CY1112828T1 - Ενωσεις αναστολης της μιτωτικης διαδικασιας - Google Patents
Ενωσεις αναστολης της μιτωτικης διαδικασιαςInfo
- Publication number
- CY1112828T1 CY1112828T1 CY20121100518T CY121100518T CY1112828T1 CY 1112828 T1 CY1112828 T1 CY 1112828T1 CY 20121100518 T CY20121100518 T CY 20121100518T CY 121100518 T CY121100518 T CY 121100518T CY 1112828 T1 CY1112828 T1 CY 1112828T1
- Authority
- CY
- Cyprus
- Prior art keywords
- union
- suspending
- suspensions
- procedures
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Enzymes And Modification Thereof (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Η παρούσα εφεύρεση αφορά ενώσεις του χημικού τύπου (Ι): και μεθόδους για την αντιμετώπιση του καρκίνου. Συγκεκριμένα, η εφεύρεση παρέχει ισχυρούς αναστολείς της κινάσης Aurora Α, φαρμακευτικές συνθέσεις που περιλαμβάνουν τις ενώσεις και μεθόδους για τη χρήση των ενώσεων στην αντιμετώπιση του καρκίνου.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US85934006P | 2006-11-16 | 2006-11-16 | |
EP07867449A EP2086981B1 (en) | 2006-11-16 | 2007-11-14 | Compounds for inhibiting mitotic progression |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1112828T1 true CY1112828T1 (el) | 2016-02-10 |
Family
ID=39315133
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20121100518T CY1112828T1 (el) | 2006-11-16 | 2012-06-06 | Ενωσεις αναστολης της μιτωτικης διαδικασιας |
Country Status (35)
Country | Link |
---|---|
US (6) | US8026246B2 (el) |
EP (4) | EP2086981B1 (el) |
JP (3) | JP5102839B2 (el) |
KR (2) | KR101342014B1 (el) |
CN (2) | CN101547924B (el) |
AR (1) | AR064246A1 (el) |
AT (1) | ATE556076T1 (el) |
AU (1) | AU2007322046B2 (el) |
BR (1) | BRPI0718803B8 (el) |
CA (1) | CA2669680C (el) |
CL (1) | CL2007003244A1 (el) |
CR (3) | CR10782A (el) |
CY (1) | CY1112828T1 (el) |
DK (2) | DK2086981T3 (el) |
EA (1) | EA015779B1 (el) |
ES (3) | ES2528793T3 (el) |
GE (1) | GEP20125459B (el) |
HK (4) | HK1134672A1 (el) |
HR (2) | HRP20120490T1 (el) |
IL (1) | IL198690A0 (el) |
MA (1) | MA30988B1 (el) |
MX (3) | MX348568B (el) |
MY (1) | MY153243A (el) |
NO (1) | NO343338B1 (el) |
NZ (3) | NZ577042A (el) |
PH (1) | PH12012502057A1 (el) |
PL (2) | PL2497772T3 (el) |
PT (2) | PT2497772E (el) |
RS (2) | RS52313B (el) |
SG (2) | SG10201503350TA (el) |
SI (2) | SI2497772T1 (el) |
TW (1) | TWI401255B (el) |
UA (1) | UA94129C2 (el) |
WO (1) | WO2008063525A1 (el) |
ZA (1) | ZA200903279B (el) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
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BRPI0511139B8 (pt) | 2004-05-14 | 2021-05-25 | Millennium Pharm Inc | compostos que inibem quinase aurora e composição farmacêutica contendo os mesmos |
CL2007003244A1 (es) | 2006-11-16 | 2008-04-04 | Millennium Pharm Inc | Compuestos derivados de pirimido[5,4-d][2]benzazepina; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento del cancer. |
EP2373657B1 (en) * | 2008-12-05 | 2016-09-14 | Millennium Pharmaceuticals, Inc. | 5,7-dihydro-6h-pyrimido[5,4-d][1]benzazepin-6-thiones as plk inhibitors |
WO2010074724A1 (en) | 2008-12-22 | 2010-07-01 | Millennium Pharmaceuticals, Inc. | Combination of aurora kinase inhibitors and anti-cd20 antibodies |
JO3635B1 (ar) * | 2009-05-18 | 2020-08-27 | Millennium Pharm Inc | مركبات صيدلانية صلبة وطرق لانتاجها |
JO3434B1 (ar) * | 2009-07-31 | 2019-10-20 | Millennium Pharm Inc | مركبات صيدلانية لمعالجة السرطان وامراض واضطرابات اخري |
RU2012140021A (ru) | 2010-02-19 | 2014-03-27 | Миллениум Фармасьютикалз, Инк. | КРИСТАЛЛИЧЕСКИЕ ФОРМЫ 4-{[9-ХЛОР-7-(2-ФТОР-6-МЕТОКСИФЕНИЛ)-5Н-ПИРИМИДО[5,4-d][2]БЕНЗАЗЕПИН-2-ИЛ]АМИНО}-2-МЕТОКСИБЕНЗОАТА НАТРИЯ |
US20120107304A1 (en) | 2010-04-27 | 2012-05-03 | Boehringer Ingelheim International Gmbh | Combination therapy in treatment of oncological and fibrotic diseases |
WO2011161031A1 (en) * | 2010-06-22 | 2011-12-29 | Glaxosmithkline Llc | Benzotriazolodiazepine compounds inhibitors of bromodomains |
TW201316991A (zh) * | 2011-06-03 | 2013-05-01 | Millennium Pharm Inc | Mek抑制劑與奧諾拉(aurora)a激酶選擇性抑制劑之組合 |
US20130303519A1 (en) * | 2012-03-20 | 2013-11-14 | Millennium Pharmaceuticals, Inc. | Methods of treating cancer using aurora kinase inhibitors |
CN103772391A (zh) * | 2012-10-23 | 2014-05-07 | 杨子娇 | 一类治疗房角狭窄的化合物及其用途 |
EP2976086B1 (en) * | 2013-03-22 | 2020-10-14 | Millennium Pharmaceuticals, Inc. | Combination of catalytic mtorc 1/2 inhibitors and selective inhibitors of aurora a kinase |
JP6525474B2 (ja) | 2013-12-06 | 2019-06-05 | ミレニアム ファーマシューティカルズ, インコーポレイテッドMillennium Pharmaceuticals, Inc. | オーロラキナーゼ阻害剤と抗cd30抗体の併用 |
JP2018502089A (ja) * | 2014-12-23 | 2018-01-25 | ミレニアム ファーマシューティカルズ, インコーポレイテッドMillennium Pharmaceuticals, Inc. | Raf阻害剤及びauroraキナーゼ阻害剤の組み合わせ |
WO2017015316A1 (en) | 2015-07-21 | 2017-01-26 | Millennium Pharmaceuticals, Inc. | Administration of aurora kinase inhibitor and chemotherapeutic agents |
CA2997769A1 (en) | 2015-09-09 | 2017-03-16 | Icahn School Of Medicine At Mount Sinai | Heterocyclic constrained tricyclic sulfonamides as anti-cancer agents |
EP3347355B1 (en) | 2015-09-09 | 2022-07-13 | Icahn School of Medicine at Mount Sinai | Heterotricyclic sulfonamides as anti-cancer agents |
WO2017146253A1 (ja) | 2016-02-26 | 2017-08-31 | 公益財団法人がん研究会 | Hp1の機能に着目した抗癌剤のスクリーニング方法及び評価系 |
BR112018068565A2 (pt) | 2016-03-15 | 2019-02-12 | Oryzon Genomics, S.A. | combinações de inibidores de lsd1 para uso no tratamento de tumores sólidos |
JP6188986B1 (ja) * | 2017-03-23 | 2017-08-30 | 株式会社ノエビア | 時計遺伝子発現量調整剤及びエラスチン産生促進剤 |
US11874276B2 (en) | 2018-04-05 | 2024-01-16 | Dana-Farber Cancer Institute, Inc. | STING levels as a biomarker for cancer immunotherapy |
WO2020049208A1 (es) | 2018-09-09 | 2020-03-12 | Fundacio Privada Institut De Recerca De La Sida - Caixa | Aurora cinasa como diana para tratar, prevenir o curar una infección por vih o sida |
US20220305048A1 (en) | 2019-08-26 | 2022-09-29 | Dana-Farber Cancer Institute, Inc. | Use of heparin to promote type 1 interferon signaling |
WO2023196959A1 (en) | 2022-04-07 | 2023-10-12 | Eli Lilly And Company | Process for making a kras g12c inhibitor |
WO2023196887A1 (en) | 2022-04-08 | 2023-10-12 | Eli Lilly And Company | Method of treatment including kras g12c inhibitors and aurora a inhibitors |
WO2024006424A1 (en) | 2022-06-30 | 2024-01-04 | Eli Lilly And Company | Kras g12c inhibitor for treating cancer |
