DE60007745D1 - Heterocyclische aminopyrrolidon-derivate als melatonergene wirkstoffe - Google Patents
Heterocyclische aminopyrrolidon-derivate als melatonergene wirkstoffeInfo
- Publication number
- DE60007745D1 DE60007745D1 DE60007745T DE60007745T DE60007745D1 DE 60007745 D1 DE60007745 D1 DE 60007745D1 DE 60007745 T DE60007745 T DE 60007745T DE 60007745 T DE60007745 T DE 60007745T DE 60007745 D1 DE60007745 D1 DE 60007745D1
- Authority
- DE
- Germany
- Prior art keywords
- heterocyclic
- agents
- melatoninergic
- aminopyrrolidone derivatives
- aminopyrrolidone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Indole Compounds (AREA)
- Cosmetics (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14189499P | 1999-06-30 | 1999-06-30 | |
US141894P | 1999-06-30 | ||
PCT/US2000/015478 WO2001002392A1 (en) | 1999-06-30 | 2000-06-06 | Heterocyclic aminopyrrolidine derivatives as melatonergic agents |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60007745D1 true DE60007745D1 (de) | 2004-02-19 |
DE60007745T2 DE60007745T2 (de) | 2005-03-10 |
Family
ID=22497702
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60007745T Expired - Lifetime DE60007745T2 (de) | 1999-06-30 | 2000-06-06 | Heterocyclische aminopyrrolidon-derivate als melatonergene wirkstoffe |
Country Status (13)
Country | Link |
---|---|
US (1) | US6211225B1 (de) |
EP (1) | EP1189900B1 (de) |
JP (2) | JP4767463B2 (de) |
AT (1) | ATE257834T1 (de) |
AU (1) | AU763963B2 (de) |
CA (1) | CA2376949C (de) |
DE (1) | DE60007745T2 (de) |
DK (1) | DK1189900T3 (de) |
ES (1) | ES2213022T3 (de) |
PE (1) | PE20010327A1 (de) |
PT (1) | PT1189900E (de) |
UY (1) | UY26226A1 (de) |
WO (1) | WO2001002392A1 (de) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6569894B1 (en) | 2001-10-04 | 2003-05-27 | Bristol-Myers Squibb Company | Arylalkylbenzofuran derivatives as melatonergic agents |
US6737431B2 (en) | 2002-03-12 | 2004-05-18 | Bristol-Myers Squibb Company | Benzoxazole derivatives as novel melatonergic agents |
AU2003254993A1 (en) * | 2002-08-12 | 2004-03-03 | Takeda Pharmaceutical Company Limited | Fused benzene derivative and use |
TW200719886A (en) * | 2005-04-22 | 2007-06-01 | Wyeth Corp | Dihydrobenzofuran derivatives and uses thereof |
EP1871754A1 (de) * | 2005-04-22 | 2008-01-02 | Wyeth a Corporation of the State of Delaware | Dihydrobenzofuran-derivate und verwendungen dafür |
JP2009538334A (ja) * | 2006-05-22 | 2009-11-05 | ヴァンダ ファーマシューティカルズ インコーポレイテッド | 抑うつ障害のための治療 |
KR20100017297A (ko) * | 2007-04-26 | 2010-02-16 | 다케다 야쿠힌 고교 가부시키가이샤 | 2환식 화합물 및 이의 약학적 용도 |
ES2331276B1 (es) * | 2007-10-25 | 2010-10-21 | Ferrer Internacional, S.A. | Compuestos de fenilpirrolidina. |
EP2266975A1 (de) * | 2009-06-15 | 2010-12-29 | Ferrer Internacional, S.A. | 1-(2-Alkyl-2,3-dihydrobenzofuran-4-yl)pyrrolidin-3-ylaminacyl-Verbindungen |
ES2646197T3 (es) | 2012-01-26 | 2017-12-12 | Vanda Pharmaceuticals Inc. | Tratamiento de trastornos del ritmo circadiano |
US11918557B2 (en) | 2012-01-26 | 2024-03-05 | Vanda Pharmaceuticals Inc. | Treatment of circadian rhythm disorders |
ES2681593T3 (es) | 2012-11-29 | 2018-09-14 | Chemocentryx, Inc. | Antagonistas de CXCR7 |
IL266159B1 (en) | 2012-12-18 | 2024-03-01 | Vanda Pharmaceuticals Inc | Treatment of circadian rhythm disorders |
US10376487B2 (en) | 2013-11-12 | 2019-08-13 | Vanda Pharmaceuticals Inc. | Method of treatment |
US11090285B2 (en) | 2013-11-12 | 2021-08-17 | Vanda Pharmaceuticals Inc | Treatment of circadian rhythm disorders |
BR102016024814A2 (pt) | 2016-10-24 | 2018-05-08 | Aché Laboratórios Farmacêuticos S.A. | composto, processo de obtenção do composto, composição farmacêutica, uso do composto e método de tratamento de desordens psiquiátricas e/ou distúrbios do sono |
US11464786B2 (en) | 2018-12-12 | 2022-10-11 | Chemocentryx, Inc. | CXCR7 inhibitors for the treatment of cancer |
CN109574970A (zh) * | 2018-12-27 | 2019-04-05 | 上海毕得医药技术有限公司 | 一种5-溴苯并二氢吡喃的合成方法 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3518273A (en) * | 1966-08-03 | 1970-06-30 | Warner Lambert Pharmaceutical | Benzopyranquinolinol derivatives and process for their production |
US3485835A (en) * | 1968-04-10 | 1969-12-23 | Haessle Ab | 2-benzoyl-3-tertiaryamino alkoxy benzofuran derivatives |
US5071875A (en) | 1989-09-25 | 1991-12-10 | Northwestern University | Substituted 2-amidotetralins as melatonin agonists and antagonists |
FR2674524B1 (fr) | 1991-03-25 | 1993-05-21 | Adir | Nouveaux amides alkyl heterocycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
FR2680366B1 (fr) | 1991-08-13 | 1995-01-20 | Adir | Nouveaux derives d'arylethylamines, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent. |
FR2689124A1 (fr) | 1992-03-27 | 1993-10-01 | Adir | Nouvelles naphtylalkylamines, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent. |
US5449683A (en) | 1992-10-01 | 1995-09-12 | Massachussetts Institute Of Technology | Methods of inducing sleep using melatonin |
GB9326192D0 (en) | 1993-12-22 | 1994-02-23 | Glaxo Group Ltd | Chemical compounds |
GB9407919D0 (en) | 1994-04-21 | 1994-06-15 | Glaxo Group Ltd | Chemical compounds |
FR2725985B1 (fr) | 1994-10-21 | 1996-11-15 | Adir | Nouveaux composes tricycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
US5753709A (en) | 1995-06-07 | 1998-05-19 | Bristol-Myers Squibb Company | N-acyl-2 aryl cyclopropylmethylamine derivatives as melatonergics |
DE69723436T2 (de) | 1996-05-14 | 2004-07-22 | Glaxo Group Ltd., Greenford | Benzofurane und benzpyrane als chronobiologische mittel |
PT1027043E (pt) * | 1996-12-10 | 2005-02-28 | Bristol Myers Squibb Co | Benzodioxole benzofurano di-hidrobenzofurano e benzodioxano como agentes melatonergicos |
FR2761358B1 (fr) * | 1997-03-27 | 1999-05-07 | Adir | Nouveaux composes de n-aryl piperidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
-
2000
- 2000-06-06 EP EP00938160A patent/EP1189900B1/de not_active Expired - Lifetime
- 2000-06-06 US US09/587,928 patent/US6211225B1/en not_active Expired - Lifetime
- 2000-06-06 JP JP2001507829A patent/JP4767463B2/ja not_active Expired - Lifetime
- 2000-06-06 WO PCT/US2000/015478 patent/WO2001002392A1/en active IP Right Grant
- 2000-06-06 DK DK00938160T patent/DK1189900T3/da active
- 2000-06-06 AT AT00938160T patent/ATE257834T1/de active
- 2000-06-06 DE DE60007745T patent/DE60007745T2/de not_active Expired - Lifetime
- 2000-06-06 PT PT00938160T patent/PT1189900E/pt unknown
- 2000-06-06 AU AU53240/00A patent/AU763963B2/en not_active Expired
- 2000-06-06 ES ES00938160T patent/ES2213022T3/es not_active Expired - Lifetime
- 2000-06-06 CA CA002376949A patent/CA2376949C/en not_active Expired - Lifetime
- 2000-06-28 UY UY26226A patent/UY26226A1/es not_active Application Discontinuation
- 2000-06-28 PE PE2000000652A patent/PE20010327A1/es not_active Application Discontinuation
-
2011
- 2011-04-07 JP JP2011085583A patent/JP5248647B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
ES2213022T3 (es) | 2004-08-16 |
PE20010327A1 (es) | 2001-06-10 |
CA2376949C (en) | 2009-05-26 |
AU763963B2 (en) | 2003-08-07 |
US6211225B1 (en) | 2001-04-03 |
JP4767463B2 (ja) | 2011-09-07 |
JP2011137043A (ja) | 2011-07-14 |
DK1189900T3 (da) | 2004-04-26 |
WO2001002392A1 (en) | 2001-01-11 |
EP1189900B1 (de) | 2004-01-14 |
AU5324000A (en) | 2001-01-22 |
EP1189900A4 (de) | 2002-07-31 |
EP1189900A1 (de) | 2002-03-27 |
CA2376949A1 (en) | 2001-01-11 |
PT1189900E (pt) | 2004-05-31 |
JP2003503492A (ja) | 2003-01-28 |
UY26226A1 (es) | 2001-01-31 |
ATE257834T1 (de) | 2004-01-15 |
DE60007745T2 (de) | 2005-03-10 |
JP5248647B2 (ja) | 2013-07-31 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE60007745D1 (de) | Heterocyclische aminopyrrolidon-derivate als melatonergene wirkstoffe | |
TR199901674T2 (de) | ||
ATE245636T1 (de) | Benzofurylpiperazine: 5-ht2c serotoninrezeptor agonisten | |
CY1105688T1 (el) | Κυανοπυρρολες ως αγωνιστες υποδοχεων προγεστερονης | |
ATE323678T1 (de) | Tri-aryl-säurederivate als ppar rezeptor liganden | |
DE60110262D1 (de) | Thiazol und oxazol-derivate als aktivatoren von menschlichen peroxisom proliferator aktivierten rezeptoren | |
CO5210884A1 (es) | DERIVADOS DE 5H-TIAZOLO[3,2-a] PIRIMIDINA | |
DE69906940T2 (de) | Bizyclische pyrrolverbindungen, deren pharmazeutische zusammensetzungen und ihre verwendung als entzündungshemmende und immunmodulierende mittel | |
EA200300064A1 (ru) | Карбоксамидные соединения и их применение в качестве антагонистов 11cby-рецептора человека | |
TR199800436A2 (xx) | Primidin t�revlerinin kanserin �nlenmesi i�in kullan�lmas�. | |
SE9702773D0 (sv) | Novel compounds | |
ES2191076T3 (es) | Nuevos derivados de 1-aril-pirazol y su empleo como plaguicidas. | |
CO5271666A1 (es) | Derivados de pirimidina | |
TR199903277T2 (xx) | Benzimidazol t�revleri. | |
ATE300543T1 (de) | Kondensierte pyrazindionderivate als pde5 inhibitore | |
DE60139382D1 (de) | 2-hydroxy-mutilin-carbamat derivate und ihre anwendung als antibakterielle mittel | |
TR200400857T4 (tr) | Yeni galantamın türevleri ve analogları | |
DE69528983D1 (de) | Indolalkaloide als antientzündliche wirkstoffe | |
SE9904674D0 (sv) | Novel compounds | |
DE60112960D1 (de) | Kondensierte pyridoindolderivate | |
YU44301A (sh) | 5ht1 antagonisti za antidepresantnu terapiju | |
CY1105373T1 (el) | Ισοκινολινυλικα καρβοξαμιδια και η χρηση τους ως αντισπαστικα | |
DE60121048D1 (de) | PYRAZINOi1'2':1,6öPYRIDOi3,4-BöINDOLDERIVATE | |
CO5261576A1 (es) | Compuestos | |
ATE207460T1 (de) | Benzocycloalken-verbindungen mit bindungsaffinität an den melatonin-rezeptor, ihre herstellung und verwendung |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |