BR0211903A - Isoxazolopiridinonas - Google Patents

Isoxazolopiridinonas

Info

Publication number
BR0211903A
BR0211903A BR0211903-0A BR0211903A BR0211903A BR 0211903 A BR0211903 A BR 0211903A BR 0211903 A BR0211903 A BR 0211903A BR 0211903 A BR0211903 A BR 0211903A
Authority
BR
Brazil
Prior art keywords
isoxazolopyridinones
compounds
formula
pharmaceuticals
useful
Prior art date
Application number
BR0211903-0A
Other languages
English (en)
Inventor
Samuel Hintermann
Bastian Hengerer
Krosigk Ulrike Von
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of BR0211903A publication Critical patent/BR0211903A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

"ISOXAZOLOPIRIDINONAS". A presente invenção refere-se a compostos de fórmula I onde X, Y, R~ 1~, R~ 2~ e R~ 3~ são como definidos na descrição, e a preparação desses compostos. Os compostos de fórmula I são úteis como produtos farmacêuticos.
BR0211903-0A 2001-08-15 2002-08-14 Isoxazolopiridinonas BR0211903A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0119911.6A GB0119911D0 (en) 2001-08-15 2001-08-15 Organic Compounds
PCT/EP2002/009134 WO2003015780A2 (en) 2001-08-15 2002-08-14 Isoxazolopyridinones and use thereof in the treatment of parkinson's disease

Publications (1)

Publication Number Publication Date
BR0211903A true BR0211903A (pt) 2004-09-21

Family

ID=9920454

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0211903-0A BR0211903A (pt) 2001-08-15 2002-08-14 Isoxazolopiridinonas

Country Status (24)

Country Link
US (1) US7087756B2 (pt)
EP (1) EP1418912B1 (pt)
JP (1) JP2005501847A (pt)
KR (1) KR20040029429A (pt)
CN (1) CN100384418C (pt)
AR (1) AR036351A1 (pt)
AT (1) ATE355059T1 (pt)
BR (1) BR0211903A (pt)
CA (1) CA2454762A1 (pt)
CO (1) CO5560566A2 (pt)
DE (1) DE60218484T2 (pt)
EC (1) ECSP044971A (pt)
ES (1) ES2282467T3 (pt)
GB (1) GB0119911D0 (pt)
HU (1) HUP0401325A3 (pt)
IL (1) IL160018A0 (pt)
MX (1) MXPA04001419A (pt)
NO (1) NO20040659D0 (pt)
PE (1) PE20030356A1 (pt)
PL (1) PL366848A1 (pt)
PT (1) PT1418912E (pt)
RU (1) RU2004107847A (pt)
WO (1) WO2003015780A2 (pt)
ZA (1) ZA200400525B (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1408042A4 (en) * 2001-06-14 2005-02-02 Banyu Pharma Co Ltd NOVEL ISOXAZOLOPYRIDONE DERIVATIVES AND THEIR USE
RU2408589C2 (ru) * 2004-05-14 2011-01-10 Айрм Ллк Соединения и композиции в качестве модуляторов ppar-рецепторов, активируемых пролифератором пероксисом
EP1983988A2 (en) * 2006-02-16 2008-10-29 The McLean Hospital Corporation Methods and compositions for the treatment of parkinson's disease
US7666888B2 (en) 2006-07-20 2010-02-23 Amgen Inc. Substituted azole aromatic heterocycles as inhibitors of 11β-HSD-1
FR2906250B1 (fr) * 2006-09-22 2008-10-31 Sanofi Aventis Sa Derives de 2-aryl-6phenyl-imidazo(1,2-a) pyridines, leur preparation et leur application en therapeutique
FR2933609B1 (fr) 2008-07-10 2010-08-27 Fournier Lab Sa Utilisation de derives d'indole comme activateurs de nurr-1, pour le traitement de la maladie de parkinson.
CA2749585A1 (en) 2009-01-13 2010-07-22 Van Andel Research Institute Methods of using substituted isoxazolo pyridinones as dissociated glucocorticoids
FR2950053B1 (fr) 2009-09-11 2014-08-01 Fournier Lab Sa Utilisation de derives d'indole benzoique comme activateurs de nurr-1, pour le traitement de la maladie de parkinson
FR2955110A1 (fr) 2010-01-08 2011-07-15 Fournier Lab Sa Nouveaux derives de type pyrrolopyridine benzoique
DE102011085038A1 (de) 2011-10-21 2013-04-25 Tesa Se Verfahren zur Kapselung einer elektronischen Anordnung
WO2015048316A1 (en) 2013-09-25 2015-04-02 Van Andel Research Institute Highly potent glucocorticoids
KR20170033630A (ko) 2015-09-17 2017-03-27 (주)다올 도로용 경계블럭
WO2018071736A1 (en) 2016-10-14 2018-04-19 Van Andel Research Institute Structures and mechanism for the design of highly potent glucocorticoids

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE7602542L (sv) 1975-03-14 1976-09-15 Sandoz Ag 3-(alfa-iminobensyl)-4-hydroxi-2(lh)-pyridoner
US4064251A (en) * 1976-06-25 1977-12-20 Sandoz, Inc. Substituted hydroxy pyridones
US4049813A (en) * 1976-07-15 1977-09-20 Sandoz, Inc. Substituted isoxazolo pyridinones
US4238616A (en) * 1977-01-19 1980-12-09 Sandoz, Inc. 3-(Substituted)phenyl-5-(β-hydroxyphenethyl)-N-(alkyl)-isoxazole-4-carboxamides
DE2801190A1 (de) * 1977-01-19 1978-07-20 Sandoz Ag 3-(alpha-iminobenzyl)-4-hydroxy-2(1h)- pyridon-derivat
US4113727A (en) * 1977-04-26 1978-09-12 Sandoz, Inc. Process for the preparation of substituted isoxazolo[4,5-c]pyridin-4-(5H)-ones
EP1408042A4 (en) * 2001-06-14 2005-02-02 Banyu Pharma Co Ltd NOVEL ISOXAZOLOPYRIDONE DERIVATIVES AND THEIR USE

Also Published As

Publication number Publication date
EP1418912A2 (en) 2004-05-19
WO2003015780A3 (en) 2003-11-13
ZA200400525B (en) 2005-04-01
WO2003015780A8 (en) 2004-05-21
CN1635889A (zh) 2005-07-06
RU2004107847A (ru) 2005-05-10
PL366848A1 (en) 2005-02-07
US20040248893A1 (en) 2004-12-09
DE60218484D1 (de) 2007-04-12
NO20040659L (no) 2004-02-13
HUP0401325A3 (en) 2005-09-28
IL160018A0 (en) 2004-06-20
ECSP044971A (es) 2004-03-23
JP2005501847A (ja) 2005-01-20
PT1418912E (pt) 2007-05-31
WO2003015780A2 (en) 2003-02-27
CN100384418C (zh) 2008-04-30
ATE355059T1 (de) 2006-03-15
DE60218484T2 (de) 2007-11-15
GB0119911D0 (en) 2001-10-10
NO20040659D0 (no) 2004-02-13
PE20030356A1 (es) 2003-05-14
ES2282467T3 (es) 2007-10-16
CO5560566A2 (es) 2005-09-30
CA2454762A1 (en) 2003-02-27
AR036351A1 (es) 2004-09-01
MXPA04001419A (es) 2004-05-27
HUP0401325A2 (hu) 2004-10-28
EP1418912B1 (en) 2007-02-28
US7087756B2 (en) 2006-08-08
KR20040029429A (ko) 2004-04-06

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 9A ANUIDADE(S)

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2116 DE 26/07/2011.