ECSP045255A - Cumarinas utiles como biomarcadores - Google Patents

Cumarinas utiles como biomarcadores

Info

Publication number
ECSP045255A
ECSP045255A EC2004005255A ECSP045255A ECSP045255A EC SP045255 A ECSP045255 A EC SP045255A EC 2004005255 A EC2004005255 A EC 2004005255A EC SP045255 A ECSP045255 A EC SP045255A EC SP045255 A ECSP045255 A EC SP045255A
Authority
EC
Ecuador
Prior art keywords
biomarkers
useful
roads
formula
compounds
Prior art date
Application number
EC2004005255A
Other languages
English (en)
Inventor
Yves Auberson
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9932424&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP045255(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of ECSP045255A publication Critical patent/ECSP045255A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

La invención proporciona compuestos de la fórmula (I), en donde R, R1, R2, R3, y R4 son como se definen en la descripción, y su preparación. Los compuestos de la fórmula I son útiles como biomarcadores.
EC2004005255A 2002-03-06 2004-08-27 Cumarinas utiles como biomarcadores ECSP045255A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0205281.9A GB0205281D0 (en) 2002-03-06 2002-03-06 Organic compounds

Publications (1)

Publication Number Publication Date
ECSP045255A true ECSP045255A (es) 2004-09-28

Family

ID=9932424

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2004005255A ECSP045255A (es) 2002-03-06 2004-08-27 Cumarinas utiles como biomarcadores

Country Status (24)

Country Link
US (1) US7569337B2 (es)
EP (1) EP1483262B1 (es)
JP (2) JP4247123B2 (es)
KR (1) KR20040095257A (es)
CN (1) CN1628114A (es)
AR (1) AR038723A1 (es)
AT (1) ATE378333T1 (es)
AU (1) AU2003210418A1 (es)
BR (1) BR0308211A (es)
CA (1) CA2472298A1 (es)
CO (1) CO5611123A2 (es)
DE (1) DE60317476T2 (es)
EC (1) ECSP045255A (es)
ES (1) ES2294304T3 (es)
GB (1) GB0205281D0 (es)
MX (1) MXPA04008570A (es)
NO (1) NO20044174L (es)
PE (1) PE20030890A1 (es)
PL (1) PL370916A1 (es)
PT (1) PT1483262E (es)
RU (1) RU2004129733A (es)
TW (1) TW200400049A (es)
WO (1) WO2003074519A1 (es)
ZA (1) ZA200405175B (es)

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GB0205281D0 (en) * 2002-03-06 2002-04-17 Novartis Ag Organic compounds
EP1624900A4 (en) * 2003-05-20 2007-05-02 Univ California METHOD OF BINDING AGENTS AT BETA AMYLOID PLAQUE
WO2006057323A1 (ja) * 2004-11-26 2006-06-01 Nagasaki University アミロイド関連疾患診断用組成物
JP2007084526A (ja) * 2004-11-26 2007-04-05 Nagasaki Univ アミロイド関連疾患診断用組成物
TW200803903A (en) * 2006-04-28 2008-01-16 Nihon Mediphysics Co Ltd Novel compound having affinity to amyloid
EP2019103B1 (en) * 2006-05-19 2011-11-30 Nihon Medi-Physics Co., Ltd. Compound having affinity for amyloid
TW200811175A (en) * 2006-06-21 2008-03-01 Nihon Mediphysics Co Ltd Novel compound with affinity with amyloid
WO2007148755A1 (ja) * 2006-06-21 2007-12-27 Nihon Medi-Physics Co., Ltd. 新規アミロイド親和性化合物
JP5258583B2 (ja) 2007-02-13 2013-08-07 日本メジフィジックス株式会社 放射性画像診断剤の製造方法
TW200918102A (en) * 2007-10-24 2009-05-01 Nihon Mediphysics Co Ltd Novel compound having affinity for amyloid
KR20100089858A (ko) * 2007-10-30 2010-08-12 니혼 메디피직스 가부시키가이샤 신규 아밀로이드 친화성 화합물의 사용 및 제조 방법
EP2216050A4 (en) * 2007-10-30 2012-11-21 Nihon Mediphysics Co Ltd USE OF NEW COMPOUNDS WITH AMYLOID AFFINITY AND METHOD OF MANUFACTURING THEREOF
US9617268B2 (en) * 2011-12-30 2017-04-11 Ptc Therapeutics, Inc. Compounds for treating spinal muscular atrophy
EP2804852A2 (en) 2012-01-20 2014-11-26 Regents Of The University Of Minnesota Therapeutic compounds
BR112014018027B1 (pt) 2012-01-26 2020-10-27 Ptc Therapeutics, Inc composto, composição farmacêutica e usos dos mesmos e métodos para aumentar a inclusão de éxon 7 de ame2 em rnam que é transcrito a partir do gene ame2 e para aumentar a quantidade de proteína smn
KR102341596B1 (ko) 2012-02-10 2021-12-21 피티씨 테라퓨틱스, 인크. 척수성 근위축증을 치료하기 위한 화합물
CA2865957C (en) * 2012-03-01 2020-02-11 F. Hoffmann-La Roche Ag Compounds for treating spinal muscular atrophy
EP2828247B1 (en) 2012-03-23 2019-01-16 PTC Therapeutics, Inc. 4h-chromen-4-one derivatives for treating spinal muscular atrophy
CN103420990B (zh) * 2012-05-23 2016-04-20 复旦大学 7-氧、硫或氮杂取代香豆素及其衍生物和用途
US10195202B2 (en) 2013-12-19 2019-02-05 Ptc Therapeutics, Inc. Methods for modulating the amount of RNA transcripts
EP4249472A3 (en) 2015-05-30 2023-12-13 PTC Therapeutics, Inc. Methods for modulating rna splicing
MX391850B (es) 2015-12-10 2025-03-19 Ptc Therapeutics Inc Compuestos para usarse en el tratamiento o mejoramiento de la enfermedad de huntington
WO2018098446A1 (en) 2016-11-28 2018-05-31 Ptc Therapeutics, Inc Methods for modulating rna splicing
SG11201810611YA (en) 2016-12-22 2018-12-28 Illumina Cambridge Ltd Coumarin compounds and their uses as fluorescent labels
CN108061725B (zh) * 2017-02-16 2020-04-21 昆明医科大学 1,8-萘啶基荧光分子探针在氯胺酮娱乐性滥用神经机制研究及成瘾程度诊断中的应用
AU2018282154B2 (en) 2017-06-05 2022-04-07 Ptc Therapeutics, Inc. Compounds for treating huntington's disease
CN111372611A (zh) 2017-06-14 2020-07-03 Ptc医疗公司 修饰rna剪接的方法
US11382918B2 (en) 2017-06-28 2022-07-12 Ptc Therapeutics, Inc. Methods for treating Huntington's Disease
EP3645121B8 (en) 2017-06-28 2025-06-18 PTC Therapeutics, Inc. Methods for treating huntington's disease
MX2020009957A (es) 2018-03-27 2021-01-15 Ptc Therapeutics Inc Compuestos para el tratamiento de enfermedad de hungtinton.
EA202092899A1 (ru) 2018-06-27 2021-05-14 ПиТиСи ТЕРАПЬЮТИКС, ИНК. Гетероарильные соединения для лечения болезни гентингтона
PL3814357T3 (pl) 2018-06-27 2024-09-16 Ptc Therapeutics, Inc. Związki heterocykliczne i heteroarylowe do leczenia choroby huntingtona
WO2020005882A1 (en) 2018-06-27 2020-01-02 Ptc Therapeutics, Inc. Heteroaryl compounds for treating huntington's disease
MY209343A (en) * 2019-03-01 2025-07-03 Illumina Cambridge Ltd Exocyclic amine substituted coumarin compounds and uses as fluorescent labels
KR20220022114A (ko) 2019-05-13 2022-02-24 피티씨 테라퓨틱스, 인크. 헌팅턴병 치료 화합물
CN112300201B (zh) * 2020-12-07 2021-11-23 南京林业大学 一种三聚茚基香豆素-咔咯-卟啉四元体系星型化合物的合成及其制备方法

