ATE421961T1 - Piperidinderivate, verfahren zu deren herstellung und pharmazeutische zusammensetzung zur behandlung von alzheimer-krankheit, die diese derivate enthält - Google Patents
Piperidinderivate, verfahren zu deren herstellung und pharmazeutische zusammensetzung zur behandlung von alzheimer-krankheit, die diese derivate enthältInfo
- Publication number
- ATE421961T1 ATE421961T1 AT02801599T AT02801599T ATE421961T1 AT E421961 T1 ATE421961 T1 AT E421961T1 AT 02801599 T AT02801599 T AT 02801599T AT 02801599 T AT02801599 T AT 02801599T AT E421961 T1 ATE421961 T1 AT E421961T1
- Authority
- AT
- Austria
- Prior art keywords
- derivatives
- alzheimer
- treatment
- production
- pharmaceutical composition
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Dermatology (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR20010063778 | 2001-10-16 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE421961T1 true ATE421961T1 (de) | 2009-02-15 |
Family
ID=19715173
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT02801599T ATE421961T1 (de) | 2001-10-16 | 2002-10-16 | Piperidinderivate, verfahren zu deren herstellung und pharmazeutische zusammensetzung zur behandlung von alzheimer-krankheit, die diese derivate enthält |
Country Status (8)
Country | Link |
---|---|
US (1) | US7288552B2 (de) |
EP (1) | EP1446400B1 (de) |
JP (1) | JP4179468B2 (de) |
KR (1) | KR100579813B1 (de) |
CN (1) | CN1301991C (de) |
AT (1) | ATE421961T1 (de) |
DE (1) | DE60231054D1 (de) |
WO (1) | WO2003033489A1 (de) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7189757B2 (en) | 2001-10-16 | 2007-03-13 | Hypnion, Inc. | Treatment of sleep disorders using CNS target modulators |
EP1443929A4 (de) | 2001-10-16 | 2008-02-06 | Hypnion Inc | Behandlung von zns-störungen mit zns-target-modulatoren |
US7355042B2 (en) | 2001-10-16 | 2008-04-08 | Hypnion, Inc. | Treatment of CNS disorders using CNS target modulators |
GB0316094D0 (en) | 2003-07-09 | 2003-08-13 | Neuropharma Sa | Acetylcholinesterase dual inhibitors |
WO2006008133A2 (en) * | 2004-07-20 | 2006-01-26 | Siena Biotech S.P.A. | Modulators of alpha7 nicotinic acetylcholine receptors and therapeutic uses thereof |
TW200901974A (en) | 2007-01-16 | 2009-01-16 | Wyeth Corp | Compounds, compositions, and methods of making and using them |
US9572820B2 (en) * | 2011-05-10 | 2017-02-21 | Stc.Unm | Methods of treating autophagy-associated disorders and related pharmaceutical compositions, diagnostics, screening techniques and kits |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS625956A (ja) * | 1985-07-02 | 1987-01-12 | Terumo Corp | ビニル誘導体およびこれを含有する5−リポキシゲナ−ゼ作用阻害剤 |
EP0637586B1 (de) * | 1993-08-05 | 1999-06-02 | HOECHST MARION ROUSSEL, Inc. | 2-(Piperidin-4-yl, Pyridin-4-yl und Tetrahydropyridin-4-yl)-benzofuran-7-carbamat Derivate, ihre Herstellung und Verwendung als Acetylcholinesterase Inhibitoren |
US5889006A (en) * | 1995-02-23 | 1999-03-30 | Schering Corporation | Muscarinic antagonists |
DE69733478T2 (de) * | 1996-08-15 | 2005-11-03 | Schering Corp. | Ether-muskarinantagonisten |
PT1209151E (pt) * | 1999-09-01 | 2007-05-31 | Eisai R&D Man Co Ltd | Derivados piperidina 4-substituídos. |
JP4242048B2 (ja) * | 1999-09-01 | 2009-03-18 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 4−置換ピペリジン誘導体 |
EP1443929A4 (de) * | 2001-10-16 | 2008-02-06 | Hypnion Inc | Behandlung von zns-störungen mit zns-target-modulatoren |
-
2001
- 2001-10-16 KR KR1020047005543A patent/KR100579813B1/ko not_active IP Right Cessation
-
2002
- 2002-10-16 AT AT02801599T patent/ATE421961T1/de not_active IP Right Cessation
- 2002-10-16 WO PCT/KR2002/001930 patent/WO2003033489A1/en active Application Filing
- 2002-10-16 EP EP02801599A patent/EP1446400B1/de not_active Expired - Lifetime
- 2002-10-16 DE DE60231054T patent/DE60231054D1/de not_active Expired - Lifetime
- 2002-10-16 US US10/492,984 patent/US7288552B2/en not_active Expired - Fee Related
- 2002-10-16 JP JP2003536229A patent/JP4179468B2/ja not_active Expired - Fee Related
- 2002-10-16 CN CNB028204670A patent/CN1301991C/zh not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JP2005505626A (ja) | 2005-02-24 |
KR100579813B1 (ko) | 2006-05-12 |
EP1446400A4 (de) | 2005-06-01 |
JP4179468B2 (ja) | 2008-11-12 |
US7288552B2 (en) | 2007-10-30 |
CN1301991C (zh) | 2007-02-28 |
EP1446400B1 (de) | 2009-01-28 |
WO2003033489A1 (en) | 2003-04-24 |
EP1446400A1 (de) | 2004-08-18 |
KR20040053173A (ko) | 2004-06-23 |
US20050043316A1 (en) | 2005-02-24 |
CN1571784A (zh) | 2005-01-26 |
DE60231054D1 (de) | 2009-03-19 |
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Legal Events
Date | Code | Title | Description |
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RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |