ATE442355T1 - Herstellung von 4,5-dialkyl-3-acylpyrrol-2- carbonsäurederivaten durch synthese nach fischer- fink und anschliebende acylierung - Google Patents
Herstellung von 4,5-dialkyl-3-acylpyrrol-2- carbonsäurederivaten durch synthese nach fischer- fink und anschliebende acylierungInfo
- Publication number
- ATE442355T1 ATE442355T1 AT04796917T AT04796917T ATE442355T1 AT E442355 T1 ATE442355 T1 AT E442355T1 AT 04796917 T AT04796917 T AT 04796917T AT 04796917 T AT04796917 T AT 04796917T AT E442355 T1 ATE442355 T1 AT E442355T1
- Authority
- AT
- Austria
- Prior art keywords
- synthesis
- acylpyrrol
- fink
- fischer
- dialkyl
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- 238000003786 synthesis reaction Methods 0.000 title abstract 2
- 230000010933 acylation Effects 0.000 title 1
- 238000005917 acylation reaction Methods 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 abstract 2
- 239000002243 precursor Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
- C07D207/40—2,5-Pyrrolidine-diones
- C07D207/416—2,5-Pyrrolidine-diones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51528303P | 2003-10-28 | 2003-10-28 | |
| PCT/US2004/037985 WO2005042484A1 (en) | 2003-10-28 | 2004-10-28 | Preparation of 4,5-dialkyl-3-acyl-pyrrole-2-carboxylic acid derivatives by fischer-fink type synthesis and subsequent acylation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE442355T1 true ATE442355T1 (de) | 2009-09-15 |
Family
ID=34549387
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04796917T ATE442355T1 (de) | 2003-10-28 | 2004-10-28 | Herstellung von 4,5-dialkyl-3-acylpyrrol-2- carbonsäurederivaten durch synthese nach fischer- fink und anschliebende acylierung |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US7250520B2 (de) |
| EP (1) | EP1678134B1 (de) |
| JP (2) | JP4942485B2 (de) |
| KR (1) | KR20060122872A (de) |
| CN (1) | CN1894211A (de) |
| AT (1) | ATE442355T1 (de) |
| AU (1) | AU2004285972A1 (de) |
| DE (1) | DE602004023105D1 (de) |
| ES (1) | ES2330944T3 (de) |
| IL (1) | IL175253A0 (de) |
| WO (1) | WO2005042484A1 (de) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ298749B6 (cs) | 1996-10-18 | 2008-01-16 | Vertex Pharmaceuticals Incorporated | Inhibitory serinových proteáz a farmaceutické prostředky s jejich obsahem |
| SV2003000617A (es) | 2000-08-31 | 2003-01-13 | Lilly Co Eli | Inhibidores de la proteasa peptidomimetica ref. x-14912m |
| TW201127828A (en) | 2003-09-05 | 2011-08-16 | Vertex Pharma | Inhibitors of serine proteases, particularly HCV NS3-NS4A protease |
| US8399615B2 (en) | 2005-08-19 | 2013-03-19 | Vertex Pharmaceuticals Incorporated | Processes and intermediates |
| US7964624B1 (en) | 2005-08-26 | 2011-06-21 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases |
| AR055395A1 (es) | 2005-08-26 | 2007-08-22 | Vertex Pharma | Compuestos inhibidores de la actividad de la serina proteasa ns3-ns4a del virus de la hepatitis c |
| CA2643688A1 (en) | 2006-02-27 | 2007-08-30 | Vertex Pharmaceuticals Incorporated | Co-crystals and pharmaceutical compositions comprising the same |
| US20070225297A1 (en) | 2006-03-16 | 2007-09-27 | Perni Robert B | Deuterated hepatitis C protease inhibitors |
| EP2134717A2 (de) | 2007-02-27 | 2009-12-23 | Vertex Pharmceuticals Incorporated | Serinprotease-hemmer |
| MX2009009182A (es) | 2007-02-27 | 2009-09-04 | Vertex Pharma | Co-cristales y composiciones farmaceuticas que los comprenden. |
| NZ583699A (en) | 2007-08-30 | 2012-04-27 | Vertex Pharma | Co-crystals of vx-950 (telaprevir) other components and pharmaceutical compositions comprising the same |
| EP2489346A1 (de) | 2011-01-26 | 2012-08-22 | NanotecMARIN GmbH | Nahrungsergänzungsmittel und injizierbares Material zur Prophylaxe und Behandlung von Osteoporose und anderen Knochenerkrankungen |
| JP2015053226A (ja) | 2013-09-09 | 2015-03-19 | タイコエレクトロニクスジャパン合同会社 | 電気コネクタの端子、及び電気コネクタ |
| US10207974B1 (en) | 2017-12-05 | 2019-02-19 | Chevron Phillips Chemical Company Lp | Synthesis of gamma dicarbonyl and pyrrole compounds |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ575692A (en) * | 2002-04-11 | 2009-10-30 | Vertex Pharma | Inhibitors of Serine Proteases, Particularly Hepatitis C Virus NS3-NS4 Protease |
| US7365092B2 (en) * | 2003-10-10 | 2008-04-29 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases, particularly HCV NS3-NS4A protease |
-
2004
- 2004-10-28 AT AT04796917T patent/ATE442355T1/de not_active IP Right Cessation
- 2004-10-28 ES ES04796917T patent/ES2330944T3/es not_active Expired - Lifetime
- 2004-10-28 WO PCT/US2004/037985 patent/WO2005042484A1/en not_active Ceased
- 2004-10-28 CN CNA2004800377619A patent/CN1894211A/zh active Pending
- 2004-10-28 AU AU2004285972A patent/AU2004285972A1/en not_active Abandoned
- 2004-10-28 EP EP04796917A patent/EP1678134B1/de not_active Expired - Lifetime
- 2004-10-28 JP JP2006538556A patent/JP4942485B2/ja not_active Expired - Fee Related
- 2004-10-28 DE DE602004023105T patent/DE602004023105D1/de not_active Expired - Lifetime
- 2004-10-28 KR KR1020067010241A patent/KR20060122872A/ko not_active Abandoned
- 2004-10-28 US US10/978,301 patent/US7250520B2/en not_active Expired - Fee Related
-
2006
- 2006-04-27 IL IL175253A patent/IL175253A0/en unknown
-
2007
- 2007-06-13 US US11/762,274 patent/US20080167480A1/en not_active Abandoned
-
2011
- 2011-06-14 JP JP2011131818A patent/JP2011231117A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US7250520B2 (en) | 2007-07-31 |
| EP1678134A1 (de) | 2006-07-12 |
| DE602004023105D1 (de) | 2009-10-22 |
| ES2330944T3 (es) | 2009-12-17 |
| CN1894211A (zh) | 2007-01-10 |
| KR20060122872A (ko) | 2006-11-30 |
| IL175253A0 (en) | 2006-09-05 |
| EP1678134B1 (de) | 2009-09-09 |
| JP2011231117A (ja) | 2011-11-17 |
| HK1092134A1 (en) | 2007-02-02 |
| WO2005042484A1 (en) | 2005-05-12 |
| US20080167480A1 (en) | 2008-07-10 |
| JP2007509991A (ja) | 2007-04-19 |
| US20050143585A1 (en) | 2005-06-30 |
| JP4942485B2 (ja) | 2012-05-30 |
| AU2004285972A1 (en) | 2005-05-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |