MA33730B1 - Procédés de synthèse pour des composés spiro-oxindoles - Google Patents

Procédés de synthèse pour des composés spiro-oxindoles

Info

Publication number
MA33730B1
MA33730B1 MA34841A MA34841A MA33730B1 MA 33730 B1 MA33730 B1 MA 33730B1 MA 34841 A MA34841 A MA 34841A MA 34841 A MA34841 A MA 34841A MA 33730 B1 MA33730 B1 MA 33730B1
Authority
MA
Morocco
Prior art keywords
spiro
synthesis methods
oxindole compounds
oxindole
compounds
Prior art date
Application number
MA34841A
Other languages
Arabic (ar)
English (en)
Inventor
Jean-Jacques Cadieux
Mikhail Chafeev
Sultan Chowdhury
Jianmin Fu
Qi Jia
Stefanie Abel
Emad El-Sayed
Elke Huthmann
Thomas Isarno
Original Assignee
Xenon Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xenon Pharmaceuticals Inc filed Critical Xenon Pharmaceuticals Inc
Publication of MA33730B1 publication Critical patent/MA33730B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/20—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Cette invention porte sur des procédés de préparation de certains dérivés spiro-oxindoles qui sont utiles pour le traitement et/ou la prévention de maladies ou d'affections à médiation par les canaux sodiques, telles que la douleur.
MA34841A 2009-10-14 2012-05-07 Procédés de synthèse pour des composés spiro-oxindoles MA33730B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25133509P 2009-10-14 2009-10-14
PCT/US2010/052704 WO2011047174A1 (fr) 2009-10-14 2010-10-14 Procédés de synthèse pour des composés spiro-oxindoles

Publications (1)

Publication Number Publication Date
MA33730B1 true MA33730B1 (fr) 2012-11-01

Family

ID=43733239

Family Applications (1)

Application Number Title Priority Date Filing Date
MA34841A MA33730B1 (fr) 2009-10-14 2012-05-07 Procédés de synthèse pour des composés spiro-oxindoles

Country Status (24)

Country Link
US (4) US8445696B2 (fr)
EP (2) EP2733145A1 (fr)
JP (3) JP5752136B2 (fr)
KR (1) KR20120099429A (fr)
CN (1) CN102753556B (fr)
AU (2) AU2010306768B2 (fr)
BR (1) BR112012008993A2 (fr)
CA (1) CA2777543A1 (fr)
CL (3) CL2012000953A1 (fr)
CO (1) CO6531444A2 (fr)
EC (1) ECSP12011815A (fr)
ES (1) ES2467166T3 (fr)
HK (1) HK1197233A1 (fr)
HR (2) HRP20120368A2 (fr)
MA (1) MA33730B1 (fr)
MX (1) MX2012004373A (fr)
MY (2) MY165579A (fr)
NZ (3) NZ599334A (fr)
PE (2) PE20121350A1 (fr)
PH (1) PH12012500726A1 (fr)
RU (2) RU2015103694A (fr)
TN (1) TN2012000171A1 (fr)
WO (1) WO2011047174A1 (fr)
ZA (1) ZA201202703B (fr)

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WO2010045251A2 (fr) 2008-10-17 2010-04-22 Xenon Pharmaceuticals, Inc. Composés spiro-oxindole et leur utilisation comme agents thérapeutiques
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US20110086899A1 (en) * 2009-10-14 2011-04-14 Xenon Pharmaceuticals Inc. Pharmaceutical compositions for oral administration
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MY165117A (en) 2010-02-26 2018-02-28 Xenon Pharmaceuticals Inc Pharmaceutical compositions of spiro-oxindole compound for topical administration and their use as therapeutic agents
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CA3202764A1 (fr) 2020-11-23 2022-05-27 Enanta Pharmaceuticals, Inc. Nouveaux agents antiviraux derives de spiropyrrolidine
US12540141B2 (en) 2020-11-23 2026-02-03 Enanta Pharmaceuticals, Inc. Spiropyrrolidine derived antiviral agents
US11970502B2 (en) 2021-05-04 2024-04-30 Enanta Pharmaceuticals, Inc. Macrocyclic antiviral agents
US12398147B2 (en) 2021-05-11 2025-08-26 Enanta Pharmaceuticals, Inc. Macrocyclic spiropyrrolidine derived antiviral agents
US12479854B2 (en) 2021-07-29 2025-11-25 Enanta Pharmaceuticals, Inc. Spiropyrrolidine derived antiviral agents
US11919910B2 (en) 2021-11-12 2024-03-05 Enanta Pharmaceuticals, Inc. Spiropyrrolidine derived antiviral agents
US11858945B2 (en) 2021-11-12 2024-01-02 Enanta Pharmaceuticals, Inc. Alkyne-containing antiviral agents
US11912714B2 (en) 2021-11-12 2024-02-27 Enanta Pharmaceuticals, Inc. Spiropyrrolidine derived antiviral agents
US11993600B2 (en) 2021-12-08 2024-05-28 Enanta Pharmaceuticals, Inc. Saturated spirocyclics as antiviral agents
KR20250002239A (ko) * 2022-03-18 2025-01-07 이난타 파마슈티칼스, 인코포레이티드 치환된 스피로옥스인돌 유도체의 제조 방법
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