TW200745039A - Isotopically substituted pantoprazole - Google Patents

Isotopically substituted pantoprazole

Info

Publication number
TW200745039A
TW200745039A TW095127342A TW95127342A TW200745039A TW 200745039 A TW200745039 A TW 200745039A TW 095127342 A TW095127342 A TW 095127342A TW 95127342 A TW95127342 A TW 95127342A TW 200745039 A TW200745039 A TW 200745039A
Authority
TW
Taiwan
Prior art keywords
pantoprazole
isotopically substituted
isotopically
substituted
compounds
Prior art date
Application number
TW095127342A
Other languages
Chinese (zh)
Other versions
TWI410409B (en
Inventor
Bernhard Kohl
Bernd Mueller
Dieter Haag
Wolfgang-Alexander Simon
Karl Zech
Michael David
Richter Oliver Von
Felix Huth
Original Assignee
Altana Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Altana Pharma Ag filed Critical Altana Pharma Ag
Publication of TW200745039A publication Critical patent/TW200745039A/en
Application granted granted Critical
Publication of TWI410409B publication Critical patent/TWI410409B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/69—Two or more oxygen atoms

Abstract

The invention relates to compounds of formula 1 and to medicaments comprising these compounds, further to intermediates of formula 2 and 3.
TW095127342A 2005-07-26 2006-07-26 Isotopically substituted pantoprazole TWI410409B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP05106874 2005-07-26

Publications (2)

Publication Number Publication Date
TW200745039A true TW200745039A (en) 2007-12-16
TWI410409B TWI410409B (en) 2013-10-01

Family

ID=35708921

Family Applications (1)

Application Number Title Priority Date Filing Date
TW095127342A TWI410409B (en) 2005-07-26 2006-07-26 Isotopically substituted pantoprazole

Country Status (8)

Country Link
EP (1) EP1912947A1 (en)
JP (1) JP5289951B2 (en)
CN (1) CN101268050B (en)
AR (1) AR054583A1 (en)
AU (1) AU2006274037B2 (en)
CA (1) CA2615678C (en)
TW (1) TWI410409B (en)
WO (1) WO2007012651A1 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2006274036B2 (en) * 2005-07-26 2012-05-24 Takeda Gmbh Isotopically substituted proton pump inhibitors
CA2624179A1 (en) * 2005-10-06 2007-04-12 Auspex Pharmaceuticals, Inc. Deuterated inhibitors of gastric h+, k+-atpase with enhanced therapeutic properties
JP5302200B2 (en) * 2006-10-23 2013-10-02 コンサート ファーマシューティカルズ インコーポレイテッド Oxazolidinone derivatives and methods of use
JP2010520291A (en) * 2007-03-07 2010-06-10 コンサート ファーマシューティカルズ インコーポレイテッド Deuterated piperazine derivatives as antianginal compounds
EP2152709B1 (en) * 2007-05-01 2012-02-22 Concert Pharmaceuticals Inc. Morphinan compounds
ES2951028T3 (en) 2007-05-01 2023-10-17 Sun Pharmaceutical Ind Inc Morphin compounds
KR20100047190A (en) * 2007-06-13 2010-05-07 오스펙스 파마슈티칼스, 인코포레이티드 Substituted piperazines
EP2242493B1 (en) * 2008-01-22 2013-06-05 Concert Pharmaceuticals Inc. Derivatives of gefitinib
JP5770997B2 (en) * 2009-12-09 2015-08-26 大塚製薬株式会社 Method for measuring metabolic function of CYP3A4
CN103349655B (en) * 2013-07-22 2015-04-29 南通广泰生化制品有限公司 Tamoxifen citrate enteric capsules
CA2959965A1 (en) * 2014-09-02 2016-03-10 Bhupinder Singh Pharmaceutical formulations comprising tetrahydrocurcumin and lipids
GB2560750A (en) * 2017-03-24 2018-09-26 Taher Darreh Shori Biological methods

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE7804231L (en) * 1978-04-14 1979-10-15 Haessle Ab Gastric acid secretion
ZA854287B (en) * 1984-06-16 1986-02-26 Byk Gulden Lomberg Chem Fab Dialkoxypyridines,process for their preparation,their use and medicaments containing them
DE69535592T2 (en) * 1994-03-25 2008-06-12 Isotechnika, Inc., Edmonton IMPROVING THE EFFECTIVENESS OF MEDICINES BY DEUTERIZATION
US6334997B1 (en) * 1994-03-25 2002-01-01 Isotechnika, Inc. Method of using deuterated calcium channel blockers
US6884429B2 (en) * 1997-09-05 2005-04-26 Isotechnika International Inc. Medical devices incorporating deuterated rapamycin for controlled delivery thereof
NO309305B1 (en) * 1999-02-19 2001-01-15 Norsk Hydro As Use of benzaldehyde derivatives in the manufacture of pharmaceutical preparations for the prevention and / or treatment of cancer, as well as certain new benzaldehyde derivatives
DE10123129A1 (en) * 2001-05-02 2002-11-14 Berolina Drug Dev Ab Svedala Deuterated 3-piperidinopropiophenones and medicinal products containing these compounds
DE10162121A1 (en) * 2001-12-12 2003-06-18 Berolina Drug Dev Ab Svedala Deuterated substituted pyrazolyl-benzenesulfonamides and drugs containing these compounds
AU2006274036B2 (en) * 2005-07-26 2012-05-24 Takeda Gmbh Isotopically substituted proton pump inhibitors

Also Published As

Publication number Publication date
CN101268050B (en) 2012-11-28
JP2009502872A (en) 2009-01-29
AU2006274037A1 (en) 2007-02-01
CA2615678A1 (en) 2007-02-01
AU2006274037B2 (en) 2012-04-26
CA2615678C (en) 2015-01-20
AR054583A1 (en) 2007-06-27
CN101268050A (en) 2008-09-17
EP1912947A1 (en) 2008-04-23
WO2007012651A1 (en) 2007-02-01
JP5289951B2 (en) 2013-09-11
TWI410409B (en) 2013-10-01

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Legal Events

Date Code Title Description
MM4A Annulment or lapse of patent due to non-payment of fees