UY26226A1 - 'derivados de aminopirrolidina heterocíclica como agentes melatonergicos'.- ley 17.164.- - Google Patents

'derivados de aminopirrolidina heterocíclica como agentes melatonergicos'.- ley 17.164.-

Info

Publication number
UY26226A1
UY26226A1 UY26226A UY26226A UY26226A1 UY 26226 A1 UY26226 A1 UY 26226A1 UY 26226 A UY26226 A UY 26226A UY 26226 A UY26226 A UY 26226A UY 26226 A1 UY26226 A1 UY 26226A1
Authority
UY
Uruguay
Prior art keywords
heterocyclic
aminopyrolidine
law
derivatives
melatonergic agents
Prior art date
Application number
UY26226A
Other languages
English (en)
Inventor
Katherine S Takaki
Guanglin Luo
Stephen R Bertenshaw
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of UY26226A1 publication Critical patent/UY26226A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives

Abstract

Se proporciona una nueva serie de compuestos de aminopirrolidina heterocíclica de la fórmula I, en donde R1, R2, R3, R4, W, Z y el enlace ondulado son como se definieron aquí los cuales enlazan al receptor de melatonina humana y por lo tanto son útiles como agentes melatonérgicos.
UY26226A 1999-06-30 2000-06-28 'derivados de aminopirrolidina heterocíclica como agentes melatonergicos'.- ley 17.164.- UY26226A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US14189499P 1999-06-30 1999-06-30

Publications (1)

Publication Number Publication Date
UY26226A1 true UY26226A1 (es) 2001-01-31

Family

ID=22497702

Family Applications (1)

Application Number Title Priority Date Filing Date
UY26226A UY26226A1 (es) 1999-06-30 2000-06-28 'derivados de aminopirrolidina heterocíclica como agentes melatonergicos'.- ley 17.164.-

Country Status (13)

Country Link
US (1) US6211225B1 (es)
EP (1) EP1189900B1 (es)
JP (2) JP4767463B2 (es)
AT (1) ATE257834T1 (es)
AU (1) AU763963B2 (es)
CA (1) CA2376949C (es)
DE (1) DE60007745T2 (es)
DK (1) DK1189900T3 (es)
ES (1) ES2213022T3 (es)
PE (1) PE20010327A1 (es)
PT (1) PT1189900E (es)
UY (1) UY26226A1 (es)
WO (1) WO2001002392A1 (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6569894B1 (en) 2001-10-04 2003-05-27 Bristol-Myers Squibb Company Arylalkylbenzofuran derivatives as melatonergic agents
US6737431B2 (en) 2002-03-12 2004-05-18 Bristol-Myers Squibb Company Benzoxazole derivatives as novel melatonergic agents
CA2495383A1 (en) 2002-08-12 2004-02-26 Takeda Pharmaceutical Company Limited Fused benzene derivative and use
EP1871754A1 (en) * 2005-04-22 2008-01-02 Wyeth a Corporation of the State of Delaware Dihydrobenzofuran derivatives and uses thereof
CN101203216A (zh) * 2005-04-22 2008-06-18 惠氏公司 二氢苯并呋喃衍生物及其用途
CN101448805B (zh) * 2006-05-22 2012-12-12 Vanda制药公司 抑郁障碍的治疗
CN101687810A (zh) * 2007-04-26 2010-03-31 武田药品工业株式会社 双环化合物及其药物用途
ES2331276B1 (es) * 2007-10-25 2010-10-21 Ferrer Internacional, S.A. Compuestos de fenilpirrolidina.
EP2266975A1 (en) * 2009-06-15 2010-12-29 Ferrer Internacional, S.A. 1-(2-alkyl-2,3-dihydro-benzofuran-4-yl)-pyrrolidin-3-ylamine acyl compounds
KR102317399B1 (ko) 2012-01-26 2021-10-26 반다 파마슈티칼즈, 인코퍼레이티드. 일주기 리듬 장애의 치료
US11918557B2 (en) 2012-01-26 2024-03-05 Vanda Pharmaceuticals Inc. Treatment of circadian rhythm disorders
WO2014085490A1 (en) 2012-11-29 2014-06-05 Chemocentryx, Inc. Cxcr7 antagonists
CN105142630A (zh) 2012-12-18 2015-12-09 万达制药公司 昼夜节律紊乱的治疗
US10376487B2 (en) 2013-11-12 2019-08-13 Vanda Pharmaceuticals Inc. Method of treatment
US11090285B2 (en) 2013-11-12 2021-08-17 Vanda Pharmaceuticals Inc Treatment of circadian rhythm disorders
BR102016024814A2 (pt) 2016-10-24 2018-05-08 Aché Laboratórios Farmacêuticos S.A. composto, processo de obtenção do composto, composição farmacêutica, uso do composto e método de tratamento de desordens psiquiátricas e/ou distúrbios do sono
CN113194956A (zh) 2018-12-12 2021-07-30 凯莫森特里克斯股份有限公司 用于癌症治疗的cxcr7抑制剂
CN109574970A (zh) * 2018-12-27 2019-04-05 上海毕得医药技术有限公司 一种5-溴苯并二氢吡喃的合成方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3518273A (en) * 1966-08-03 1970-06-30 Warner Lambert Pharmaceutical Benzopyranquinolinol derivatives and process for their production
US3485835A (en) * 1968-04-10 1969-12-23 Haessle Ab 2-benzoyl-3-tertiaryamino alkoxy benzofuran derivatives
US5071875A (en) 1989-09-25 1991-12-10 Northwestern University Substituted 2-amidotetralins as melatonin agonists and antagonists
FR2674524B1 (fr) 1991-03-25 1993-05-21 Adir Nouveaux amides alkyl heterocycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
FR2680366B1 (fr) 1991-08-13 1995-01-20 Adir Nouveaux derives d'arylethylamines, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
FR2689124A1 (fr) 1992-03-27 1993-10-01 Adir Nouvelles naphtylalkylamines, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
US5449683A (en) 1992-10-01 1995-09-12 Massachussetts Institute Of Technology Methods of inducing sleep using melatonin
GB9326192D0 (en) 1993-12-22 1994-02-23 Glaxo Group Ltd Chemical compounds
GB9407919D0 (en) 1994-04-21 1994-06-15 Glaxo Group Ltd Chemical compounds
FR2725985B1 (fr) 1994-10-21 1996-11-15 Adir Nouveaux composes tricycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US5753709A (en) * 1995-06-07 1998-05-19 Bristol-Myers Squibb Company N-acyl-2 aryl cyclopropylmethylamine derivatives as melatonergics
CN1228775A (zh) 1996-05-14 1999-09-15 葛兰素集团有限公司 作为时间生物学药物的苯并呋喃和苯并吡喃
PL190499B1 (pl) * 1996-12-10 2005-12-30 Bristol Myers Squibb Co Pochodna benzodioksolu, benzofuranu, dihydrobenzofuranu lub benzodioksanu, jej zastosowanie i kompozycja farmaceutyczna
FR2761358B1 (fr) * 1997-03-27 1999-05-07 Adir Nouveaux composes de n-aryl piperidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Also Published As

Publication number Publication date
EP1189900B1 (en) 2004-01-14
JP2011137043A (ja) 2011-07-14
JP4767463B2 (ja) 2011-09-07
EP1189900A4 (en) 2002-07-31
ATE257834T1 (de) 2004-01-15
US6211225B1 (en) 2001-04-03
AU5324000A (en) 2001-01-22
EP1189900A1 (en) 2002-03-27
CA2376949A1 (en) 2001-01-11
ES2213022T3 (es) 2004-08-16
JP2003503492A (ja) 2003-01-28
DK1189900T3 (da) 2004-04-26
DE60007745D1 (de) 2004-02-19
PE20010327A1 (es) 2001-06-10
JP5248647B2 (ja) 2013-07-31
DE60007745T2 (de) 2005-03-10
AU763963B2 (en) 2003-08-07
CA2376949C (en) 2009-05-26
PT1189900E (pt) 2004-05-31
WO2001002392A1 (en) 2001-01-11

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Legal Events

Date Code Title Description
109 Application deemed to be withdrawn

Effective date: 20100518