AR065718A1 - Compuestos heterociclicos nitrogenados,utiles en el diagnostico y tratamiento de trastornos hiperproliferativos. - Google Patents
Compuestos heterociclicos nitrogenados,utiles en el diagnostico y tratamiento de trastornos hiperproliferativos.Info
- Publication number
- AR065718A1 AR065718A1 ARP080101030A ARP080101030A AR065718A1 AR 065718 A1 AR065718 A1 AR 065718A1 AR P080101030 A ARP080101030 A AR P080101030A AR P080101030 A ARP080101030 A AR P080101030A AR 065718 A1 AR065718 A1 AR 065718A1
- Authority
- AR
- Argentina
- Prior art keywords
- het
- aryl
- substituted
- alkyl
- unsubstituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/30—Phthalazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
Abstract
Reivindicacion 1: Un compuesto de la formula (1) y las sales farmacéuticamente aceptables del mismo, en donde: R1 es fenilo que puede estar insustituido o sustituido; R2 es het, siendo N cuando menos un heteroátomo del anillo, y el cual puede estarinsustituido o sustituido; L es alquilo inferior, (CH2)1-2-A, A-(CH2)1-2, o CH2-A-CH2, y A es O, S, NH, o N-aIquilo, en donde alquilo inferior puede estar insustituido o sustituido con alquilo inferior, o uno o más átomos de fluor; X es N o CH, ycuando menos un X es N; Y es un enlace, CH2, C(O), o SO2; R3 es arilo o het, el cual está sustituido, Z es H, alquilo inferior, alcoxilo inferior, oxo, C(O)OR6, o -CN; en donde alquilo inferior y alcoxilo inferior pueden estar insustituidos osustituidos con uno o más de halogeno, -OH, -CN, -NH2, u oxo, y dos Z conectados al mismo átomo pueden formar un anillo de cicloalquilo, y m es de 0 a 3, las sustituciones de fenilo, arilo o het de R1, R2, o R3 pueden ser uno o más de alquilo,cicloalquilo, alcoxilo, cicloalcoxilo, halogeno, -CN, oxo, arilo, carbalcoxilo, OCF3, CF3, OH, -C(O)N(R6)2, C(O)R6, -C(O)OR6, -N(R6)2, -NHC(O)R6, -SO2(R6), -SO2N(R6)2, CH2OC(O)N(R6)2, -CH2N(R6)2, -NHC(O)OR6, NHC(O)N(R6)2, -CH2NHC(O)R6,CH2NHC(O)N(R6)2, CH2NHSO2(R6), CHNHC(O)OR6, -OC(O)R6, NHC(O)R6, O-arilo, het, u O-het, en donde alquilo, het, cicloalquilo, cicloalcoxilo, N(R6)2, arilo, carbalcoxilo, y alcoxilo pueden estar insustituidos o sustituidos con uno o más de halogeno, -OCH3, -OCF3, -OH, -NH2, alquilo, OR6, oxo, N(H)0-2-R6, -CN, -C(O)N(R6)2, C(O)R6, C(O)OR6, -N(R6)2, NHC(O)R6, -SO2(R6), -SO2N(R6)2, OSO2R6, -CH2N(R6)2, -CH2NHC(O)R6, -OC(O)R6, arilo, NHC(O)-(R6), O-arilo, het, O-het, o cicloalquilo; R6 es H, alquilo,alquenilo, arilo, het, o dos R6 sobre un átomo pueden formar cicloalquilo, arilo, o het; y alquilo, alquenilo, arilo, het, cicloalquilo, o het pueden estar insustituidos o sustituidos por OH, oxo, alcoxilo, NR6, N-alquilo, acilo, arilo o un grupohet; het es un anillo heterocíclico monocíclico de 5 a 7 miembros, el cual puede ser aromático o no aromático, que contiene de 1 a 4 heteroátomos del anillo seleccionados a partir de N, O, y S; o un sistema de anillos fusionados de 8 a 12 miembrosque incluye cuando menos un anillo heterocíclico de 5 a 7 miembros, el cual puede ser aromático o no aromático, que contiene 1, 2, o 3 heteroátomos de anillo seleccionados a partir de N, O y S, cuyo het está insustituido o sustituido; arilo es unradical aromático que tiene de 6 a 14 átomos de carbono del anillo, y ningun heteroátomo del anillo, en donde este grupo arilo puede ser monocíclico o bicíclico o tricíclico fusionado, que puede estar insustituido o sustituido por uno o mássustituyentes; y n es 0, 1, 2, o 3.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US89499107P | 2007-03-15 | 2007-03-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR065718A1 true AR065718A1 (es) | 2009-06-24 |
Family
ID=39472520
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP080101030A AR065718A1 (es) | 2007-03-15 | 2008-03-13 | Compuestos heterociclicos nitrogenados,utiles en el diagnostico y tratamiento de trastornos hiperproliferativos. |
Country Status (33)
Country | Link |
---|---|
US (1) | US8536168B2 (es) |
EP (1) | EP2137162B1 (es) |
JP (1) | JP5550352B2 (es) |
KR (1) | KR101473504B1 (es) |
CN (1) | CN101657430B (es) |
AR (1) | AR065718A1 (es) |
AU (1) | AU2008225766B2 (es) |
BR (1) | BRPI0809193A2 (es) |
CA (1) | CA2681162C (es) |
CL (1) | CL2008000754A1 (es) |
CO (1) | CO6220967A2 (es) |
CR (1) | CR11016A (es) |
CU (1) | CU23769B7 (es) |
DK (1) | DK2137162T3 (es) |
DO (1) | DOP2009000217A (es) |
EA (1) | EA016564B1 (es) |
EC (1) | ECSP099636A (es) |
GE (1) | GEP20125487B (es) |
GT (1) | GT200900244A (es) |
IL (1) | IL200654A (es) |
MA (1) | MA31258B1 (es) |
MX (1) | MX2009009873A (es) |
MY (1) | MY156814A (es) |
NI (1) | NI200900168A (es) |
NZ (1) | NZ579402A (es) |
PE (1) | PE20090188A1 (es) |
SG (1) | SG182205A1 (es) |
SM (1) | SMP200900082B (es) |
TN (1) | TN2009000373A1 (es) |
TW (1) | TWI406857B (es) |
UA (1) | UA100684C2 (es) |
WO (1) | WO2008110611A1 (es) |
ZA (1) | ZA200905949B (es) |
Families Citing this family (84)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI433674B (zh) | 2006-12-28 | 2014-04-11 | Infinity Discovery Inc | 環杷明(cyclopamine)類似物類 |
UA100684C2 (uk) | 2007-03-15 | 2013-01-25 | Новартіс Аг | Похідні бензилу та піридинілу як модулятори сигнального шляху hedgehog |
CN101801954B (zh) | 2007-09-20 | 2013-10-09 | Irm责任有限公司 | 作为gpr119活性调节剂的化合物和组合物 |
WO2009086451A1 (en) | 2007-12-27 | 2009-07-09 | Infinity Pharmaceuticals, Inc. | Methods for stereoselective reduction |
US8193182B2 (en) | 2008-01-04 | 2012-06-05 | Intellikine, Inc. | Substituted isoquinolin-1(2H)-ones, and methods of use thereof |
PE20091556A1 (es) * | 2008-02-26 | 2009-11-03 | Takeda Pharmaceutical | Derivado heterociclico fusionado y su uso |
WO2009134574A2 (en) * | 2008-04-29 | 2009-11-05 | Eli Lilly And Company | Disubstituted phthalazine hedgehog pathway antagonists |
US20100041663A1 (en) * | 2008-07-18 | 2010-02-18 | Novartis Ag | Organic Compounds as Smo Inhibitors |
CN102170873B (zh) * | 2008-10-01 | 2014-07-30 | 诺华股份有限公司 | 用于治疗与hedgehog通路有关的病症的smoothened拮抗 |
NZ591945A (en) * | 2008-11-03 | 2012-10-26 | Lilly Co Eli | Disubstituted phthalazine hedgehog pathway antagonists |
US8445493B2 (en) | 2008-11-17 | 2013-05-21 | Eli Lilly And Company | Tetrasubstituted pyridazines hedgehog pathway antagonists |
DK2358698T3 (da) * | 2008-11-17 | 2012-10-08 | Lilly Co Eli | Tetrasubstitueret pyridazin som hedgehog-pathway antagonister |
AR077014A1 (es) | 2009-06-19 | 2011-07-27 | Lilly Co Eli | Compuesto derivado de ftalazina 1,4-disustituida, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para el tratamiento de cancer |
JP6141015B2 (ja) | 2009-08-05 | 2017-06-07 | インフィニティ ファーマスーティカルズ、インク. | シクロパミン類似体の酵素によるアミノ基転移 |
US20110039850A1 (en) * | 2009-08-12 | 2011-02-17 | Mhairi Copland | Leukemia Treatment |
NZ598588A (en) * | 2009-08-25 | 2014-05-30 | Abraxis Bioscience Llc | Combination therapy with nanoparticle compositions of taxane and hedgehog inhibitors |
CA2781210A1 (en) * | 2009-11-18 | 2011-05-26 | Novartis Ag | Methods and compositions for treating solid tumors and other malignancies |
US8604032B2 (en) | 2010-05-21 | 2013-12-10 | Infinity Pharmaceuticals, Inc. | Chemical compounds, compositions and methods for kinase modulation |
WO2011153359A1 (en) | 2010-06-04 | 2011-12-08 | Albany Molecular Research, Inc. | Glycine transporter-1 inhibitors, methods of making them, and uses thereof |
US9006450B2 (en) | 2010-07-01 | 2015-04-14 | Boehringer Ingelheim International Gmbh | Compounds, pharmaceutical compositions and uses thereof |
WO2012037217A1 (en) | 2010-09-14 | 2012-03-22 | Infinity Pharmaceuticals, Inc. | Transfer hydrogenation of cyclopamine analogs |
EP2637669A4 (en) | 2010-11-10 | 2014-04-02 | Infinity Pharmaceuticals Inc | Heterocyclic compounds and their use |
CA2824197C (en) | 2011-01-10 | 2020-02-25 | Michael Martin | Processes for preparing isoquinolinones and solid forms of isoquinolinones |
US8969363B2 (en) | 2011-07-19 | 2015-03-03 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
CA2842190A1 (en) | 2011-07-19 | 2013-01-24 | Infinity Pharmaceuticals Inc. | Heterocyclic compounds and uses thereof |
RU2014111823A (ru) | 2011-08-29 | 2015-10-10 | Инфинити Фармасьютикалз, Инк. | Гетероциклические соединения и их применения |
US9630979B2 (en) | 2011-09-29 | 2017-04-25 | Infinity Pharmaceuticals, Inc. | Inhibitors of monoacylglycerol lipase and methods of their use |
EP2785690B1 (en) * | 2011-12-02 | 2016-07-13 | Boehringer Ingelheim International GmbH | Piperidine derivatives, pharmaceutical compositions and uses thereof |
EA037918B1 (ru) | 2011-12-21 | 2021-06-07 | Новира Терапьютикс, Инк. | Противовирусные агенты против гепатита в |
US8940742B2 (en) | 2012-04-10 | 2015-01-27 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
SG10201605291WA (en) | 2012-08-28 | 2016-08-30 | Janssen Sciences Ireland Uc | Sulfamoyl-arylamides and the use thereof as medicaments for the treatment of hepatitis b |
PT2914296T (pt) | 2012-11-01 | 2018-10-30 | Infinity Pharmaceuticals Inc | Tratamento de cancros utilizando moduladores de isoformas de pi3-quinase |
CA2893133A1 (en) | 2012-11-29 | 2014-06-05 | Strasspharma Llc | Methods of modulating follicle stimulating hormone activity |
HUE034820T2 (en) | 2013-02-28 | 2018-02-28 | Janssen Sciences Ireland Uc | Sulphamoyl arylamides and their use as medicaments for the treatment of hepatitis B |
NZ629037A (en) | 2013-03-15 | 2017-04-28 | Infinity Pharmaceuticals Inc | Salts and solid forms of isoquinolinones and composition comprising and methods of using the same |
BR112015025052A2 (pt) | 2013-04-03 | 2021-07-06 | Janssen Sciences Ireland Uc | derivados de n-fenil-carboxamida e o seu uso como medicamentos para o tratamento da hepatite b |
US9192609B2 (en) | 2013-04-17 | 2015-11-24 | Hedgepath Pharmaceuticals, Inc. | Treatment and prognostic monitoring of proliferation disorders using hedgehog pathway inhibitors |
PL2997019T3 (pl) | 2013-05-17 | 2019-03-29 | Janssen Sciences Ireland Uc | Pochodne sulfamoilotiofenamidu i ich zastosowanie jako leków do leczenia wirusowego zapalenia wątroby typu B |
JO3603B1 (ar) | 2013-05-17 | 2020-07-05 | Janssen Sciences Ireland Uc | مشتقات سلفامويل بيرولاميد واستخدامها كادوية لمعالجة التهاب الكبد نوع بي |
KR20160013204A (ko) | 2013-05-30 | 2016-02-03 | 인피니티 파마슈티칼스, 인코포레이티드 | Pi3 키나아제 동형단백질 조절제를 사용하는 암의 치료 |
AP2015008968A0 (en) | 2013-07-25 | 2015-12-31 | Janssen Sciences Ireland Uc | Glyoxamide substituted pyrrolamide derivatives andthe use thereof as medicaments for the treatment of hepatitis b |
BR112016007467B1 (pt) | 2013-10-04 | 2022-09-20 | Infinity Pharmaceuticals, Inc | Compostos heterocíclicos e usos dos mesmos |
US9751888B2 (en) | 2013-10-04 | 2017-09-05 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
US20160244452A1 (en) | 2013-10-21 | 2016-08-25 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
EP3060547B1 (en) | 2013-10-23 | 2017-10-11 | Janssen Sciences Ireland UC | Carboxamide derivatives and the use thereof as medicaments for the treatment of hepatitis b |
US10392349B2 (en) | 2014-01-16 | 2019-08-27 | Novira Therapeutics, Inc. | Azepane derivatives and methods of treating hepatitis B infections |
US9169212B2 (en) | 2014-01-16 | 2015-10-27 | Novira Therapeutics, Inc. | Azepane derivatives and methods of treating hepatitis B infections |
JO3517B1 (ar) | 2014-01-17 | 2020-07-05 | Novartis Ag | ان-ازاسبيرو الكان حلقي كبديل مركبات اريل-ان مغايرة وتركيبات لتثبيط نشاط shp2 |
WO2015107493A1 (en) * | 2014-01-17 | 2015-07-23 | Novartis Ag | 1 -pyridazin-/triazin-3-yl-piper(-azine)/idine/pyrolidine derivatives and and compositions thereof for inhibiting the activity of shp2 |
US9815813B2 (en) | 2014-01-17 | 2017-11-14 | Novartis Ag | 1-(triazin-3-yl/pyridazin-3-yl)-piper(-azine)idine derivatives and compositions therefor for inhibiting the activity of SHP2 |
ES2792848T3 (es) | 2014-02-05 | 2020-11-12 | Novira Therapeutics Inc | Politerapia para el tratamiento de infecciones por VHB |
