ID27884A - Asam-asam indolealkanoat yang disubstitusikan. - Google Patents

Asam-asam indolealkanoat yang disubstitusikan.

Info

Publication number
ID27884A
ID27884A IDW20002212A ID20002212A ID27884A ID 27884 A ID27884 A ID 27884A ID W20002212 A IDW20002212 A ID W20002212A ID 20002212 A ID20002212 A ID 20002212A ID 27884 A ID27884 A ID 27884A
Authority
ID
Indonesia
Prior art keywords
indolealanic
acids substituted
acids
substituted
indolealanic acids
Prior art date
Application number
IDW20002212A
Other languages
English (en)
Inventor
Michael Lee Jones
David Gunn
John Howard Jones
Michael C Van Zandt
Original Assignee
Inst For Pharm Discovery Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inst For Pharm Discovery Inc filed Critical Inst For Pharm Discovery Inc
Publication of ID27884A publication Critical patent/ID27884A/id

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Ophthalmology & Optometry (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
IDW20002212A 1998-03-31 1999-03-31 Asam-asam indolealkanoat yang disubstitusikan. ID27884A (id)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US8014398P 1998-03-31 1998-03-31

Publications (1)

Publication Number Publication Date
ID27884A true ID27884A (id) 2001-05-03

Family

ID=22155536

Family Applications (1)

Application Number Title Priority Date Filing Date
IDW20002212A ID27884A (id) 1998-03-31 1999-03-31 Asam-asam indolealkanoat yang disubstitusikan.

Country Status (29)

Country Link
US (9) US6214991B1 (id)
EP (1) EP1066283B1 (id)
JP (2) JP3494990B2 (id)
KR (1) KR100584650B1 (id)
CN (1) CN1205207C (id)
AP (1) AP2000001929A0 (id)
AT (1) ATE269861T1 (id)
AU (1) AU774929B2 (id)
BG (1) BG65446B1 (id)
BR (1) BR9909358A (id)
CA (1) CA2383983C (id)
CZ (1) CZ300706B6 (id)
DE (1) DE69918278T2 (id)
EE (1) EE200000573A (id)
ES (1) ES2224632T3 (id)
HU (1) HUP0101672A3 (id)
ID (1) ID27884A (id)
IL (2) IL138711A0 (id)
MX (1) MXPA02003122A (id)
NO (1) NO20004900L (id)
NZ (1) NZ507172A (id)
OA (1) OA11622A (id)
PL (1) PL201645B1 (id)
SK (1) SK7522001A3 (id)
TR (1) TR200002869T2 (id)
TW (1) TWI243163B (id)
WO (1) WO1999050268A2 (id)
YU (1) YU59600A (id)
ZA (1) ZA200005577B (id)

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TNSN99224A1 (fr) 1998-12-01 2005-11-10 Inst For Pharm Discovery Inc Methodes de reduction des niveaux de glucose et triglyceride en serum et pour suppression de l'antigenese utilisant les acides la indolealkanoique
EP1196380A2 (en) * 1999-07-15 2002-04-17 NPS Allelix Corp. Indoles and indazoles for the treatment of migraine
WO2001064205A2 (en) * 2000-03-02 2001-09-07 The Institutes For Pharmaceutical Discovery, Llc Compositions containing a substituted indolealkanoic acid and an angiotensin converting enzyme inhibitor
US20020012630A1 (en) * 2000-05-09 2002-01-31 James Nolan Methods for testing compounds useful in treating diabetic complications
CA2433100A1 (en) 2000-12-27 2002-07-04 Helmut Haning Indole derivatives as ligands of thyroid receptors
ATE367812T1 (de) 2001-06-20 2007-08-15 Wyeth Corp Substituierte indolsäurederivate als inhibitoren von plasminogen-aktivator-inhibitor-1 (pai-1)
TWI224101B (en) 2001-06-20 2004-11-21 Wyeth Corp Substituted naphthyl indole derivatives as inhibitors of plasminogen activator inhibitor type-1 (PAI-1)
AU2003210610B2 (en) 2002-01-18 2007-11-29 Aryx Therapeutics 5-HT3 receptor antagonists and methods of use
CA2395871A1 (en) * 2002-07-26 2004-01-26 The Institutes For Pharmaceutical Discovery, Llc Substituted indolealkanoic acids derivatives and formulations containing same for use in treatment of diabetic complications
KR20050026002A (ko) * 2002-07-26 2005-03-14 디 인스티튜트스 포 파마슈티컬 디스커버리, 엘엘씨 치환된 인돌알칸산 유도체 및 이를 함유하는 당뇨 합병증치료용 제형
ES2342596T3 (es) * 2002-08-29 2010-07-09 MERCK SHARP & DOHME CORP. Indoles con actividad anti-diabetica.
UA80453C2 (en) 2002-12-10 2007-09-25 Derivatives of substituted dyhydropyranoindol-3,4-dion as inhibitors of plasminogen activator inhibitor-1 (pai-1)
CA2509238A1 (en) 2002-12-10 2004-06-24 Wyeth Substituted 3-carbonyl-1h-indol-1-yl acetic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (pai-1)
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US7348351B2 (en) 2002-12-10 2008-03-25 Wyeth Substituted 3-alkyl and 3-arylalkyl 1H-indol-1yl acetic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1)
CA2509191A1 (en) 2002-12-10 2004-06-24 Wyeth Aryl, aryloxy, and alkyloxy substituted 1h-indol-3-yl glyoxylic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (pai-1)
CA2523245C (en) 2003-04-28 2012-03-06 Bayer Pharmaceuticals Corporation Indole acetic acid derivatives and their use as pharmaceutical agents
CN1812977A (zh) * 2003-04-30 2006-08-02 药物研发有限责任公司 取代羧酸
US7511145B2 (en) * 2003-08-01 2009-03-31 Genelabs Technologies, Inc. Bicyclic heteroaryl derivatives
US7411083B2 (en) 2003-09-25 2008-08-12 Wyeth Substituted acetic acid derivatives
US7163954B2 (en) 2003-09-25 2007-01-16 Wyeth Substituted naphthyl benzothiophene acids
US7446201B2 (en) 2003-09-25 2008-11-04 Wyeth Substituted heteroaryl benzofuran acids
US7582773B2 (en) 2003-09-25 2009-09-01 Wyeth Substituted phenyl indoles
US7265148B2 (en) 2003-09-25 2007-09-04 Wyeth Substituted pyrrole-indoles
US7332521B2 (en) 2003-09-25 2008-02-19 Wyeth Substituted indoles
US7268159B2 (en) 2003-09-25 2007-09-11 Wyeth Substituted indoles
US7141592B2 (en) 2003-09-25 2006-11-28 Wyeth Substituted oxadiazolidinediones
US7351726B2 (en) 2003-09-25 2008-04-01 Wyeth Substituted oxadiazolidinediones
US7442805B2 (en) 2003-09-25 2008-10-28 Wyeth Substituted sulfonamide-indoles
GB0324763D0 (en) * 2003-10-23 2003-11-26 Oxagen Ltd Use of compounds in therapy
US20060100251A1 (en) * 2004-10-28 2006-05-11 The Institutes For Pharmaceutical Discovery, Llc Substituted phenylalkanoic acids
WO2006076529A1 (en) * 2005-01-14 2006-07-20 Genelabs Technologies, Inc. Indole derivatives for treating viral infections
GB0505048D0 (en) * 2005-03-11 2005-04-20 Oxagen Ltd Compounds with PGD antagonist activity
US20080051384A1 (en) * 2006-07-14 2008-02-28 Genelabs Technologies, Inc. Antiviral agents
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US7750027B2 (en) * 2008-01-18 2010-07-06 Oxagen Limited Compounds having CRTH2 antagonist activity
MX2010007833A (es) 2008-01-18 2010-08-11 Oxagen Ltd Compuestos que tienen actividad antagonista de crth2.
JP2011509991A (ja) * 2008-01-22 2011-03-31 オキサジェン リミテッド Ｃｒｔｈ２アンタゴニスト活性を有する化合物
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GB2457040A (en) * 2008-01-30 2009-08-05 Oxagen Ltd 1-Acetic acid indole derivatives with PGD2 activity
AU2010241567B2 (en) 2009-04-29 2013-10-31 Amarin Pharmaceuticals Ireland Limited Pharmaceutical compositions comprising EPA and a cardiovascular agent and methods of using the same
HUE047346T2 (hu) * 2010-07-16 2020-04-28 Univ Columbia Aldóz reduktáz inhibitorok és alkalmazásuk
US8916563B2 (en) 2010-07-16 2014-12-23 The Trustees Of Columbia University In The City Of New York Aldose reductase inhibitors and uses thereof
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PT3757107T (pt) 2016-06-21 2023-12-14 Univ Columbia Compostos de 4-oxo-3,4-di-hidrotieno[3,4-d]piridazina como inibidores de aldose redutase e métodos de utilização dos mesmos
US11590131B2 (en) 2017-07-28 2023-02-28 Applied Therapeutics, Inc. Compositions and methods for treating galactosemia
WO2019191410A1 (en) * 2018-03-29 2019-10-03 H. Lee Moffitt Cancer Center And Research Institute, Inc. Inhibitors for the β-catenin / t-cell factor protein–protein interaction

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OA11622A (en) * 1998-03-31 2004-09-16 Inst For Pharm Discovery Inc Substituted indolealkanoic acids.
TNSN99224A1 (fr) 1998-12-01 2005-11-10 Inst For Pharm Discovery Inc Methodes de reduction des niveaux de glucose et triglyceride en serum et pour suppression de l'antigenese utilisant les acides la indolealkanoique
WO2001064205A2 (en) * 2000-03-02 2001-09-07 The Institutes For Pharmaceutical Discovery, Llc Compositions containing a substituted indolealkanoic acid and an angiotensin converting enzyme inhibitor

Also Published As

Publication number Publication date
US7659269B2 (en) 2010-02-09
WO1999050268A2 (en) 1999-10-07
US20100137301A1 (en) 2010-06-03
US6214991B1 (en) 2001-04-10
JP2002509931A (ja) 2002-04-02
US20030018053A1 (en) 2003-01-23
NZ507172A (en) 2003-10-31
ATE269861T1 (de) 2004-07-15
ZA200005577B (en) 2002-02-11
US7105514B2 (en) 2006-09-12
US6426344B2 (en) 2002-07-30
CN1205207C (zh) 2005-06-08
IL138711A (en) 2006-09-05
BR9909358A (pt) 2000-12-12
ES2224632T3 (es) 2005-03-01
CN1296485A (zh) 2001-05-23
OA11622A (en) 2004-09-16
US20120270912A1 (en) 2012-10-25
EP1066283A2 (en) 2001-01-10
EP1066283B1 (en) 2004-06-23
MXPA02003122A (es) 2004-04-21
AU3459599A (en) 1999-10-18
NO20004900L (no) 2000-10-17
KR100584650B1 (ko) 2006-05-30
US20070093530A1 (en) 2007-04-26
US20100324039A1 (en) 2010-12-23
CA2383983A1 (en) 1999-10-07
JP2003155274A (ja) 2003-05-27
PL201645B1 (pl) 2009-04-30
DE69918278T2 (de) 2005-07-14
KR20010042330A (ko) 2001-05-25
JP3494990B2 (ja) 2004-02-09
CZ300706B6 (cs) 2009-07-22
BG104819A (en) 2001-05-31
US6730794B2 (en) 2004-05-04
US20010016661A1 (en) 2001-08-23
CA2383983C (en) 2009-09-29
HUP0101672A2 (hu) 2002-04-29
US20080214540A1 (en) 2008-09-04
NO20004900D0 (no) 2000-09-29
EE200000573A (et) 2002-04-15
CZ20003607A3 (cs) 2001-03-14
AU774929B2 (en) 2004-07-15
US7304079B2 (en) 2007-12-04
US8163932B2 (en) 2012-04-24
HUP0101672A3 (en) 2002-05-28
BG65446B1 (bg) 2008-08-29
US20040235933A1 (en) 2004-11-25
WO1999050268A3 (en) 1999-12-16
PL348244A1 (en) 2002-05-20
AP2000001929A0 (en) 2000-09-30
IL138711A0 (en) 2001-10-31
TR200002869T2 (tr) 2000-12-21
SK7522001A3 (en) 2002-02-05
YU59600A (sh) 2002-12-10
DE69918278D1 (de) 2004-07-29
TWI243163B (en) 2005-11-11

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