ECSP044971A - Isoxazolopiridinonas y su uso en el tratamiento de enfermedad de parkinson - Google Patents

Isoxazolopiridinonas y su uso en el tratamiento de enfermedad de parkinson

Info

Publication number
ECSP044971A
ECSP044971A EC2004004971A ECSP044971A ECSP044971A EC SP044971 A ECSP044971 A EC SP044971A EC 2004004971 A EC2004004971 A EC 2004004971A EC SP044971 A ECSP044971 A EC SP044971A EC SP044971 A ECSP044971 A EC SP044971A
Authority
EC
Ecuador
Prior art keywords
isoxazolopiridinonas
parkinson
disease treatment
formula
compounds
Prior art date
Application number
EC2004004971A
Other languages
English (en)
Inventor
Samuel Hintermann
Bastian Hengerer
Krosigk Ulrike Von
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of ECSP044971A publication Critical patent/ECSP044971A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

La invención proporciona compuestos de la fórmula I en donde X, Y, R1, R2 y R3 son como se definen en la descripción, y su preparación. Los compuestos de la fórmula I son útiles como farmacéuticos.
EC2004004971A 2001-08-15 2004-02-03 Isoxazolopiridinonas y su uso en el tratamiento de enfermedad de parkinson ECSP044971A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0119911.6A GB0119911D0 (en) 2001-08-15 2001-08-15 Organic Compounds

Publications (1)

Publication Number Publication Date
ECSP044971A true ECSP044971A (es) 2004-03-23

Family

ID=9920454

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2004004971A ECSP044971A (es) 2001-08-15 2004-02-03 Isoxazolopiridinonas y su uso en el tratamiento de enfermedad de parkinson

Country Status (24)

Country Link
US (1) US7087756B2 (es)
EP (1) EP1418912B1 (es)
JP (1) JP2005501847A (es)
KR (1) KR20040029429A (es)
CN (1) CN100384418C (es)
AR (1) AR036351A1 (es)
AT (1) ATE355059T1 (es)
BR (1) BR0211903A (es)
CA (1) CA2454762A1 (es)
CO (1) CO5560566A2 (es)
DE (1) DE60218484T2 (es)
EC (1) ECSP044971A (es)
ES (1) ES2282467T3 (es)
GB (1) GB0119911D0 (es)
HU (1) HUP0401325A3 (es)
IL (1) IL160018A0 (es)
MX (1) MXPA04001419A (es)
NO (1) NO20040659D0 (es)
PE (1) PE20030356A1 (es)
PL (1) PL366848A1 (es)
PT (1) PT1418912E (es)
RU (1) RU2004107847A (es)
WO (1) WO2003015780A2 (es)
ZA (1) ZA200400525B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2451057A1 (en) * 2001-06-14 2002-12-27 Banyu Pharmaceutical Co., Ltd. Novel isoxazolopyridone derivatives and use thereof
US7820705B2 (en) * 2004-05-14 2010-10-26 Irm Llc Compounds and compositions as PPAR modulators
CA2642672A1 (en) * 2006-02-16 2007-08-30 The Mclean Hospital Corporation Methods and compositions for the treatment of parkinson's disease
AU2007275301A1 (en) 2006-07-20 2008-01-24 Amgen Inc. Substituted azole aromatic heterocycles as inhibitors of 11-beta-HSD-1
FR2906250B1 (fr) * 2006-09-22 2008-10-31 Sanofi Aventis Sa Derives de 2-aryl-6phenyl-imidazo(1,2-a) pyridines, leur preparation et leur application en therapeutique
FR2933609B1 (fr) 2008-07-10 2010-08-27 Fournier Lab Sa Utilisation de derives d'indole comme activateurs de nurr-1, pour le traitement de la maladie de parkinson.
EP2376079B1 (en) * 2009-01-13 2016-08-10 Van Andel Research Institute Methods of using substituted isoxazolo pyridinones as dissociated glucocorticoids
FR2950053B1 (fr) 2009-09-11 2014-08-01 Fournier Lab Sa Utilisation de derives d'indole benzoique comme activateurs de nurr-1, pour le traitement de la maladie de parkinson
FR2955110A1 (fr) 2010-01-08 2011-07-15 Fournier Lab Sa Nouveaux derives de type pyrrolopyridine benzoique
DE102011085038A1 (de) 2011-10-21 2013-04-25 Tesa Se Verfahren zur Kapselung einer elektronischen Anordnung
WO2015048316A1 (en) 2013-09-25 2015-04-02 Van Andel Research Institute Highly potent glucocorticoids
KR20170033630A (ko) 2015-09-17 2017-03-27 (주)다올 도로용 경계블럭
JP7146750B2 (ja) 2016-10-14 2022-10-04 ヴァン アンデル リサーチ インスティテュート 非常に強力な糖質コルチコイドの構造およびデザインのための機構