EA035848B1 (ru) | 2014-02-06 | 2020-08-20 | Янссен Сайенсиз Айрлэнд Юси | Производные сульфамоилпирроламида и их применение в качестве медикаментов для лечения гепатита b |
CN113620958A (zh) | 2014-03-19 | 2021-11-09 | 无限药品股份有限公司 | 用于治疗PI3K-γ介导的障碍的杂环化合物 |
WO2015160986A2 (en) | 2014-04-16 | 2015-10-22 | Infinity Pharmaceuticals, Inc. | Combination therapies |
WO2015168079A1 (en) | 2014-04-29 | 2015-11-05 | Infinity Pharmaceuticals, Inc. | Pyrimidine or pyridine derivatives useful as pi3k inhibitors |
US9708348B2 (en) | 2014-10-03 | 2017-07-18 | Infinity Pharmaceuticals, Inc. | Trisubstituted bicyclic heterocyclic compounds with kinase activities and uses thereof |
CN105985319B (zh) * | 2015-02-11 | 2019-02-26 | 复旦大学 | 芳基酞嗪化合物及其制备方法和用途 |
CN105985321B (zh) * | 2015-02-11 | 2018-10-26 | 复旦大学 | 吡唑酞嗪化合物及其制备方法和用途 |
CN105985320B (zh) * | 2015-02-11 | 2018-10-26 | 复旦大学 | 苄基酞嗪化合物及其制备方法和用途 |
EP3271019A1 (en) | 2015-03-19 | 2018-01-24 | Novira Therapeutics Inc. | Azocane and azonane derivatives and methods of treating hepatitis b infections |
JP6796638B2 (ja) | 2015-06-04 | 2020-12-09 | ペレファーム, インク.Pellepharm, Inc. | ヘッジホッグ阻害性化合物の送達のための局所的製剤及びその使用 |
WO2016203405A1 (en) | 2015-06-19 | 2016-12-22 | Novartis Ag | Compounds and compositions for inhibiting the activity of shp2 |
CN107922388B (zh) | 2015-06-19 | 2020-12-29 | 诺华股份有限公司 | 用于抑制shp2活性的化合物和组合物 |
ES2741746T3 (es) | 2015-06-19 | 2020-02-12 | Novartis Ag | Compuestos y composiciones para inhibir la actividad de SHP2 |
US10875876B2 (en) | 2015-07-02 | 2020-12-29 | Janssen Sciences Ireland Uc | Cyclized sulfamoylarylamide derivatives and the use thereof as medicaments for the treatment of hepatitis B |
WO2017059059A1 (en) | 2015-09-29 | 2017-04-06 | Novira Therapeutics, Inc. | Crystalline forms of a hepatitis b antiviral agent |
US20170231968A1 (en) | 2016-02-11 | 2017-08-17 | PellePharm, Inc. | Method for relief of and treatment of pruritus |
US10195283B2 (en) * | 2016-03-18 | 2019-02-05 | R.P. Scherer Technologies, Llc | Hydrazinyl-substituted heteroaryl compounds and methods for producing a conjugate |
SG11201808949SA (en) | 2016-04-15 | 2018-11-29 | Novira Therapeutics Inc | Combinations and methods comprising a capsid assembly inhibitor |
WO2017214269A1 (en) | 2016-06-08 | 2017-12-14 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
PT3468972T (pt) | 2016-06-14 | 2020-08-21 | Novartis Ag | Compostos e composições para inibir a atividade da shp2 |
US11147818B2 (en) | 2016-06-24 | 2021-10-19 | Infinity Pharmaceuticals, Inc. | Combination therapies |
KR20200095467A (ko) | 2017-10-27 | 2020-08-10 | 베링거 인겔하임 인터내셔날 게엠베하 | 피리딘 카보닐 유도체 및 trpc6 억제제로서 이의 치료학적 용도 |
DE102018105524A1 (de) * | 2018-03-09 | 2019-09-12 | Universität Duisburg-Essen | Verwendung von Modulatoren der Sphingosin-1-phosphat-Signaltransduktion |
US10973801B2 (en) | 2018-03-14 | 2021-04-13 | Janssen Sciences Ireland Unlimited Company | Capsid assembly modulator dosing regimen |
WO2020007807A1 (en) * | 2018-07-02 | 2020-01-09 | Ecole Polytechnique Federale De Lausanne (Epfl) | Lactate enhancing compounds and uses thereof |
CN108997224B (zh) * | 2018-08-28 | 2023-04-28 | 韶远科技(上海)有限公司 | 一种2-氯-5-氰基含氮六元杂环化合物的制备方法 |
CA3121202A1 (en) | 2018-11-30 | 2020-06-04 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
TW202045499A (zh) | 2019-02-22 | 2020-12-16 | 愛爾蘭商健生科學愛爾蘭無限公司 | 用於治療hbv感染或hbv誘發疾病之醯胺衍生物 |
CA3132554A1 (en) | 2019-05-06 | 2020-11-12 | Bart Rudolf Romanie Kesteleyn | Amide derivatives useful in the treatment of hbv infection or hbv-induced diseases |
CN110845426A (zh) * | 2019-11-29 | 2020-02-28 | 都创(上海)医药科技有限公司 | 一种2-氯-5-氰基嘧啶化合物制备方法 |
KR102394110B1 (ko) * | 2020-01-22 | 2022-05-04 | 가톨릭대학교 산학협력단 | 신규 화합물 및 이의 용도 |
EP4074317A1 (en) | 2021-04-14 | 2022-10-19 | Bayer AG | Phosphorus derivatives as novel sos1 inhibitors |
CN116199625A (zh) * | 2023-01-19 | 2023-06-02 | 上海昱菘医药科技有限公司 | 一种烟酸酯类化合物的制备方法 |
Family Cites Families (77)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1293565A (en) * | 1969-05-03 | 1972-10-18 | Aspro Nicholas Ltd | Aminophthalazines and pharmaceutical compositions thereof |
US3668207A (en) * | 1970-01-22 | 1972-06-06 | Ciba Geigy Corp | 2-amino-4-aryl-quinolines |
DE2643753A1 (de) * | 1976-09-29 | 1978-04-06 | Thomae Gmbh Dr K | Neue 1h-pyrazolo eckige klammer auf 3,4-b eckige klammer zu pyridine |
FR2421900A1 (fr) * | 1977-03-17 | 1979-11-02 | Sauba Lab | Piperazino-3-indoles, leur procede de preparation et leurs applications therapeutiques |
FI70411C (fi) | 1980-12-29 | 1986-09-19 | Pfizer | Foerfarande foer framstaellning av nya antihypertensiva 4-amino-6,7-dimetoxi-2-piperazinokinazolin derivat |
MA20387A1 (fr) * | 1984-03-26 | 1985-10-01 | Janssen Pharmaceutica Nv | Pyridazinamines utiles comme agents anti-viraux et procede pour leur preparation |
EP0157037A3 (en) | 1984-03-29 | 1986-11-05 | Bowmar Instrument Corporation | Long-stroke push-button switch |
US4569934A (en) | 1984-10-09 | 1986-02-11 | American Cyanamid Company | Imidazo[1,2-b]pyridazines |
CA1307786C (en) | 1984-12-14 | 1992-09-22 | Keiichi Yokoyama | Quinazoline derivatives and antihypertensive preparations containing same as effective components |
US4760064A (en) * | 1984-12-18 | 1988-07-26 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril compounds, compositions containing same and processes for preparing same |
JP2544939B2 (ja) | 1987-09-01 | 1996-10-16 | 大塚製薬株式会社 | ベンゾヘテロ環誘導体 |
JPH02193992A (ja) * | 1989-01-23 | 1990-07-31 | Kyowa Hakko Kogyo Co Ltd | キナゾリン誘導体 |
JPH03106875A (ja) * | 1989-09-20 | 1991-05-07 | Morishita Pharmaceut Co Ltd | 1―(3―ピリジルメチル)フタラジン誘導体 |
AU705229B2 (en) | 1994-08-09 | 1999-05-20 | Eisai R&D Management Co., Ltd. | Fused pyridazine compound |
JP3919835B2 (ja) * | 1994-08-09 | 2007-05-30 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 縮合ピリダジン系化合物 |
US5889006A (en) | 1995-02-23 | 1999-03-30 | Schering Corporation | Muscarinic antagonists |
US5859012A (en) | 1996-04-03 | 1999-01-12 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
US5935958A (en) * | 1996-07-01 | 1999-08-10 | Schering Corporation | Muscarinic antagonists |
TR200003004T2 (tr) | 1998-04-20 | 2001-02-21 | Basf Aktiengesellschaft | Kalpain önleyicileri olarak heterosiklik ikame edilmiş amidler |
KR20010053254A (ko) | 1998-06-30 | 2001-06-25 | 둘락 노먼 씨. | 무스카린성 길항제 |
US6066636A (en) | 1998-06-30 | 2000-05-23 | Schering Corporation | Muscarinic antagonists |
EP1146871A4 (en) | 1999-01-28 | 2002-04-17 | Bristol Myers Squibb Co | HETEROCYCLIC ANTIDEPRESSANT COMPOUNDS |
JP2000281660A (ja) | 1999-03-29 | 2000-10-10 | Sumitomo Pharmaceut Co Ltd | キナゾリン誘導体 |
AU766081B2 (en) * | 1999-03-30 | 2003-10-09 | Novartis Ag | Phthalazine derivatives for treating inflammatory diseases |
IL145741A0 (en) | 1999-05-04 | 2002-07-25 | Schering Corp | Piperazine derivatives useful as ccrs antagonists |
ES2165274B1 (es) | 1999-06-04 | 2003-04-01 | Almirall Prodesfarma Sa | Nuevos derivados de indolilpiperidina como agentes antihistaminicos y antialergicos. |
JP2003501395A (ja) | 1999-06-08 | 2003-01-14 | ローランティス・リミテッド | 治療的使用 |
FR2803593B1 (fr) * | 2000-01-06 | 2002-02-15 | Sanofi Synthelabo | Nouvelles tetrahydropyridines, procede pour leur preparation et compositions pharmaceutiques les contenant |
CA2407573C (en) | 2000-04-27 | 2011-09-13 | Yamanouchi Pharmaceutical Co. Ltd. | Imidazopyridine derivatives |
DE10043659A1 (de) | 2000-09-05 | 2002-03-14 | Merck Patent Gmbh | Arylpiperazinderivate |
ES2172436B1 (es) * | 2000-10-31 | 2004-01-16 | Almirall Prodesfarma Sa | Derivados de indolilpiperidina como agentes antihistaminicos y antialergicos. |
EP1353674A1 (en) | 2000-12-29 | 2003-10-22 | Alteon, Inc. | Method for treating glaucoma ivb |
SE0103754L (sv) | 2001-04-05 | 2002-10-06 | Forskarpatent I Syd Ab | Peptider från apolipoprotein B, användning därav immunisering, diagnosmetod eller terapeutisk behandling av ischemiska kardiovaskulära sjukdomar, samt farmaceutisk komposition och vaccin innehållande sådan peptid |
WO2002080952A2 (en) | 2001-04-09 | 2002-10-17 | Lorantis Limited | Therapeutic use and identification of modulators of a hedgehog signalling pathway or one of its target pathways |
JP4929547B2 (ja) | 2001-09-03 | 2012-05-09 | コニカミノルタホールディングス株式会社 | アゾメチン化合物、アゾメチン化合物と金属イオン含有化合物との混合物、感熱転写記録材料、カラートナー |
ATE369854T1 (de) | 2001-10-19 | 2007-09-15 | Ortho Mcneil Pharm Inc | 2-phenyl benzimidazole und imidazo-[4,5]-pyridine als cds1/chk2-inhibitoren und adjuvantien in der chemotherapie oder strahlungstherapie zur behandlung von krebs |
PT1956004E (pt) * | 2002-03-27 | 2012-08-31 | Glaxo Group Ltd | Derivados de quinolina e sua utilização como ligandos 5-ht6 |
US20060290712A1 (en) | 2002-10-16 | 2006-12-28 | Electronics And Telecommunications Research Institute | Method and system for transforming adaptively visual contents according to user's symptom characteristics of low vision impairment and user's presentation preferences |
PL378295A1 (pl) | 2003-02-24 | 2006-03-20 | Arena Pharmaceuticals, Inc. | Podstawione pochodne arylowe i heteroarylowe jako modulatory metabolizmu glukozy oraz profilaktyka i leczenie zaburzeń tego metabolizmu |
EP2316826A1 (en) * | 2003-07-30 | 2011-05-04 | Xenon Pharmaceuticals Inc. | Pyridazine derivatives and their use as therapeutics agents |
DE10337184A1 (de) | 2003-08-13 | 2005-03-10 | Gruenenthal Gmbh | Substituierte 3-Pyrrolidin-Indol-Derivate |
WO2005020897A2 (en) | 2003-08-22 | 2005-03-10 | Dendreon Corporation | Compositions and methods for the treatment of disease associated with trp-p8 expression |
US8067608B2 (en) | 2003-09-29 | 2011-11-29 | The Johns Hopkins University | Hedgehog pathway antagonists |
WO2005117909A2 (en) * | 2004-04-23 | 2005-12-15 | Exelixis, Inc. | Kinase modulators and methods of use |
JP5143558B2 (ja) * | 2004-09-02 | 2013-02-13 | ジェネンテック,インコーポレイティド | ヘッジホッグシグナル伝達のピリジルインヒビター |
GB0422263D0 (en) * | 2004-10-07 | 2004-11-10 | Glaxo Group Ltd | Novel compounds |
US7759337B2 (en) | 2005-03-03 | 2010-07-20 | Amgen Inc. | Phthalazine compounds and methods of use |
DE102005023943A1 (de) | 2005-05-20 | 2006-11-23 | Grünenthal GmbH | Pentafluorsulfanyl-substituierte Verbindung und deren Verwendung zur Herstellung von Arzneimitteln |
NZ564222A (en) | 2005-06-14 | 2011-10-28 | Taigen Biotechnology Co Ltd | Pyrimidine compounds |
US8364148B2 (en) | 2005-07-07 | 2013-01-29 | Qualcomm Incorporated | Methods and devices for interworking of wireless wide area networks and wireless local area networks or wireless personal area networks |
WO2007059157A1 (en) | 2005-11-14 | 2007-05-24 | Genentech, Inc. | Bisamide inhibitors of hedgehog signaling |
NZ568666A (en) * | 2005-11-30 | 2011-09-30 | Vertex Pharma | [1,2,4]Triazolo[3,4-b][1,3,4]thiadiazole derivative as inhibitors of c-Met |
GB0602335D0 (en) * | 2006-02-07 | 2006-03-15 | Remynd Nv | Thiadiazole Derivatives For The Treatment Of Neurodegenerative Diseases |
AR059898A1 (es) * | 2006-03-15 | 2008-05-07 | Janssen Pharmaceutica Nv | Derivados de 3-ciano-piridona 1,4-disustituida y su uso como moduladores alostericos de los receptores mglur2 |
WO2007109238A1 (en) * | 2006-03-21 | 2007-09-27 | Schering Corporation | Heterocyclic substituted pyridine compounds with cxcr3 antagonist activity |
WO2007127475A2 (en) | 2006-04-28 | 2007-11-08 | Northwestern University | Pyridazines for demyelinating diseases and neuropathic pain |
EP1849781A1 (en) * | 2006-04-28 | 2007-10-31 | Laboratorios del Dr. Esteve S.A. | Substituted 3-Amino-4-hydroxy pyrrolidines compounds, their preparation and use as medicaments |
AU2007243280A1 (en) | 2006-04-28 | 2007-11-08 | Northwestern University | Formulations containing pyridazine compounds for treating neuroinflammatory diseases |
EP2015751A2 (en) | 2006-04-28 | 2009-01-21 | Northwestern University | Salts of pyridazine compounds |
KR20090043512A (ko) | 2006-07-14 | 2009-05-06 | 쉐링 코포레이션 | Cxcr3 길항제 활성을 갖는 헤테로사이클릭 치환된 피페라진 화합물 |
GB0623258D0 (en) * | 2006-11-22 | 2007-01-03 | Remynd Nv | Thiadiazole derivatives for the treatment of neuro-degenerative diseases |
BRPI0720789A2 (pt) | 2006-12-14 | 2014-03-11 | Syngenta Participations Ag | Herbicidas |
JP2010513520A (ja) | 2006-12-22 | 2010-04-30 | シェーリング コーポレイション | Cxcr3アンタゴニスト活性を有する複素環式化合物 |
TW200900391A (en) | 2007-03-07 | 2009-01-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-phenyl-piperidin-1-yl)-pyridin-2-one derivatives |
TW200900065A (en) | 2007-03-07 | 2009-01-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives |
TW200845978A (en) | 2007-03-07 | 2008-12-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives |
CA2680583A1 (en) | 2007-03-15 | 2008-09-25 | Schering Corporation | Pyridazinone derivatives useful as glucan synthase inhibitors |
EP2121579B1 (en) | 2007-03-15 | 2011-04-20 | F. Hoffmann-La Roche AG | Malonamides as orexin antagonists |
UA100684C2 (uk) | 2007-03-15 | 2013-01-25 | Новартіс Аг | Похідні бензилу та піридинілу як модулятори сигнального шляху hedgehog |
WO2009035568A1 (en) | 2007-09-07 | 2009-03-19 | Amgen Inc. | Annelated pyridazines for the treatment of tumors driven by inappropriate hedgehog signalling |
GB0808888D0 (en) * | 2008-05-15 | 2008-06-25 | Syngenta Participations Ag | Insecticidal compounds |
AU2009266001B2 (en) * | 2008-07-03 | 2014-03-27 | Janssen Pharmaceutica Nv | Substituted 6- (1-piperazinyl) -pyridazines as 5-HT6 receptor antagonists |
WO2010006096A1 (en) * | 2008-07-11 | 2010-01-14 | Smithkline Beecham Corporation | Processes for the preparation of anti-viral compounds and compositions containing them |
US20110301162A1 (en) * | 2008-08-04 | 2011-12-08 | Amgen Inc. | Aurora kinase modulators and methods of use |
NZ591945A (en) * | 2008-11-03 | 2012-10-26 | Lilly Co Eli | Disubstituted phthalazine hedgehog pathway antagonists |
FR2939134A1 (fr) | 2008-12-01 | 2010-06-04 | Sanofi Aventis | Derives de 6-cycloamino-3-(1h-pyrrolo°2,3-b!pyridin-4-yl) imidazo°1,2-b!-pyridazine, leur preparation et leur application en therapeutique |
TWI520989B (zh) * | 2015-03-02 | 2016-02-11 | 國立交通大學 | 製備高分子球的方法 |
-
2008
- 2008-03-13 UA UAA200909484A patent/UA100684C2/uk unknown
- 2008-03-13 CA CA2681162A patent/CA2681162C/en not_active Expired - Fee Related
- 2008-03-13 PE PE2008000477A patent/PE20090188A1/es not_active Application Discontinuation
- 2008-03-13 MX MX2009009873A patent/MX2009009873A/es active IP Right Grant
- 2008-03-13 JP JP2009553152A patent/JP5550352B2/ja not_active Expired - Fee Related
- 2008-03-13 US US12/531,341 patent/US8536168B2/en active Active
- 2008-03-13 EA EA200901170A patent/EA016564B1/ru not_active IP Right Cessation
- 2008-03-13 MY MYPI20093757A patent/MY156814A/en unknown
- 2008-03-13 AU AU2008225766A patent/AU2008225766B2/en not_active Ceased
- 2008-03-13 CN CN2008800121920A patent/CN101657430B/zh not_active Expired - Fee Related
- 2008-03-13 NZ NZ579402A patent/NZ579402A/en not_active IP Right Cessation
- 2008-03-13 EP EP08717784.6A patent/EP2137162B1/en active Active
- 2008-03-13 GE GEAP200811474A patent/GEP20125487B/en unknown
- 2008-03-13 AR ARP080101030A patent/AR065718A1/es unknown
- 2008-03-13 KR KR1020097021399A patent/KR101473504B1/ko active IP Right Grant
- 2008-03-13 SG SG2012044004A patent/SG182205A1/en unknown
- 2008-03-13 DK DK08717784.6T patent/DK2137162T3/en active
- 2008-03-13 WO PCT/EP2008/053040 patent/WO2008110611A1/en active Application Filing
- 2008-03-13 BR BRPI0809193-5A patent/BRPI0809193A2/pt active Search and Examination
- 2008-03-14 CL CL200800754A patent/CL2008000754A1/es unknown
- 2008-03-14 TW TW097109177A patent/TWI406857B/zh not_active IP Right Cessation
-
2009
- 2009-08-27 ZA ZA200905949A patent/ZA200905949B/xx unknown
- 2009-08-31 IL IL200654A patent/IL200654A/en not_active IP Right Cessation
- 2009-09-08 CR CR11016A patent/CR11016A/es unknown
- 2009-09-11 NI NI200900168A patent/NI200900168A/es unknown
- 2009-09-11 TN TNP2009000373A patent/TN2009000373A1/fr unknown
- 2009-09-14 DO DO2009000217A patent/DOP2009000217A/es unknown
