PE20010327A1 - Derivados de aminopirrolidina heterociclica como agentes melatonergicos - Google Patents
Derivados de aminopirrolidina heterociclica como agentes melatonergicosInfo
- Publication number
- PE20010327A1 PE20010327A1 PE2000000652A PE0006522000A PE20010327A1 PE 20010327 A1 PE20010327 A1 PE 20010327A1 PE 2000000652 A PE2000000652 A PE 2000000652A PE 0006522000 A PE0006522000 A PE 0006522000A PE 20010327 A1 PE20010327 A1 PE 20010327A1
- Authority
- PE
- Peru
- Prior art keywords
- heterociclic
- melatonergic agents
- aminopyrrolidine derivatives
- custom
- character
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Indole Compounds (AREA)
- Cosmetics (AREA)
Abstract
SE REFIERE A DERIVADOS DE AMINOPIRROLIDINA HETEROCICLICA DONDE R1 Y R2 SON H, HALOGENO; W ES CR5, CR5R6, (CH2)n; n ES 1-2; Z ES CH2, CH, O; R3 ES H, ALQUILO C1-C4; R4 ES ALQUILO C1-C6, CICLOALQUILO C3-C6, HALOALQUILO C1-C3, ALQUENILO C2-C6, ALQUILAMINO C1-C6, CICLOALQUILAMINO C3-C6, ENTRE OTROS; R5 Y R6 SON H, ALQUILO C1-C4. SON COMPUESTOS PREFERIDOS (S)-N-[N-(2,3-DIHIDROBENZOFURAN-4-IL)-PIRROLIDIN-3-IL]ACETAMIDA; (R)-N-[N-(2,3-METILENDIOXIFEN-1-IL)-PIRROLIDIN-3-IL]PROPANAMIDA, (S)-N-[N-(2,3-DIHIDROBENZOFURAN-4-IL)-PIRROLIDIN-3-IL]BUTIRAMINA, (S)-N-[N-(2,3-DIHIDRO-1,4-BENZODIOXIN-5-IL)-PIRROLIDIN-3-IL]CICLOPROPAN CARBOXAMIDA, ENTRE OTROS. LOS COMPUESTOS TIENEN AFINIDAD POR LOS RECEPTORES DE LA HORMONA PINEAL ENDOGENA MELATONINA POR LO QUE PUEDEN SER UTILES EN EL TRATAMIENTO DE DESORDENES RELACIONADOS CON EL RITMO CIRCADIANO, DESORDENES DE SUENO, GLAUCOMA
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14189499P | 1999-06-30 | 1999-06-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20010327A1 true PE20010327A1 (es) | 2001-06-10 |
Family
ID=22497702
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2000000652A PE20010327A1 (es) | 1999-06-30 | 2000-06-28 | Derivados de aminopirrolidina heterociclica como agentes melatonergicos |
Country Status (13)
Country | Link |
---|---|
US (1) | US6211225B1 (es) |
EP (1) | EP1189900B1 (es) |
JP (2) | JP4767463B2 (es) |
AT (1) | ATE257834T1 (es) |
AU (1) | AU763963B2 (es) |
CA (1) | CA2376949C (es) |
DE (1) | DE60007745T2 (es) |
DK (1) | DK1189900T3 (es) |
ES (1) | ES2213022T3 (es) |
PE (1) | PE20010327A1 (es) |
PT (1) | PT1189900E (es) |
UY (1) | UY26226A1 (es) |
WO (1) | WO2001002392A1 (es) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6569894B1 (en) | 2001-10-04 | 2003-05-27 | Bristol-Myers Squibb Company | Arylalkylbenzofuran derivatives as melatonergic agents |
US6737431B2 (en) | 2002-03-12 | 2004-05-18 | Bristol-Myers Squibb Company | Benzoxazole derivatives as novel melatonergic agents |
CN1688527A (zh) | 2002-08-12 | 2005-10-26 | 武田药品工业株式会社 | 稠合的苯衍生物以及用途 |
EP1871356A1 (en) * | 2005-04-22 | 2008-01-02 | Wyeth a Corporation of the State of Delaware | Dihydrobenzofuran derivatives and uses thereof |
CN101180283A (zh) * | 2005-04-22 | 2008-05-14 | 惠氏公司 | 二氢苯并呋喃衍生物和其用途 |
JP2009538334A (ja) | 2006-05-22 | 2009-11-05 | ヴァンダ ファーマシューティカルズ インコーポレイテッド | 抑うつ障害のための治療 |
CN101687810A (zh) * | 2007-04-26 | 2010-03-31 | 武田药品工业株式会社 | 双环化合物及其药物用途 |
ES2331276B1 (es) * | 2007-10-25 | 2010-10-21 | Ferrer Internacional, S.A. | Compuestos de fenilpirrolidina. |
EP2266975A1 (en) * | 2009-06-15 | 2010-12-29 | Ferrer Internacional, S.A. | 1-(2-alkyl-2,3-dihydro-benzofuran-4-yl)-pyrrolidin-3-ylamine acyl compounds |
KR102593047B1 (ko) | 2012-01-26 | 2023-10-24 | 반다 파마슈티칼즈, 인코퍼레이티드. | 일주기 리듬 장애의 치료 |
US11918557B2 (en) | 2012-01-26 | 2024-03-05 | Vanda Pharmaceuticals Inc. | Treatment of circadian rhythm disorders |
BR112015012366A8 (pt) | 2012-11-29 | 2019-10-01 | Chemocentryx Inc | antagonistas de cxcr7, uso dos mesmos, composição farmacêutica, bem como métodos para detectar níveis elevados de cxcr7 em uma amostra e para imagear um tumor, órgão, ou tecido |
CA2893542C (en) | 2012-12-18 | 2022-07-19 | Vanda Pharmaceuticals Inc. | Use of tasimelteon in the treatment of circadian rhythm disorders |
US11090285B2 (en) | 2013-11-12 | 2021-08-17 | Vanda Pharmaceuticals Inc | Treatment of circadian rhythm disorders |
US10376487B2 (en) | 2013-11-12 | 2019-08-13 | Vanda Pharmaceuticals Inc. | Method of treatment |
BR102016024814A2 (pt) | 2016-10-24 | 2018-05-08 | Aché Laboratórios Farmacêuticos S.A. | composto, processo de obtenção do composto, composição farmacêutica, uso do composto e método de tratamento de desordens psiquiátricas e/ou distúrbios do sono |
BR112021011222A2 (pt) | 2018-12-12 | 2021-08-24 | Chemocentryx, Inc. | Inibidores de cxcr7 para o tratamento de câncer |
CN109574970A (zh) * | 2018-12-27 | 2019-04-05 | 上海毕得医药技术有限公司 | 一种5-溴苯并二氢吡喃的合成方法 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3518273A (en) * | 1966-08-03 | 1970-06-30 | Warner Lambert Pharmaceutical | Benzopyranquinolinol derivatives and process for their production |
US3485835A (en) * | 1968-04-10 | 1969-12-23 | Haessle Ab | 2-benzoyl-3-tertiaryamino alkoxy benzofuran derivatives |
US5071875A (en) | 1989-09-25 | 1991-12-10 | Northwestern University | Substituted 2-amidotetralins as melatonin agonists and antagonists |
FR2674524B1 (fr) | 1991-03-25 | 1993-05-21 | Adir | Nouveaux amides alkyl heterocycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
FR2680366B1 (fr) | 1991-08-13 | 1995-01-20 | Adir | Nouveaux derives d'arylethylamines, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent. |
FR2689124A1 (fr) | 1992-03-27 | 1993-10-01 | Adir | Nouvelles naphtylalkylamines, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent. |
US5449683A (en) | 1992-10-01 | 1995-09-12 | Massachussetts Institute Of Technology | Methods of inducing sleep using melatonin |
GB9326192D0 (en) | 1993-12-22 | 1994-02-23 | Glaxo Group Ltd | Chemical compounds |
GB9407919D0 (en) | 1994-04-21 | 1994-06-15 | Glaxo Group Ltd | Chemical compounds |
FR2725985B1 (fr) | 1994-10-21 | 1996-11-15 | Adir | Nouveaux composes tricycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
US5753709A (en) * | 1995-06-07 | 1998-05-19 | Bristol-Myers Squibb Company | N-acyl-2 aryl cyclopropylmethylamine derivatives as melatonergics |
JP2000511518A (ja) | 1996-05-14 | 2000-09-05 | グラクソ、グループ、リミテッド | 時間生物学的薬剤としてのベンゾフランおよびベンゾピラン |
TW476758B (en) * | 1996-12-10 | 2002-02-21 | Bristol Myers Squibb Co | Benzodioxole, benzofuran, dihydrobenzofuran and benzodioxane melatonergic agents |
FR2761358B1 (fr) * | 1997-03-27 | 1999-05-07 | Adir | Nouveaux composes de n-aryl piperidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
-
2000
- 2000-06-06 DE DE60007745T patent/DE60007745T2/de not_active Expired - Lifetime
- 2000-06-06 CA CA002376949A patent/CA2376949C/en not_active Expired - Lifetime
- 2000-06-06 WO PCT/US2000/015478 patent/WO2001002392A1/en active IP Right Grant
- 2000-06-06 US US09/587,928 patent/US6211225B1/en not_active Expired - Lifetime
- 2000-06-06 EP EP00938160A patent/EP1189900B1/en not_active Expired - Lifetime
- 2000-06-06 DK DK00938160T patent/DK1189900T3/da active
- 2000-06-06 AU AU53240/00A patent/AU763963B2/en not_active Expired
- 2000-06-06 ES ES00938160T patent/ES2213022T3/es not_active Expired - Lifetime
- 2000-06-06 PT PT00938160T patent/PT1189900E/pt unknown
- 2000-06-06 AT AT00938160T patent/ATE257834T1/de active
- 2000-06-06 JP JP2001507829A patent/JP4767463B2/ja not_active Expired - Lifetime
- 2000-06-28 UY UY26226A patent/UY26226A1/es not_active Application Discontinuation
- 2000-06-28 PE PE2000000652A patent/PE20010327A1/es not_active Application Discontinuation
-
2011
- 2011-04-07 JP JP2011085583A patent/JP5248647B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
ATE257834T1 (de) | 2004-01-15 |
EP1189900A4 (en) | 2002-07-31 |
AU763963B2 (en) | 2003-08-07 |
WO2001002392A1 (en) | 2001-01-11 |
EP1189900B1 (en) | 2004-01-14 |
CA2376949C (en) | 2009-05-26 |
AU5324000A (en) | 2001-01-22 |
UY26226A1 (es) | 2001-01-31 |
JP5248647B2 (ja) | 2013-07-31 |
JP4767463B2 (ja) | 2011-09-07 |
US6211225B1 (en) | 2001-04-03 |
DK1189900T3 (da) | 2004-04-26 |
DE60007745T2 (de) | 2005-03-10 |
ES2213022T3 (es) | 2004-08-16 |
DE60007745D1 (de) | 2004-02-19 |
PT1189900E (pt) | 2004-05-31 |
JP2003503492A (ja) | 2003-01-28 |
CA2376949A1 (en) | 2001-01-11 |
JP2011137043A (ja) | 2011-07-14 |
EP1189900A1 (en) | 2002-03-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |