tratamiento de trastornos proliferativos e inflamatorios, en particular cancer. |
RU2535032C2 (ru) * | 2008-12-22 | 2014-12-10 | Милленниум Фармасьютикалз, Инк. | Сочетание ингибиторов аврора киназы и анти-cd 20 антител |
JO3635B1 (ar) | 2009-05-18 | 2020-08-27 | Millennium Pharm Inc | مركبات صيدلانية صلبة وطرق لانتاجها |
JO3434B1 (ar) | 2009-07-31 | 2019-10-20 | Millennium Pharm Inc | مركبات صيدلانية لمعالجة السرطان وامراض واضطرابات اخري |
JP2013520424A (ja) * | 2010-02-19 | 2013-06-06 | ミレニアム ファーマシューティカルズ, インコーポレイテッド | ナトリウム4−{[9−クロロ−7−(2−フルオロ−6−メトキシフェニル)−5H−ピリミド[5,4−d][2]ベンゾアゼピン−2−イル]アミノ}−2−メトキシベンゾエートの結晶形 |
US20120107304A1 (en) | 2010-04-27 | 2012-05-03 | Boehringer Ingelheim International Gmbh | Combination therapy in treatment of oncological and fibrotic diseases |
ES2526671T3 (es) * | 2010-06-22 | 2015-01-14 | Glaxosmithkline Llc | Compuestos de benzotriazoldiazepina inhibidores de bromodominios |
TW201316991A (zh) | 2011-06-03 | 2013-05-01 | Millennium Pharm Inc | Mek抑制劑與奧諾拉(aurora)a激酶選擇性抑制劑之組合 |
US20130303519A1 (en) * | 2012-03-20 | 2013-11-14 | Millennium Pharmaceuticals, Inc. | Methods of treating cancer using aurora kinase inhibitors |
CN103772391A (zh) * | 2012-10-23 | 2014-05-07 | 杨子娇 | 一类治疗房角狭窄的化合物及其用途 |
CN105209042B (zh) * | 2013-03-22 | 2019-03-08 | 米伦纽姆医药公司 | 催化性mtorc 1/2抑制剂与选择性极光a激酶抑制剂的组合 |
US10335494B2 (en) | 2013-12-06 | 2019-07-02 | Millennium Pharmaceuticals, Inc. | Combination of aurora kinase inhibitors and anti-CD30 antibodies |
CA2972076A1 (fr) * | 2014-12-23 | 2016-06-30 | Millennium Pharmaceuticals, Inc. | Combinaison d'inhibiteurs de raf et d'inhibiteurs de kinases aurora |
JP6955485B2 (ja) | 2015-09-09 | 2021-10-27 | アイカーン スクール オブ メディスン アット マウント サイナイIcahn School of Medicine at Mt. Sinai | 抗がん剤としての複素環式の限定された三環系スルホンアミド |
CA2997769A1 (fr) | 2015-09-09 | 2017-03-16 | Icahn School Of Medicine At Mount Sinai | Sulfonamides heterocycliques tricycliques contraints en tant qu'agents anti-cancereux |
JP6591036B2 (ja) | 2016-02-26 | 2019-10-16 | 公益財団法人がん研究会 | Hp1の機能に着目した抗癌剤のスクリーニング方法及び評価系 |
CA3017411A1 (fr) | 2016-03-15 | 2017-09-21 | Oryzon Genomics, S.A. | Combinaisons d'inhibiteurs de lsd1 pour leur utilisation dans le traitement des tumeurs solides |
JP6188986B1 (ja) * | 2017-03-23 | 2017-08-30 | 株式会社ノエビア | 時計遺伝子発現量調整剤及びエラスチン産生促進剤 |
US11874276B2 (en) | 2018-04-05 | 2024-01-16 | Dana-Farber Cancer Institute, Inc. | STING levels as a biomarker for cancer immunotherapy |
WO2020049208A1 (fr) | 2018-09-09 | 2020-03-12 | Fundacio Privada Institut De Recerca De La Sida - Caixa | Aurora cinasa comme cible pour traiter, prévenir ou soigner une infection par vih ou le sida |
WO2021041532A1 (fr) | 2019-08-26 | 2021-03-04 | Dana-Farber Cancer Institute, Inc. | Utilisation d'héparine pour favoriser la signalisation de l'interféron de type 1 |
WO2023196959A1 (fr) | 2022-04-07 | 2023-10-12 | Eli Lilly And Company | Procédé de fabrication d'un inhibiteur de kras g12c |
WO2023196887A1 (fr) | 2022-04-08 | 2023-10-12 | Eli Lilly And Company | Méthode de traitement comprenant des inhibiteurs de kras g12c et des inhibiteurs d'aurora a |
US20240108618A1 (en) | 2022-06-30 | 2024-04-04 | Eli Lilly And Company | Kras g12c inhibitor dosing regimens |
Family Cites Families (27)
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US4099012A (en) | 1975-08-28 | 1978-07-04 | Ciba-Geigy Corporation | 2-pyrazolyl-benzophenones |
US4481142A (en) | 1979-02-07 | 1984-11-06 | Hoffmann-La Roche Inc. | Pyrimido-2-benzazepines |
IL59316A (en) | 1979-02-07 | 1983-07-31 | Sparamedica Ag | Phenylpyrimidobenzazepine derivatives,their preparation and pharmaceutical compositions containing them |
US4469633A (en) | 1980-05-16 | 1984-09-04 | Hoffmann-La Roche Inc. | N-oxides of 5-oxo-1-phenyl-2-benzazepines |
EP0273697A3 (fr) | 1986-12-30 | 1989-11-29 | Merck & Co. Inc. | 2-Benzazépines à cycles hétérocycliques de 5 et 6 côtés |
US5166151A (en) | 1988-03-25 | 1992-11-24 | Merck & Co., Inc. | 2-Benzazepines with 5- and 6-membered heterocyclic rings, compositions and medical methods of use thereof |
US5210082A (en) | 1991-05-16 | 1993-05-11 | Merck & Co., Inc. | 2-benzazepines with 5- and 6-membered heterocyclic rings to treat pain and anxiety disorders |
GB9523675D0 (en) | 1995-11-20 | 1996-01-24 | Celltech Therapeutics Ltd | Chemical compounds |
CN1084747C (zh) * | 1996-03-08 | 2002-05-15 | 曾尼卡有限公司 | 作为神经活性剂的吡咯并苯并氮杂䓬衍生物 |
JP2001507349A (ja) * | 1996-12-23 | 2001-06-05 | セルテック セラピューティックス リミテッド | 縮合多環式2−アミノピリミジン誘導体、それらの製造およびたんぱく質チロシンキナーゼ抑制因子としてのそれらの使用 |
GB9713087D0 (en) | 1997-06-20 | 1997-08-27 | Celltech Therapeutics Ltd | Chemical compounds |
CN1155599C (zh) | 1997-09-29 | 2004-06-30 | 明治制果株式会社 | 三环三唑并苯并氮杂�衍生物、用于制备该衍生物的方法和抗变态反应剂 |
US6277844B1 (en) | 1998-09-14 | 2001-08-21 | Sydney Spector | Compound for selective treatment of malignant cells by inhibiting cell cycle progression, decreasing Bcl2, and increasing apoptosis |
AU4841700A (en) | 1999-05-12 | 2000-11-21 | Nitromed, Inc. | Nitrosated and nitrosylated potassium channel activators, compositions and methods of use |
ATE403644T1 (de) | 1999-12-06 | 2008-08-15 | Ajinomoto Kk | Amidinophenylbrenztraubensäure-derivat |
MXPA03005610A (es) | 2000-12-21 | 2003-10-06 | Vertex Pharma | Compuestos de pirazol utiles como inhibidores de la proteina cinasa. |
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DE10135457A1 (de) * | 2001-07-20 | 2003-02-06 | Adc Automotive Dist Control | Optische Sensoranordnung |
MXPA04001252A (es) | 2001-08-09 | 2004-05-27 | Actelion Pharmaceuticals Ltd | Nuevos heterociclos benzo-fusionados como antagonistas de endotelina. |
CN1897950A (zh) | 2003-10-14 | 2007-01-17 | 惠氏公司 | 稠合芳基和杂芳基衍生物及其使用方法 |
JP4467616B2 (ja) | 2004-05-14 | 2010-05-26 | ミレニアム・ファーマシューティカルズ・インコーポレイテッド | Auroraキナーゼの阻害により有糸分裂の進行を阻止するための化合物および方法 |
KR20070086188A (ko) | 2004-11-17 | 2007-08-27 | 미카나 테라퓨틱스, 인크. | 키나제 억제제 |
WO2006070198A1 (fr) | 2004-12-30 | 2006-07-06 | Astex Therapeutics Limited | Derives pyrazoliques modulant l'activite des kinases cdk, gsk et aurora |
CN101389324A (zh) | 2005-12-23 | 2009-03-18 | 史密丝克莱恩比彻姆公司 | Aurora激酶的氮杂吲哚抑制剂 |
US7718648B2 (en) | 2006-08-09 | 2010-05-18 | Millennium Pharmaceuticals, Inc. | Pyridobenzazepine compounds and methods for inhibiting mitotic progression |
CL2007003244A1 (es) * | 2006-11-16 | 2008-04-04 | Millennium Pharm Inc | Compuestos derivados de pirimido[5,4-d][2]benzazepina; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento del cancer. |
JO3635B1 (ar) * | 2009-05-18 | 2020-08-27 | Millennium Pharm Inc | مركبات صيدلانية صلبة وطرق لانتاجها |
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2007
- 2007-11-09 CL CL200703244A patent/CL2007003244A1/es unknown
- 2007-11-14 RS RS20150047A patent/RS53788B1/en unknown
- 2007-11-14 EP EP12153134.7A patent/EP2497773B1/fr active Active
- 2007-11-14 EP EP12153131.3A patent/EP2497772B1/fr active Active
- 2007-11-14 US US11/985,277 patent/US8026246B2/en active Active
- 2007-11-14 GE GEAP200711309A patent/GEP20125459B/en unknown
- 2007-11-14 NZ NZ577042A patent/NZ577042A/en unknown
- 2007-11-14 KR KR1020097012501A patent/KR101110458B1/ko active IP Right Grant
- 2007-11-14 PT PT07867449T patent/PT2086981E/pt unknown
- 2007-11-14 RS RS20120247A patent/RS52313B/en unknown
- 2007-11-14 CN CN201310367332.9A patent/CN103483343B/zh active Active
- 2007-11-14 SG SG2011080652A patent/SG176443A1/en unknown
- 2007-11-14 MX MX2012011398A patent/MX343391B/es unknown
- 2007-11-14 DK DK07867449.6T patent/DK2086981T3/da active
- 2007-11-14 MY MYPI20091846A patent/MY153243A/en unknown
- 2007-11-14 JP JP2009537199A patent/JP5102839B2/ja active Active
- 2007-11-14 SG SG10201503350TA patent/SG10201503350TA/en unknown
- 2007-11-14 CA CA2669680A patent/CA2669680C/fr active Active
- 2007-11-14 PT PT121531313T patent/PT2497772E/pt unknown
- 2007-11-14 SI SI200730975T patent/SI2086981T1/sl unknown
- 2007-11-14 PL PL12153131T patent/PL2497772T3/pl unknown
- 2007-11-14 NZ NZ597252A patent/NZ597252A/xx unknown
- 2007-11-14 WO PCT/US2007/023948 patent/WO2008063525A1/fr active Application Filing
- 2007-11-14 SI SI200731591T patent/SI2497772T1/sl unknown
- 2007-11-14 BR BRPI0718803A patent/BRPI0718803B8/pt active IP Right Grant
- 2007-11-14 PL PL07867449T patent/PL2086981T3/pl unknown
- 2007-11-14 NZ NZ611898A patent/NZ611898A/en not_active IP Right Cessation
- 2007-11-14 ES ES07867449T patent/ES2384123T3/es active Active
- 2007-11-14 AU AU2007322046A patent/AU2007322046B2/en active Active
- 2007-11-14 MX MX2012011396A patent/MX348568B/es unknown
- 2007-11-14 ES ES12153131.3T patent/ES2528793T3/es active Active
- 2007-11-14 DK DK12153131.3T patent/DK2497772T3/en active
- 2007-11-14 MX MX2009004670A patent/MX2009004670A/es active IP Right Grant
- 2007-11-14 AT AT07867449T patent/ATE556076T1/de active
- 2007-11-14 CN CN2007800423837A patent/CN101547924B/zh active Active
- 2007-11-14 EP EP15155821.0A patent/EP2944639B1/fr active Active
- 2007-11-14 EA EA200970486A patent/EA015779B1/ru unknown
- 2007-11-14 UA UAA200906211A patent/UA94129C2/ru unknown
- 2007-11-14 KR KR1020117022355A patent/KR101342014B1/ko active IP Right Grant
- 2007-11-14 ZA ZA200903279A patent/ZA200903279B/xx unknown
- 2007-11-14 ES ES12153134.7T patent/ES2537451T3/es active Active
- 2007-11-14 EP EP07867449A patent/EP2086981B1/fr active Active
- 2007-11-14 TW TW096143087A patent/TWI401255B/zh active
- 2007-11-16 AR ARP070105104A patent/AR064246A1/es unknown
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2009
- 2009-05-08 CR CR10782A patent/CR10782A/es unknown
- 2009-05-11 IL IL198690A patent/IL198690A0/en active IP Right Grant
- 2009-05-13 NO NO20091864A patent/NO343338B1/no unknown
- 2009-06-12 MA MA31985A patent/MA30988B1/fr unknown
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2010
- 2010-02-11 HK HK10101590.0A patent/HK1134672A1/xx unknown
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2011
- 2011-08-25 US US13/217,659 patent/US20110312942A1/en not_active Abandoned
- 2011-08-25 US US13/217,729 patent/US9988384B2/en active Active
- 2011-08-30 JP JP2011187930A patent/JP5452811B2/ja active Active
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2012
- 2012-06-06 CY CY20121100518T patent/CY1112828T1/el unknown
- 2012-06-12 HR HRP20120490TT patent/HRP20120490T1/hr unknown
- 2012-10-12 PH PH12012502057A patent/PH12012502057A1/en unknown
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2013
- 2013-03-08 HK HK13102944.8A patent/HK1175777A1/xx unknown
- 2013-03-11 HK HK13102986.7A patent/HK1175778A1/xx unknown
- 2013-11-15 JP JP2013236439A patent/JP2014055166A/ja active Pending
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2014
- 2014-04-04 CR CR20140154A patent/CR20140154A/es unknown
- 2014-10-15 US US14/514,687 patent/US9765076B2/en active Active
- 2014-11-27 CR CR20140544A patent/CR20140544A/es unknown
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2015
- 2015-01-13 HR HRP20150047TT patent/HRP20150047T1/hr unknown
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2016
- 2016-05-17 HK HK16105677.1A patent/HK1217699A1/zh unknown
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2018
- 2018-06-01 US US15/996,166 patent/US10836766B2/en active Active
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2020
- 2020-11-16 US US17/099,266 patent/US11958855B2/en active Active
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