CO5180556A1 - Derivados de la indolilpiperidina como agentes antihistaminicos y antialergicos - Google Patents

Derivados de la indolilpiperidina como agentes antihistaminicos y antialergicos

Info

Publication number
CO5180556A1
CO5180556A1 CO00041546A CO00041546A CO5180556A1 CO 5180556 A1 CO5180556 A1 CO 5180556A1 CO 00041546 A CO00041546 A CO 00041546A CO 00041546 A CO00041546 A CO 00041546A CO 5180556 A1 CO5180556 A1 CO 5180556A1
Authority
CO
Colombia
Prior art keywords
group
alkoxy
alkyl
groups
optionally substituted
Prior art date
Application number
CO00041546A
Other languages
English (en)
Inventor
Lluis Pages Santacana
Silvia Fonquerna Pou
Carles Puig Duran
Dolors Fernandez Forner
Original Assignee
Almirall Prodesfarma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Almirall Prodesfarma Sa filed Critical Almirall Prodesfarma Sa
Publication of CO5180556A1 publication Critical patent/CO5180556A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/04—Drugs for disorders of the respiratory system for throat disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pulmonology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Otolaryngology (AREA)
  • Immunology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Un compuesto de fórmula (I)<EMI FILE="00041546_1" ID="1" IMF=JPEG >en donde:A1 representa un grupo alquileno, alquilenoxi, alquilentio, alcanoil o hidroxialquileno;A2 representa un enlace sencillo, un grupo alquileno o alquenileno;W representa un enlace sencillo, un grupo fenileno o furanileno opcionalmente sustituido por uno o más átomos de halógeno, o grupos alcoxi y/o grupos alquilo;R1 representa un átomo de hidrógeno o un grupo alquilo, alquenilo, alquinilo, alcoxialquilo, alqueniloxialquilo, alquiniloxialquilo, alcoxi-alcoxialquilo, fenilalquilo en donde el anillo fenilo está opcionalmente sustituido por uno o más átomos de halógeno o grupos alquilo, alcoxi o arilalcoxi o un grupo cicloalquilalquilo en donde el grupo cicloalquilo está opcionalmente sustituido por uno o más átomos de halógeno, grupos alquilo o grupos alcoxi;R2 representa un átomo de hidrógeno o halógeno, o un grupo alquilo o alcoxi; yR3 representa un grupo carboxilo o un grupo tetrazolilo;y sus correspondientes sales farmacéuticamente aceptables.
CO00041546A 1999-06-04 2000-06-02 Derivados de la indolilpiperidina como agentes antihistaminicos y antialergicos CO5180556A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES009901232A ES2165274B1 (es) 1999-06-04 1999-06-04 Nuevos derivados de indolilpiperidina como agentes antihistaminicos y antialergicos.

Publications (1)

Publication Number Publication Date
CO5180556A1 true CO5180556A1 (es) 2002-07-30

Family

ID=8308707

Family Applications (1)

Application Number Title Priority Date Filing Date
CO00041546A CO5180556A1 (es) 1999-06-04 2000-06-02 Derivados de la indolilpiperidina como agentes antihistaminicos y antialergicos

Country Status (35)

