DE602004023105D1 - HERSTELLUNG VON 4,5-DIALKYL-3-ACYLPYRROL-2-CARBONS ANSCHLIEßENDE ACYLIERUNG - Google Patents

HERSTELLUNG VON 4,5-DIALKYL-3-ACYLPYRROL-2-CARBONS ANSCHLIEßENDE ACYLIERUNG

Info

Publication number
DE602004023105D1
DE602004023105D1 DE602004023105T DE602004023105T DE602004023105D1 DE 602004023105 D1 DE602004023105 D1 DE 602004023105D1 DE 602004023105 T DE602004023105 T DE 602004023105T DE 602004023105 T DE602004023105 T DE 602004023105T DE 602004023105 D1 DE602004023105 D1 DE 602004023105D1
Authority
DE
Germany
Prior art keywords
acylpyrrol
acylation
dialkyl
preparation
carbon connecting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602004023105T
Other languages
English (en)
Inventor
Michael Wallace
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vertex Pharmaceuticals Inc
Original Assignee
Vertex Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharmaceuticals Inc filed Critical Vertex Pharmaceuticals Inc
Publication of DE602004023105D1 publication Critical patent/DE602004023105D1/de
Anticipated expiration legal-status Critical
Active legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/40—2,5-Pyrrolidine-diones
    • C07D207/416—2,5-Pyrrolidine-diones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE602004023105T 2003-10-28 2004-10-28 HERSTELLUNG VON 4,5-DIALKYL-3-ACYLPYRROL-2-CARBONS ANSCHLIEßENDE ACYLIERUNG Active DE602004023105D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US51528303P 2003-10-28 2003-10-28
PCT/US2004/037985 WO2005042484A1 (en) 2003-10-28 2004-10-28 Preparation of 4,5-dialkyl-3-acyl-pyrrole-2-carboxylic acid derivatives by fischer-fink type synthesis and subsequent acylation

Publications (1)

Publication Number Publication Date
DE602004023105D1 true DE602004023105D1 (de) 2009-10-22

Family

ID=34549387

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602004023105T Active DE602004023105D1 (de) 2003-10-28 2004-10-28 HERSTELLUNG VON 4,5-DIALKYL-3-ACYLPYRROL-2-CARBONS ANSCHLIEßENDE ACYLIERUNG

Country Status (12)

Country Link
US (2) US7250520B2 (de)
EP (1) EP1678134B1 (de)
JP (2) JP4942485B2 (de)
KR (1) KR20060122872A (de)
CN (1) CN1894211A (de)
AT (1) ATE442355T1 (de)
AU (1) AU2004285972A1 (de)
DE (1) DE602004023105D1 (de)
ES (1) ES2330944T3 (de)
HK (1) HK1092134A1 (de)
IL (1) IL175253A0 (de)
WO (1) WO2005042484A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2409985A3 (de) 1996-10-18 2013-05-01 Vertex Pharmaceuticals Incorporated Inhibitoren von Serinproteasen, insbesondere von NS3-Protease des Hepatitis-C-Virus
SV2003000617A (es) * 2000-08-31 2003-01-13 Lilly Co Eli Inhibidores de la proteasa peptidomimetica ref. x-14912m
MY148123A (en) 2003-09-05 2013-02-28 Vertex Pharma Inhibitors of serine proteases, particularly hcv ns3-ns4a protease
US8399615B2 (en) 2005-08-19 2013-03-19 Vertex Pharmaceuticals Incorporated Processes and intermediates
AR055395A1 (es) 2005-08-26 2007-08-22 Vertex Pharma Compuestos inhibidores de la actividad de la serina proteasa ns3-ns4a del virus de la hepatitis c
US7964624B1 (en) 2005-08-26 2011-06-21 Vertex Pharmaceuticals Incorporated Inhibitors of serine proteases
CN102614490A (zh) 2006-02-27 2012-08-01 弗特克斯药品有限公司 包含vx-950的共晶体和包含所述共晶体的药物组合物
WO2007109080A2 (en) 2006-03-16 2007-09-27 Vertex Pharmaceuticals Incorporated Deuterated hepatitis c protease inhibitors
CA2679426A1 (en) 2007-02-27 2008-09-04 Luc Farmer Inhibitors of serine proteases
ATE542815T1 (de) 2007-02-27 2012-02-15 Vertex Pharma Kokristalle und pharmazeutische zusammensetzungen damit
JP5443360B2 (ja) 2007-08-30 2014-03-19 バーテックス ファーマシューティカルズ インコーポレイテッド 共結晶体およびそれを含む医薬組成物
EP2489346A1 (de) 2011-01-26 2012-08-22 NanotecMARIN GmbH Nahrungsergänzungsmittel und injizierbares Material zur Prophylaxe und Behandlung von Osteoporose und anderen Knochenerkrankungen
JP2015053226A (ja) 2013-09-09 2015-03-19 タイコエレクトロニクスジャパン合同会社 電気コネクタの端子、及び電気コネクタ
US10207974B1 (en) 2017-12-05 2019-02-19 Chevron Phillips Chemical Company Lp Synthesis of gamma dicarbonyl and pyrrole compounds

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL373399A1 (en) * 2002-04-11 2005-08-22 Vertex Pharmaceuticals Incorporated Inhibitors of serine proteases, particularly hcv ns3-ns4a protease
TW200510391A (en) * 2003-04-11 2005-03-16 Vertex Pharma Inhibitors of serine proteases, particularly HCV NS3-NS4A protease

Also Published As

Publication number Publication date
CN1894211A (zh) 2007-01-10
WO2005042484A1 (en) 2005-05-12
US20050143585A1 (en) 2005-06-30
JP2011231117A (ja) 2011-11-17
ATE442355T1 (de) 2009-09-15
US20080167480A1 (en) 2008-07-10
EP1678134A1 (de) 2006-07-12
JP2007509991A (ja) 2007-04-19
AU2004285972A1 (en) 2005-05-12
HK1092134A1 (en) 2007-02-02
IL175253A0 (en) 2006-09-05
JP4942485B2 (ja) 2012-05-30
EP1678134B1 (de) 2009-09-09
US7250520B2 (en) 2007-07-31
KR20060122872A (ko) 2006-11-30
ES2330944T3 (es) 2009-12-17

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition