BR0308211A - Cumarinas úteis como biomarcadores - Google Patents

Cumarinas úteis como biomarcadores

Info

Publication number
BR0308211A
BR0308211A BR0308211-3A BR0308211A BR0308211A BR 0308211 A BR0308211 A BR 0308211A BR 0308211 A BR0308211 A BR 0308211A BR 0308211 A BR0308211 A BR 0308211A
Authority
BR
Brazil
Prior art keywords
biomarkers
useful
coumarins
coumarins useful
formula
Prior art date
Application number
BR0308211-3A
Other languages
English (en)
Inventor
Yves Auberson
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9932424&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR0308211(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of BR0308211A publication Critical patent/BR0308211A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Sampling And Sample Adjustment (AREA)

Abstract

"CUMARINAS úTEIS COMO BIOMARCADORES". A invenção proporciona compostos de fórmula I em que R, R~ 1~, R~ 2~, R~ 3~ e R~ 4~ São como definidos na descrição, e a sua preparação. Os compostos de fórmula i são úteis como biomarcadores.
BR0308211-3A 2002-03-06 2003-03-05 Cumarinas úteis como biomarcadores BR0308211A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0205281.9A GB0205281D0 (en) 2002-03-06 2002-03-06 Organic compounds
PCT/EP2003/002251 WO2003074519A1 (en) 2002-03-06 2003-03-05 Coumarines useful as biomarkers

Publications (1)

Publication Number Publication Date
BR0308211A true BR0308211A (pt) 2004-12-21

Family

ID=9932424

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0308211-3A BR0308211A (pt) 2002-03-06 2003-03-05 Cumarinas úteis como biomarcadores

Country Status (24)