Country Link
US (1) US6683096B2 (es)
EP (1) EP1183251B1 (es)
JP (1) JP2003501424A (es)
KR (1) KR100683454B1 (es)
CN (1) CN1191246C (es)
AR (1) AR029640A1 (es)
AT (1) ATE259362T1 (es)
AU (1) AU773164B2 (es)
BG (1) BG106168A (es)
BR (1) BR0011340A (es)
CA (1) CA2375985A1 (es)
CO (1) CO5180556A1 (es)
CZ (1) CZ20014334A3 (es)
DE (1) DE60008239T2 (es)
DK (1) DK1183251T3 (es)
EE (1) EE04717B1 (es)
ES (2) ES2165274B1 (es)
HK (1) HK1040990A1 (es)
HU (1) HUP0203320A3 (es)
IL (1) IL146629A0 (es)
MX (1) MXPA01012425A (es)
MY (1) MY127033A (es)
NO (1) NO20015897L (es)
NZ (1) NZ515649A (es)
PE (1) PE20010208A1 (es)
PL (1) PL196774B1 (es)
PT (1) PT1183251E (es)
RU (1) RU2246493C2 (es)
SI (1) SI1183251T1 (es)
SK (1) SK17042001A3 (es)
TR (1) TR200103490T2 (es)
TW (1) TWI226889B (es)
UA (1) UA72517C2 (es)
WO (1) WO2000075130A1 (es)
ZA (1) ZA200109676B (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0107624A (pt) * 2000-01-17 2002-11-12 Bayer Ag Arilcetonas substituìdas
ES2172436B1 (es) 2000-10-31 2004-01-16 Almirall Prodesfarma Sa Derivados de indolilpiperidina como agentes antihistaminicos y antialergicos.
AU2002243394A1 (en) * 2000-11-16 2002-06-24 Wyeth Aryloxy piperidinyl derivatives for the treatment of depression
ES2201899B1 (es) * 2002-04-01 2005-06-01 Almirall Prodesfarma, S.A. Derivados de la azaindolilpiperidina como agentes antihistaminicos y antialergicos.
ES2201907B1 (es) 2002-05-29 2005-06-01 Almirall Prodesfarma, S.A. Nuevos derivados de indolilpiperidina como potentes agentes antihistaminicos y antialergicos.
EP1687294B1 (en) 2003-11-17 2014-05-21 Boehringer Ingelheim International GmbH Novel piperidine-substituted indoles-or hetero-derivatives thereof and their use as modulators of chemokine receptor (ccr-3)
US20050245540A1 (en) * 2003-12-09 2005-11-03 Fujisawa Pharmaceutical Co., Ltd. New methods
BRPI0509803A (pt) * 2004-04-13 2007-09-18 Incyte Corp derivados de piperazinilpiperidina como antagonistas de receptor de quimiocina
JP2008504279A (ja) * 2004-06-24 2008-02-14 インサイト・コーポレイション アミド化合物およびその医薬としての使用
MXPA06014574A (es) 2004-06-24 2007-03-12 Incyte Corp Piperidinas n-sustituidas y su uso como farmaceuticos.
DE602006012650D1 (de) * 2005-04-26 2010-04-15 Hypnion Inc Benzisoxazolpiperidinverbindungen und verfahren zu deren anwendung
WO2006117314A2 (en) 2005-04-30 2006-11-09 Boehringer Ingelheim International Gmbh Novel piperidin- substituted indoles and their use as ccr-3 modulators
US20060275516A1 (en) * 2005-06-02 2006-12-07 Ram A N S Compositions and methods for the treatment of allergic rhinitis
US20080108586A1 (en) * 2006-09-06 2008-05-08 Incyte Corporation Combination therapy for human immunodeficiency virus infection
WO2008049874A1 (en) 2006-10-27 2008-05-02 Boehringer Ingelheim International Gmbh Piperidyl-propane-thiol ccr3 modulators
PE20090188A1 (es) * 2007-03-15 2009-03-20 Novartis Ag Compuestos heterociclicos como moduladores de la senda de hedgehog
US20100041663A1 (en) 2008-07-18 2010-02-18 Novartis Ag Organic Compounds as Smo Inhibitors
CN101560179B (zh) * 2009-05-25 2012-04-18 浙江大学 具有h3受体亲和能力的含氮吲哚衍生物和用途
CN101747321B (zh) * 2009-12-22 2013-01-02 浙江大学 吲哚-3-苄胺衍生物及制备方法和用途
EP3040334A1 (en) 2014-12-29 2016-07-06 Faes Farma, S.A. New benzimidazole derivatives as antihistamine agents
KR20240063881A (ko) * 2021-07-30 2024-05-13 콘포 테라퓨틱스 엔.브이. 통증, 특히 신경병증성 통증, 및/또는 at2r 및/또는 at2r 매개 신호전달과 연관된 다른 질환 또는 장애의 치료를 위한 화합물

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4742057A (en) * 1985-12-05 1988-05-03 Fujisawa Pharmaceutical Co., Ltd. Antiallergic thiazole compounds
JPS63301881A (ja) * 1987-06-01 1988-12-08 Fujisawa Pharmaceut Co Ltd インドリルピペリジン誘導体
DK733788A (da) * 1988-01-14 1989-07-15 Fujisawa Pharmaceutical Co Indolylpiperidinderivater og fremgangsmaade til fremstilling deraf
GB8900382D0 (en) * 1989-01-09 1989-03-08 Janssen Pharmaceutica Nv 2-aminopyrimidinone derivatives
AU669156B2 (en) * 1992-02-13 1996-05-30 Merrell Dow Pharmaceuticals Inc. Piperidinyl thiacyclic derivatives
IT1271417B (it) * 1993-10-15 1997-05-28 Erregierre Ind Chim Composti ad attivita' antiistaminica procedimento per la loro preperazione e composizioni farmaceutiche che li contengono.
DE19500689A1 (de) 1995-01-12 1996-07-18 Merck Patent Gmbh Indolpiperidin-Derivate
DE19707628A1 (de) 1997-02-26 1998-08-27 Merck Patent Gmbh Oxazolidinone
AR013669A1 (es) * 1997-10-07 2001-01-10 Smithkline Beecham Corp Compuestos y metodos
AR028685A1 (es) * 2000-06-14 2003-05-21 Lundbeck & Co As H Derivados de indol

Also Published As

Publication number Publication date
RU2246493C2 (ru) 2005-02-20
CN1368969A (zh) 2002-09-11
TWI226889B (en) 2005-01-21
US20020147344A1 (en) 2002-10-10
US6683096B2 (en) 2004-01-27
IL146629A0 (en) 2002-07-25
ES2165274B1 (es) 2003-04-01
WO2000075130A1 (en) 2000-12-14
HK1040990A1 (zh) 2002-06-28
EP1183251B1 (en) 2004-02-11
MY127033A (en) 2006-11-30
HUP0203320A3 (en) 2004-01-28
NO20015897D0 (no) 2001-12-03
MXPA01012425A (es) 2002-06-04
CA2375985A1 (en) 2000-12-14
DE60008239D1 (de) 2004-03-18
PL196774B1 (pl) 2008-01-31
ES2165274A1 (es) 2002-03-01
ATE259362T1 (de) 2004-02-15
EE200100653A (et) 2003-02-17
ES2211559T3 (es) 2004-07-16
SK17042001A3 (sk) 2002-04-04
CN1191246C (zh) 2005-03-02
AU5527600A (en) 2000-12-28
BG106168A (bg) 2002-07-31
DK1183251T3 (da) 2004-06-07
NO20015897L (no) 2001-12-03
KR100683454B1 (ko) 2007-02-20
AU773164B2 (en) 2004-05-20
DE60008239T2 (de) 2004-11-18
RU2002100073A (ru) 2004-01-10
HUP0203320A2 (hu) 2003-02-28
BR0011340A (pt) 2002-03-05
UA72517C2 (uk) 2005-03-15
TR200103490T2 (tr) 2002-04-22
EP1183251A1 (en) 2002-03-06
PE20010208A1 (es) 2001-03-19
AR029640A1 (es) 2003-07-10
EE04717B1 (et) 2006-10-16
CZ20014334A3 (cs) 2002-03-13
SI1183251T1 (en) 2004-06-30
PL353164A1 (en) 2003-10-20
PT1183251E (pt) 2004-05-31
KR20020020721A (ko) 2002-03-15
NZ515649A (en) 2003-08-29
JP2003501424A (ja) 2003-01-14
ZA200109676B (en) 2003-02-24

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