- 2009-09-14 CO CO09098892A patent/CO6220967A2/es active IP Right Grant
- 2009-09-14 GT GT200900244A patent/GT200900244A/es unknown
- 2009-09-15 EC EC2009009636A patent/ECSP099636A/es unknown
- 2009-09-15 CU CU20090159A patent/CU23769B7/es active IP Right Grant
- 2009-09-24 MA MA32227A patent/MA31258B1/fr unknown
- 2009-10-15 SM SM200900082T patent/SMP200900082B/it unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AR065718A1 (es) | Compuestos heterociclicos nitrogenados,utiles en el diagnostico y tratamiento de trastornos hiperproliferativos. | |
AR077147A1 (es) | Compuestos biciclicos y triciclicos como inhibidores de kat ii | |
AR058984A1 (es) | Derivados de ciclohexil piperazinil metanona | |
AR069849A1 (es) | Derivados de heteroarilo como antagonistas de receptor de orexina | |
AR050953A1 (es) | Compuestos de sulfonamida inhibidores de los receptores de cck1/cck2 duales | |
AR065322A1 (es) | 2-aminooxazolinas comoligandos de taar1 | |
AR060807A1 (es) | Derivados de arilaminopiridina heteroaril - susutituidos como inhibidores de mek | |
ES2655391T3 (es) | Inhibidores isoindolinona de fosfatidilinositol 3-quinasa | |
CO6140056A2 (es) | Compuestos amino -5-4(difluorometoxi)fenil sustituido-5-fenilimidazolona como inhibidores de beta -secretasa | |
AR048789A1 (es) | Derivados de oxazol y sus composiciones como moduladores de receptor activado de proliferador de peroxisoma (ppar) | |
PE20080841A1 (es) | Derivados de quinazolinona e isoquinolinona y su uso para el tratamiento o prevencion de trastornos relacionados con el estres o la depresion | |
AR067413A1 (es) | Compuestos heterociclicos que contienen ciclopenta[d]pirimidina inhibidores de proteinquinasas akt, composiciones farmaceuticas que los contienen, metodo de preparacion y uso de las mismas para el tratamiento de enfermedades hiperproliferativas, tales como cancer | |
AR073406A1 (es) | Aminodihidrotiazinas fusionadas con tetrahidropiranos,inhibidoras de bace1 y de la produccion de abeta amiloide, composiciones farmaceuticas que las contienen y usos de las mismas para el tratamiento de enfermedades neurodegenerativas,tales como alzheimer. | |
AR084457A1 (es) | Derivados de biciclo[3,2,1]octilamida | |
AR081075A1 (es) | Derivados de imidazo[1,2-c]pirimidina, composiciones farmaceuticas que los contienen, metodo para prepararlos y uso de los mismos en el tratamiento de enfermedades autoinmunes e inflamatorias. | |
AR076098A1 (es) | Derivados de benzofurano | |
CO6160296A2 (es) | Derivados de acido benzoazepin-oxi-acetico como agonistas de receptores activados por proliferador de peroxisona delta usados para incrementar la lipoproteina de alta densidad-colesterol-colesterol reducir la lipoproteina de baja densidad-colesterol | |
AR076008A1 (es) | Derivados de hidroximetil-isoxazol moduladores de receptores gaba a, composiciones farmaceuticas que los contienen, metodo para prepararlos y uso de los mismos para el tratamiento del alzheimer y otros trastornos cognitivos. | |
AR040626A1 (es) | Derivados de quinolina utiles como ligandos del receptor del neuropeptido y (npy) | |
AR070274A1 (es) | Derivados arilamida diazepinopirimidona sustituidos utiles en el tratamiento y/o prevencion de enfermedades neurodegenerativas y otras, provocadas por la actividad anormal de quinasas gsk3beta, medicamentos que los contienen y proceso de preparacion e intermediarios. | |
PE20120900A1 (es) | Compuestos heterociclicos de fenoximetilo | |
AR049954A1 (es) | Derivados de azepina sustituidos como moduladores de los receptores de la serotonina | |
AR066421A1 (es) | Compuestos derivados de piridona | |
AR046603A1 (es) | Alcanaminas dihidrobenzofuranilo y metodos para su uso como farmacos en el snc | |
AR070635A1 (es) | DERIVADOS DE PIRIDOPIRAZINONA QUE ESTIMULAN LA SECRECIoN DE INSULINA, MÉTODOS PARA OBTENERLOS, SU USO EN EL TRATAMIENTO DE LA DIABETES Y COMPOSICIONES FARMACEUTICAS. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FB | Suspension of granting procedure |