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE7602542L (sv) 1975-03-14 1976-09-15 Sandoz Ag 3-(alfa-iminobensyl)-4-hydroxi-2(lh)-pyridoner
US4064251A (en) * 1976-06-25 1977-12-20 Sandoz, Inc. Substituted hydroxy pyridones
US4049813A (en) * 1976-07-15 1977-09-20 Sandoz, Inc. Substituted isoxazolo pyridinones
DE2801190A1 (de) * 1977-01-19 1978-07-20 Sandoz Ag 3-(alpha-iminobenzyl)-4-hydroxy-2(1h)- pyridon-derivat
US4238616A (en) * 1977-01-19 1980-12-09 Sandoz, Inc. 3-(Substituted)phenyl-5-(β-hydroxyphenethyl)-N-(alkyl)-isoxazole-4-carboxamides
US4113727A (en) * 1977-04-26 1978-09-12 Sandoz, Inc. Process for the preparation of substituted isoxazolo[4,5-c]pyridin-4-(5H)-ones
CA2451057A1 (en) * 2001-06-14 2002-12-27 Banyu Pharmaceutical Co., Ltd. Novel isoxazolopyridone derivatives and use thereof

Also Published As

Publication number Publication date
JP2005501847A (ja) 2005-01-20
CO5560566A2 (es) 2005-09-30
DE60218484D1 (de) 2007-04-12
WO2003015780A3 (en) 2003-11-13
HUP0401325A2 (hu) 2004-10-28
WO2003015780A2 (en) 2003-02-27
MXPA04001419A (es) 2004-05-27
PL366848A1 (en) 2005-02-07
ZA200400525B (en) 2005-04-01
CN1635889A (zh) 2005-07-06
ATE355059T1 (de) 2006-03-15
DE60218484T2 (de) 2007-11-15
ES2282467T3 (es) 2007-10-16
US7087756B2 (en) 2006-08-08
GB0119911D0 (en) 2001-10-10
NO20040659L (no) 2004-02-13
RU2004107847A (ru) 2005-05-10
CN100384418C (zh) 2008-04-30
BR0211903A (pt) 2004-09-21
CA2454762A1 (en) 2003-02-27
AR036351A1 (es) 2004-09-01
IL160018A0 (en) 2004-06-20
US20040248893A1 (en) 2004-12-09
PE20030356A1 (es) 2003-05-14
PT1418912E (pt) 2007-05-31
EP1418912A2 (en) 2004-05-19
EP1418912B1 (en) 2007-02-28
NO20040659D0 (no) 2004-02-13
HUP0401325A3 (en) 2005-09-28
KR20040029429A (ko) 2004-04-06
WO2003015780A8 (en) 2004-05-21

Similar Documents

Publication Publication Date Title
ATE469892T1 (de) Substituierte 1h-dihydropyrazole, ihre herstellung und verwendung
BR0116452A (pt) Composto, composição farmacêutica, uso de um composto
BRPI0413022A (pt) derivados de 3-amino cromado e 2-amino tetralina
UY28150A1 (es) Agentes terapeuticos
AR028948A1 (es) Compuestos novedosos
ECSP045255A (es) Cumarinas utiles como biomarcadores
AR023727A1 (es) Compuestos empleados en el tratamiento de padecimientos inflamatorios
SE0302811D0 (sv) Novel compounds
PT1453512E (pt) Derivados de acetileno tendo actividade antagonistica do mglur 5
BR0115436A (pt) Compostos de piperazinilpirazina atuando como antagonistas do receptor 5ht-2 de serotonina
BR0014352A (pt) Cetoenóis espirocìclicos substituìdos por trifluormetila
UY28623A1 (es) Derivados de pirazol y usos de los mismos
SE0201544D0 (sv) Novel compounds and thier use
ECSP044971A (es) Isoxazolopiridinonas y su uso en el tratamiento de enfermedad de parkinson
SE0303541D0 (sv) New compounds
ATE515262T1 (de) Verwendung von parthenolid-derivaten als antileukämische und zytotoxische mittel
BR0313385A (pt) Derivados de pirimidina-2,4-diona como inibidores de metaloproteinase da matriz
SE9902765D0 (sv) Novel compounds
SE0003476D0 (sv) Compounds
ECSP034754A (es) Derivados de beta-carbolina y su uso farmaceutico contra depresion y ansiedad
AR020563A1 (es) Compuestos (poli)tia-alquinoicos y sus derivados, composiciones que los incluyen y su utilizacion
MY136297A (en) Piperazine derivatives having sst1 antagonistic activity
ATE417856T1 (de) Motilidverbindungen
SE0303280D0 (sv) Novel compounds
BRPI0408117A (pt) compostos heterocìclicos bifuncionais e métodos de produção e uso dos mesmos