Country Link
US (1) US7569337B2 (pt)
EP (1) EP1483262B1 (pt)
JP (2) JP4247123B2 (pt)
KR (1) KR20040095257A (pt)
CN (1) CN1628114A (pt)
AR (1) AR038723A1 (pt)
AT (1) ATE378333T1 (pt)
AU (1) AU2003210418A1 (pt)
BR (1) BR0308211A (pt)
CA (1) CA2472298A1 (pt)
CO (1) CO5611123A2 (pt)
DE (1) DE60317476T2 (pt)
EC (1) ECSP045255A (pt)
ES (1) ES2294304T3 (pt)
GB (1) GB0205281D0 (pt)
MX (1) MXPA04008570A (pt)
NO (1) NO20044174L (pt)
PE (1) PE20030890A1 (pt)
PL (1) PL370916A1 (pt)
PT (1) PT1483262E (pt)
RU (1) RU2004129733A (pt)
TW (1) TW200400049A (pt)
WO (1) WO2003074519A1 (pt)
ZA (1) ZA200405175B (pt)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0205281D0 (en) * 2002-03-06 2002-04-17 Novartis Ag Organic compounds
JP2007504283A (ja) * 2003-05-20 2007-03-01 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア β−アミロイド斑に作用物質を結合させる方法
JP2007084526A (ja) * 2004-11-26 2007-04-05 Nagasaki Univ アミロイド関連疾患診断用組成物
EP1815872A4 (en) * 2004-11-26 2011-06-15 Univ Nagasaki COMPOSITION FOR THE DIAGNOSIS OF AMYLOID ASSOCIATED DISEASE
TW200803903A (en) * 2006-04-28 2008-01-16 Nihon Mediphysics Co Ltd Novel compound having affinity to amyloid
CA2653783A1 (en) * 2006-05-19 2007-11-29 Nihon Medi-Physics Co., Ltd. Novel compound having affinity for amyloid
CA2655826A1 (en) * 2006-06-21 2007-12-27 Nihon Medi-Physics Co., Ltd. Novel compound having affinity for amyloid
TW200811175A (en) * 2006-06-21 2008-03-01 Nihon Mediphysics Co Ltd Novel compound with affinity with amyloid
WO2008099800A1 (ja) 2007-02-13 2008-08-21 Nihon Medi-Physics Co., Ltd. 放射性画像診断剤の製造方法
AU2008314870A1 (en) * 2007-10-24 2009-04-30 Nihon Medi-Physics Co., Ltd. Novel compound having affinity for amyloid
EP2216050A4 (en) * 2007-10-30 2012-11-21 Nihon Mediphysics Co Ltd USE OF NEW COMPOUNDS WITH AMYLOID AFFINITY AND METHOD OF MANUFACTURING THEREOF
CA2704172A1 (en) * 2007-10-30 2009-05-07 Nihon Medi-Physics Co., Ltd. Use of novel compound having affinity for amyloid, and process for production of the same
BR112014016287B1 (pt) * 2011-12-30 2022-08-09 F. Hoffmann - La Roche Ag Composto e composição farmacêutica
EP2804852A2 (en) 2012-01-20 2014-11-26 Regents Of The University Of Minnesota Therapeutic compounds
ES2733644T3 (es) 2012-01-26 2019-12-02 Ptc Therapeutics Inc Compuestos para tratar atrofia muscular espinal
WO2013119916A2 (en) 2012-02-10 2013-08-15 Ptc Therapeutics, Inc. Compounds for treating spinal muscular atrophy
KR102099997B1 (ko) 2012-03-01 2020-04-13 피티씨 테라퓨틱스, 인크. 척수성 근위축증을 치료하기 위한 화합물
CA2868026C (en) 2012-03-23 2021-02-16 Ptc Therapeutics, Inc. Compounds for treating spinal muscular atrophy
CN104987328A (zh) * 2012-05-23 2015-10-21 复旦大学 7-氧、硫或氮杂取代香豆素及其衍生物和用途
EP3082820B1 (en) 2013-12-19 2022-07-20 PTC Therapeutics, Inc. Methods for modulating the amount of rna transcripts
EP4249472A3 (en) 2015-05-30 2023-12-13 PTC Therapeutics, Inc. Methods for modulating rna splicing
KR20220100719A (ko) 2015-12-10 2022-07-15 피티씨 테라퓨틱스, 인크. 헌팅턴병 치료 또는 개선을 위한 조성물
CA3043755A1 (en) 2016-11-28 2018-05-31 Ptc Therapeutics, Inc. Methods for modulating rna splicing
JP2020504074A (ja) * 2016-12-22 2020-02-06 イルミナ ケンブリッジ リミテッド クマリン化合物および蛍光標識としてのそれらの使用
CN108061725B (zh) * 2017-02-16 2020-04-21 昆明医科大学 1,8-萘啶基荧光分子探针在氯胺酮娱乐性滥用神经机制研究及成瘾程度诊断中的应用
WO2018226622A1 (en) 2017-06-05 2018-12-13 Ptc Therapeutics, Inc. Compounds for treating huntington's disease
EA202090034A1 (ru) 2017-06-14 2020-04-16 ПиТиСи ТЕРАПЬЮТИКС, ИНК. Способы модификации сплайсинга рнк
CA3067592A1 (en) 2017-06-28 2019-01-03 Ptc Therapeutics, Inc. Methods for treating huntington's disease
CN111182898B (zh) 2017-06-28 2024-04-16 Ptc医疗公司 用于治疗亨廷顿氏病的方法
EA202092001A1 (ru) 2018-03-27 2021-01-29 ПиТиСи ТЕРАПЬЮТИКС, ИНК. Соединения для лечения болезни гентингтона
WO2020005882A1 (en) 2018-06-27 2020-01-02 Ptc Therapeutics, Inc. Heteroaryl compounds for treating huntington's disease
SG11202012674PA (en) 2018-06-27 2021-01-28 Ptc Therapeutics Inc Heterocyclic and heteroaryl compounds for treating huntington's disease
WO2020178162A1 (en) * 2019-03-01 2020-09-10 Illumina Cambridge Limited Exocyclic amine-substituted coumarin compounds and their uses as fluorescent labels
CN112300201B (zh) * 2020-12-07 2021-11-23 南京林业大学 一种三聚茚基香豆素-咔咯-卟啉四元体系星型化合物的合成及其制备方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH390250A (de) * 1958-06-19 1965-07-30 Geigy Ag J R Verfahren zur Herstellung von fluoreszierenden Farbstoffen
DE2030507C3 (de) * 1970-06-20 1975-05-22 Bayer Ag, 5090 Leverkusen Oxazolyl-cumarine, deren Herstellung und Verwendung
JPS5529110B2 (pt) * 1972-12-25 1980-08-01
DE2410634A1 (de) * 1974-03-06 1975-09-18 Basf Ag 3-benzofurylcumarine
DE2411969A1 (de) * 1974-03-13 1975-09-25 Bayer Ag Farbstofflaser
DE2525986A1 (de) * 1975-06-11 1977-05-05 Bayer Ag Cumarinverbindungen
LU78311A1 (de) * 1977-10-13 1979-06-01 Ciba Geigy Ag Neue cumarinfarbstoffe,deren herstellung und verwendung
US4892922A (en) * 1987-11-30 1990-01-09 Eastman Kodak Company Polyester polymer containing the residue of a benzopyran colorant compound and shaped articles produced therefrom
JPH01169327A (ja) * 1987-12-25 1989-07-04 Mitsui Toatsu Chem Inc 紫外線検知用樹脂組成物
JP2999841B2 (ja) * 1991-04-03 2000-01-17 三井化学株式会社 発光スクリーン用樹脂組成物
ATE147400T1 (de) 1991-08-13 1997-01-15 Bayer Ag Fluoreszierendes etikett
JPH073179A (ja) * 1993-06-15 1995-01-06 Nippon Kayaku Co Ltd インクジェットプリント用インク組成物及びこれを用いる染色法
JP4028155B2 (ja) 2000-04-11 2007-12-26 日本カーバイド工業株式会社 蛍光性再帰反射シート
GB0205281D0 (en) * 2002-03-06 2002-04-17 Novartis Ag Organic compounds

Also Published As

Publication number Publication date
DE60317476D1 (de) 2007-12-27
CA2472298A1 (en) 2003-09-12
ZA200405175B (en) 2005-06-21
PE20030890A1 (es) 2003-12-05
TW200400049A (en) 2004-01-01
JP2009102322A (ja) 2009-05-14
ECSP045255A (es) 2004-09-28
EP1483262B1 (en) 2007-11-14
CN1628114A (zh) 2005-06-15
AR038723A1 (es) 2005-01-26
CO5611123A2 (es) 2006-02-28
NO20044174L (no) 2004-09-30
DE60317476T2 (de) 2008-05-21
EP1483262A1 (en) 2004-12-08
PL370916A1 (en) 2005-06-13
ES2294304T3 (es) 2008-04-01
WO2003074519A1 (en) 2003-09-12
KR20040095257A (ko) 2004-11-12
PT1483262E (pt) 2008-02-11
JP2005526749A (ja) 2005-09-08
US7569337B2 (en) 2009-08-04
AU2003210418A1 (en) 2003-09-16
RU2004129733A (ru) 2005-06-27
ATE378333T1 (de) 2007-11-15
US20050169837A1 (en) 2005-08-04
GB0205281D0 (en) 2002-04-17
JP4247123B2 (ja) 2009-04-02
MXPA04008570A (es) 2004-12-06

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7A E 8A ANUIDADE(S).

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2116 DE 26/07/2011.