AR068898A1 - Compuestos de tienopirimidinas y pirazolopirimidina y su uso como inhibidores de mtor y pi3k - Google Patents
Compuestos de tienopirimidinas y pirazolopirimidina y su uso como inhibidores de mtor y pi3kInfo
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- AR068898A1 AR068898A1 ARP080104520A ARP080104520A AR068898A1 AR 068898 A1 AR068898 A1 AR 068898A1 AR P080104520 A ARP080104520 A AR P080104520A AR P080104520 A ARP080104520 A AR P080104520A AR 068898 A1 AR068898 A1 AR 068898A1
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- alkyl
- optionally substituted
- dialkylamino
- alkylamino
- nhc
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Transplantation (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Obesity (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Composicion farmacéutica, proceso y métodos para tratar cáncer, restenosis, ateroesclerosis, artritis, soriasis, entre otras. Reivindicacion 1: Un compuesto de la formula (1) o de la formula (2) o sales farmacéuticamente aceptables de éstos, caracterizado porque het es un grupo heterobiciclilo puenteado de 5-10-miembros que contiene por lo menos un átomo de oxígeno, por lo menos un átomo de nitrogeno, y opcionalmente heteroátomos adicionales seleccionados de oxígeno, azufre y nitrogeno, y se conecta al grupo tienopirimidinilo o pirazolopirimidinilo a través de uno de los átomos de nitrogeno; R20 se selecciona independientemente de halogeno, hidroxilo, alcoxi C1-2, NH2, NH(alquilo C1-2), N(alquilo C1-2)(alquilo C1-2), NHC(O)(alquilo C1-2), N(alquilo C1-2)C(O)(alquilo C1-2), NHC(O)H, C(O)NH2, C(O)NH(alquilo C1-2), C(O)N(alquilo C1-2)(alquilo C1-2), CN, C(O)OH, y alcoxicarbonilo C1-4; t es 0-16; cada R1 es independientemente halogeno; alquilo C1-6 opcionalmente sustituido con de 1 a 3 sustituyentes independientemente seleccionados de halogeno, -NH2, -alquilamino, -dialquilamino, -N(alquilo C1-3)C(O)(alquilo C1-6), -NHC(O)(alquilo C1-6), -NHC(O)H, -C(O)NH2, -C(O)NH(alquilo C1-6), -C(O)N(alquilo C1-6)(alquilo C1-6), -CN, hidroxilo, -alcoxi C1-6, alquilo C1-6, -C(O)OH, -alcoxicarbonilo C1-6, -acilo C1-8, arilo C6-14, heteroarilo, y carbociclo C3-8; alcoxi C1-6 opcionalmente sustituido con de 1 a 3 sustituyentes independientemente seleccionados de halogeno, -NH2, -alquilamino, -dialquilamino, -N(alquilo C1-3)C(O)(alquilo C1-6), -NHC(O)(alquilo C1-6), -NHC(O)H, -C(O)NH2, -C(O)NH(alquilo C1-6), -C(O)N(alquilo C1-6)(alquilo C1-6), -CN, hidroxilo, -alcoxi C1-6, alquilo C1-6, -C(O)OH, -alcoxicarbonilo C1-6, -acilo C1-8, arilo C6-14, heteroarilo, y carbociclo C3-8; alquenilo C2-6 opcionalmente sustituido con de 1 a 3 sustituyentes independientemente seleccionados de halogeno, -NH2, -alquilamino, -dialquilamino, -N(alquilo C1-3)C(O)(alquilo C1-6), -NHC(O)(alquilo C1-6), -NHC(O)H, -C(O)NH2, -C(O)NH(alquilo C1-6), -C(O)N(alquilo C1-6)(alquilo C1-6), -CN, hidroxilo, -alcoxi C1-6, alquilo C1-6, -C(O)OH, -alcoxicarbonilo C1-6, -acilo C1-8, arilo C6-14, heteroarilo, y carbociclo C3-8; alquinilo C2-6 opcionalmente sustituido con de 1 a 3 sustituyentes independientemente seleccionados de halogeno, -NH2, -alquilamino, -dialquilamino, -N(alquilo C1-3)C(O)(alquilo C1-6), -NHC(O)(alquilo C1-6), -NHC(O)H, -C(O)NH2, -C(O)NH(alquilo C1-6), -C(O)N(alquilo C1-6)(alquilo C1-6), -CN, hidroxilo, -alcoxi C1-6, alquilo C1-6, -C(O)OH, -alcoxicarbonilo C1-6, -acilo C1-8, arilo C6-14, heteroarilo, y carbociclo C3-8, arilo C6-14 opcionalmente sustituido con de 1 a 3 sustituyentes independientemente seleccionados de alquilo C1-6, halo, -haloalquilo, hidroxilo, hidroxialquilo C1-6, -NH2, -alquilamino, -dialquilamino, -COOH, -alcoxicarbonilo C1-6, -(alquilo C1-6)carboxilo, -N-alquilamido C1-6, -C(O)NH2, -alquilcarboxamido y -NO2; heteroarilo opcionalmente sustituido con de 1 a 3 sustituyentes independientemente seleccionados de alquilo C1-6, halo, -haloalquilo, hidroxilo, hidroxialquilo C1-6, -NH2, -alquilamino, -dialquilamino, -COOH, -alcoxicarbonilo C1-6, -(alquilo C1-6)carboxilo, -N-alquilamido C1-6, -C(O)NH2, -alquilcarboxamido y -NO2; acilo C1-8; alcoxicarbonilo C1-8; alquilcarboxi C1-8; -N-alquilamido C1-6; hidroxilo; NR4R5; -NHC(O)NR4R5; -NHC(O)NHNR4R5; -NHC(O)OR6; -NH(SO2)NH-alquilo C1-6; -NH(SO2)NH-arilo C6-14; -NHC(S)-NR4R5; -NHC(=N-CN)-NR4R5; -NHC(=NR4)-NR4R5; -N=C(S-alquilo C1-6)(NH-alquilo C1-6); o -N(H)-C(=N-(CN))-(O-arilo C6-14); m es 0, 1, 2, 3 o 4; r es 0 o 1; cada R4 y R5 es independientemente H; un heterociclo monocíclico de 4- a 7- miembros opcionalmente sustituido con de 1 a 3 sustituyentes independientemente seleccionados de alquilo C1-6, heterociclilalquilo, arilalquilo C7-24, acilo C1-8, alcoxicarbonilo C1-8, alquilcarboxi C1-8, halo, -haloalquilo C1-8, hidroxilo, hidroxialquilo C1-6, -NH2, -alquilamino, -dialquilamino, -COOH, -alcoxicarbonilo C1-6, -(alquilo C1-6)carboxilo, -N-alquilamido C1-6, -C(O)NH2, -alquilcarboxamido y -NO2; arilo C6-14 opcionalmente sustituido con de 1 a 3 sustituyentes independientemente seleccionados de alquilo C1-6 opcionalmente sustituido con -NH2, -alquilamino, o -dialquilamino, halo, -haloalquilo, hidroxilo, hidroxialquilo C1-6, -NH2, -alquilamino, -dialquilamino, -COOH, -alcoxicarbonilo C1-6, -(alquilo C1-6)carboxilo, -N-alquilamido C1-6 opcionalmente sustituido con -NH2, -alquilamino, o -dialquilamino, -C(O)NH2, -alquilcarboxamido, heterociclo opcionalmente sustituido con alquilo C1-6, -S(O)2-heterociclilalquilo opcionalmente sustituido con alquilo C1-6, heterociclilalquilo opcionalmente sustituido con alquilo C1-6, alcoxi C1-6 opcionalmente sustituido con -NH2, -alquilamino, -dialquilamino, heterociclo, o hidroxilo, -C(O)NH-NH2, -C(O)NH-NH(alquilo C1-6), -C(O)NH-N(alquilo C1-6)(alquilo C1-6), -C(O)NH-heterociclo, -SO2(alquilo C1-6), -CN, y -NO2; heteroarilo opcionalmente sustituido con de 1 a 3 sustituyentes independientemente seleccionados de alquilo C1-6 opcionalmente sustituido con -NH2, -alquilamino, o -dialquilamino, halo, -haloalquilo, hidroxilo, hidroxialquilo C1-6, -NH2, -aminoalquilo, -dialquilamino, -COOH, -alcoxicarbonilo C1-6, -(alquilo C1-6)carboxilo, -N-alquilamido C1-6 opcionalmente sustituido con -NH2, -alquilamino, o -dialquilamino, -C(O)NH2, -alquilcarboxamido, heterociclo opcionalmente sustituido con alquilo C1-6, -S(O)2-heterociclilalquilo opcionalmente sustituido con alquilo C1-6, heterociclilalquilo opcionalmente sustituido con alquilo C1-6, alcoxi C1-6 opcionalmente sustituido con -NH2, -alquilamino, -dialquilamino, heterociclo opcionalmente sustituido con alquilo C1-6, o hidroxilo, -C(O)NH-NH2, -C(O)NH-NH(alquilo C1-6), -C(O)NH-N(alquilo C1-6)(alquilo C1-6), -C(O)NH-heterociclo, -SO2(alquilo C1-6), -CN; y -NO2; -carbociclo C3-8 opcionalmente sustituido con de 1 a 3 sustituyentes independientemente seleccionados de alquilo C1-6, halo, -haloalquilo, hidroxilo, alcoxi C1-6, -NH2, alquilamino, -dialquilamino, -COOH, -alcoxicarbonilo C1-6, -(alquilo C1-6)carboxilo, -N-alquilamido C1-6, -C(O)NH2, alquilcarboxiamido, y -NO2, en donde cualquiera de dos átomos de hidrogeno en el mismo átomo carbono del anillo carbocíclico se puede reemplazar por un átomo de oxígeno para formar un sustituyente oxo (=O), y en donde cualquiera de dos átomos de hidrogeno en el mismo átomo carbono del anillo carbocíclico se puede reemplazar por un grupo alquilendioxi de tal manera que el grupo alquilendioxi, cuando se toma junto con el átomo de carbono al que éste se adhiere, forma un heterociclo de 5- a 7-miembros que contiene dos átomos de oxígeno; heterociclilalquilo opcionalmente sustituido con alquilo C1-6; carbociclo C6-10; heterociclo bicíclico; o alquilo C1-6 opcionalmente sustituido con de 1 a 3 sustituyentes independientemente seleccionados de halogeno, -NH2, -alquilamino, -dialquilamino, -N(alquilo C1-3)C(O)(alquilo C1-6), -NHC(O)(alquilo C1-6), -NHC(O)H, -C(O)NH2, -C(O)NH(alquilo C1-6), -C(O)N(alquilo C1-6)(alquilo C1-6), -CN, hidroxilo, -alcoxi C1-6 opcionalmente sustituido con -NH2, alquilo C1-6, -C(O)OH, -alcoxicarbonilo C1-6, -acilo C1-8, arilo C6-14, heteroarilo, -alquilcarboxamido opcionalmente sustituido con -NH2, -alquilamino, o -dialquilamino, -C(O)-heterociclo opcionalmente sustituido con alquilo C1-6, y carbociclo C3-8; o R4 y R5 cuando se toman junto con el nitrogeno al cual ellos se adhieren pueden formar un heterociclo de 3- a 7-miembros en donde hasta dos de los átomos de carbono del heterociclo se puede reemplazar independientemente con -N(R7)-, -O-, -C(O)-, o -S(=O)s; cada s es independientemente 1 o 2; R6 es alquilo C1-6 opcionalmente sustituido con de 1 a 3 sustituyentes independientemente seleccionados de halogeno, -NH2, -alquilamino, -dialquilamino, -N(alquilo C1-3)C(O)(alquilo C1-6), -NHC(O)(alquilo C1-6), -NHC(O)H, -C(O)NH2, -C(O)NH(alquilo C1-6), -C(O)N(alquilo C1-6)(alquilo C1-6), -CN, hidroxilo, -alcoxi C1-6, alquilo C1-6, -C(O)OH, -alcoxicarbonilo C1-6, -acilo C1-8, arilo C6-14 opcionalmente sustituido con -NH2, -alquilamino, o -dialquilamino, heteroarilo, y carbociclo C3-8; heterociclilalquilo opcionalmente sustituido con alquilo C1-6, carbociclo C6-10; heterociclo bicíclico; o arilo C6-14 opcionalmente sustituido con de 1 a 3 sustituyentes independientemente seleccionados de alquilo C1-6, halo, -haloalquilo, hidroxilo, hidroxialquilo C1-6, -NH2, -alquilamino, -dialquilamino, -COOH, -alcoxicarbonilo C1-6, -(alquilo C1-6)carboxilo, -N-alquilamido C1-6, -C(O)NH2, -alquilcarboxamido y -NO2; R7 es hidrogeno; acilo C1-8 alquilo C1-6 opcionalmente sustituido con de 1 a 3 sustituyentes independientemente seleccionados de halogeno, -NH2, -alquilamino, -dialquilamino, -N(alquilo C1-3)C(O)(alquilo C1-6), -NHC(O)(alquilo C1-6), -NHC(O)H, -C(O)NH2, -C(O)NH(alquilo C1-6), -C(O)N(alquilo C1-6)(alquilo C1-6), -CN, hidroxilo, -alcoxi C1-6, alquilo C1-6, -C(O)OH, -alcoxicarbonilo C1-6, -acilo C1-8, arilo C6-14, heteroarilo, y carbociclo C3-8; carbociclo C3-8 opcionalmente sustituido con de 1 a 3 sustituyentes independientemente seleccionados de alquilo C1-6, halo, -haloalquilo, hidroxilo, alcoxi C1-6, -NH2, -alquilamino, -dialquilamino, -COOH, -alcoxicarbonilo C1-6, -(alquilo C1-6)carboxilo, -N-alquilamido C1-6, -C(O)NH2, alquilcarboxiamido, y -NO2; arilo C6-14 opcionalmente sustituido con de 1 a 3 sustituyentes independientemente seleccionados de alquilo C1-6, halo, -haloalquilo, hidroxilo, hidroxialquilo C1-6, -NH2, -alquilamino, -dialquilamino, -COOH, -alcoxicarbonilo C1-6, -(alquilo C1-6)carboxilo, -N-alquilamido C1-6, -C(O)NH2, -alquilcarboxamido y -NO2; heteroarilo opcionalmente sustituido con de 1 a 3 sustituyentes independientemente seleccionados de alquilo C1-6, halo, -haloalquilo, hidroxilo, hidroxialquilo C1-6, -NH2, -alquilamino, -dialquilamino, -COOH, -alcoxicarbonilo C1-6, -(alquilo C1-6)carboxilo, -N-alquilamido C1-6, -C(O)NH2, -alquilcarboxamido y -NO2; alquilami
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US98033207P | 2007-10-16 | 2007-10-16 | |
US2759508P | 2008-02-11 | 2008-02-11 |
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ARP080104520A AR068898A1 (es) | 2007-10-16 | 2008-10-16 | Compuestos de tienopirimidinas y pirazolopirimidina y su uso como inhibidores de mtor y pi3k |
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US (1) | US8129371B2 (es) |
EP (1) | EP2212333A1 (es) |
JP (1) | JP2011500702A (es) |
KR (1) | KR20100083170A (es) |
CN (1) | CN101883774A (es) |
AP (1) | AP2010005234A0 (es) |
AR (1) | AR068898A1 (es) |
AU (1) | AU2008312631A1 (es) |
BR (1) | BRPI0817681A2 (es) |
CA (1) | CA2702838A1 (es) |
CL (1) | CL2008003061A1 (es) |
CO (1) | CO6321257A2 (es) |
CR (1) | CR11373A (es) |
DO (1) | DOP2010000118A (es) |
EA (1) | EA201000484A1 (es) |
EC (1) | ECSP10010112A (es) |
IL (1) | IL205109A0 (es) |
MA (1) | MA31884B1 (es) |
MX (1) | MX2010004260A (es) |
NI (1) | NI201000060A (es) |
PA (1) | PA8799101A1 (es) |
PE (1) | PE20091384A1 (es) |
TN (1) | TN2010000171A1 (es) |
TW (1) | TW200922593A (es) |
WO (1) | WO2009052145A1 (es) |
ZA (1) | ZA201003430B (es) |
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US20030133939A1 (en) | 2001-01-17 | 2003-07-17 | Genecraft, Inc. | Binding domain-immunoglobulin fusion proteins |
US7754208B2 (en) | 2001-01-17 | 2010-07-13 | Trubion Pharmaceuticals, Inc. | Binding domain-immunoglobulin fusion proteins |
HUE026303T2 (hu) | 2005-07-25 | 2016-06-28 | Emergent Product Dev Seattle | B-sejt csökkentés CD37-specifikus és CD20-specifikus kapcsoló molekulák alkalmazásával |
EP2418223A3 (en) | 2006-06-12 | 2013-01-16 | Emergent Product Development Seattle, LLC | Single-chain multivalent binding proteins with effector function |
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EP2212333A1 (en) | 2010-08-04 |
CN101883774A (zh) | 2010-11-10 |
MA31884B1 (fr) | 2010-12-01 |
JP2011500702A (ja) | 2011-01-06 |
TN2010000171A1 (fr) | 2011-11-11 |
NI201000060A (es) | 2010-10-04 |
WO2009052145A1 (en) | 2009-04-23 |
PA8799101A1 (es) | 2009-05-15 |
IL205109A0 (en) | 2010-11-30 |
CA2702838A1 (en) | 2009-04-23 |
AU2008312631A1 (en) | 2009-04-23 |
EA201000484A1 (ru) | 2010-12-30 |
PE20091384A1 (es) | 2009-09-09 |
ZA201003430B (en) | 2011-02-23 |
KR20100083170A (ko) | 2010-07-21 |
BRPI0817681A2 (pt) | 2015-04-14 |
ECSP10010112A (es) | 2010-08-31 |
DOP2010000118A (es) | 2010-06-30 |
CL2008003061A1 (es) | 2009-01-09 |
AP2010005234A0 (en) | 2010-04-30 |
MX2010004260A (es) | 2010-04-30 |
CR11373A (es) | 2010-05-03 |
US8129371B2 (en) | 2012-03-06 |
US20090098086A1 (en) | 2009-04-16 |
CO6321257A2 (es) | 2011-09-20 |
TW200922593A (en) | 2009-06-01 |
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