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CH390250A (de) * 1958-06-19 1965-07-30 Geigy Ag J R Verfahren zur Herstellung von fluoreszierenden Farbstoffen
DE2065552A1 (de) * 1970-06-20 1974-03-07 Bayer Ag Oxazolyl-essigsaeurederivate
JPS5529110B2 (es) * 1972-12-25 1980-08-01
DE2410634A1 (de) * 1974-03-06 1975-09-18 Basf Ag 3-benzofurylcumarine
DE2411969A1 (de) * 1974-03-13 1975-09-25 Bayer Ag Farbstofflaser
DE2525986A1 (de) * 1975-06-11 1977-05-05 Bayer Ag Cumarinverbindungen
LU78311A1 (de) * 1977-10-13 1979-06-01 Ciba Geigy Ag Neue cumarinfarbstoffe,deren herstellung und verwendung
US4892922A (en) * 1987-11-30 1990-01-09 Eastman Kodak Company Polyester polymer containing the residue of a benzopyran colorant compound and shaped articles produced therefrom
JPH01169327A (ja) * 1987-12-25 1989-07-04 Mitsui Toatsu Chem Inc 紫外線検知用樹脂組成物
JP2999841B2 (ja) * 1991-04-03 2000-01-17 三井化学株式会社 発光スクリーン用樹脂組成物
EP0527433B1 (en) * 1991-08-13 1997-01-08 Bayer Corporation Novel fluorescent label
JPH073179A (ja) * 1993-06-15 1995-01-06 Nippon Kayaku Co Ltd インクジェットプリント用インク組成物及びこれを用いる染色法
JP4028155B2 (ja) 2000-04-11 2007-12-26 日本カーバイド工業株式会社 蛍光性再帰反射シート
GB0205281D0 (en) * 2002-03-06 2002-04-17 Novartis Ag Organic compounds

Also Published As

Publication number Publication date
ATE378333T1 (de) 2007-11-15
GB0205281D0 (en) 2002-04-17
ZA200405175B (en) 2005-06-21
NO20044174L (no) 2004-09-30
WO2003074519A1 (en) 2003-09-12
DE60317476D1 (de) 2007-12-27
US7569337B2 (en) 2009-08-04
AR038723A1 (es) 2005-01-26
KR20040095257A (ko) 2004-11-12
PE20030890A1 (es) 2003-12-05
US20050169837A1 (en) 2005-08-04
JP2009102322A (ja) 2009-05-14
PL370916A1 (en) 2005-06-13
AU2003210418A1 (en) 2003-09-16
EP1483262A1 (en) 2004-12-08
EP1483262B1 (en) 2007-11-14
BR0308211A (pt) 2004-12-21
JP2005526749A (ja) 2005-09-08
CN1628114A (zh) 2005-06-15
ES2294304T3 (es) 2008-04-01
DE60317476T2 (de) 2008-05-21
MXPA04008570A (es) 2004-12-06
RU2004129733A (ru) 2005-06-27
CO5611123A2 (es) 2006-02-28
TW200400049A (en) 2004-01-01
JP4247123B2 (ja) 2009-04-02
PT1483262E (pt) 2008-02-11
CA2472298A1 (en) 2003-09-12

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