ATE388958T1 - 4'-c-substituierte 2-haloadenosinderivate - Google Patents

4'-c-substituierte 2-haloadenosinderivate

Info

Publication number
ATE388958T1
ATE388958T1 AT05006326T AT05006326T ATE388958T1 AT E388958 T1 ATE388958 T1 AT E388958T1 AT 05006326 T AT05006326 T AT 05006326T AT 05006326 T AT05006326 T AT 05006326T AT E388958 T1 ATE388958 T1 AT E388958T1
Authority
AT
Austria
Prior art keywords
substituted
haloadenosine
derivative
derivatives
provides
Prior art date
Application number
AT05006326T
Other languages
English (en)
Inventor
Satoru Kohgo
Hiroshi Ohrui
Eiichi Kodama
Masao Matsuoka
Hiroaki Mitsuya
Original Assignee
Yamasa Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamasa Corp filed Critical Yamasa Corp
Application granted granted Critical
Publication of ATE388958T1 publication Critical patent/ATE388958T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
AT05006326T 2004-03-24 2005-03-23 4'-c-substituierte 2-haloadenosinderivate ATE388958T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2004087198 2004-03-24
JP2004263409 2004-09-10

Publications (1)

Publication Number Publication Date
ATE388958T1 true ATE388958T1 (de) 2008-03-15

Family

ID=34934441

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05006326T ATE388958T1 (de) 2004-03-24 2005-03-23 4'-c-substituierte 2-haloadenosinderivate

Country Status (8)

Country Link
US (3) US7339053B2 (de)
EP (1) EP1589026B1 (de)
JP (2) JP4253342B2 (de)
AT (1) ATE388958T1 (de)
CA (1) CA2502109C (de)
DE (1) DE602005005240T2 (de)
ES (1) ES2300892T3 (de)
WO (1) WO2005090349A1 (de)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60336441D1 (de) 2002-09-02 2011-05-05 Samsung Electronics Co Ltd Kontaktstruktur für eine Halbleitervorrichtung, dünnschichtige Transistoranordnung mit einer solchen Kontaktstruktur und dessen Herstellungsmethode
CA2502109C (en) * 2004-03-24 2010-02-23 Yamasa Corporation 4'-c-substituted-2-haloadenosine derivative
US9636317B2 (en) 2007-01-31 2017-05-02 Biosuccess Biotech Co. Ltd. Compositions and methods of use of phorbol esters
US11564901B2 (en) 2007-01-31 2023-01-31 Biosuccess Biotech Co., Ltd. Compositions and methods of use of phorbol esters
US11696908B2 (en) 2007-01-31 2023-07-11 Biosuccess Biotech Co. Ltd. Compositions and methods of use of phorbol esters
US10369222B2 (en) 2012-01-18 2019-08-06 Biosuccess Biotech Co., Ltd. Compositions and methods of use of phorbol esters for the treatment of stroke
JP2010516813A (ja) 2007-01-31 2010-05-20 バイオサクセス バイオテック カンパニー ホルボールエステルを含む組成物及びその使用法
US9974764B2 (en) 2007-01-31 2018-05-22 Biosuccess Biotech Co. Ltd. Compositions and methods of use of phorbol esters in the treatment of neoplasms
US9533938B2 (en) 2007-01-31 2017-01-03 Biosuccess Biotech Co., Ltd. Compositions and methods of use of phorbol esters for the treatment of stroke
KR101156330B1 (ko) 2007-02-13 2012-06-13 미쓰비시덴키 가부시키가이샤 표시 장치 및 그 제조 방법
US10099996B2 (en) 2012-01-18 2018-10-16 Biosuccess Biotech Co. Ltd. Compositions and methods of use of phorbol esters in the treatment of neoplasms
US9550722B2 (en) 2012-01-18 2017-01-24 Biosuccess Biotech Co. Ltd. Compositions and methods of use of phorbal esters for the treatment of stroke
JP6191989B2 (ja) * 2014-02-12 2017-09-06 学校法人東京理科大学 アデニン誘導体又はその薬理学的に許容しうる塩、その製造方法、及びその用途
WO2015143712A1 (en) 2014-03-28 2015-10-01 Merck Sharp & Dohme Corp. 4'-substituted nucleoside reverse transcriptase inhibitors
MA41213A (fr) * 2014-12-19 2017-10-24 Alios Biopharma Inc Nucléosides substitués, nucléotides et analogues de ceux-ci
KR102185996B1 (ko) * 2015-09-23 2020-12-02 머크 샤프 앤드 돔 코포레이션 4'-치환된 뉴클레오시드 리버스 트랜스크립타제 억제제 및 그의 제조법
JOP20170038B1 (ar) 2016-02-12 2021-08-17 Merck Sharp & Dohme مركبات للاستخدام لعلاج عدوى بفيروس hiv والوقاية منه
AU2017263253B2 (en) 2016-05-12 2022-04-14 Merck Sharp & Dohme Llc Drug delivery system for the delivery of antiviral agents
EP3471829A4 (de) * 2016-06-20 2020-01-15 Merck Sharp & Dohme Corp. Wirkstofffreisetzungssystem zur freisetzung von viruziden
EP3543238B1 (de) 2016-11-16 2021-05-19 National Center for Global Health and Medicine Nukleosidderivate mit antiviraler aktivität
US11419817B2 (en) 2017-04-10 2022-08-23 Merck Sharp & Dohme Llc Drug delivery system for the delivery of antiviral agents
US20200138845A1 (en) * 2017-07-18 2020-05-07 Viiv Healthcare Company Combination Drug Therapy
US11040975B2 (en) 2017-12-08 2021-06-22 Merck Sharp & Dohme Corp. Carbocyclic nucleoside reverse transcriptase inhibitors
JP2021515771A (ja) * 2018-03-07 2021-06-24 グラクソスミスクライン、インテレクチュアル、プロパティー、（ナンバー２）、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ （Ｎｏ．２） Ｌｉｍｉｔｅｄ Ｈｉｖ療法に有用な化合物
JP7402225B2 (ja) 2018-05-11 2023-12-20 ロード アイランド ホスピタル ヌクレオシド系逆転写酵素阻害剤を用いて関節障害を処置するための組成物および方法
CN109893536B (zh) * 2018-07-02 2021-04-27 河南真实生物科技有限公司 4’-取代核苷的晶型、制备和应用
MX2021000278A (es) 2018-07-09 2021-03-31 Merck Sharp & Dohme Llc Sintesis enzimatica de analogos de nucleosido de 4'-etinilo.
US20220117993A1 (en) * 2018-08-09 2022-04-21 Glaxosmithkline Intellectual Property (No. 2) Limited Compounds Useful in HIV Therapy
US20210323993A1 (en) * 2018-08-30 2021-10-21 Glaxosmithkline Intellectual Property (No. 2) Limited Compounds Useful in HIV Therapy
AU2019403024A1 (en) * 2018-12-20 2021-07-15 Merck Sharp & Dohme Llc Novel crystalline forms of an NRTTI compound
EP3914604B1 (de) 2019-01-25 2026-03-04 Brown University Zusammensetzungen enthaltend censavudin oder elvucitabin zur behandlung der altersbedingten entzündung und der störungen
EA202192433A1 (ru) * 2019-03-06 2021-12-28 Глэксосмитклайн Интеллекчуал Проперти (№2) Лимитед Соединения, полезные в терапии вич
WO2020263660A1 (en) 2019-06-24 2020-12-30 Merck Sharp & Dohme Corp. Process for the preparation of 2-fluoroadenine
BR112022000965A2 (pt) * 2019-07-27 2022-06-14 Brii Biosciences Inc Derivado de adenosina e composição farmacêutica que compreende o mesmo
EP4010349A1 (de) * 2019-08-08 2022-06-15 GlaxoSmithKline Intellectual Property (No. 2) Limited 4'-ethynyl-2'-deoxyadenosinderivate und ihre verwendung in der hiv-therapie
KR20220047307A (ko) * 2019-08-13 2022-04-15 머크 샤프 앤드 돔 코포레이션 항바이러스제의 전달을 위한 약물 전달 시스템
US20220298160A1 (en) * 2019-08-28 2022-09-22 Glaxosmithkline Intellectual Property (No.2) Limited Compounds useful in hiv therapy
EP4028020A4 (de) * 2019-09-11 2023-09-27 The Scripps Research Institute Antivirale prodrugs und deren formulierungen
AR121620A1 (es) * 2020-03-20 2022-06-22 Gilead Sciences Inc Profármacos de nucleósidos 4’-c-sustituidos-2-halo-2’-deoxiadenosina y métodos de preparación y uso de los mismos
AU2021268584A1 (en) * 2020-05-05 2022-12-01 Merck Sharp & Dohme Llc Drug delivery system for the delivery of antiviral agents and contraceptives
CN116801884B (zh) 2021-01-25 2026-02-27 腾盛博药生物科技有限公司 使用腺苷衍生物和衣壳抑制剂的针对hiv的组合疗法
CA3202049A1 (en) 2021-01-25 2022-07-28 Brii Biosciences, Inc. Adenosine derivative and pharmaceutical composition comprising the same
JP2024507550A (ja) * 2021-02-23 2024-02-20 ヴィーブ、ヘルスケア、カンパニー Ｈｉｖ療法に有用な化合物
WO2022271878A1 (en) * 2021-06-22 2022-12-29 Rome Therapeutics, Inc. 4-ethynyl-3-hydroxy-tetrahydrofuranyl-adenine phosphoramidates and related compounds and their use in treating medical conditions
JP2025509635A (ja) 2022-03-15 2025-04-11 ローム・セラピューティクス・インコーポレイテッド 疾患を治療するための化合物及び方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5192749A (en) * 1990-05-21 1993-03-09 Syntex (U.S.A.) Inc. 4'-substituted nucleosides
DE60005501T2 (de) 1999-05-12 2004-06-24 Yamasa Corp., Choshi 4'-c-ethynyl-pyrimidine nukleoside
JP4076114B2 (ja) * 1999-05-12 2008-04-16 ヤマサ醤油株式会社 ４’−ｃ−エチニルプリンヌクレオシド化合物
AU2003211483A1 (en) 2002-02-15 2003-09-04 Yamasa Corporation 4'-c-cyano-2'-deoxypurine nucleosides
CA2514466C (en) * 2003-02-19 2015-05-26 Yale University Anti-viral nucleoside analogs and methods for treating viral infections, especially hiv infections
CA2502109C (en) * 2004-03-24 2010-02-23 Yamasa Corporation 4'-c-substituted-2-haloadenosine derivative

Also Published As

Publication number Publication date
DE602005005240D1 (de) 2008-04-24
US20050215512A1 (en) 2005-09-29
EP1589026B1 (de) 2008-03-12
JP2011256173A (ja) 2011-12-22
US20080153774A1 (en) 2008-06-26
JPWO2005090349A1 (ja) 2008-01-31
US20090234110A1 (en) 2009-09-17
JP4253342B2 (ja) 2009-04-08
CA2502109A1 (en) 2005-09-24
US7339053B2 (en) 2008-03-04
CA2502109C (en) 2010-02-23
US7625877B2 (en) 2009-12-01
WO2005090349A1 (ja) 2005-09-29
EP1589026A1 (de) 2005-10-26
US8039614B2 (en) 2011-10-18
ES2300892T3 (es) 2008-06-16
JP5213194B2 (ja) 2013-06-19
DE602005005240T2 (de) 2009-03-12

Similar Documents

Publication Publication Date Title
ATE388958T1 (de) 4'-c-substituierte 2-haloadenosinderivate
AP1753A (en) Thiophene derivatives as antiviral agents for flavvivirus infection
ATE324371T1 (de) N-substituierte heterocyclische nichtaryl- nmda/nr2b-antagonisten
DE60032780D1 (de) Tetrahydroquinolin-derivate
AU3599701A (en) Fluorescent probes for the quantitation of zinc
DE602004009200D1 (de) Tetrahydrochinazolinderivate als cfr-antagonisten
ATE503746T1 (de) Neue imidazolidinderivate
TW200738667A (en) Preparation method for dioxan-2-ylalkylcarbamate derivatives and intermediate thereof
BRPI0409376A (pt) derivados de indeno como agentes farmacêuticos
IL169184A0 (en) Aromatic compounds as anti-inflammatory, immunomdulatory and anti-proliferatory agents
MY138826A (en) 2,7-substituted indoles
TW200744589A (en) Pharmaceutical composition
EP1845780A4 (de) Verwendung von methylphenidat-derivaten
DE60239491D1 (de) Thiazolidindionderivate und diese enthaltende pharmazeutische zusammensetzung
EA200801139A1 (ru) Композиция для аэрозольной ингаляции
AR034313A1 (es) Utilizacion de derivados de piridoindolona para la preparacion de medicamentos
MXPA03008725A (es) Medicamentos para hiperactividad vesicular.
WO2004093796A3 (en) Lactam derivatives and methods of their use
DE602006013828D1 (en) 4-aryloxy-chinolin-derivate als 5-ht6-modulatoren
DK1433480T3 (da) Lægemiddel indeholdende pyrimidin-derivat
AU2003235359A1 (en) Biguanide derivative and therapeutic agent for diabetes containing the same
EP1557407A4 (de) Neue alpha-ketoamidderivate und deren verwendung
EP1325913A3 (de) Piperidincarbonsäuramid-Derivate
TH103345A (th) อนุพันธ์ 3-ไซยาโน-ควิโนลีนที่มีกิจกรรมต้านการงอกขยาย
SE0403084D0 (sv) Chemical process

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1589026

Country of ref document: EP