ES2165274B1 - Nuevos derivados de indolilpiperidina como agentes antihistaminicos y antialergicos. - Google Patents
Nuevos derivados de indolilpiperidina como agentes antihistaminicos y antialergicos.Info
- Publication number
- ES2165274B1 ES2165274B1 ES009901232A ES9901232A ES2165274B1 ES 2165274 B1 ES2165274 B1 ES 2165274B1 ES 009901232 A ES009901232 A ES 009901232A ES 9901232 A ES9901232 A ES 9901232A ES 2165274 B1 ES2165274 B1 ES 2165274B1
- Authority
- ES
- Spain
- Prior art keywords
- group
- sup
- alkoxy
- alkyl
- alkylene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/04—Drugs for disorders of the respiratory system for throat disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Abstract
Nuevos derivados de indolilpiperidina como agentes antihistamínicos y antialérgicos de fórmula (1) **FORMULA**en donde A{sup,1} representa un grupo alquileno, alquilenoxi, alquilentio, alquilenamino, alcanoilo o hidroxialquileno; A{sup,2} representa un enlace sencillo, un grupo alquileno o alquenileno; W representa un enlace sencillo, o un grupo fenileno o furanileno opcionalmente sustituido por uno o más átomos de halógeno, o grupos alcoxi o alquilo; R{sup,1} representa un átomo de hidrógeno o un grupo alquilo, alcoxialquilo, alcoxi-alcoxialquilo o fenilalquilo donde el anillo fenilo está opcionalmente sustituido por uno o más átomos de halógeno o grupos alquilo o alcoxi; R{sup,2} representa un átomo de hidrógeno o halógeno, o un grupo alquilo, alcoxi, amino, aminoalquilo, tioalquilo o alcanoilo; y R{sup,3} representa un grupo carboxilo o un grupo tetrazol;
Priority Applications (36)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES009901232A ES2165274B1 (es) | 1999-06-04 | 1999-06-04 | Nuevos derivados de indolilpiperidina como agentes antihistaminicos y antialergicos. |
EP00940296A EP1183251B1 (en) | 1999-06-04 | 2000-05-31 | Indolylpiperidine derivatives as antihistaminic and antiallergic agents |
DE2000608239 DE60008239T2 (de) | 1999-06-04 | 2000-05-31 | Indolylpiperidinderivate als antihistaminische und antiallergische mittel |
AT00940296T ATE259362T1 (de) | 1999-06-04 | 2000-05-31 | Indolylpiperidinderivate als antihistaminische und antiallergische mittel |
CNB008112819A CN1191246C (zh) | 1999-06-04 | 2000-05-31 | 作为抗组胺剂和抗过敏剂的吲哚基哌啶衍生物 |
JP2001502413A JP2003501424A (ja) | 1999-06-04 | 2000-05-31 | 抗ヒスタミンおよび抗アレルギー剤としてのインドリルピペリジン誘導体 |
MXPA01012425A MXPA01012425A (es) | 1999-06-04 | 2000-05-31 | Derivados de indolilpiperidina como agentes antihistaminicos y antialergicos. |
CA002375985A CA2375985A1 (en) | 1999-06-04 | 2000-05-31 | Indolylpiperidine derivatives as antihistaminic and antiallergic agents |
DK00940296T DK1183251T3 (da) | 1999-06-04 | 2000-05-31 | Indolylpiperidinderivater som antihistamin- og antiallergimidler |
SK1704-2001A SK17042001A3 (sk) | 1999-06-04 | 2000-05-31 | Derivát indolylpiperidínu ako antihistaminické a antialergické činidlo |
HU0203320A HUP0203320A3 (en) | 1999-06-04 | 2000-05-31 | Indolylpiperidine derivatives and their use as antihistaminic and antiallergic agents, process for their preparation, pharmaceutical compositions containing them |
PE2000000524A PE20010208A1 (es) | 1999-06-04 | 2000-05-31 | Derivados de indolilpiperidina como agentes antihistaminicos y antialergicos |
IL14662900A IL146629A0 (en) | 1999-06-04 | 2000-05-31 | Indolylpiperidine derivatives as antihistaminic and antiallergic agents |
AU55276/00A AU773164B2 (en) | 1999-06-04 | 2000-05-31 | Indolylpiperidine derivatives as antihistaminic and antiallergic agents |
TR2001/03490T TR200103490T2 (tr) | 1999-06-04 | 2000-05-31 | Antihistaminik ve antialerjik maddeler olarak indolilpiperidin türevleri |
PL353164A PL196774B1 (pl) | 1999-06-04 | 2000-05-31 | Pochodne indolilopiperydyny jako środki przeciwhistaminowe i przeciwalergiczne |
PCT/EP2000/005010 WO2000075130A1 (en) | 1999-06-04 | 2000-05-31 | Indolylpiperidine derivatives as antihistaminic and antiallergic agents |
ES00940296T ES2211559T3 (es) | 1999-06-04 | 2000-05-31 | Derivados de indolilpiperidina como agentes anhistaminicos y antialergicos. |
EEP200100653A EE04717B1 (et) | 1999-06-04 | 2000-05-31 | Indolüülpiperidiinühendid, nende valmistamismeetod, kompositsioon ja nende kasutamine |
KR1020017015570A KR100683454B1 (ko) | 1999-06-04 | 2000-05-31 | 항히스타민제 그리고 항알레르기제로서의 인돌일피페리딘유도체 |
SI200030323T SI1183251T1 (en) | 1999-06-04 | 2000-05-31 | Indolylpiperidine derivatives as antihistaminic and antiallergic agents |
CZ20014334A CZ20014334A3 (cs) | 1999-06-04 | 2000-05-31 | Derivát indolylpiperidinu jako antihistaminické a antialergické činidlo |
UA2001118222A UA72517C2 (uk) | 1999-06-04 | 2000-05-31 | Похідні індолілпіперидину як антигістамінні та антиалергенні агенти |
RU2002100073/04A RU2246493C2 (ru) | 1999-06-04 | 2000-05-31 | Производные индолилпиперидина в качестве антигистаминных и противоаллергических средств |
NZ515649A NZ515649A (en) | 1999-06-04 | 2000-05-31 | Indolylpiperidine derivatives as antihistaminic and antiallergic agents |
MYPI20002439A MY127033A (en) | 1999-06-04 | 2000-05-31 | Indolylpiperidine derivatives as antihistaminic and antiallergic agents. |
PT00940296T PT1183251E (pt) | 1999-06-04 | 2000-05-31 | Derivados de indolilpiperidina como agentes anti-histaminicos e anti-alergicos |
BR0011340-9A BR0011340A (pt) | 1999-06-04 | 2000-05-31 | Composto, processo para preparar o composto, composição, uso de um composto, e, método de tratar doenças alérgicas incluindo a asma brÈnquica, rinite, conjuntivite, dematose e urticária |
TW089110816A TWI226889B (en) | 1999-06-04 | 2000-06-02 | Indolylpiperidine derivatives as antihistaminic and antiallergic agents |
ARP000102755A AR029640A1 (es) | 1999-06-04 | 2000-06-02 | Derivados de indolilpiperidinas que poseen actividad antihistaminica y antialergica, procesos para preparar dichos derivados y compuestos intermediarios utilizables en dicho proceso, composiciones formuladas con dichos derivados y uso de los derivados mencionados para el tratamiento del cuerpo human |
CO00041546A CO5180556A1 (es) | 1999-06-04 | 2000-06-02 | Derivados de la indolilpiperidina como agentes antihistaminicos y antialergicos |
