DE69918278D1 - Substituierte indolalkansäure - Google Patents

Substituierte indolalkansäure

Info

Publication number
DE69918278D1
DE69918278D1 DE69918278T DE69918278T DE69918278D1 DE 69918278 D1 DE69918278 D1 DE 69918278D1 DE 69918278 T DE69918278 T DE 69918278T DE 69918278 T DE69918278 T DE 69918278T DE 69918278 D1 DE69918278 D1 DE 69918278D1
Authority
DE
Germany
Prior art keywords
indolalcanic
substituted
acid
substituted indolalcanic
indolalcanic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69918278T
Other languages
English (en)
Other versions
DE69918278T2 (de
Inventor
L Jones
David Gunn
Howard Jones
Zandt C Van
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institute for Pharmaceutical Discovery Inc
Institutes for Pharmaceutical Discovery Inc
Original Assignee
Institute for Pharmaceutical Discovery Inc
Institutes for Pharmaceutical Discovery Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institute for Pharmaceutical Discovery Inc, Institutes for Pharmaceutical Discovery Inc filed Critical Institute for Pharmaceutical Discovery Inc
Application granted granted Critical
Publication of DE69918278D1 publication Critical patent/DE69918278D1/de
Publication of DE69918278T2 publication Critical patent/DE69918278T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
DE69918278T 1998-03-31 1999-03-31 Substituierte indolalkansäure Expired - Lifetime DE69918278T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US8014398P 1998-03-31 1998-03-31
US80143P 1998-03-31
PCT/US1999/007116 WO1999050268A2 (en) 1998-03-31 1999-03-31 Substituted indolealkanoic acids

Publications (2)

Publication Number Publication Date
DE69918278D1 true DE69918278D1 (de) 2004-07-29
DE69918278T2 DE69918278T2 (de) 2005-07-14

Family

ID=22155536

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69918278T Expired - Lifetime DE69918278T2 (de) 1998-03-31 1999-03-31 Substituierte indolalkansäure

Country Status (29)

Country Link
US (9) US6214991B1 (de)
EP (1) EP1066283B1 (de)
JP (2) JP3494990B2 (de)
KR (1) KR100584650B1 (de)
CN (1) CN1205207C (de)
AP (1) AP2000001929A0 (de)
AT (1) ATE269861T1 (de)
AU (1) AU774929B2 (de)
BG (1) BG65446B1 (de)
BR (1) BR9909358A (de)
CA (1) CA2383983C (de)
CZ (1) CZ300706B6 (de)
DE (1) DE69918278T2 (de)
EE (1) EE200000573A (de)
ES (1) ES2224632T3 (de)
HU (1) HUP0101672A3 (de)
ID (1) ID27884A (de)
IL (2) IL138711A0 (de)
MX (1) MXPA02003122A (de)
NO (1) NO20004900L (de)
NZ (1) NZ507172A (de)
OA (1) OA11622A (de)
PL (1) PL201645B1 (de)
SK (1) SK7522001A3 (de)
TR (1) TR200002869T2 (de)
TW (1) TWI243163B (de)
WO (1) WO1999050268A2 (de)
YU (1) YU59600A (de)
ZA (1) ZA200005577B (de)

