TN2010000171A1 - Derives de thienopyrimidine et pyrazolopyrimidine et leur utilisation comme inhibiteurs de la kinase mtor te de la kinase k13 - Google Patents
Derives de thienopyrimidine et pyrazolopyrimidine et leur utilisation comme inhibiteurs de la kinase mtor te de la kinase k13Info
- Publication number
- TN2010000171A1 TN2010000171A1 TN2010000171A TN2010000171A TN2010000171A1 TN 2010000171 A1 TN2010000171 A1 TN 2010000171A1 TN 2010000171 A TN2010000171 A TN 2010000171A TN 2010000171 A TN2010000171 A TN 2010000171A TN 2010000171 A1 TN2010000171 A1 TN 2010000171A1
- Authority
- TN
- Tunisia
- Prior art keywords
- kinase
- thienopyrimidine
- inhibitors
- pyrazolopyrimidine derivatives
- compounds
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Vascular Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Transplantation (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
La présente invention concerne des composés de thiénopyrimidine et pyrazolopyrimidine de formules (Ia) et (IIa) Ou un de leurs sels pharmaceutiquement acceptables, formule dans lesquelles les variables constitutives sont telles que définies dans le présent mémoire, des compositions comprenant les composés et des procédés pour la préparation et l'utilisation des composés
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US98033207P | 2007-10-16 | 2007-10-16 | |
US2759508P | 2008-02-11 | 2008-02-11 | |
PCT/US2008/079940 WO2009052145A1 (fr) | 2007-10-16 | 2008-10-15 | Composés thiénopyrimidine et pyrazolopyrimidine et leur utilisation en tant que des inhibiteurs de la kinase mtor et de la kinase pi3 |
Publications (1)
Publication Number | Publication Date |
---|---|
TN2010000171A1 true TN2010000171A1 (fr) | 2011-11-11 |
Family
ID=40345078
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TN2010000171A TN2010000171A1 (fr) | 2007-10-16 | 2010-04-16 | Derives de thienopyrimidine et pyrazolopyrimidine et leur utilisation comme inhibiteurs de la kinase mtor te de la kinase k13 |
Country Status (26)
Country | Link |
---|---|
US (1) | US8129371B2 (fr) |
EP (1) | EP2212333A1 (fr) |
JP (1) | JP2011500702A (fr) |
KR (1) | KR20100083170A (fr) |
CN (1) | CN101883774A (fr) |
AP (1) | AP2010005234A0 (fr) |
AR (1) | AR068898A1 (fr) |
AU (1) | AU2008312631A1 (fr) |
BR (1) | BRPI0817681A2 (fr) |
CA (1) | CA2702838A1 (fr) |
CL (1) | CL2008003061A1 (fr) |
CO (1) | CO6321257A2 (fr) |
CR (1) | CR11373A (fr) |
DO (1) | DOP2010000118A (fr) |
EA (1) | EA201000484A1 (fr) |
EC (1) | ECSP10010112A (fr) |
IL (1) | IL205109A0 (fr) |
MA (1) | MA31884B1 (fr) |
MX (1) | MX2010004260A (fr) |
NI (1) | NI201000060A (fr) |
PA (1) | PA8799101A1 (fr) |
PE (1) | PE20091384A1 (fr) |
TN (1) | TN2010000171A1 (fr) |
TW (1) | TW200922593A (fr) |
WO (1) | WO2009052145A1 (fr) |
ZA (1) | ZA201003430B (fr) |
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- 2008-10-15 CN CN2008801190434A patent/CN101883774A/zh active Pending
- 2008-10-15 WO PCT/US2008/079940 patent/WO2009052145A1/fr active Application Filing
- 2008-10-15 CA CA2702838A patent/CA2702838A1/fr not_active Abandoned
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- 2008-10-15 KR KR1020107010683A patent/KR20100083170A/ko not_active Application Discontinuation
- 2008-10-15 EP EP08839537A patent/EP2212333A1/fr not_active Withdrawn
- 2008-10-15 EA EA201000484A patent/EA201000484A1/ru unknown
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- 2008-10-15 BR BRPI0817681 patent/BRPI0817681A2/pt not_active Application Discontinuation
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EP2212333A1 (fr) | 2010-08-04 |
CL2008003061A1 (es) | 2009-01-09 |
IL205109A0 (en) | 2010-11-30 |
PA8799101A1 (es) | 2009-05-15 |
MA31884B1 (fr) | 2010-12-01 |
CR11373A (es) | 2010-05-03 |
NI201000060A (es) | 2010-10-04 |
AR068898A1 (es) | 2009-12-16 |
ECSP10010112A (es) | 2010-08-31 |
AP2010005234A0 (en) | 2010-04-30 |
CN101883774A (zh) | 2010-11-10 |
MX2010004260A (es) | 2010-04-30 |
BRPI0817681A2 (pt) | 2015-04-14 |
TW200922593A (en) | 2009-06-01 |
PE20091384A1 (es) | 2009-09-09 |
CA2702838A1 (fr) | 2009-04-23 |
KR20100083170A (ko) | 2010-07-21 |
JP2011500702A (ja) | 2011-01-06 |
WO2009052145A1 (fr) | 2009-04-23 |
ZA201003430B (en) | 2011-02-23 |
US20090098086A1 (en) | 2009-04-16 |
CO6321257A2 (es) | 2011-09-20 |
DOP2010000118A (es) | 2010-06-30 |
AU2008312631A1 (en) | 2009-04-23 |
US8129371B2 (en) | 2012-03-06 |
EA201000484A1 (ru) | 2010-12-30 |
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