ECSP045255A - Cumarinas utiles como biomarcadores - Google Patents

Cumarinas utiles como biomarcadores

Info

Publication number
ECSP045255A
ECSP045255A EC2004005255A ECSP045255A ECSP045255A EC SP045255 A ECSP045255 A EC SP045255A EC 2004005255 A EC2004005255 A EC 2004005255A EC SP045255 A ECSP045255 A EC SP045255A EC SP045255 A ECSP045255 A EC SP045255A
Authority
EC
Ecuador
Prior art keywords
biomarkers
useful
roads
formula
compounds
Prior art date
Application number
EC2004005255A
Other languages
English (en)
Inventor
Yves Auberson
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9932424&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP045255(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of ECSP045255A publication Critical patent/ECSP045255A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La invención proporciona compuestos de la fórmula (I), en donde R, R1, R2, R3, y R4 son como se definen en la descripción, y su preparación. Los compuestos de la fórmula I son útiles como biomarcadores.
EC2004005255A 2002-03-06 2004-08-27 Cumarinas utiles como biomarcadores ECSP045255A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0205281.9A GB0205281D0 (en) 2002-03-06 2002-03-06 Organic compounds

Publications (1)

Publication Number Publication Date
ECSP045255A true ECSP045255A (es) 2004-09-28

Family

ID=9932424

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2004005255A ECSP045255A (es) 2002-03-06 2004-08-27 Cumarinas utiles como biomarcadores

Country Status (24)

Country Link
US (1) US7569337B2 (es)
EP (1) EP1483262B1 (es)
JP (2) JP4247123B2 (es)
KR (1) KR20040095257A (es)
CN (1) CN1628114A (es)
AR (1) AR038723A1 (es)
AT (1) ATE378333T1 (es)
AU (1) AU2003210418A1 (es)
BR (1) BR0308211A (es)
CA (1) CA2472298A1 (es)
CO (1) CO5611123A2 (es)
DE (1) DE60317476T2 (es)
EC (1) ECSP045255A (es)
ES (1) ES2294304T3 (es)
GB (1) GB0205281D0 (es)
MX (1) MXPA04008570A (es)
NO (1) NO20044174L (es)
PE (1) PE20030890A1 (es)
PL (1) PL370916A1 (es)
PT (1) PT1483262E (es)
RU (1) RU2004129733A (es)
TW (1) TW200400049A (es)
WO (1) WO2003074519A1 (es)
ZA (1) ZA200405175B (es)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0205281D0 (en) * 2002-03-06 2002-04-17 Novartis Ag Organic compounds
WO2005040337A2 (en) * 2003-05-20 2005-05-06 The Regents Of The University Of California METHODS FOR BINDING AGENTS TO β-AMYLOID PLAQUES
EP1815872A4 (en) * 2004-11-26 2011-06-15 Univ Nagasaki COMPOSITION FOR THE DIAGNOSIS OF AMYLOID ASSOCIATED DISEASE
JP2007084526A (ja) * 2004-11-26 2007-04-05 Nagasaki Univ アミロイド関連疾患診断用組成物
TW200803903A (en) * 2006-04-28 2008-01-16 Nihon Mediphysics Co Ltd Novel compound having affinity to amyloid
JP5238496B2 (ja) * 2006-05-19 2013-07-17 日本メジフィジックス株式会社 新規アミロイド親和性化合物
TW200811175A (en) * 2006-06-21 2008-03-01 Nihon Mediphysics Co Ltd Novel compound with affinity with amyloid
CN101501033B (zh) 2006-06-21 2012-08-01 通用电气医疗有限公司 对淀粉状蛋白具有亲和性的化合物
EP2119458B9 (en) 2007-02-13 2013-08-21 Nihon Medi-Physics Co., Ltd. Method for production of radiation diagnostic imaging agent
TW200918102A (en) * 2007-10-24 2009-05-01 Nihon Mediphysics Co Ltd Novel compound having affinity for amyloid
KR20100089858A (ko) * 2007-10-30 2010-08-12 니혼 메디피직스 가부시키가이샤 신규 아밀로이드 친화성 화합물의 사용 및 제조 방법
KR20100101577A (ko) * 2007-10-30 2010-09-17 니혼 메디피직스 가부시키가이샤 신규 아밀로이드 친화성 화합물의 사용 및 제조 방법
MX352861B (es) * 2011-12-30 2017-12-13 Ptc Therapeutics Inc Compuestos para tratar la atrofia muscular espinal.
US9296728B2 (en) 2012-01-20 2016-03-29 Regents Of The University Of Minnesota Therapeutic compounds
MX357834B (es) * 2012-01-26 2018-07-26 Ptc Therapeutics Inc Compuestos de tipo isocumarina sustituidos para tratar la atrofia muscular espinal.
EP3406252B1 (en) 2012-02-10 2020-05-13 PTC Therapeutics, Inc. Compounds for treating spinal muscular atrophy
US9371336B2 (en) 2012-03-01 2016-06-21 Ptc Therapeutics, Inc. Compounds for treating spinal muscular atrophy
EP2828247B1 (en) 2012-03-23 2019-01-16 PTC Therapeutics, Inc. 4h-chromen-4-one derivatives for treating spinal muscular atrophy
CN104987328A (zh) * 2012-05-23 2015-10-21 复旦大学 7-氧、硫或氮杂取代香豆素及其衍生物和用途
WO2015105657A1 (en) 2013-12-19 2015-07-16 Ptc Therapeutics, Inc. Methods for modulating the amount of rna transcripts
EP3310169B1 (en) 2015-05-30 2023-05-17 PTC Therapeutics, Inc. Methods for modulating rna splicing
CA3119019C (en) 2015-12-10 2024-06-11 Ptc Therapeutics, Inc. Compounds and methods for treating huntington's disease
JP2019535789A (ja) 2016-11-28 2019-12-12 ピーティーシー セラピューティクス，インコーポレーテッド Ｒｎａスプライシングを調節する方法
CN109476674B (zh) 2016-12-22 2021-12-10 伊鲁米纳剑桥有限公司 香豆素化合物及其作为荧光标记物的用途
CN108061725B (zh) * 2017-02-16 2020-04-21 昆明医科大学 1,8-萘啶基荧光分子探针在氯胺酮娱乐性滥用神经机制研究及成瘾程度诊断中的应用
EP4151627A1 (en) 2017-06-05 2023-03-22 PTC Therapeutics, Inc. Compounds for treating huntington's disease
CN111372611A (zh) 2017-06-14 2020-07-03 Ptc医疗公司 修饰rna剪接的方法
CN111182898B (zh) 2017-06-28 2024-04-16 Ptc医疗公司 用于治疗亨廷顿氏病的方法
CN111163838B (zh) 2017-06-28 2023-03-28 Ptc医疗公司 用于治疗亨廷顿氏病的方法
BR112020019373A2 (pt) 2018-03-27 2020-12-29 Ptc Therapeutics, Inc. Compostos para o tratamento da doença de hutington
WO2020005882A1 (en) 2018-06-27 2020-01-02 Ptc Therapeutics, Inc. Heteroaryl compounds for treating huntington's disease
IL279688B2 (en) 2018-06-27 2025-01-01 Ptc Therapeutics Inc Heterocyclic and heteroaryl compounds for the treatment of Huntington's disease
KR20210038845A (ko) 2018-06-27 2021-04-08 피티씨 테라퓨틱스, 인크. 헌팅턴병 치료를 위한 헤테로아릴 화합물
CN112654681B (zh) 2019-03-01 2023-01-06 伊卢米纳剑桥有限公司 环外胺取代的香豆素化合物及其作为荧光标记物的用途
CA3139821A1 (en) 2019-05-13 2020-11-19 Ptc Therapeutics, Inc. Compounds for treating huntington's disease
CN112300201B (zh) * 2020-12-07 2021-11-23 南京林业大学 一种三聚茚基香豆素-咔咯-卟啉四元体系星型化合物的合成及其制备方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH390250A (de) * 1958-06-19 1965-07-30 Geigy Ag J R Verfahren zur Herstellung von fluoreszierenden Farbstoffen
DE2030507C3 (de) * 1970-06-20 1975-05-22 Bayer Ag, 5090 Leverkusen Oxazolyl-cumarine, deren Herstellung und Verwendung
JPS5529110B2 (es) * 1972-12-25 1980-08-01
DE2410634A1 (de) * 1974-03-06 1975-09-18 Basf Ag 3-benzofurylcumarine
DE2411969A1 (de) * 1974-03-13 1975-09-25 Bayer Ag Farbstofflaser
DE2525986A1 (de) * 1975-06-11 1977-05-05 Bayer Ag Cumarinverbindungen
LU78311A1 (de) * 1977-10-13 1979-06-01 Ciba Geigy Ag Neue cumarinfarbstoffe,deren herstellung und verwendung
US4892922A (en) * 1987-11-30 1990-01-09 Eastman Kodak Company Polyester polymer containing the residue of a benzopyran colorant compound and shaped articles produced therefrom
JPH01169327A (ja) * 1987-12-25 1989-07-04 Mitsui Toatsu Chem Inc 紫外線検知用樹脂組成物
JP2999841B2 (ja) * 1991-04-03 2000-01-17 三井化学株式会社 発光スクリーン用樹脂組成物
DE69216498T2 (de) 1991-08-13 1997-04-30 Bayer Ag Fluoreszierendes Etikett
JPH073179A (ja) * 1993-06-15 1995-01-06 Nippon Kayaku Co Ltd インクジェットプリント用インク組成物及びこれを用いる染色法
JP4028155B2 (ja) 2000-04-11 2007-12-26 日本カーバイド工業株式会社 蛍光性再帰反射シート
GB0205281D0 (en) * 2002-03-06 2002-04-17 Novartis Ag Organic compounds

Also Published As

Publication number Publication date
CA2472298A1 (en) 2003-09-12
JP2005526749A (ja) 2005-09-08
DE60317476T2 (de) 2008-05-21
WO2003074519A1 (en) 2003-09-12
PL370916A1 (en) 2005-06-13
EP1483262B1 (en) 2007-11-14
JP4247123B2 (ja) 2009-04-02
CN1628114A (zh) 2005-06-15
US20050169837A1 (en) 2005-08-04
RU2004129733A (ru) 2005-06-27
CO5611123A2 (es) 2006-02-28
JP2009102322A (ja) 2009-05-14
MXPA04008570A (es) 2004-12-06
ZA200405175B (en) 2005-06-21
PT1483262E (pt) 2008-02-11
GB0205281D0 (en) 2002-04-17
TW200400049A (en) 2004-01-01
BR0308211A (pt) 2004-12-21
ES2294304T3 (es) 2008-04-01
US7569337B2 (en) 2009-08-04
ATE378333T1 (de) 2007-11-15
AU2003210418A1 (en) 2003-09-16
KR20040095257A (ko) 2004-11-12
AR038723A1 (es) 2005-01-26
PE20030890A1 (es) 2003-12-05
DE60317476D1 (de) 2007-12-27
NO20044174L (no) 2004-09-30
EP1483262A1 (en) 2004-12-08

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