BRPI0414599A - pirrol-indóis substituìdos - Google Patents

pirrol-indóis substituìdos

Info

Publication number
BRPI0414599A
BRPI0414599A BRPI0414599-2A BRPI0414599A BRPI0414599A BR PI0414599 A BRPI0414599 A BR PI0414599A BR PI0414599 A BRPI0414599 A BR PI0414599A BR PI0414599 A BRPI0414599 A BR PI0414599A
Authority
BR
Brazil
Prior art keywords
indoles
substituted pyrrol
substituted
pyrrol
substituted pyrrole
Prior art date
Application number
BRPI0414599-2A
Other languages
English (en)
Inventor
Baihua Hu
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of BRPI0414599A publication Critical patent/BRPI0414599A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Abstract

"PIRROL-INDóIS SUBSTITUìDOS COMO INIBIDORES DE PAI-1". A presente invenção refere-se aos pirrol-indóis substituídos da Fórmula 1 e métodos de usá-los como inibidores de PAI-1.
BRPI0414599-2A 2003-09-25 2004-09-24 pirrol-indóis substituìdos BRPI0414599A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US50582103P 2003-09-25 2003-09-25
US10/947,727 US7265148B2 (en) 2003-09-25 2004-09-23 Substituted pyrrole-indoles
PCT/US2004/031395 WO2005030756A1 (en) 2003-09-25 2004-09-24 Substituted pyrrole-indoles as inhibitors of pai-1

Publications (1)

Publication Number Publication Date
BRPI0414599A true BRPI0414599A (pt) 2006-11-07

Family

ID=34396270

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0414599-2A BRPI0414599A (pt) 2003-09-25 2004-09-24 pirrol-indóis substituìdos

Country Status (13)

Country Link
US (2) US7265148B2 (pt)
EP (1) EP1682530B1 (pt)
JP (1) JP2007506762A (pt)
AT (1) ATE361922T1 (pt)
AU (1) AU2004276311A1 (pt)
BR (1) BRPI0414599A (pt)
CA (1) CA2538355A1 (pt)
DE (1) DE602004006433T2 (pt)
DK (1) DK1682530T3 (pt)
ES (1) ES2285523T3 (pt)
MX (1) MXPA06003245A (pt)
PL (1) PL1682530T3 (pt)
WO (1) WO2005030756A1 (pt)

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DK1569900T3 (da) * 2002-12-10 2006-10-23 Wyeth Corp Substituerede 3-carbonyl-1-yl-eddikesyrederivater som inhibitorer af plasminogenaktivator-inhibitor-1 (PAI-1)
CA2509170A1 (en) * 2002-12-10 2004-06-24 Wyeth Substituted 3-alkyl and 3-arylalkyl 1h-indol-1-yl acetic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (pai-1)
US7446201B2 (en) * 2003-09-25 2008-11-04 Wyeth Substituted heteroaryl benzofuran acids
US7351726B2 (en) 2003-09-25 2008-04-01 Wyeth Substituted oxadiazolidinediones
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US7141592B2 (en) * 2003-09-25 2006-11-28 Wyeth Substituted oxadiazolidinediones
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KR20100097113A (ko) 2007-10-23 2010-09-02 가부시키가이샤 이야쿠 분지 셋케이 겐쿠쇼 Ｐａｉ－１ 생산 억제제
US8633245B2 (en) * 2008-04-11 2014-01-21 Institute Of Medicinal Molecular Design, Inc. PAI-1 inhibitor
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KR102261104B1 (ko) * 2012-12-26 2021-06-04 에스에프씨 주식회사 유기발광 화합물 및 이를 포함하는 유기전계발광소자
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Also Published As

Publication number Publication date
CA2538355A1 (en) 2005-04-07
EP1682530A1 (en) 2006-07-26
ES2285523T3 (es) 2007-11-16
DE602004006433T2 (de) 2008-01-10
AU2004276311A1 (en) 2005-04-07
WO2005030756A1 (en) 2005-04-07
EP1682530B1 (en) 2007-05-09
US7265148B2 (en) 2007-09-04
JP2007506762A (ja) 2007-03-22
MXPA06003245A (es) 2006-05-22
DK1682530T3 (da) 2007-07-16
ATE361922T1 (de) 2007-06-15
US20070299126A1 (en) 2007-12-27
PL1682530T3 (pl) 2007-09-28
US20050113439A1 (en) 2005-05-26
DE602004006433D1 (de) 2007-06-21

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