MA30952B1 - Cyclopenta [d] pyrimidines utiles en tant qu'inhibiteurs de la proteine kinase akt - Google Patents

Cyclopenta [d] pyrimidines utiles en tant qu'inhibiteurs de la proteine kinase akt

Info

Publication number
MA30952B1
MA30952B1 MA31611A MA31611A MA30952B1 MA 30952 B1 MA30952 B1 MA 30952B1 MA 31611 A MA31611 A MA 31611A MA 31611 A MA31611 A MA 31611A MA 30952 B1 MA30952 B1 MA 30952B1
Authority
MA
Morocco
Prior art keywords
inhibitors
protein kinase
cyclopenta
kinase akt
pyrimidines useful
Prior art date
Application number
MA31611A
Other languages
English (en)
Inventor
Ian S Mitchell
James F Blake
Rui Xu
Nicholas C Kallan
Dengming Xiao
Keith Lee Spencer
Josef R Bencsik
Jun Liang
Brian Safina
Jun Li
Christine Chabot
Eli M Wallace
Anna L Banka
Stephen T Schlachter
Original Assignee
Array Biopharma Inc
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38686844&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA30952(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Array Biopharma Inc, Genentech Inc filed Critical Array Biopharma Inc
Publication of MA30952B1 publication Critical patent/MA30952B1/fr

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    • C—CHEMISTRY; METALLURGY
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    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

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Abstract

LA PRÉSENTE INVENTION CONCERNE DES COMPOSÉS DE FORMULE (I) ET LEURS TAUTOMÈRES, LEURS ÉNANTIOMÈRES RÉSOLUS, LEURS DIASTÉRÉOMÈRES, LEURS SOLVATES, LEURS MÉTABOLITES ET LEURS SELS, AINSI QUE LEURS PROMÉDICAMENTS PHARMACEUTIQUEMENT ACCEPTABLES. [INSÉRER FORMULE (I)]. L'INVENTION CONCERNE ÉGALEMENT DES PROCÉDÉS D'UTILISATION DES COMPOSÉS DE LA PRÉSENTE INVENTION EN TANT QU'INHIBITEURS DE LA PROTÉINE KINASE AKT ET POUR LE TRAITEMENT DE MALADIES HYPERPROLIFÉRATIVES TELLES QUE LE CANCER.
MA31611A 2006-07-06 2009-02-03 Cyclopenta [d] pyrimidines utiles en tant qu'inhibiteurs de la proteine kinase akt MA30952B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US81876206P 2006-07-06 2006-07-06

Publications (1)

Publication Number Publication Date
MA30952B1 true MA30952B1 (fr) 2009-12-01

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ID=38686844

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Application Number Title Priority Date Filing Date
MA31611A MA30952B1 (fr) 2006-07-06 2009-02-03 Cyclopenta [d] pyrimidines utiles en tant qu'inhibiteurs de la proteine kinase akt

Country Status (31)

Country Link
US (3) US8003651B2 (fr)
EP (1) EP2049500B1 (fr)
JP (3) JP5268904B2 (fr)
KR (2) KR101527232B1 (fr)
CN (2) CN103288753A (fr)
AR (1) AR061844A1 (fr)
AT (1) ATE523499T1 (fr)
AU (1) AU2007269052B2 (fr)
BR (1) BRPI0713555A2 (fr)
CA (1) CA2656618C (fr)
CL (1) CL2007001992A1 (fr)
CO (1) CO6160229A2 (fr)
CR (2) CR10601A (fr)
CY (1) CY1112142T1 (fr)
DK (1) DK2049500T3 (fr)
ES (1) ES2372955T3 (fr)
HR (1) HRP20110882T1 (fr)
IL (1) IL196051A (fr)
MA (1) MA30952B1 (fr)
MX (1) MX2008016203A (fr)
MY (1) MY147628A (fr)
NO (1) NO20090580L (fr)
NZ (1) NZ573979A (fr)
PL (1) PL2049500T3 (fr)
PT (1) PT2049500E (fr)
RS (1) RS52210B (fr)
RU (1) RU2481336C2 (fr)
SI (1) SI2049500T1 (fr)
TW (1) TWI428335B (fr)
UA (1) UA99597C2 (fr)
WO (1) WO2008006032A1 (fr)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100047338A1 (en) 2008-03-14 2010-02-25 Angela Brodie Novel C-17-Heteroaryl Steroidal CYP17 Inhibitors/Antiandrogens, In Vitro Biological Activities, Pharmacokinetics and Antitumor Activity
EP2054418B1 (fr) 2006-07-06 2011-11-09 Array Biopharma Inc. Dihydrothiéno pyrimidines comme inhibiteurs de la protéine kinase akt
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BRPI0713555A2 (pt) 2012-03-20
CR20140215A (es) 2014-07-11
ATE523499T1 (de) 2011-09-15
JP5586735B2 (ja) 2014-09-10
RU2481336C2 (ru) 2013-05-10
DK2049500T3 (da) 2011-12-12
US20080058327A1 (en) 2008-03-06
HRP20110882T1 (hr) 2012-01-31
JP2009542721A (ja) 2009-12-03
CA2656618C (fr) 2014-08-26
CN101631778B (zh) 2013-05-08
TWI428335B (zh) 2014-03-01
AU2007269052A1 (en) 2008-01-10
NO20090580L (no) 2009-04-06
WO2008006032A1 (fr) 2008-01-10
EP2049500A1 (fr) 2009-04-22
JP2013209381A (ja) 2013-10-10
US8003651B2 (en) 2011-08-23
PT2049500E (pt) 2011-12-23
CA2656618A1 (fr) 2008-01-10

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