ZA200109676A ZA200109676B (en) | 1999-06-04 | 2001-11-23 | Indolylpiperidine derivatives as antihistaminic and anti-allergic agents. |
NO20015897A NO20015897D0 (no) | 1999-06-04 | 2001-12-03 | Indolylpiperidinderivater som antihistaminiske og antiallergiske midler |
BG106168A BG106168A (bg) | 1999-06-04 | 2001-12-03 | Индолилпиперидинови производни като антихистаминови и антиалергични средства |
US10/006,416 US6683096B2 (en) | 1999-06-04 | 2001-12-04 | Indolylpiperidine derivatives as antihistaminic and antiallergic agents |
HK02102119.0A HK1040990A1 (zh) | 1999-06-04 | 2002-03-20 | 作為抗組胺劑和抗過敏劑的吲基哌啶衍生物 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES009901232A ES2165274B1 (es) | 1999-06-04 | 1999-06-04 | Nuevos derivados de indolilpiperidina como agentes antihistaminicos y antialergicos. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2165274A1 ES2165274A1 (es) | 2002-03-01 |
ES2165274B1 true ES2165274B1 (es) | 2003-04-01 |
Family
ID=8308707
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES009901232A Expired - Fee Related ES2165274B1 (es) | 1999-06-04 | 1999-06-04 | Nuevos derivados de indolilpiperidina como agentes antihistaminicos y antialergicos. |
ES00940296T Expired - Lifetime ES2211559T3 (es) | 1999-06-04 | 2000-05-31 | Derivados de indolilpiperidina como agentes anhistaminicos y antialergicos. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES00940296T Expired - Lifetime ES2211559T3 (es) | 1999-06-04 | 2000-05-31 | Derivados de indolilpiperidina como agentes anhistaminicos y antialergicos. |
Country Status (35)
Country | Link |
---|---|
US (1) | US6683096B2 (es) |
EP (1) | EP1183251B1 (es) |
JP (1) | JP2003501424A (es) |
KR (1) | KR100683454B1 (es) |
CN (1) | CN1191246C (es) |
AR (1) | AR029640A1 (es) |
AT (1) | ATE259362T1 (es) |
AU (1) | AU773164B2 (es) |
BG (1) | BG106168A (es) |
BR (1) | BR0011340A (es) |
CA (1) | CA2375985A1 (es) |
CO (1) | CO5180556A1 (es) |
CZ (1) | CZ20014334A3 (es) |
DE (1) | DE60008239T2 (es) |
DK (1) | DK1183251T3 (es) |
EE (1) | EE04717B1 (es) |
ES (2) | ES2165274B1 (es) |
HK (1) | HK1040990A1 (es) |
HU (1) | HUP0203320A3 (es) |
IL (1) | IL146629A0 (es) |
MX (1) | MXPA01012425A (es) |
MY (1) | MY127033A (es) |
NO (1) | NO20015897D0 (es) |
NZ (1) | NZ515649A (es) |
PE (1) | PE20010208A1 (es) |
PL (1) | PL196774B1 (es) |
PT (1) | PT1183251E (es) |
RU (1) | RU2246493C2 (es) |
SI (1) | SI1183251T1 (es) |
SK (1) | SK17042001A3 (es) |
TR (1) | TR200103490T2 (es) |
TW (1) | TWI226889B (es) |
UA (1) | UA72517C2 (es) |
WO (1) | WO2000075130A1 (es) |
ZA (1) | ZA200109676B (es) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2397387A1 (en) | 2000-01-17 | 2001-07-26 | Bayer Aktiengesellschaft | Substituted aryl ketones |
ES2172436B1 (es) | 2000-10-31 | 2004-01-16 | Almirall Prodesfarma Sa | Derivados de indolilpiperidina como agentes antihistaminicos y antialergicos. |
WO2002048105A2 (en) * | 2000-11-16 | 2002-06-20 | Wyeth | Aryloxy piperidinyl derivatives for the treatment of depression |
ES2201899B1 (es) * | 2002-04-01 | 2005-06-01 | Almirall Prodesfarma, S.A. | Derivados de la azaindolilpiperidina como agentes antihistaminicos y antialergicos. |
ES2201907B1 (es) * | 2002-05-29 | 2005-06-01 | Almirall Prodesfarma, S.A. | Nuevos derivados de indolilpiperidina como potentes agentes antihistaminicos y antialergicos. |
CA2545261C (en) * | 2003-11-17 | 2013-07-23 | Boehringer Ingelheim International Gmbh | Piperidine-substituted indoles- or heteroderivatives thereof |
US20050245540A1 (en) * | 2003-12-09 | 2005-11-03 | Fujisawa Pharmaceutical Co., Ltd. | New methods |
AU2005234596B8 (en) * | 2004-04-13 | 2011-06-16 | Incyte Holdings Corporation | Piperazinylpiperidine derivatives as chemokine receptor antagonists |
WO2006002350A1 (en) * | 2004-06-24 | 2006-01-05 | Incyte Corporation | Amido compounds and their use as pharmaceuticals |
US8071624B2 (en) | 2004-06-24 | 2011-12-06 | Incyte Corporation | N-substituted piperidines and their use as pharmaceuticals |
CA2606473C (en) * | 2005-04-26 | 2013-08-13 | Hypnion, Inc. | Benzisoxazole piperazine compounds and methods of use thereof |
US7759365B2 (en) | 2005-04-30 | 2010-07-20 | Boehringer Ingelheim International Gmbh | Piperidine-substituted indoles |
US20060275516A1 (en) * | 2005-06-02 | 2006-12-07 | Ram A N S | Compositions and methods for the treatment of allergic rhinitis |
WO2008030853A2 (en) * | 2006-09-06 | 2008-03-13 | Incyte Corporation | Combination therapy for human immunodeficiency virus infection |
EP2079725B1 (en) * | 2006-10-27 | 2011-12-14 | Boehringer Ingelheim International GmbH | Piperidyl-propane-thiol ccr3 modulators |
EA016564B1 (ru) | 2007-03-15 | 2012-05-30 | Новартис Аг | Бензил- и пиридинилпроизводные в качестве модуляторов пути передачи сигнала hedgehog |
US20100041663A1 (en) | 2008-07-18 | 2010-02-18 | Novartis Ag | Organic Compounds as Smo Inhibitors |
CN101560179B (zh) * | 2009-05-25 | 2012-04-18 | 浙江大学 | 具有h3受体亲和能力的含氮吲哚衍生物和用途 |
CN101747321B (zh) * | 2009-12-22 | 2013-01-02 | 浙江大学 | 吲哚-3-苄胺衍生物及制备方法和用途 |
EP3040334A1 (en) * | 2014-12-29 | 2016-07-06 | Faes Farma, S.A. | New benzimidazole derivatives as antihistamine agents |
CA3227194A1 (en) * | 2021-07-30 | 2023-02-02 | Ann De Blieck | Compounds for the treatment of pain, in particular neuropathic pain, and/or other diseases or disorders that are associated with at2r and/or at2r mediated signaling |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4742057A (en) * | 1985-12-05 | 1988-05-03 | Fujisawa Pharmaceutical Co., Ltd. | Antiallergic thiazole compounds |
JPS63301881A (ja) * | 1987-06-01 | 1988-12-08 | Fujisawa Pharmaceut Co Ltd | インドリルピペリジン誘導体 |
DK733788A (da) * | 1988-01-14 | 1989-07-15 | Fujisawa Pharmaceutical Co | Indolylpiperidinderivater og fremgangsmaade til fremstilling deraf |
GB8900382D0 (en) * | 1989-01-09 | 1989-03-08 | Janssen Pharmaceutica Nv | 2-aminopyrimidinone derivatives |
KR100269756B1 (ko) * | 1992-02-13 | 2000-10-16 | 슈테펜엘.네스비트 | 피페리디닐티아시클릭유도체(Piperidinyl Thiacyclic Derivatives) |
IT1271417B (it) * | 1993-10-15 | 1997-05-28 | Erregierre Ind Chim | Composti ad attivita' antiistaminica procedimento per la loro preperazione e composizioni farmaceutiche che li contengono. |
DE19500689A1 (de) | 1995-01-12 | 1996-07-18 | Merck Patent Gmbh | Indolpiperidin-Derivate |
DE19707628A1 (de) | 1997-02-26 | 1998-08-27 | Merck Patent Gmbh | Oxazolidinone |
AR013669A1 (es) * | 1997-10-07 | 2001-01-10 | Smithkline Beecham Corp | Compuestos y metodos |
AR028685A1 (es) * | 2000-06-14 | 2003-05-21 | Lundbeck & Co As H | Derivados de indol |
-
1999
- 1999-06-04 ES ES009901232A patent/ES2165274B1/es not_active Expired - Fee Related
-
2000
- 2000-05-31 NZ NZ515649A patent/NZ515649A/en unknown
- 2000-05-31 EP EP00940296A patent/EP1183251B1/en not_active Expired - Lifetime
- 2000-05-31 SK SK1704-2001A patent/SK17042001A3/sk unknown
- 2000-05-31 MY MYPI20002439A patent/MY127033A/en unknown
- 2000-05-31 JP JP2001502413A patent/JP2003501424A/ja not_active Ceased
- 2000-05-31 BR BR0011340-9A patent/BR0011340A/pt not_active Application Discontinuation
- 2000-05-31 MX MXPA01012425A patent/MXPA01012425A/es unknown
- 2000-05-31 DK DK00940296T patent/DK1183251T3/da active
- 2000-05-31 ES ES00940296T patent/ES2211559T3/es not_active Expired - Lifetime
- 2000-05-31 EE EEP200100653A patent/EE04717B1/xx not_active IP Right Cessation
- 2000-05-31 DE DE2000608239 patent/DE60008239T2/de not_active Expired - Lifetime
- 2000-05-31 AT AT00940296T patent/ATE259362T1/de not_active IP Right Cessation
- 2000-05-31 UA UA2001118222A patent/UA72517C2/uk unknown
- 2000-05-31 AU AU55276/00A patent/AU773164B2/en not_active Ceased
- 2000-05-31 PE PE2000000524A patent/PE20010208A1/es not_active Application Discontinuation
- 2000-05-31 PT PT00940296T patent/PT1183251E/pt unknown
- 2000-05-31 PL PL353164A patent/PL196774B1/pl not_active IP Right Cessation
- 2000-05-31 RU RU2002100073/04A patent/RU2246493C2/ru not_active IP Right Cessation
- 2000-05-31 HU HU0203320A patent/HUP0203320A3/hu unknown
- 2000-05-31 SI SI200030323T patent/SI1183251T1/xx unknown
- 2000-05-31 TR TR2001/03490T patent/TR200103490T2/xx unknown
- 2000-05-31 CN CNB008112819A patent/CN1191246C/zh not_active Expired - Fee Related
- 2000-05-31 CZ CZ20014334A patent/CZ20014334A3/cs unknown
- 2000-05-31 KR KR1020017015570A patent/KR100683454B1/ko not_active IP Right Cessation
- 2000-05-31 IL IL14662900A patent/IL146629A0/xx unknown
- 2000-05-31 CA CA002375985A patent/CA2375985A1/en not_active Abandoned
- 2000-05-31 WO PCT/EP2000/005010 patent/WO2000075130A1/en active IP Right Grant
- 2000-06-02 AR ARP000102755A patent/AR029640A1/es not_active Application Discontinuation
- 2000-06-02 CO CO00041546A patent/CO5180556A1/es not_active Application Discontinuation
- 2000-06-02 TW TW089110816A patent/TWI226889B/zh not_active IP Right Cessation
-
2001
- 2001-11-23 ZA ZA200109676A patent/ZA200109676B/en unknown
- 2001-12-03 NO NO20015897A patent/NO20015897D0/no not_active Application Discontinuation
- 2001-12-03 BG BG106168A patent/BG106168A/bg unknown
- 2001-12-04 US US10/006,416 patent/US6683096B2/en not_active Expired - Fee Related
-
2002
- 2002-03-20 HK HK02102119.0A patent/HK1040990A1/zh unknown
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