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EP0273697A3 (en) | 1986-12-30 | 1989-11-29 | Merck & Co. Inc. | 2-benzazepines with 5- and 6- membered heterocyclic rings |
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EP0946523A1 (en) * | 1996-12-23 | 1999-10-06 | Celltech Therapeutics Limited | Fused polycyclic 2-aminopyrimidine derivatives, their preparation and their use as protein tyrosine kinase inhibitors |
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BRPI0511139B8 (pt) | 2004-05-14 | 2021-05-25 | Millennium Pharm Inc | compostos que inibem quinase aurora e composição farmacêutica contendo os mesmos |
JP2008520713A (ja) | 2004-11-17 | 2008-06-19 | ミイカナ セラピューティクス インコーポレイテッド | キナーゼ阻害剤 |
WO2006070198A1 (en) | 2004-12-30 | 2006-07-06 | Astex Therapeutics Limited | Pyrazole derivatives as that modulate the activity of cdk, gsk and aurora kinases |
PT1962830E (pt) | 2005-12-23 | 2013-05-29 | Glaxosmithkline Llc | Inibidores azaindólicos de cinases aurora |
WO2008021038A2 (en) | 2006-08-09 | 2008-02-21 | Millennium Pharmaceuticals, Inc. | Pyridobenzazepine compounds and methods for inhibiting mitotic progression |
CL2007003244A1 (es) | 2006-11-16 | 2008-04-04 | Millennium Pharm Inc | Compuestos derivados de pirimido[5,4-d][2]benzazepina; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento del cancer. |
JO3635B1 (ar) * | 2009-05-18 | 2020-08-27 | Millennium Pharm Inc | مركبات صيدلانية صلبة وطرق لانتاجها |
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2007
- 2007-11-09 CL CL200703244A patent/CL2007003244A1/es unknown
- 2007-11-14 SI SI200731591T patent/SI2497772T1/sl unknown
- 2007-11-14 SG SG10201503350TA patent/SG10201503350TA/en unknown
- 2007-11-14 CA CA2669680A patent/CA2669680C/en active Active
- 2007-11-14 KR KR1020117022355A patent/KR101342014B1/ko active IP Right Grant
- 2007-11-14 ZA ZA200903279A patent/ZA200903279B/xx unknown
- 2007-11-14 AU AU2007322046A patent/AU2007322046B2/en active Active
- 2007-11-14 ES ES12153131.3T patent/ES2528793T3/es active Active
- 2007-11-14 NZ NZ577042A patent/NZ577042A/en unknown
- 2007-11-14 ES ES12153134.7T patent/ES2537451T3/es active Active
- 2007-11-14 NZ NZ597252A patent/NZ597252A/xx unknown
- 2007-11-14 EP EP07867449A patent/EP2086981B1/en active Active
- 2007-11-14 EP EP12153131.3A patent/EP2497772B1/en active Active
- 2007-11-14 DK DK07867449.6T patent/DK2086981T3/da active
- 2007-11-14 SI SI200730975T patent/SI2086981T1/sl unknown
- 2007-11-14 PT PT121531313T patent/PT2497772E/pt unknown
- 2007-11-14 EP EP12153134.7A patent/EP2497773B1/en active Active
- 2007-11-14 GE GEAP200711309A patent/GEP20125459B/en unknown
- 2007-11-14 KR KR1020097012501A patent/KR101110458B1/ko active IP Right Grant
- 2007-11-14 RS RS20120247A patent/RS52313B/en unknown
- 2007-11-14 PT PT07867449T patent/PT2086981E/pt unknown
- 2007-11-14 WO PCT/US2007/023948 patent/WO2008063525A1/en active Application Filing
- 2007-11-14 JP JP2009537199A patent/JP5102839B2/ja active Active
- 2007-11-14 ES ES07867449T patent/ES2384123T3/es active Active
- 2007-11-14 NZ NZ611898A patent/NZ611898A/en not_active IP Right Cessation
- 2007-11-14 CN CN2007800423837A patent/CN101547924B/zh active Active
- 2007-11-14 RS RS20150047A patent/RS53788B1/en unknown
- 2007-11-14 MX MX2012011396A patent/MX348568B/es unknown
- 2007-11-14 MX MX2012011398A patent/MX343391B/es unknown
- 2007-11-14 DK DK12153131.3T patent/DK2497772T3/en active
- 2007-11-14 PL PL12153131T patent/PL2497772T3/pl unknown
- 2007-11-14 TW TW096143087A patent/TWI401255B/zh active
- 2007-11-14 SG SG2011080652A patent/SG176443A1/en unknown
- 2007-11-14 MY MYPI20091846A patent/MY153243A/en unknown
- 2007-11-14 PL PL07867449T patent/PL2086981T3/pl unknown
- 2007-11-14 CN CN201310367332.9A patent/CN103483343B/zh active Active
- 2007-11-14 MX MX2009004670A patent/MX2009004670A/es active IP Right Grant
- 2007-11-14 EA EA200970486A patent/EA015779B1/ru unknown
- 2007-11-14 EP EP15155821.0A patent/EP2944639B1/en active Active
- 2007-11-14 UA UAA200906211A patent/UA94129C2/ru unknown
- 2007-11-14 BR BRPI0718803A patent/BRPI0718803B8/pt active IP Right Grant
- 2007-11-14 US US11/985,277 patent/US8026246B2/en active Active
- 2007-11-14 AT AT07867449T patent/ATE556076T1/de active
- 2007-11-16 AR ARP070105104A patent/AR064246A1/es unknown
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2009
- 2009-05-08 CR CR10782A patent/CR10782A/es unknown
- 2009-05-11 IL IL198690A patent/IL198690A0/en active IP Right Grant
- 2009-05-13 NO NO20091864A patent/NO343338B1/no unknown
- 2009-06-12 MA MA31985A patent/MA30988B1/fr unknown
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2010
- 2010-02-11 HK HK10101590.0A patent/HK1134672A1/xx unknown
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2011
- 2011-08-25 US US13/217,729 patent/US9988384B2/en active Active
- 2011-08-25 US US13/217,659 patent/US20110312942A1/en not_active Abandoned
- 2011-08-30 JP JP2011187930A patent/JP5452811B2/ja active Active
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2012
- 2012-06-06 CY CY20121100518T patent/CY1112828T1/el unknown
- 2012-06-12 HR HRP20120490TT patent/HRP20120490T1/hr unknown
- 2012-10-12 PH PH12012502057A patent/PH12012502057A1/en unknown
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2013
- 2013-03-08 HK HK13102944.8A patent/HK1175777A1/xx unknown
- 2013-03-11 HK HK13102986.7A patent/HK1175778A1/xx unknown
- 2013-11-15 JP JP2013236439A patent/JP2014055166A/ja active Pending
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2014
- 2014-04-04 CR CR20140154A patent/CR20140154A/es unknown
- 2014-10-15 US US14/514,687 patent/US9765076B2/en active Active
- 2014-11-27 CR CR20140544A patent/CR20140544A/es unknown
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2015
- 2015-01-13 HR HRP20150047TT patent/HRP20150047T1/hr unknown
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2016
- 2016-05-17 HK HK16105677.1A patent/HK1217699A1/zh unknown
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2018
- 2018-06-01 US US15/996,166 patent/US10836766B2/en active Active
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2020
- 2020-11-16 US US17/099,266 patent/US11958855B2/en active Active
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