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WO2001085983A2 (en) * 2000-05-09 2001-11-15 The Institute For Pharmaceutical Discovery Llc Methods for testing compounds useful for treating diabetic complications
EP1347959A1 (de) 2000-12-27 2003-10-01 Bayer Aktiengesellschaft Indol-derivate
US7074817B2 (en) 2001-06-20 2006-07-11 Wyeth Substituted indole acid derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1)
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ATE356623T1 (de) 2002-01-18 2007-04-15 Aryx Therapeutics 5-ht3-rezeptorantagonisten und verwendungsverfahren
CA2395871A1 (en) * 2002-07-26 2004-01-26 The Institutes For Pharmaceutical Discovery, Llc Substituted indolealkanoic acids derivatives and formulations containing same for use in treatment of diabetic complications
CA2493755A1 (en) * 2002-07-26 2004-02-05 The Institutes For Pharmaceutical Discovery, Llc Substituted indolealkanoic acids derivative and formulations containing same for use in treatment of diabetic complications
CA2495943C (en) * 2002-08-29 2009-07-21 Merck & Co., Inc. Indoles having anti-diabetic activity
DE60306548T2 (de) 2002-12-10 2007-06-21 Wyeth Substituierte 3-carbonyl-1-yl-essigsäure-derivate als plasminogen aktivator inhibitor(pai-1) inhibitoren
JP2006510673A (ja) 2002-12-10 2006-03-30 ワイス プラスミノゲンアクティベータインヒビター１（ｐａｉ−１）のインヒビターとしての、アリール、アリールオキシ、および、アルキルオキシ置換１ｈ−インドール−３−イルグリオキシル酸誘導体
DE60306547T2 (de) 2002-12-10 2007-06-28 Wyeth Substituierte 3-alkyl- und 3-arylalkyl-1h-indol-1-yl-essigsäure-derivate als plasminogen-aktivator
DE60327550D1 (de) 2002-12-10 2009-06-18 Wyeth Corp Substituierte indoloxoacetylaminoessigsäurederivate als inhibitoren des plasminogenaktivatorinhibitors-1 (pai-1)
UA80453C2 (en) 2002-12-10 2007-09-25 Derivatives of substituted dyhydropyranoindol-3,4-dion as inhibitors of plasminogen activator inhibitor-1 (pai-1)
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US7582773B2 (en) 2003-09-25 2009-09-01 Wyeth Substituted phenyl indoles
US7268159B2 (en) 2003-09-25 2007-09-11 Wyeth Substituted indoles
US7442805B2 (en) 2003-09-25 2008-10-28 Wyeth Substituted sulfonamide-indoles
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US7332521B2 (en) 2003-09-25 2008-02-19 Wyeth Substituted indoles
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TNSN99224A1 (fr) * 1998-12-01 2005-11-10 Inst For Pharm Discovery Inc Methodes de reduction des niveaux de glucose et triglyceride en serum et pour suppression de l'antigenese utilisant les acides la indolealkanoique
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Also Published As

Publication number Publication date
WO1999050268A3 (en) 1999-12-16
NO20004900L (no) 2000-10-17
NO20004900D0 (no) 2000-09-29
US20010016661A1 (en) 2001-08-23
OA11622A (en) 2004-09-16
US20120270912A1 (en) 2012-10-25
HUP0101672A2 (hu) 2002-04-29
CZ300706B6 (cs) 2009-07-22
YU59600A (sh) 2002-12-10
WO1999050268A2 (en) 1999-10-07
US20070093530A1 (en) 2007-04-26
KR20010042330A (ko) 2001-05-25
US7659269B2 (en) 2010-02-09
AU774929B2 (en) 2004-07-15
ID27884A (id) 2001-05-03
EP1066283B1 (de) 2004-06-23
US20040235933A1 (en) 2004-11-25
TWI243163B (en) 2005-11-11
US7105514B2 (en) 2006-09-12
DE69918278T2 (de) 2005-07-14
ZA200005577B (en) 2002-02-11
JP2003155274A (ja) 2003-05-27
BG65446B1 (bg) 2008-08-29
US6730794B2 (en) 2004-05-04
SK7522001A3 (en) 2002-02-05
CA2383983A1 (en) 1999-10-07
EP1066283A2 (de) 2001-01-10
PL348244A1 (en) 2002-05-20
US8163932B2 (en) 2012-04-24
IL138711A (en) 2006-09-05
US20100324039A1 (en) 2010-12-23
CA2383983C (en) 2009-09-29
TR200002869T2 (tr) 2000-12-21
US20080214540A1 (en) 2008-09-04
JP2002509931A (ja) 2002-04-02
CN1296485A (zh) 2001-05-23
US20030018053A1 (en) 2003-01-23
MXPA02003122A (es) 2004-04-21
PL201645B1 (pl) 2009-04-30
ATE269861T1 (de) 2004-07-15
US6214991B1 (en) 2001-04-10
EE200000573A (et) 2002-04-15
JP3494990B2 (ja) 2004-02-09
US20100137301A1 (en) 2010-06-03
CZ20003607A3 (cs) 2001-03-14
AU3459599A (en) 1999-10-18
BG104819A (en) 2001-05-31
NZ507172A (en) 2003-10-31
AP2000001929A0 (en) 2000-09-30
KR100584650B1 (ko) 2006-05-30
HUP0101672A3 (en) 2002-05-28
ES2224632T3 (es) 2005-03-01
CN1205207C (zh) 2005-06-08
IL138711A0 (en) 2001-10-31
BR9909358A (pt) 2000-12-12
US7304079B2 (en) 2007-12-04
US6426344B2 (en) 2002-07-30

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