TW200714596A - Isotopically substituted proton pump inhibitors - Google Patents

Isotopically substituted proton pump inhibitors

Info

Publication number
TW200714596A
TW200714596A TW095127340A TW95127340A TW200714596A TW 200714596 A TW200714596 A TW 200714596A TW 095127340 A TW095127340 A TW 095127340A TW 95127340 A TW95127340 A TW 95127340A TW 200714596 A TW200714596 A TW 200714596A
Authority
TW
Taiwan
Prior art keywords
proton pump
pump inhibitors
isotopically substituted
substituted proton
isotopically
Prior art date
Application number
TW095127340A
Other languages
Chinese (zh)
Other versions
TWI394750B (en
Inventor
Bernhard Kohl
Bernd Muller
Dieter Haag
Wolfgang-Alexander Simon
Karl Zech
Michael David
Richter Oliver Von
Felix Huth
Original Assignee
Altana Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Altana Pharma Ag filed Critical Altana Pharma Ag
Publication of TW200714596A publication Critical patent/TW200714596A/en
Application granted granted Critical
Publication of TWI394750B publication Critical patent/TWI394750B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/69—Two or more oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

The invention relates to benzimidazoles of formula 1 and to pharmaceutical compositions comprising these compounds, further to intermediates of formula 2 and 3.
TW095127340A 2005-07-26 2006-07-26 Isotopically substituted proton pump inhibitors TWI394750B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP05106868 2005-07-26

Publications (2)

Publication Number Publication Date
TW200714596A true TW200714596A (en) 2007-04-16
TWI394750B TWI394750B (en) 2013-05-01

Family

ID=35734406

Family Applications (1)

Application Number Title Priority Date Filing Date
TW095127340A TWI394750B (en) 2005-07-26 2006-07-26 Isotopically substituted proton pump inhibitors

Country Status (17)

Country Link
EP (1) EP1910293A1 (en)
JP (1) JP5448448B2 (en)
KR (1) KR101358509B1 (en)
CN (2) CN101268051B (en)
AR (1) AR054584A1 (en)
AU (1) AU2006274036B2 (en)
BR (1) BRPI0614039A2 (en)
CA (1) CA2615670C (en)
EA (1) EA016814B1 (en)
HK (2) HK1125098A1 (en)
IL (1) IL188773A (en)
MX (1) MX2008000901A (en)
NO (1) NO20080839L (en)
NZ (1) NZ565078A (en)
TW (1) TWI394750B (en)
WO (1) WO2007012650A1 (en)
ZA (1) ZA200800303B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2615678C (en) * 2005-07-26 2015-01-20 Nycomed Gmbh Isotopically substituted pantoprazole
BRPI0617987A2 (en) * 2005-10-06 2011-08-16 Auspex Pharmaceuticals Inc composition, pharmaceutical composition, effervescent dosage form, multiple unit oral oral pharmaceutical composition, extended release pharmaceutical dosage form, enteric coated pharmaceutical dosage form, stable pharmaceutical dosage form for oral administration to mammalian subjects, method for treating diseases acid-related diseases by inhibiting gastric acid secretion, method for treating a bacterial infection caused or caused by helicobacter pylori, process for preparing a compound of formula 3, process for preparing a compound of formula 5, use of a compound of formula 1 for the preparation of a medicament for treating gastric acid-related diseases by inhibiting gastric acid secretion, use of a compound of formula 1 for the preparation of a medicament for treating a bacterial infection caused or caused by helicobacter pyl or use of a compound of formula 1 for the preparation of a medicament for treating gastric acid-related diseases by inhibiting gastric acid secretion
WO2008127640A2 (en) * 2007-04-11 2008-10-23 Auspex Pharmaceuticals, Inc. Substituted benzimidazoles
WO2008130863A2 (en) * 2007-04-11 2008-10-30 Auspex Pharmaceuticals, Inc. Substituted benzimidazoles
CN102770423B (en) 2010-02-12 2014-10-15 埃斯特维化学股份有限公司 Preparation process of the sodium salt of esomeprazole
CN104530003A (en) * 2014-06-10 2015-04-22 广东东阳光药业有限公司 Preparation method of salts of pyridylmethyl sulfinyl-1H-benzimidazole compounds

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE7804231L (en) * 1978-04-14 1979-10-15 Haessle Ab Gastric acid secretion
JPH0643426B2 (en) * 1986-07-25 1994-06-08 東京田辺製薬株式会社 Imidazo [4,5-b] pyridine derivative, method for producing the same, and antiulcer agent containing the same
US6334997B1 (en) * 1994-03-25 2002-01-01 Isotechnika, Inc. Method of using deuterated calcium channel blockers
AU707748B2 (en) * 1994-03-25 1999-07-22 Isotechnika Inc. Enhancement of the efficacy of drugs by deuteration
US6884429B2 (en) * 1997-09-05 2005-04-26 Isotechnika International Inc. Medical devices incorporating deuterated rapamycin for controlled delivery thereof
NO309305B1 (en) * 1999-02-19 2001-01-15 Norsk Hydro As Use of benzaldehyde derivatives in the manufacture of pharmaceutical preparations for the prevention and / or treatment of cancer, as well as certain new benzaldehyde derivatives
DE10123129A1 (en) * 2001-05-02 2002-11-14 Berolina Drug Dev Ab Svedala Deuterated 3-piperidinopropiophenones and medicinal products containing these compounds
DE10162121A1 (en) * 2001-12-12 2003-06-18 Berolina Drug Dev Ab Svedala Deuterated substituted pyrazolyl-benzenesulfonamides and drugs containing these compounds
CA2615678C (en) * 2005-07-26 2015-01-20 Nycomed Gmbh Isotopically substituted pantoprazole

Also Published As

Publication number Publication date
CA2615670A1 (en) 2007-02-01
WO2007012650A1 (en) 2007-02-01
AR054584A1 (en) 2007-06-27
CN102134232B (en) 2012-11-21
AU2006274036A1 (en) 2007-02-01
IL188773A0 (en) 2008-08-07
CN101268051B (en) 2011-08-31
ZA200800303B (en) 2009-01-28
HK1125098A1 (en) 2009-07-31
MX2008000901A (en) 2008-03-26
NO20080839L (en) 2008-02-18
EP1910293A1 (en) 2008-04-16
KR20080037676A (en) 2008-04-30
NZ565078A (en) 2010-03-26
JP2009502871A (en) 2009-01-29
EA016814B1 (en) 2012-07-30
CA2615670C (en) 2015-01-20
AU2006274036B2 (en) 2012-05-24
KR101358509B1 (en) 2014-02-05
AU2006274036A2 (en) 2008-03-20
IL188773A (en) 2014-02-27
EA200800203A1 (en) 2008-08-29
CN101268051A (en) 2008-09-17
CN102134232A (en) 2011-07-27
HK1160126A1 (en) 2012-08-10
JP5448448B2 (en) 2014-03-19
TWI394750B (en) 2013-05-01
BRPI0614039A2 (en) 2011-03-09

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Legal Events

Date Code Title Description
MM4A Annulment or lapse of patent due to non-payment of fees